NO330532B1 - Immunogent preparat, vaksine fremstilt av dette, anvendelse for fremstilling av et medikament og fremgangsmate for fremstilling - Google Patents
Immunogent preparat, vaksine fremstilt av dette, anvendelse for fremstilling av et medikament og fremgangsmate for fremstilling Download PDFInfo
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- NO330532B1 NO330532B1 NO20014323A NO20014323A NO330532B1 NO 330532 B1 NO330532 B1 NO 330532B1 NO 20014323 A NO20014323 A NO 20014323A NO 20014323 A NO20014323 A NO 20014323A NO 330532 B1 NO330532 B1 NO 330532B1
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- protein
- polysaccharide
- vaccine
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- mpl
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB9906437.0A GB9906437D0 (en) | 1999-03-19 | 1999-03-19 | Vaccine |
| GBGB9909077.1A GB9909077D0 (en) | 1999-04-20 | 1999-04-20 | Novel compositions |
| GBGB9909466.6A GB9909466D0 (en) | 1999-04-23 | 1999-04-23 | Vaccines |
| GBGB9916677.9A GB9916677D0 (en) | 1999-07-15 | 1999-07-15 | Vaccine |
| PCT/EP2000/002467 WO2000056359A2 (en) | 1999-03-19 | 2000-03-17 | Vaccine against streptococcus pneumoniae |
Publications (3)
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| NO20014323D0 NO20014323D0 (no) | 2001-09-05 |
| NO20014323L NO20014323L (no) | 2001-11-14 |
| NO330532B1 true NO330532B1 (no) | 2011-05-09 |
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| NO20014322A NO20014322L (no) | 1999-03-19 | 2001-09-05 | Vaksine |
| NO20014325A NO330736B1 (no) | 1999-03-19 | 2001-09-05 | Immunogen sammensetning omfattende polysakkarid konjugat antigener, fremgangsmtae for fremstilling, vaksine og anvendelse av nevnte sammensetning. |
| NO2011014C NO2011014I1 (no) | 1999-03-19 | 2011-08-30 | Vaksine omfattende flere polysakkarid konjugat antigener som består av polysakkarid antigen fra streptococcus pneumoniae konjugert til protein D fra Haemophilus influenzae |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
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| NO20014322A NO20014322L (no) | 1999-03-19 | 2001-09-05 | Vaksine |
| NO20014325A NO330736B1 (no) | 1999-03-19 | 2001-09-05 | Immunogen sammensetning omfattende polysakkarid konjugat antigener, fremgangsmtae for fremstilling, vaksine og anvendelse av nevnte sammensetning. |
| NO2011014C NO2011014I1 (no) | 1999-03-19 | 2011-08-30 | Vaksine omfattende flere polysakkarid konjugat antigener som består av polysakkarid antigen fra streptococcus pneumoniae konjugert til protein D fra Haemophilus influenzae |
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| CN (3) | CN100339130C (de) |
| AR (3) | AR022965A1 (de) |
| AT (3) | ATE459373T1 (de) |
| AU (3) | AU750788B2 (de) |
| BE (1) | BE1025464I2 (de) |
| BR (4) | BR0009163A (de) |
| CA (3) | CA2366314C (de) |
| CY (3) | CY1107561T1 (de) |
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| IL (5) | IL145044A0 (de) |
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| MX (1) | MXPA01009452A (de) |
| MY (2) | MY125387A (de) |
| NL (1) | NL300415I1 (de) |
| NO (4) | NO330532B1 (de) |
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| PT (2) | PT1162999E (de) |
| SI (2) | SI1162999T1 (de) |
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| TW (3) | TWI286938B (de) |
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| US20030157129A1 (en) * | 1995-06-23 | 2003-08-21 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein |
| US7078042B2 (en) * | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| ATE355375T1 (de) | 1996-01-04 | 2006-03-15 | Novartis Vaccines & Diagnostic | Bakterioferritin aus helicobacter pylori |
| FR2763244B1 (fr) | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| US20010016200A1 (en) * | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| BR9910643A (pt) | 1998-05-22 | 2001-10-30 | Loeb Health Res Inst At The Ot | Processos e produtos para a indução de imunidadede mucosa |
| US6797275B1 (en) * | 1998-12-04 | 2004-09-28 | The United States Of America As Represented By The Department Of Health And Human Services | Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine |
| EP1880735A3 (de) * | 1999-03-19 | 2008-03-12 | GlaxoSmithKline Biologicals S.A. | Impfstoff |
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| GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| NZ593617A (en) | 2000-10-27 | 2012-04-27 | Novartis Vaccines & Diagnostic | Nucleic acids and proteins from streptococcus groups A & B |
| GB2370770B (en) * | 2001-01-03 | 2005-06-01 | Simon Connolly | Uses of Streptococcus Vaccines |
| US7082569B2 (en) | 2001-01-17 | 2006-07-25 | Outlooksoft Corporation | Systems and methods providing dynamic spreadsheet functionality |
| AP1897A (en) | 2001-01-23 | 2008-10-10 | Aventis Pasteur | Multivalent Meningococcal polysaccharide-Protein Conjugate Vaccine. |
| EP2269639B1 (de) | 2001-02-23 | 2018-11-28 | GlaxoSmithKline Biologicals s.a. | Influenza Vakzinzusammensetzungen zur intradermaler Verabreichung |
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| ES2386386T3 (es) | 2001-12-12 | 2012-08-20 | Novartis Vaccines And Diagnostics S.R.L. | Inmunización contra Chlamydia trachomatis |
| GB0130215D0 (en) * | 2001-12-18 | 2002-02-06 | Glaxosmithkline Biolog Sa | Vaccine |
| EP2572707A3 (de) | 2002-02-20 | 2013-11-06 | Novartis Vaccines and Diagnostics, Inc. | Mikropartikel mit adsorbierten polypeptidhaltigen Molekülen |
| MXPA04011249A (es) * | 2002-05-14 | 2005-06-06 | Chiron Srl | Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos. |
| CN1684707B (zh) * | 2002-05-14 | 2012-09-05 | 诺华疫苗和诊断有限公司 | 用于细菌性脑膜炎的粘膜结合疫苗 |
| GB0302218D0 (en) | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
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| HUE047780T2 (hu) | 2002-10-11 | 2020-05-28 | Glaxosmithkline Biologicals Sa | Polipeptid vakcinák hipervirulens meningokokkusz vonalak elleni széles-spektrumú védelemre |
| CN102174533A (zh) * | 2002-10-15 | 2011-09-07 | 英特塞尔股份公司 | 编码b族链球菌粘着因子的核酸、b族链球菌的粘着因子和它们的用途 |
| LT1556477T (lt) | 2002-11-01 | 2017-10-25 | Glaxosmithkline Biologicals S.A. | Džiovinimo būdas |
| MXPA05005045A (es) | 2002-11-12 | 2005-07-01 | Brigham & Womens Hospital | Vacuna de polisacarido para infecciones estafilococicas. |
| DK2279746T3 (da) | 2002-11-15 | 2013-11-25 | Novartis Vaccines & Diagnostic | Overfladeproteiner i neisseria meningitidis |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| EP1578954A4 (de) | 2002-12-11 | 2010-08-11 | Coley Pharm Group Inc | 5'-cpg-nukleinsäuren und verwendungsverfahren |
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| FR2850106B1 (fr) | 2003-01-17 | 2005-02-25 | Aventis Pasteur | Conjugues obtenus par amination reductrice du polysaccharide capsulaire du pneumocoque de serotype 5 |
| CN102302776B (zh) * | 2003-01-30 | 2014-06-18 | 诺华疫苗和诊断有限公司 | 抗多种脑膜炎球菌血清组的可注射性疫苗 |
| NZ561879A (en) | 2003-03-07 | 2009-05-31 | Wyeth Corp | Polysaccharide - staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections |
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| US7893096B2 (en) | 2003-03-28 | 2011-02-22 | Novartis Vaccines And Diagnostics, Inc. | Use of small molecule compounds for immunopotentiation |
| DE602004022286D1 (de) | 2003-06-02 | 2009-09-10 | Novartis Vaccines & Diagnostic | Immunogene zusammensetzungen auf basis von biologisch abbaubaren mikroteilchen enthaltend ein diphtherie- und ein tetanustoxoid |
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| EP2272531A3 (de) | 2004-04-30 | 2011-04-13 | Novartis Vaccines and Diagnostics S.r.l. | Integration von Meningokokkenkonjugatimpfstoff |
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| US7444197B2 (en) * | 2004-05-06 | 2008-10-28 | Smp Logic Systems Llc | Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes |
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| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| EP2583678A3 (de) | 2004-06-24 | 2013-11-13 | Novartis Vaccines and Diagnostics, Inc. | Immunstimulatoren kleiner Moleküle und Assays für deren Nachweis |
| JP2008504292A (ja) | 2004-06-24 | 2008-02-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド | 免疫増強用の化合物 |
| EP2612679A1 (de) | 2004-07-29 | 2013-07-10 | Novartis Vaccines and Diagnostics, Inc. | Immunogene Zusammensetzungen für grampositive Bakterien wie etwa Streptococcus agalactiae |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| US9034345B2 (en) | 2005-01-27 | 2015-05-19 | Children's Hospital & Research Center Oakland | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| PL2351772T3 (pl) | 2005-02-18 | 2017-01-31 | Glaxosmithkline Biologicals Sa | Białka i kwasy nukleinowe z bakterii Escherichia coli związanej z zapaleniem opon mózgowo-rdzeniowych/posocznicą |
| NZ560929A (en) | 2005-02-18 | 2009-12-24 | Novartis Vaccines & Diagnostic | Immunogens from uropathogenic escherichia coli |
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| US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| ES2382048T3 (es) * | 2005-04-08 | 2012-06-04 | Wyeth Llc | Composición conjugada de proteína-polisacárido neumococico multivante |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| BRPI0610297A2 (pt) | 2005-04-18 | 2010-06-08 | Novartis Vaccines & Diagnostic | expressão de antìgeno de superfìcie de vìrus da hepatite b para a preparação de vacina |
| DK2283857T3 (da) | 2005-06-27 | 2019-10-28 | Glaxosmithkline Biologicals Sa | Vaccinesammensætning omfattende konjugerede native N. Meningitidis kapselpolysaccharider |
| WO2007026249A2 (en) | 2005-09-01 | 2007-03-08 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Multiple vaccination including serogroup c meningococcus |
| GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
| US7527801B2 (en) | 2005-11-22 | 2009-05-05 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and Sapovirus antigens |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| TWI457133B (zh) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| TWI465248B (zh) * | 2005-12-22 | 2014-12-21 | Glaxosmithkline Biolog Sa | 包含莢膜醣結合物之肺炎鏈球菌免疫原組合物、包含其之疫苗及套組及其用途 |
| KR20080096775A (ko) * | 2006-01-17 | 2008-11-03 | 아르네 포르스그렌 | 표면 노출된 헤모필루스 인플루엔자 단백질 （단백질 Ｅ ―ｐＥ） |
| CN101024079B (zh) * | 2006-02-17 | 2012-02-01 | 福州昌晖生物工程有限公司 | 肺炎链球菌多糖-外膜蛋白结合疫苗及制备方法 |
| EP1993604B1 (de) * | 2006-03-17 | 2015-12-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Verfahren zum herstellen komplexer mehrwertiger immunogener konjugate |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| ES2383209T3 (es) | 2006-03-22 | 2012-06-19 | Novartis Ag | Regímenes para la inmunización con conjugados meningococicos |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| EP2357184B1 (de) | 2006-03-23 | 2015-02-25 | Novartis AG | Imidazochinoxalinverbindungen als Immunmodulatoren |
| CL2007000839A1 (es) * | 2006-03-30 | 2008-01-25 | Glaxosmithline Biolog S A | Procedimiento para producir un conjugado que comprende un polisacárido u oligosacárido de tipo 5 u 8 de s. aureus y una proteína portadora; conjugado inmunogénico que lo comprende; vacuna que comprende al conjugado; procedimiento de obtención de dicha vacuna; y uso del conjugado para tratar o prevenir la infección por estafilococos |
| EP2476434A1 (de) * | 2006-03-30 | 2012-07-18 | GlaxoSmithKline Biologicals S.A. | Immunogene Zusammensetzung |
| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| US20110206692A1 (en) * | 2006-06-09 | 2011-08-25 | Novartis Ag | Conformers of bacterial adhesins |
| GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
| EP2586790A3 (de) | 2006-08-16 | 2013-08-14 | Novartis AG | Immunogene von uropathogenen Escherichia coli |
| RU2460539C2 (ru) * | 2006-10-10 | 2012-09-10 | Вайет | СПОСОБ ОЧИСТКИ ПОЛИСАХАРИДОВ Streptococcus pneumoniae 3 ТИПА (ВАРИАНТЫ) |
| GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| EA200901578A1 (ru) * | 2007-06-26 | 2010-08-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| AU2008299376B2 (en) | 2007-09-12 | 2013-02-28 | Glaxosmithkline Biologicals S.A. | GAS57 mutant antigens and GAS57 antibodies |
| BRPI0818545A2 (pt) | 2007-10-19 | 2017-07-04 | Novartis Ag | formulações de vacinais meningocócicas |
| JP2011503104A (ja) | 2007-11-09 | 2011-01-27 | カリフォルニア インスティテュート オブ テクノロジー | 免疫調節化合物ならびに関連組成物および方法 |
| EP3067048B1 (de) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Zusammensetzungen zur induzierung von immunreaktionen |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| KR101773114B1 (ko) | 2007-12-21 | 2017-08-30 | 노파르티스 아게 | 스트렙토라이신 ｏ의 돌연변이 형태 |
| US8226959B2 (en) * | 2008-02-01 | 2012-07-24 | Newcastle Innovation Pty Ltd | Vaccine compositions |
| AU2009215364B2 (en) | 2008-02-21 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Meningococcal fHBP polypeptides |
| EP2631245A1 (de) | 2008-03-10 | 2013-08-28 | Children's Hospital & Research Center at Oakland | Chimere Faktor-H-bindende Proteine (FHBP), die eine heterologe B-Domäne enthalten, und Anwendungsverfahren |
| KR20110031393A (ko) | 2008-07-21 | 2011-03-25 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 합성 베타-1,6 글루코사민 올리고당에 관한 방법 및 조성물 |
| PL2349520T3 (pl) | 2008-10-27 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Sposób oczyszczania węglowodanów z paciorkowców grupy a |
| MX337723B (es) | 2008-12-09 | 2016-03-15 | Pfizer Vaccines Llc | Vacuna de peptido ch3 de ige. |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| EP2367568A2 (de) | 2008-12-17 | 2011-09-28 | Novartis AG | Meningokokken-impfstoffe mit hämoglobin-rezeptor |
| AU2010203223B9 (en) | 2009-01-05 | 2015-10-08 | Epitogenesis Inc. | Adjuvant compositions and methods of use |
| CA2749367A1 (en) | 2009-01-12 | 2010-07-15 | Novartis Ag | Cna_b domain antigens in vaccines against gram positive bacteria |
| EP2411045A1 (de) | 2009-03-24 | 2012-02-01 | Novartis AG | Kombinationen aus meningokokken-faktor-h-bindungsprotein und pneumokokken-saccharid-konjugaten |
| PT2411048T (pt) | 2009-03-24 | 2020-07-14 | Glaxosmithkline Biologicals Sa | Proteína de ligação ao fator h meningocócica com adjuvante |
| SG175092A1 (en) | 2009-04-14 | 2011-11-28 | Novartis Ag | Compositions for immunising against staphylococcus aerus |
| US8668911B2 (en) | 2009-05-14 | 2014-03-11 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
| US8568735B2 (en) | 2009-06-22 | 2013-10-29 | Wyeth Llc | Immunogenic compositions of Staphylococcus aureus antigens |
| PE20110065A1 (es) | 2009-06-22 | 2011-01-31 | Wyeth Llc | Composiciones y metodos para preparar composiciones inmunogenicas de conjugado de polisacarido capsular de staphylococcus aureus serotipos 5 y 8 |
| WO2011017101A2 (en) * | 2009-07-27 | 2011-02-10 | Fina Biosolutions, Llc | Method for producing protein-carbohydrate vaccines reduced in free carbohydrate |
| MX2012001194A (es) | 2009-07-30 | 2012-03-07 | Pfizer Vaccines Llc | Peptidos tau antigenicos y usos de los mismos. |
| BR112012004275A2 (pt) | 2009-08-27 | 2016-11-16 | Novartis Ag | polipeptídios híbridos incluindo sequências meningocócicas de fhbp |
| EP2865752A1 (de) * | 2009-09-03 | 2015-04-29 | Pfizer Vaccines LLC | PCSK9-Impfstoff |
| CA2773637A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| CN102917730A (zh) | 2009-10-27 | 2013-02-06 | 诺华有限公司 | 修饰的脑膜炎球菌fHBP多肽 |
| RU2579900C2 (ru) | 2009-10-30 | 2016-04-10 | Новартис Аг | Очистка капсульных сахаридов staphylococcus aureus типа 5 и типа 8 |
| GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
| MX2012006961A (es) * | 2009-12-17 | 2012-10-03 | Fina Biosolutions Llc | Reactivos quimicos para la activacion de polisacaridos en la preparacion de vacunas conjugadas. |
| CN107412754A (zh) | 2009-12-22 | 2017-12-01 | 塞尔德克斯医疗公司 | 疫苗组合物 |
| GB201003333D0 (en) | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| CN110845585A (zh) | 2010-03-30 | 2020-02-28 | 奥克兰儿童医院及研究中心 | 改性的h因子结合蛋白（fhbp）及其使用方法 |
| GB201005625D0 (en) | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
| HUE040658T2 (hu) | 2010-04-07 | 2019-03-28 | California Inst Of Techn | Vivõanyag vegyület mukózus membránhoz juttatásához és kapcsolódó készítmények, eljárások és rendszerek |
| EP2571982A4 (de) * | 2010-05-20 | 2014-01-01 | California Inst Of Techn | Antigenspezifische tregs sowie entsprechende zusammensetzungen, verfahren und systeme |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| DK2575870T3 (en) * | 2010-06-04 | 2017-02-13 | Wyeth Llc | vaccine Formulations |
| EP2575868A1 (de) | 2010-06-07 | 2013-04-10 | Pfizer Vaccines LLC | Ige-ch3-peptidimpfstoff |
| US8895017B2 (en) | 2010-06-07 | 2014-11-25 | Pfizer Inc. | HER-2 peptides and vaccines |
| US10478483B2 (en) | 2010-06-25 | 2019-11-19 | Glaxosmithkline Biologicals Sa | Combinations of meningococcal factor H binding proteins |
| GB201101665D0 (en) | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
| US20130315959A1 (en) | 2010-12-24 | 2013-11-28 | Novartis Ag | Compounds |
| US10286056B2 (en) | 2011-01-27 | 2019-05-14 | Glaxosmithkline Biologicals S.A. | Adjuvant nanoemulsions with crystallisation inhibitors |
| US20140112950A1 (en) | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| GB201103836D0 (en) | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
| US10357568B2 (en) | 2011-03-24 | 2019-07-23 | Glaxosmithkline Biologicals S.A. | Adjuvant nanoemulsions with phospholipids |
| EP2511295A1 (de) | 2011-04-15 | 2012-10-17 | Institut National De La Sante Et De La Recherche Medicale | Zusammensetzungen zur Vorbeugung und/oder Behandlung einer Infektion durch einen HIV-1-Virus |
| ES2686875T3 (es) | 2011-05-06 | 2018-10-22 | Aparin, Petr Gennadievich | Exopolisacárido de la bacteria Shigella sonnei, método para producirlo, vacuna y composición farmacéutica que lo contienen |
| CN107837394A (zh) | 2011-06-24 | 2018-03-27 | 埃皮托吉尼西斯有限公司 | 作为抗原特异性免疫调节剂的包含选择的载体、维生素、单宁和类黄酮的组合的药物组合物 |
| WO2013009564A1 (en) | 2011-07-08 | 2013-01-17 | Novartis Ag | Tyrosine ligation process |
| GB201114923D0 (en) | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
| TR201909110T4 (tr) | 2011-09-14 | 2019-07-22 | Glaxosmithkline Biologicals Sa | Sakarit-protein glikokonjugatları yapmaya yönelik yöntemler. |
| EP2757882B1 (de) | 2011-09-22 | 2020-11-04 | Merck Sharp & Dohme Corp. | Imidazopyridylverbindungen als aldosteronsynthasehemmer |
| US9493517B2 (en) | 2011-11-07 | 2016-11-15 | Glaxosmithkline Biologicals Sa | Conjugates comprising an antigen and a carrier molecule |
| GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
| DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
| EP2592137A1 (de) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentierungsmedium ohne Bestandteile tierischen Ursprungs zur Herstellung von Diphtherie-Impfstoffen zur menschlichen Impfung |
| RU2014127714A (ru) | 2011-12-08 | 2016-01-27 | Новартис Аг | ВАКЦИНА НА ОСНОВЕ ТОКСИНОВ Clostridium difficile |
| GB201121301D0 (en) | 2011-12-12 | 2012-01-25 | Novartis Ag | Method |
| JP2015505309A (ja) | 2011-12-29 | 2015-02-19 | ノバルティス アーゲー | 髄膜炎菌ｈ因子結合タンパク質のアジュバントされた組み合わせ |
| JP2015509713A (ja) | 2012-02-24 | 2015-04-02 | ノバルティス アーゲー | 線毛タンパク質および組成物 |
| EP2822586A1 (de) | 2012-03-07 | 2015-01-14 | Novartis AG | Adjuvierte formulierungen von streptococcus pneumoniae-antigenen |
| EP2822584A1 (de) | 2012-03-08 | 2015-01-14 | Novartis AG | Kombinationsimpfstoffe mit tlr4-agonisten |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| WO2013160335A2 (en) | 2012-04-26 | 2013-10-31 | Novartis Ag | Antigens and antigen combinations |
| US10279026B2 (en) | 2012-04-26 | 2019-05-07 | Glaxosmithkline Biologicals Sa | Antigens and antigen combinations |
| WO2013164754A2 (en) | 2012-05-04 | 2013-11-07 | Pfizer Inc. | Prostate-associated antigens and vaccine-based immunotherapy regimens |
| RU2014151567A (ru) | 2012-05-22 | 2016-07-10 | Новартис Аг | Конъюгат менингококка серогруппы х |
| KR102057217B1 (ko) * | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| EP2892553A1 (de) | 2012-09-06 | 2015-07-15 | Novartis AG | Kombinationsvakzine mit serogruppe-b-meningokokken und d/t/p |
| US9855325B2 (en) | 2012-10-03 | 2018-01-02 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| CA2886938A1 (en) | 2012-10-12 | 2014-04-17 | Glaxosmithkline Biologicals S.A. | Non-cross-linked acellular pertussis antigens for use in combination vaccines |
| US20140193451A1 (en) * | 2012-10-17 | 2014-07-10 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| JP6236086B2 (ja) * | 2012-10-17 | 2017-11-22 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | １種以上の肺炎球菌莢膜糖類コンジュゲートとインフルエンザ菌由来のタンパク質Ｅおよび／またはＰｉｌＡを含むタンパク質成分とを含む免疫原性組成物 |
| KR20140075201A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| EP2950819B1 (de) | 2013-02-01 | 2018-03-28 | GlaxoSmithKline Biologicals SA | Intradermale abgabe von immunologischen zusammensetzungen mit toll-like-rezeptor-agonisten |
| WO2014182966A1 (en) | 2013-05-10 | 2014-11-13 | California Institute Of Technology | Probiotic prevention and treatment of colon cancer |
| WO2015132619A1 (en) | 2013-05-15 | 2015-09-11 | The Governors Of The University Of Alberta | E1e2 hcv vaccines and methods of use |
| CN103386126B (zh) * | 2013-06-25 | 2015-06-17 | 北京科兴生物制品有限公司 | 一种含肠道病毒抗原的多价免疫原性组合物 |
| KR102199096B1 (ko) | 2013-09-08 | 2021-01-06 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
| WO2015095868A1 (en) * | 2013-12-20 | 2015-06-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| NZ760783A (en) | 2014-01-21 | 2023-07-28 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2015208820B2 (en) * | 2014-01-21 | 2020-05-14 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| EP3104877B1 (de) | 2014-02-11 | 2020-01-22 | The USA, as represented by The Secretary, Department of Health and Human Services | Pcsk9-impfstoff und verfahren zur verwendung davon |
| LT3110442T (lt) | 2014-02-28 | 2020-12-28 | Glaxosmithkline Biologicals Sa | Modifikuoti meningokokinio fhbp polipeptidai |
| EP2921856B1 (de) * | 2014-03-18 | 2016-09-14 | Serum Institute Of India Private Limited | Quantitativer test für 4-pyrrolidinopyridin (4-ppy) in konjugatimpfstoffen aus polysaccharid-protein |
| CN104829711B (zh) * | 2014-04-08 | 2018-04-03 | 北京天成新脉生物技术有限公司 | 脑膜炎球菌荚膜多糖单克隆抗体及其应用 |
| NZ766003A (en) | 2014-07-23 | 2024-01-26 | Children’S Hospital & Res Center At Oakland | Factor h binding protein variants and methods of use thereof |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| EP3034516A1 (de) | 2014-12-19 | 2016-06-22 | Novartis AG | Reinigung von Streptokokkenkapselpolysaccharid |
| IL252915B2 (en) | 2015-01-15 | 2024-04-01 | Pfizer | Immunogenic preparations for use in pneumococcal vaccines |
| CN104548090B (zh) * | 2015-01-27 | 2016-11-30 | 中国科学院过程工程研究所 | 一种β-葡聚糖修饰的脑膜炎多糖结合疫苗及其制备方法 |
| WO2016184963A1 (en) | 2015-05-19 | 2016-11-24 | Innavirvax | Treatment of hiv-infected individuals |
| US11331335B2 (en) | 2015-06-10 | 2022-05-17 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| EP3109255A1 (de) | 2015-06-26 | 2016-12-28 | Institut National De La Recherche Agronomique | Immunogene zusammensetzung |
| CN107849119A (zh) | 2015-07-07 | 2018-03-27 | 阿费里斯股份公司 | 用于治疗和预防IgE介导的疾病的疫苗 |
| AU2016295566B2 (en) | 2015-07-21 | 2019-06-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| EP3377098A1 (de) | 2015-11-20 | 2018-09-26 | Pfizer Inc | Immunogene zusammensetzungen zur verwendung in pneumokokkenimpfstoffen |
| JP7099956B2 (ja) | 2015-12-04 | 2022-07-12 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
| SG11201805621SA (en) | 2016-01-19 | 2018-08-30 | Pfizer | Cancer vaccines |
| WO2017175082A1 (en) | 2016-04-05 | 2017-10-12 | Gsk Vaccines S.R.L. | Immunogenic compositions |
| US11191822B2 (en) * | 2016-06-22 | 2021-12-07 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Pneumococcal polysaccharide-protein conjugate composition |
| JP7001686B2 (ja) | 2016-08-05 | 2022-02-04 | サノフィ パスツール インコーポレイティッド | 多価肺炎球菌多糖体－タンパク質コンジュゲート組成物 |
| TWI789357B (zh) | 2016-08-05 | 2023-01-11 | 南韓商Ｓｋ生物科技股份有限公司 | 多價肺炎球菌多醣-蛋白質共軛物組成物(二) |
| JP7104027B2 (ja) | 2016-09-02 | 2022-07-20 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 淋菌に対するワクチン |
| EP3522916A2 (de) | 2016-10-07 | 2019-08-14 | Enterome S.A. | Immunogene verbindungen zur krebstherapie |
| AU2017339577B2 (en) | 2016-10-07 | 2021-12-02 | Enterome S.A. | Immunogenic compounds for cancer therapy |
| BE1025162B9 (fr) | 2016-12-06 | 2019-01-07 | Glaxosmithkline Biologicals Sa | Procede de purification pour les polysaccharides capsulaires |
| BR112019014833A2 (pt) | 2017-01-20 | 2020-04-14 | Pfizer | composições imunogênicas para uso em vacinas pneumococais |
| CA3051801A1 (en) | 2017-01-31 | 2018-08-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| WO2018169303A1 (ko) * | 2017-03-15 | 2018-09-20 | 주식회사 엘지화학 | 다가 폐렴구균 백신 조성물 |
| CN110662557A (zh) | 2017-03-31 | 2020-01-07 | 葛兰素史克知识产权开发有限公司 | 免疫原性组合物、用途和治疗方法 |
| WO2018178265A1 (en) | 2017-03-31 | 2018-10-04 | Glaxosmithkline Intellectual Property Development Limited | Immunogenic composition, use and method of treatment |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| CA3066911C (en) | 2017-06-10 | 2022-05-24 | Inventprise, Llc | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
| CN110996994A (zh) | 2017-08-14 | 2020-04-10 | 葛兰素史密丝克莱恩生物有限公司 | 加强免疫应答的方法 |
| NZ765694A (en) | 2017-12-06 | 2024-03-22 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| JP6950099B2 (ja) | 2018-02-05 | 2021-10-13 | サノフィ パスツール インコーポレイティッド | 多価肺炎球菌多糖体−タンパク質複合体組成物 |
| CA3087572A1 (en) | 2018-02-05 | 2019-08-08 | Sanofi Pasteur Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11633471B2 (en) | 2018-03-06 | 2023-04-25 | Unm Rainforest Innovations | Compositions and methods for reducing serum triglycerides |
| EP3773689B1 (de) | 2018-04-11 | 2022-11-09 | Enterome S.A. | Antigene peptide zur prävention und behandlung von krebs |
| EP3773673A2 (de) | 2018-04-11 | 2021-02-17 | Enterome S.A. | Immunogene verbindungen zur behandlung von fibrose, autoimmunerkrankungen und entzündungen |
| JP2021522213A (ja) | 2018-04-18 | 2021-08-30 | エスケー バイオサイエンス カンパニー リミテッド | ストレプトコッカス・ニューモニエ莢膜多糖類及びその免疫原性接合体 |
| WO2020016322A1 (en) | 2018-07-19 | 2020-01-23 | Glaxosmithkline Biologicals Sa | Processes for preparing dried polysaccharides |
| MX2021001479A (es) | 2018-08-07 | 2021-04-28 | Glaxosmithkline Biologicals Sa | Novedosos procesos y vacunas. |
| US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| EP3894431A2 (de) | 2018-12-12 | 2021-10-20 | GlaxoSmithKline Biologicals SA | Modifizierte trägerproteine zur o-verknüpften glykosylierung |
| US20220016229A1 (en) | 2018-12-12 | 2022-01-20 | Pfizer Inc. | Immunogenic Multiple Hetero-Antigen Polysaccharide-Protein Conjugates and uses thereof |
| US20220296695A1 (en) | 2018-12-19 | 2022-09-22 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| WO2020165711A1 (en) | 2019-02-11 | 2020-08-20 | Pfizer Inc. | Neisseria meningitidiscompositions and methods thereof |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| CA3136278A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| EP3956666A1 (de) | 2019-04-18 | 2022-02-23 | GlaxoSmithKline Biologicals S.A. | Antigenbindendes protein und assays |
| WO2020229964A1 (en) | 2019-05-10 | 2020-11-19 | Glaxosmithkline Biologicals Sa | Conjugate production |
| MX2022001489A (es) | 2019-08-05 | 2022-03-02 | Glaxosmithkline Biologicals Sa | Proceso para la preparacion de una composicion que comprende un polipeptido de proteina d. |
| MX2022001488A (es) | 2019-08-05 | 2022-03-02 | Glaxosmithkline Biologicals Sa | Composicion inmunogenica. |
| EP4034157A1 (de) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria-meningitidis-zusammensetzungen und verfahren dafür |
| EP4045150A1 (de) | 2019-10-16 | 2022-08-24 | Enterome S.A. | Immunogene verbindungen zur behandlung von nebennierenkrebs |
| EP4051696A1 (de) | 2019-11-01 | 2022-09-07 | Pfizer Inc. | Escherichia-zusammensetzungen und verfahren dafür |
| JP2023501204A (ja) | 2019-11-15 | 2023-01-18 | エンテローム エスエー | Ｂ細胞悪性腫瘍の予防及び治療のための抗原性ペプチド |
| JP2023503086A (ja) | 2019-11-22 | 2023-01-26 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 細菌サッカリド複合糖質ワクチンの用法及び用量 |
| US20220409539A1 (en) * | 2019-12-30 | 2022-12-29 | Fraunhofer Usa Inc. | Particles for multi-dose delivery |
| US20230085173A1 (en) | 2020-02-21 | 2023-03-16 | Pfizer Inc. | Purification of saccharides |
| EP4107170A2 (de) | 2020-02-23 | 2022-12-28 | Pfizer Inc. | <smallcaps/>? ? escherichia coli ? ? ? -zusammensetzungen und verfahren dafür |
| CN111588847B (zh) * | 2020-05-18 | 2023-05-26 | 广州中医药大学(广州中医药研究院) | 一种含有单磷酸化的脂质a与糖抗原的缀合物及其制备方法和应用 |
| US20230250142A1 (en) | 2020-06-12 | 2023-08-10 | Glaxosmithkline Biologicals Sa | Dock tag system |
| CA3199610A1 (en) | 2020-10-27 | 2022-05-05 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| WO2022097010A1 (en) | 2020-11-04 | 2022-05-12 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| JP2023549736A (ja) | 2020-11-10 | 2023-11-29 | ファイザー・インク | コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用 |
| US20220202923A1 (en) | 2020-12-23 | 2022-06-30 | Pfizer Inc. | E. coli fimh mutants and uses thereof |
| MX2023009728A (es) | 2021-02-19 | 2023-08-30 | Sanofi Pasteur Inc | Vacuna recombinante meningococica b. |
| WO2022175423A1 (en) | 2021-02-22 | 2022-08-25 | Glaxosmithkline Biologicals Sa | Immunogenic composition, use and methods |
| EP4070814A1 (de) | 2021-04-07 | 2022-10-12 | Lama France | Sars-cov-2-polypeptide und verwendungen davon |
| TW202306969A (zh) | 2021-05-28 | 2023-02-16 | 美商輝瑞大藥廠 | 包含結合之莢膜醣抗原的免疫原組合物及其用途 |
| CA3221074A1 (en) | 2021-05-28 | 2022-12-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CA3237496A1 (en) | 2021-11-18 | 2023-05-25 | Matrivax, Inc. | Immunogenic fusion protein compositions and methods of use thereof |
| WO2023135515A1 (en) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| KR20230116601A (ko) | 2022-01-28 | 2023-08-04 | 이동민 | 머신 좌표계와 영상 좌표계의 정합 방법 및 장치 |
| WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
| WO2023187127A1 (en) | 2022-03-31 | 2023-10-05 | Enterome S.A. | Antigenic peptides for prevention and treatment of cancer |
| WO2023218322A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Process for producing of vaccine formulations with preservatives |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US5360897A (en) * | 1981-08-31 | 1994-11-01 | The University Of Rochester | Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad |
| US4761283A (en) * | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US5173294A (en) | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| MC2178A1 (fr) | 1988-12-16 | 1992-05-22 | Nederlanden Staat | Mutants de la pneumolysine et vaccins a base de pneumocoque prepares a partir de ces mutants |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| NZ239643A (en) * | 1990-09-17 | 1996-05-28 | North American Vaccine Inc | Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group. |
| CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| US6592876B1 (en) | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| US5476929A (en) | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
| US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
| SG90042A1 (en) | 1992-06-25 | 2002-07-23 | Smithkline Beecham Biolog | Vaccine composition containing adjuvants |
| WO1994006465A1 (en) * | 1992-09-16 | 1994-03-31 | The University Of Tennessee Research Corporation | Antigen of hybrid m protein and carrier for group a streptococcal vaccine |
| WO1994021292A1 (en) | 1993-03-23 | 1994-09-29 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-o deacylated monophosphoryl lipid a |
| ATE226831T1 (de) | 1993-05-18 | 2002-11-15 | Univ Ohio State Res Found | Impfstoff gegen mittelohrentzündung |
| CA2171942C (en) | 1993-09-22 | 2010-12-14 | Andrew Lees | Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| JP3468773B2 (ja) | 1994-07-15 | 2003-11-17 | ザ ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 免疫調節オリゴヌクレオチド |
| US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| US5681570A (en) * | 1995-01-12 | 1997-10-28 | Connaught Laboratories Limited | Immunogenic conjugate molecules |
| NZ306316A (en) * | 1995-04-17 | 2001-06-29 | Smithkline Beecham Biolog S | use of lipoprotein and a type 2T independent antigen to induce an immune response to the antigen |
| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US6440425B1 (en) | 1995-05-01 | 2002-08-27 | Aventis Pasteur Limited | High molecular weight major outer membrane protein of moraxella |
| US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
| EP0831901B2 (de) | 1995-06-07 | 2005-12-07 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vakzine mit einem polysaccharide antigen-trägerprotein konjugat und freien trägerprotein |
| US5736533A (en) * | 1995-06-07 | 1998-04-07 | Neose Technologies, Inc. | Bacterial inhibition with an oligosaccharide compound |
| AP9701163A0 (en) | 1995-06-07 | 1998-01-31 | Biochem Vaccines Inc | Streptococcal heat shock proteins members of the HSP70 family. |
| GB9513074D0 (en) | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
| US6290970B1 (en) | 1995-10-11 | 2001-09-18 | Aventis Pasteur Limited | Transferrin receptor protein of Moraxella |
| US6090576A (en) | 1996-03-08 | 2000-07-18 | Connaught Laboratories Limited | DNA encoding a transferrin receptor of Moraxella |
| SE9601158D0 (sv) | 1996-03-26 | 1996-03-26 | Stefan Svenson | Method of producing immunogenic products and vaccines |
| JP2000511411A (ja) | 1996-05-01 | 2000-09-05 | ザ ロックフェラー ユニヴァーシティ | 抗―肺炎球菌ワクチン用のコリン結合タンパク質 |
| US6245335B1 (en) * | 1996-05-01 | 2001-06-12 | The Rockefeller University | Choline binding proteins for anti-pneumococcal vaccines |
| US7341727B1 (en) | 1996-05-03 | 2008-03-11 | Emergent Product Development Gaithersburg Inc. | M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same |
| JPH102001A (ja) * | 1996-06-15 | 1998-01-06 | Okajima Kogyo Kk | グレーチング |
| US5882871A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | Saliva binding protein |
| US5882896A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
| FR2763244B1 (fr) | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| JP2001502925A (ja) | 1997-06-03 | 2001-03-06 | コノート ラボラトリーズ リミテッド | モラクセラのラクトフェリン受容体遺伝子 |
| EP0998557A2 (de) | 1997-07-21 | 2000-05-10 | North American Vaccine, Inc. | Modifizierte immunogene pneumolysin, deren zusammensetzungen und deren verwendungen als impfung |
| US6224880B1 (en) * | 1997-09-24 | 2001-05-01 | Merck & Co., Inc. | Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines |
| US20050031638A1 (en) * | 1997-12-24 | 2005-02-10 | Smithkline Beecham Biologicals S.A. | Vaccine |
| GB9727262D0 (en) * | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| US6709658B1 (en) * | 1998-02-12 | 2004-03-23 | Wyeth Holdings Corporation | Pneumococcal vaccines formulated with interleukin-12 |
| EP1067962B1 (de) | 1998-04-07 | 2010-03-24 | MedImmune, LLC | Choline-bindende proteine derivate aus pneumokoken als impfstoff |
| GB9812613D0 (en) | 1998-06-11 | 1998-08-12 | Smithkline Beecham Biolog | Vaccine |
| NZ509986A (en) | 1998-08-19 | 2003-10-31 | Baxter Healthcare S | Immunogenic beta-propionamido-linked polysaccharide and oligosaccharide protein conjugates as vaccines |
| EP1140157B1 (de) * | 1998-12-21 | 2009-02-18 | MedImmune, Inc. | Streptococcus pneumoniae proteine und immunogene fragmente für impstoffe |
| GB9909077D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Biolog | Novel compositions |
| EP1880735A3 (de) * | 1999-03-19 | 2008-03-12 | GlaxoSmithKline Biologicals S.A. | Impfstoff |
| GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| CN201252175Y (zh) * | 2008-08-04 | 2009-06-03 | 富士康(昆山)电脑接插件有限公司 | 线缆连接器组件 |
-
2000
- 2000-03-17 EP EP07119247A patent/EP1880735A3/de not_active Withdrawn
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2005
- 2005-08-31 US US11/216,226 patent/US20060002961A1/en not_active Abandoned
- 2005-09-30 US US11/240,193 patent/US20060093626A1/en not_active Abandoned
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2007
- 2007-02-21 CY CY20071100247T patent/CY1107561T1/el unknown
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2008
- 2008-04-10 CY CY20081100394T patent/CY1107390T1/el unknown
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2009
- 2009-09-24 NL NL300415C patent/NL300415I1/nl unknown
- 2009-09-24 CY CY2009014C patent/CY2009014I1/el unknown
- 2009-09-24 BE BE2009C043C patent/BE1025464I2/fr unknown
- 2009-11-05 US US12/612,988 patent/US8926985B2/en not_active Expired - Lifetime
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2010
- 2010-02-11 LU LU91652C patent/LU91652I2/fr unknown
- 2010-02-16 FR FR10C0008C patent/FR10C0008I2/fr active Active
- 2010-06-03 US US12/793,408 patent/US20100291138A1/en not_active Abandoned
- 2010-12-21 US US12/973,899 patent/US20110217329A1/en not_active Abandoned
- 2010-12-24 JP JP2010288197A patent/JP5551579B2/ja not_active Expired - Fee Related
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2011
- 2011-08-30 NO NO2011014C patent/NO2011014I1/no unknown
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2014
- 2014-11-21 US US14/550,345 patent/US9168313B2/en not_active Expired - Fee Related
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2015
- 2015-07-14 HU HUS1500040C patent/HUS1500040I1/hu unknown
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