NO328363B1 - Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat - Google Patents
Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat Download PDFInfo
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- NO328363B1 NO328363B1 NO20014128A NO20014128A NO328363B1 NO 328363 B1 NO328363 B1 NO 328363B1 NO 20014128 A NO20014128 A NO 20014128A NO 20014128 A NO20014128 A NO 20014128A NO 328363 B1 NO328363 B1 NO 328363B1
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- iminomethylcamptothecin
- cpt
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- C—CHEMISTRY; METALLURGY
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- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99830124A EP1044977B1 (en) | 1999-03-09 | 1999-03-09 | Camptothecin derivatives having antitumor activity |
| PCT/EP2000/001570 WO2000053607A1 (en) | 1999-03-09 | 2000-03-08 | Camptothecin derivatives having antitumor activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20014128L NO20014128L (no) | 2001-08-24 |
| NO20014128D0 NO20014128D0 (no) | 2001-08-24 |
| NO328363B1 true NO328363B1 (no) | 2010-02-01 |
Family
ID=8243303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014128A NO328363B1 (no) | 1999-03-09 | 2001-08-24 | Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US6242457B1 (et) |
| EP (1) | EP1044977B1 (et) |
| JP (1) | JP4610743B2 (et) |
| KR (1) | KR100702085B1 (et) |
| CN (1) | CN1139592C (et) |
| AR (1) | AR022860A1 (et) |
| AT (1) | ATE216998T1 (et) |
| AU (1) | AU774174B2 (et) |
| BG (1) | BG65032B1 (et) |
| BR (1) | BR0008840B1 (et) |
| CA (1) | CA2362760C (et) |
| CO (1) | CO5180590A1 (et) |
| CZ (1) | CZ304465B6 (et) |
| DE (1) | DE69901379T2 (et) |
| DK (1) | DK1044977T3 (et) |
| EA (1) | EA003605B1 (et) |
| EE (1) | EE04679B1 (et) |
| EG (1) | EG23999A (et) |
| ES (1) | ES2175919T3 (et) |
| HK (1) | HK1031222A1 (et) |
| HR (1) | HRP20010667B1 (et) |
| HU (1) | HU229506B1 (et) |
| IL (2) | IL144958A0 (et) |
| IS (1) | IS2003B (et) |
| ME (2) | MEP4008A (et) |
| MX (1) | MXPA01009081A (et) |
| NO (1) | NO328363B1 (et) |
| NZ (1) | NZ513393A (et) |
| PE (1) | PE20001485A1 (et) |
| PL (1) | PL222208B1 (et) |
| PT (1) | PT1044977E (et) |
| RS (1) | RS50405B (et) |
| SI (1) | SI1044977T1 (et) |
| SK (1) | SK287561B6 (et) |
| TN (1) | TNSN00045A1 (et) |
| TR (1) | TR200102603T2 (et) |
| TW (1) | TWI272272B (et) |
| WO (1) | WO2000053607A1 (et) |
| ZA (1) | ZA200107408B (et) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60036915T2 (de) | 1999-01-13 | 2008-08-07 | Alchemia Oncology Pty Ltd., Hawthorn | Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln |
| US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| FR2794123B1 (fr) * | 1999-05-28 | 2001-07-27 | Aventis Pharma Sa | Preparation de derives de la camptothecine et de la nothapodytine |
| US6352996B1 (en) * | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| US20040029906A1 (en) * | 2001-07-31 | 2004-02-12 | Michael Christman | Inhibitors of dna polymerase sigma |
| WO2003018062A1 (en) * | 2001-08-27 | 2003-03-06 | Meditech Research Limited | Improved therapeutic protocols |
| WO2003033525A1 (en) * | 2001-10-12 | 2003-04-24 | Debio Recherche Pharmacuetique S.A. | Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament |
| ITRM20020305A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Camptotecine con anello lattonico modificato. |
| ITRM20020306A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
| FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
| US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
| ITRM20030344A1 (it) | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
| US20080262014A1 (en) * | 2004-03-26 | 2008-10-23 | Schran Horst F | Use of Camptothecin Derivatives for the Treatment of Proliferative Diseases in a Fixed Dosing Regimen |
| MXPA06012145A (es) | 2004-04-27 | 2007-01-31 | Wellstat Biologics Corp | Tratamiento del cancer utilizando virus y camptotecinas. |
| ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
| ITRM20040241A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 20 con antagonisti delle integrine. |
| ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
| CN100334089C (zh) * | 2004-07-21 | 2007-08-29 | 王洋 | 一种9－硝基喜树碱的生产方法 |
| GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| PT1827437E (pt) * | 2004-12-15 | 2012-01-12 | Sigma Tau Ind Farmaceuti | Combinação de agentes terapêuticos para o tratamento do cancro |
| RS52585B (en) | 2004-12-21 | 2013-04-30 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | STEREOSELECTIVE PROCEDURE AND CRYSTAL FORMS OF CAMPTOTECIN |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| US7767200B2 (en) | 2005-07-14 | 2010-08-03 | Wellstat Biologics Corporation | Cancer treatment using viruses, fluoropyrimidines and camptothecins |
| CA2616607C (en) * | 2005-07-27 | 2015-06-02 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
| ITRM20050418A1 (it) * | 2005-08-04 | 2007-02-05 | Sigma Tau Ind Farmaceuti | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
| KR20080034149A (ko) * | 2005-08-10 | 2008-04-18 | 노파르티스 아게 | 7-(ｔ-부톡시)이미노메틸 캄토테신에 대한 제형 |
| AU2006289651B2 (en) * | 2005-09-07 | 2012-07-26 | Alchemia Oncology Pty Limited | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
| SI1962850T1 (sl) * | 2005-12-21 | 2012-06-29 | Sigma Tau Ind Farmaceuti | Zdravljenje tumorjev, odpornih proti zdravilom |
| JP5596924B2 (ja) * | 2006-02-17 | 2014-09-24 | カスケード プロドラッグ インコーポレイテッド | ビンカアルカロイドｎ酸化物および類似体による過剰増殖疾患の処置 |
| KR101394768B1 (ko) | 2006-03-30 | 2014-05-21 | 드라이스 파마슈티컬스 아이엔씨 | 캄토테신-세포 투과 펩티드 결합체 및 이를 포함하는 약학 조성물 |
| WO2008094959A1 (en) * | 2007-02-01 | 2008-08-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Pharmaceutical composition comprising a campothecin derivative |
| EP2120948A1 (en) * | 2007-02-13 | 2009-11-25 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives |
| JP5765937B2 (ja) * | 2007-08-01 | 2015-08-19 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ | 小児腫瘍の治療 |
| EP2096113A1 (en) | 2008-02-05 | 2009-09-02 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | 9-substituted camptothecin derivatives as antitumor compounds |
| TWI482621B (zh) | 2009-12-23 | 2015-05-01 | Sigma Tau Ind Farmaceuti | 青蒿素基藥物與其他化學治療劑的抗癌組合物 |
| JP6877049B2 (ja) | 2015-09-25 | 2021-05-26 | ゼットワイ セラピューティクス インク．Ｚｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 多糖類−ビタミン共役体を含む粒状物に基づく薬物製剤 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
| MX9206577A (es) * | 1991-11-15 | 1993-05-01 | Smithkline Beecham Corp | COMPOSICIóN FARMACEUTICA PARA INHIBIR EL CRECIMIENTO DE CELULAS TUMORALES |
| US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
| US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
| GB9512670D0 (en) * | 1995-06-21 | 1995-08-23 | Sod Conseils Rech Applic | Camptothecin analogues |
| IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
| KR100516593B1 (ko) * | 1996-08-19 | 2005-09-22 | 바이오누머릭 파마슈티칼스, 인코포레이티드 | 고 친유성 캠프토테신 유도체 |
-
1999
- 1999-03-09 ES ES99830124T patent/ES2175919T3/es not_active Expired - Lifetime
- 1999-03-09 AT AT99830124T patent/ATE216998T1/de active
- 1999-03-09 PT PT99830124T patent/PT1044977E/pt unknown
- 1999-03-09 DK DK99830124T patent/DK1044977T3/da active
- 1999-03-09 SI SI9930010T patent/SI1044977T1/xx unknown
- 1999-03-09 DE DE69901379T patent/DE69901379T2/de not_active Expired - Lifetime
- 1999-03-09 EP EP99830124A patent/EP1044977B1/en not_active Expired - Lifetime
-
2000
- 2000-02-22 US US09/507,928 patent/US6242457B1/en not_active Expired - Lifetime
- 2000-03-07 TW TW089104090A patent/TWI272272B/zh not_active IP Right Cessation
- 2000-03-07 EG EG20000293A patent/EG23999A/xx active
- 2000-03-08 JP JP2000604043A patent/JP4610743B2/ja not_active Expired - Fee Related
- 2000-03-08 RS YUP-643/01A patent/RS50405B/sr unknown
- 2000-03-08 CZ CZ2001-3077A patent/CZ304465B6/cs not_active IP Right Cessation
- 2000-03-08 HU HU0200210A patent/HU229506B1/hu not_active IP Right Cessation
- 2000-03-08 MX MXPA01009081A patent/MXPA01009081A/es unknown
- 2000-03-08 TR TR2001/02603T patent/TR200102603T2/xx unknown
- 2000-03-08 EA EA200100954A patent/EA003605B1/ru not_active IP Right Cessation
- 2000-03-08 CO CO00016957A patent/CO5180590A1/es active IP Right Grant
- 2000-03-08 ME MEP-40/08A patent/MEP4008A/xx unknown
- 2000-03-08 NZ NZ513393A patent/NZ513393A/xx not_active IP Right Cessation
- 2000-03-08 BR BRPI0008840-4A patent/BR0008840B1/pt not_active IP Right Cessation
- 2000-03-08 CA CA002362760A patent/CA2362760C/en not_active Expired - Fee Related
- 2000-03-08 TN TNTNSN00045A patent/TNSN00045A1/fr unknown
- 2000-03-08 AU AU31604/00A patent/AU774174B2/en not_active Ceased
- 2000-03-08 KR KR1020017011336A patent/KR100702085B1/ko not_active IP Right Cessation
- 2000-03-08 EE EEP200100466A patent/EE04679B1/et not_active IP Right Cessation
- 2000-03-08 SK SK1164-2001A patent/SK287561B6/sk not_active IP Right Cessation
- 2000-03-08 WO PCT/EP2000/001570 patent/WO2000053607A1/en active IP Right Grant
- 2000-03-08 PE PE2000000206A patent/PE20001485A1/es not_active Application Discontinuation
- 2000-03-08 IL IL14495800A patent/IL144958A0/xx unknown
- 2000-03-08 PL PL355094A patent/PL222208B1/pl unknown
- 2000-03-08 CN CNB008047804A patent/CN1139592C/zh not_active Expired - Fee Related
- 2000-03-08 AR ARP000101013A patent/AR022860A1/es not_active Application Discontinuation
- 2000-03-08 ME MEP-2008-40A patent/ME00017B/me unknown
- 2000-11-29 HK HK00107660A patent/HK1031222A1/xx not_active IP Right Cessation
- 2000-12-22 US US09/741,818 patent/US6589939B2/en not_active Expired - Lifetime
-
2001
- 2001-07-31 IS IS6031A patent/IS2003B/is unknown
- 2001-08-10 BG BG105810A patent/BG65032B1/bg unknown
- 2001-08-16 IL IL144958A patent/IL144958A/en not_active IP Right Cessation
- 2001-08-24 NO NO20014128A patent/NO328363B1/no not_active IP Right Cessation
- 2001-09-07 ZA ZA200107408A patent/ZA200107408B/xx unknown
- 2001-09-10 HR HR960321A patent/HRP20010667B1/xx not_active IP Right Cessation
Also Published As
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| NO328363B1 (no) | Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat | |
| EP2112154B1 (en) | Esters in position 20 of camptothecins | |
| CA2643400C (en) | Camptothecin derivatives and their uses | |
| US7105492B2 (en) | Camptothecin derivatives having antitumor activity | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |