DK114788A - Fremgangsmaade til fremstilling af et fysiologisk aktivt peptid - Google Patents

Fremgangsmaade til fremstilling af et fysiologisk aktivt peptid

Info

Publication number
DK114788A
DK114788A DK114788A DK114788A DK114788A DK 114788 A DK114788 A DK 114788A DK 114788 A DK114788 A DK 114788A DK 114788 A DK114788 A DK 114788A DK 114788 A DK114788 A DK 114788A
Authority
DK
Denmark
Prior art keywords
amino acid
target peptide
fusion protein
terminal
linker amino
Prior art date
Application number
DK114788A
Other languages
English (en)
Other versions
DK175535B1 (da
DK114788D0 (da
Inventor
Koji Magota
Takehiro Oshima
Shoji Tanaka
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Publication of DK114788D0 publication Critical patent/DK114788D0/da
Publication of DK114788A publication Critical patent/DK114788A/da
Application granted granted Critical
Publication of DK175535B1 publication Critical patent/DK175535B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
    • C12N9/2471—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cardiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK198801147A 1987-03-04 1988-03-03 Fremgangsmåde til fremstilling af et fysiologisk aktivt cysteinholdigt peptid DK175535B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4779687 1987-03-04
JP4779687 1987-03-04

Publications (3)

Publication Number Publication Date
DK114788D0 DK114788D0 (da) 1988-03-03
DK114788A true DK114788A (da) 1988-09-05
DK175535B1 DK175535B1 (da) 2004-11-29

Family

ID=12785332

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198801147A DK175535B1 (da) 1987-03-04 1988-03-03 Fremgangsmåde til fremstilling af et fysiologisk aktivt cysteinholdigt peptid

Country Status (11)

Country Link
US (1) US4987070A (da)
EP (1) EP0281418B1 (da)
JP (1) JPH0687788B2 (da)
AT (1) ATE117023T1 (da)
AU (1) AU607973B2 (da)
CA (1) CA1340830C (da)
DE (1) DE3852706T2 (da)
DK (1) DK175535B1 (da)
ES (1) ES2065907T3 (da)
GR (1) GR3015328T3 (da)
HU (1) HU210625B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3686365T3 (de) * 1985-06-20 2000-07-27 Fujisawa Pharmaceutical Co Herstellungsverfahren für humanes atriales natriuretisches Polypeptid.
DE3805150A1 (de) * 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE3716722A1 (de) * 1987-05-19 1988-12-01 Hoechst Ag Gentechnologisches verfahren zur herstellung von angiogeninen
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
JP2535398B2 (ja) * 1989-01-17 1996-09-18 サントリー株式会社 アミド化ペプチドの製造方法
CA2051375C (en) * 1989-05-04 2000-09-12 Dennis J. Henner Process and compositions for the isolation of human relaxin
US5202239A (en) * 1990-08-07 1993-04-13 Scios Nova Inc. Expression of recombinant polypeptides with improved purification
US6077694A (en) * 1990-09-21 2000-06-20 The United States Of America As Represented By The Department Of Health And Human Services Method for over-expression and rapid purification of biosynthetic proteins
US5525491A (en) * 1991-02-27 1996-06-11 Creative Biomolecules, Inc. Serine-rich peptide linkers
JP3531947B2 (ja) * 1991-08-19 2004-05-31 第一サントリーファーマ株式会社 ペプチドの製造方法
ATE253639T1 (de) * 1991-08-19 2003-11-15 Daiichi Suntory Pharma Co Ltd Verfahren zur herstellung von peptiden
US5795776A (en) * 1994-03-22 1998-08-18 Bio-Technology General Corp. Expression plasmids regulated by an OSMB promoter
EP0816510A4 (en) * 1995-12-22 2001-04-11 Toray Industries PROCESS FOR PRODUCING BIOLOGICALLY ACTIVE FUSED PROTEINS
EP2305815B1 (en) * 1998-07-10 2014-11-05 Scios, Inc. Method for producing a natriuretic peptide with a pI above 8 or below 5
BR9914519A (pt) * 1998-10-13 2001-07-03 Univ Georgia Res Found Peptìdios bioativos estabilizados e métodos de identificação, sìntese e uso
US20030190740A1 (en) 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
US20020090646A1 (en) * 2000-05-03 2002-07-11 Amgen Inc. Calcitonin-related molecules
AU783954B2 (en) 2000-05-10 2006-01-05 Asubio Pharma Co., Ltd. Method of inhibiting the formation of by-product in the production of genetically modified polypeptide
CN100427506C (zh) * 2001-07-26 2008-10-22 高级蛋白质技术公司 从融合多肽制备感兴趣的多肽的方法
AU2003244053A1 (en) * 2003-06-03 2005-01-21 Shanghai Centre Of Research And Development Of New Drugs A fusion protein suitable to be expressed high effectively and the production method thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO158880C (no) * 1977-11-08 1988-11-09 Genentech Inc Fremgangsmaate for fremstilling av et spesifikt pattedyrhormon.
NL7811040A (nl) * 1977-11-08 1979-05-10 Genentech Inc Synthetische dna en werkwijze ter bereiding daarvan.
BR7807290A (pt) * 1977-11-08 1979-06-12 Genentech Inc Plasmideo,processo para producao de um polipeptido especifico veiculo clonal,cultura bacteriana transformante,processo para produzir uma substancia imunogenica processo para preparar um gene estrutural,e polidesoxirribonucleotido de faixa dupla
US4431739A (en) * 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4769326A (en) * 1980-02-29 1988-09-06 The Regents Of The University Of California Expression linkers
JPS5869897A (ja) * 1981-10-20 1983-04-26 Gakuzo Tamura Ｄｎａ遺伝子
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
SE8300693L (sv) * 1983-02-09 1984-08-10 Sven Lofdahl Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
US4711844A (en) * 1983-03-09 1987-12-08 Cetus Corporation Modified signal peptides
GB8308483D0 (en) * 1983-03-28 1983-05-05 Health Lab Service Board Secretion of gene products
GB2140810B (en) * 1983-05-24 1987-07-08 Celltech Ltd Polypeptide and protein products, and process for their production
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
US4549986A (en) * 1983-12-23 1985-10-29 The Salk Institute For Biological Studies Human CGRP
US4736023A (en) * 1983-12-23 1988-04-05 The Salk Institute For Biological Studies DNA encoding human CGRP
JPH0672155B2 (ja) * 1984-08-24 1994-09-14 塩野義製薬株式会社 α−ｈＡＮＰ抗血清作製用ポリペプチド
GB8600754D0 (en) 1986-01-14 1986-02-19 Fujisawa Pharmaceutical Co Human atrial natriuretic polypeptide
DE3686365T3 (de) * 1985-06-20 2000-07-27 Fujisawa Pharmaceutical Co Herstellungsverfahren für humanes atriales natriuretisches Polypeptid.
GB8515686D0 (en) * 1985-06-20 1985-07-24 Fujisawa Pharmaceutical Co Production of-human atrial natriuretic polypeptide
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
DE3805150A1 (de) * 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden

Also Published As

Publication number Publication date
DK175535B1 (da) 2004-11-29
CA1340830C (en) 1999-11-30
EP0281418B1 (en) 1995-01-11
GR3015328T3 (en) 1995-06-30
DE3852706D1 (de) 1995-02-23
AU607973B2 (en) 1991-03-21
HUT46071A (en) 1988-09-28
JPS6410999A (en) 1989-01-13
ES2065907T3 (es) 1995-03-01
EP0281418A2 (en) 1988-09-07
DK114788D0 (da) 1988-03-03
AU1272488A (en) 1988-09-15
US4987070A (en) 1991-01-22
HU210625B (en) 1995-06-28
EP0281418A3 (en) 1989-04-26
JPH0687788B2 (ja) 1994-11-09
DE3852706T2 (de) 1995-05-24
ATE117023T1 (de) 1995-01-15

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