FR2630112B1 - Preparation de composes antihypercholesterolemiques de tetrazole et leurs intermediaires - Google Patents

Preparation de composes antihypercholesterolemiques de tetrazole et leurs intermediaires

Info

Publication number
FR2630112B1
FR2630112B1 FR898900786A FR8900786A FR2630112B1 FR 2630112 B1 FR2630112 B1 FR 2630112B1 FR 898900786 A FR898900786 A FR 898900786A FR 8900786 A FR8900786 A FR 8900786A FR 2630112 B1 FR2630112 B1 FR 2630112B1
Authority
FR
France
Prior art keywords
tetrazole
intermediates
preparation
antihypercholesterolemic compounds
antihypercholesterolemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR898900786A
Other languages
English (en)
Other versions
FR2630112A1 (fr
Inventor
William T Han
John J Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2630112A1 publication Critical patent/FR2630112A1/fr
Application granted granted Critical
Publication of FR2630112B1 publication Critical patent/FR2630112B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)
FR898900786A 1988-02-18 1989-01-24 Preparation de composes antihypercholesterolemiques de tetrazole et leurs intermediaires Expired - Lifetime FR2630112B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/156,865 US4824959A (en) 1988-02-18 1988-02-18 Intermediates for antihypercholesterolemic tetrazole compounds

Publications (2)

Publication Number Publication Date
FR2630112A1 FR2630112A1 (fr) 1989-10-20
FR2630112B1 true FR2630112B1 (fr) 1994-07-29

Family

ID=22561419

Family Applications (1)

Application Number Title Priority Date Filing Date
FR898900786A Expired - Lifetime FR2630112B1 (fr) 1988-02-18 1989-01-24 Preparation de composes antihypercholesterolemiques de tetrazole et leurs intermediaires

Country Status (32)

Country Link
US (1) US4824959A (fr)
JP (2) JP2871707B2 (fr)
KR (1) KR970002233B1 (fr)
CN (1) CN1025619C (fr)
AT (1) AT401057B (fr)
AU (1) AU621586B2 (fr)
BE (1) BE1002136A5 (fr)
CA (1) CA1340430C (fr)
CH (1) CH680792A5 (fr)
CY (1) CY1874A (fr)
DD (4) DD285603A5 (fr)
DE (1) DE3904899A1 (fr)
DK (1) DK75289A (fr)
EG (1) EG19217A (fr)
ES (1) ES2017810A6 (fr)
FI (1) FI890725A (fr)
FR (1) FR2630112B1 (fr)
GB (1) GB2216121B (fr)
GR (1) GR1000664B (fr)
HK (3) HK129295A (fr)
HU (2) HU209905B (fr)
IE (1) IE65090B1 (fr)
IT (1) IT1230750B (fr)
LU (1) LU87456A1 (fr)
MY (1) MY106279A (fr)
NL (1) NL8900397A (fr)
NO (1) NO172439C (fr)
NZ (1) NZ227935A (fr)
PT (1) PT89748B (fr)
SE (2) SE503179C2 (fr)
YU (1) YU34189A (fr)
ZA (1) ZA891239B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
GB2244706B (en) * 1988-02-18 1992-07-15 Bristol Myers Co Preparation of antihypercholesterolemic tetrazole intermediates
US5010205A (en) * 1988-08-23 1991-04-23 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl intermediates
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
DE4128345C1 (en) * 1991-08-27 1993-06-09 Hoechst Ag, 6230 Frankfurt, De 3R,5S 3,5,6-tri:hydroxy-hexanoic acid isopropylidene ketal derivs. prepn. - from 7-benzyl:oxy 4,6-di:hydroxy:heptene by multistage process
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
CA2137049A1 (fr) * 1993-12-15 1995-06-16 John K. Thottathil Sels d'acides amines de composes antihypercholesterolemiques a base de tetrazole et leur methode de preparation
DE10147030A1 (de) * 2001-09-04 2003-03-27 Forschungszentrum Juelich Gmbh Verfahren zur Trennung diastereomerer 1,3-Diol-Acetale
EP1746988A1 (fr) * 2004-05-11 2007-01-31 Darley Pharmaceuticals Ltd. Spiroderives pour le traitement de l'hypertension
US20050272808A1 (en) * 2004-05-11 2005-12-08 Nadav Zamir Compositions and methods for the treatment of hypertension
CN104303915B (zh) * 2014-08-25 2016-05-25 李世峰 一种机插水稻水浮式育秧技术

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225085A (ja) * 1982-06-24 1983-12-27 Nippon Kayaku Co Ltd アセタ−ルグリコ−ルジアクリレ−トおよびその製造法
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4837205A (en) * 1986-09-02 1989-06-06 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US4751229A (en) * 1987-07-09 1988-06-14 Warner-Lambert Company Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles
DE3807929A1 (de) * 1988-03-10 1989-09-28 Basf Ag Verfahren zur herstellung von reliefformen

Also Published As

Publication number Publication date
DK75289D0 (da) 1989-02-17
HU204045B (en) 1991-11-28
EG19217A (en) 1995-09-30
FI890725A0 (fi) 1989-02-15
AT401057B (de) 1996-06-25
ZA891239B (en) 1991-12-24
FI890725A (fi) 1989-08-19
NL8900397A (nl) 1989-09-18
DD285600A5 (de) 1990-12-19
AU621586B2 (en) 1992-03-19
CN1036013A (zh) 1989-10-04
KR970002233B1 (ko) 1997-02-26
BE1002136A5 (fr) 1990-07-24
SE503179C2 (sv) 1996-04-15
KR890012992A (ko) 1989-09-20
MY106279A (en) 1995-04-29
PT89748A (pt) 1989-10-04
LU87456A1 (fr) 1989-09-20
NO172439B (no) 1993-04-13
CA1340430C (fr) 1999-03-09
YU34189A (en) 1991-02-28
ATA36189A (de) 1995-10-15
PT89748B (pt) 1994-05-31
JPH115791A (ja) 1999-01-12
IE65090B1 (en) 1995-10-04
HUT50809A (en) 1990-03-28
CY1874A (en) 1996-04-05
NO172439C (no) 1993-07-21
ES2017810A6 (es) 1991-03-01
DD285603A5 (de) 1990-12-19
FR2630112A1 (fr) 1989-10-20
DE3904899A1 (de) 1989-08-31
US4824959A (en) 1989-04-25
JPH01249771A (ja) 1989-10-05
SE8900565L (sv) 1989-08-19
IT1230750B (it) 1991-10-29
AU3007589A (en) 1989-08-24
SE9300595A0 (sv) 1993-02-23
GB2216121B (en) 1992-07-15
DK75289A (da) 1989-08-19
GR1000664B (el) 1992-09-25
GB8903604D0 (en) 1989-04-05
DD285602A5 (de) 1990-12-19
GB2216121A (en) 1989-10-04
NO890661L (no) 1989-08-21
JP2922887B2 (ja) 1999-07-26
DD283618A5 (de) 1990-10-17
JP2871707B2 (ja) 1999-03-17
HU209905B (en) 1994-11-28
HK129295A (en) 1995-08-24
CH680792A5 (fr) 1992-11-13
NO890661D0 (no) 1989-02-16
HK47596A (en) 1996-03-29
HK129395A (en) 1995-08-24
CN1025619C (zh) 1994-08-10
IT8919474A0 (it) 1989-02-17
IE890523L (en) 1989-08-18
SE8900565D0 (sv) 1989-02-17
HUT50167A (en) 1989-12-28
NZ227935A (en) 1990-07-26
SE9300595D0 (sv) 1993-02-23

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Legal Events

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CD Change of name or company name