NL8900397A - Antihypercholesterolemische tetrazoolverbindingen en tussenprodukten daarvoor, alsmede werkwijzen ter bereiding van deze verbindingen en tussenprodukten. - Google Patents

Antihypercholesterolemische tetrazoolverbindingen en tussenprodukten daarvoor, alsmede werkwijzen ter bereiding van deze verbindingen en tussenprodukten. Download PDF

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Publication number
NL8900397A
NL8900397A NL8900397A NL8900397A NL8900397A NL 8900397 A NL8900397 A NL 8900397A NL 8900397 A NL8900397 A NL 8900397A NL 8900397 A NL8900397 A NL 8900397A NL 8900397 A NL8900397 A NL 8900397A
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NL
Netherlands
Prior art keywords
alkyl
formula
compound
represent
hydrogen
Prior art date
Application number
NL8900397A
Other languages
English (en)
Dutch (nl)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of NL8900397A publication Critical patent/NL8900397A/nl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/061,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/081,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)
NL8900397A 1988-02-18 1989-02-17 Antihypercholesterolemische tetrazoolverbindingen en tussenprodukten daarvoor, alsmede werkwijzen ter bereiding van deze verbindingen en tussenprodukten. NL8900397A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/156,865 US4824959A (en) 1988-02-18 1988-02-18 Intermediates for antihypercholesterolemic tetrazole compounds
US15686588 1988-02-18

Publications (1)

Publication Number Publication Date
NL8900397A true NL8900397A (nl) 1989-09-18

Family

ID=22561419

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8900397A NL8900397A (nl) 1988-02-18 1989-02-17 Antihypercholesterolemische tetrazoolverbindingen en tussenprodukten daarvoor, alsmede werkwijzen ter bereiding van deze verbindingen en tussenprodukten.

Country Status (32)

Country Link
US (1) US4824959A (ja)
JP (2) JP2871707B2 (ja)
KR (1) KR970002233B1 (ja)
CN (1) CN1025619C (ja)
AT (1) AT401057B (ja)
AU (1) AU621586B2 (ja)
BE (1) BE1002136A5 (ja)
CA (1) CA1340430C (ja)
CH (1) CH680792A5 (ja)
CY (1) CY1874A (ja)
DD (4) DD285603A5 (ja)
DE (1) DE3904899A1 (ja)
DK (1) DK75289A (ja)
EG (1) EG19217A (ja)
ES (1) ES2017810A6 (ja)
FI (1) FI890725A (ja)
FR (1) FR2630112B1 (ja)
GB (1) GB2216121B (ja)
GR (1) GR1000664B (ja)
HK (3) HK129295A (ja)
HU (2) HU204045B (ja)
IE (1) IE65090B1 (ja)
IT (1) IT1230750B (ja)
LU (1) LU87456A1 (ja)
MY (1) MY106279A (ja)
NL (1) NL8900397A (ja)
NO (1) NO172439C (ja)
NZ (1) NZ227935A (ja)
PT (1) PT89748B (ja)
SE (2) SE503179C2 (ja)
YU (1) YU34189A (ja)
ZA (1) ZA891239B (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
GB2244706B (en) * 1988-02-18 1992-07-15 Bristol Myers Co Preparation of antihypercholesterolemic tetrazole intermediates
US5010205A (en) * 1988-08-23 1991-04-23 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl intermediates
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
DE4128345C1 (en) * 1991-08-27 1993-06-09 Hoechst Ag, 6230 Frankfurt, De 3R,5S 3,5,6-tri:hydroxy-hexanoic acid isopropylidene ketal derivs. prepn. - from 7-benzyl:oxy 4,6-di:hydroxy:heptene by multistage process
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
CA2137049A1 (en) * 1993-12-15 1995-06-16 John K. Thottathil Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
DE10147030A1 (de) * 2001-09-04 2003-03-27 Forschungszentrum Juelich Gmbh Verfahren zur Trennung diastereomerer 1,3-Diol-Acetale
US20050272808A1 (en) * 2004-05-11 2005-12-08 Nadav Zamir Compositions and methods for the treatment of hypertension
WO2005107739A1 (en) * 2004-05-11 2005-11-17 Darley Pharmaceuticals Ltd. Spiroderivatives for the treatment of hypertension
CN104303915B (zh) * 2014-08-25 2016-05-25 李世峰 一种机插水稻水浮式育秧技术

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225085A (ja) * 1982-06-24 1983-12-27 Nippon Kayaku Co Ltd アセタ−ルグリコ−ルジアクリレ−トおよびその製造法
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4837205A (en) * 1986-09-02 1989-06-06 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US4751229A (en) * 1987-07-09 1988-06-14 Warner-Lambert Company Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles
DE3807929A1 (de) * 1988-03-10 1989-09-28 Basf Ag Verfahren zur herstellung von reliefformen

Also Published As

Publication number Publication date
ZA891239B (en) 1991-12-24
CN1036013A (zh) 1989-10-04
FR2630112B1 (fr) 1994-07-29
HUT50167A (en) 1989-12-28
HK129295A (en) 1995-08-24
KR890012992A (ko) 1989-09-20
NO172439C (no) 1993-07-21
SE8900565D0 (sv) 1989-02-17
ATA36189A (de) 1995-10-15
DE3904899A1 (de) 1989-08-31
CH680792A5 (ja) 1992-11-13
AU3007589A (en) 1989-08-24
LU87456A1 (fr) 1989-09-20
DK75289D0 (da) 1989-02-17
FI890725A (fi) 1989-08-19
SE503179C2 (sv) 1996-04-15
NO890661L (no) 1989-08-21
SE9300595A0 (sv) 1993-02-23
IT1230750B (it) 1991-10-29
BE1002136A5 (fr) 1990-07-24
HU209905B (en) 1994-11-28
GB8903604D0 (en) 1989-04-05
EG19217A (en) 1995-09-30
NO890661D0 (no) 1989-02-16
IE890523L (en) 1989-08-18
FR2630112A1 (fr) 1989-10-20
GB2216121A (en) 1989-10-04
FI890725A0 (fi) 1989-02-15
PT89748A (pt) 1989-10-04
PT89748B (pt) 1994-05-31
NZ227935A (en) 1990-07-26
SE9300595D0 (sv) 1993-02-23
CY1874A (en) 1996-04-05
JPH115791A (ja) 1999-01-12
JPH01249771A (ja) 1989-10-05
HUT50809A (en) 1990-03-28
GR1000664B (el) 1992-09-25
MY106279A (en) 1995-04-29
ES2017810A6 (es) 1991-03-01
DD285602A5 (de) 1990-12-19
NO172439B (no) 1993-04-13
HK129395A (en) 1995-08-24
AU621586B2 (en) 1992-03-19
JP2922887B2 (ja) 1999-07-26
DD283618A5 (de) 1990-10-17
CA1340430C (en) 1999-03-09
IE65090B1 (en) 1995-10-04
DD285600A5 (de) 1990-12-19
SE8900565L (sv) 1989-08-19
AT401057B (de) 1996-06-25
JP2871707B2 (ja) 1999-03-17
US4824959A (en) 1989-04-25
CN1025619C (zh) 1994-08-10
DK75289A (da) 1989-08-19
DD285603A5 (de) 1990-12-19
YU34189A (en) 1991-02-28
HK47596A (en) 1996-03-29
GB2216121B (en) 1992-07-15
HU204045B (en) 1991-11-28
IT8919474A0 (it) 1989-02-17
KR970002233B1 (ko) 1997-02-26

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Legal Events

Date Code Title Description
DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

Free format text: BRISTOL-MYERS SQUIBB COMPANY

BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BN A decision not to publish the application has become irrevocable