NL192683B - - Google Patents

Info

Publication number
NL192683B
NL192683B NL8801934A NL8801934A NL192683B NL 192683 B NL192683 B NL 192683B NL 8801934 A NL8801934 A NL 8801934A NL 8801934 A NL8801934 A NL 8801934A NL 192683 B NL192683 B NL 192683B
Authority
NL
Netherlands
Application number
NL8801934A
Other versions
NL192683C (nl
NL8801934A (nl
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NL8801934A publication Critical patent/NL8801934A/nl
Publication of NL192683B publication Critical patent/NL192683B/xx
Application granted granted Critical
Publication of NL192683C publication Critical patent/NL192683C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
NL8801934A 1987-08-04 1988-08-03 "4"-Demethyl-epipodophyllotoxineglucoside verbinding alsmede farmaceutisch preparaat met antitumor activiteit NL192683C (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US8149387 1987-08-04
US19973188 1988-05-27
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (3)

Publication Number Publication Date
NL8801934A NL8801934A (nl) 1989-03-01
NL192683B true NL192683B (cs) 1997-08-01
NL192683C NL192683C (nl) 1997-12-02

Family

ID=26765636

Family Applications (2)

Application Number Title Priority Date Filing Date
NL8801934A NL192683C (nl) 1987-08-04 1988-08-03 "4"-Demethyl-epipodophyllotoxineglucoside verbinding alsmede farmaceutisch preparaat met antitumor activiteit
NL970042C NL970042I1 (nl) 1987-08-04 1997-12-05 4'-Demethyl-epipodophyllotoxineglucoside verbinding, alsmede farmaceutisch preparaat met antitumor activiteit.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL970042C NL970042I1 (nl) 1987-08-04 1997-12-05 4'-Demethyl-epipodophyllotoxineglucoside verbinding, alsmede farmaceutisch preparaat met antitumor activiteit.

Country Status (34)

Country Link
US (3) US4904768A (cs)
JP (1) JPH0699465B2 (cs)
KR (1) KR900006230B1 (cs)
CN (1) CN1027169C (cs)
AT (1) AT398974B (cs)
BE (1) BE1002982A4 (cs)
CA (1) CA1310637C (cs)
CH (1) CH676716A5 (cs)
CY (1) CY1625A (cs)
CZ (1) CZ286893B6 (cs)
DD (2) DD299067A5 (cs)
DE (1) DE3826562A1 (cs)
DK (2) DK169344B1 (cs)
ES (1) ES2010775A6 (cs)
FI (1) FI87790C (cs)
FR (1) FR2622193B1 (cs)
GB (1) GB2207674B (cs)
GR (1) GR1000490B (cs)
HK (1) HK6392A (cs)
HU (3) HU208147B (cs)
IE (1) IE61040B1 (cs)
IL (1) IL87290A (cs)
IT (1) IT1226825B (cs)
LU (2) LU87290A1 (cs)
MX (1) MX173843B (cs)
MY (1) MY104321A (cs)
NL (2) NL192683C (cs)
NO (4) NO170284C (cs)
NZ (1) NZ225615A (cs)
PT (1) PT88186B (cs)
SE (1) SE502214C2 (cs)
SG (1) SG101291G (cs)
SK (1) SK541288A3 (cs)
YU (3) YU143688A (cs)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (cs) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
AU726914B2 (en) * 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
WO2003035661A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
EP2283868B1 (en) 2002-07-15 2016-03-30 Board of Regents, The University of Texas System Peptides binding to phosphatidylethanolamine and their use in treating viral infections and cancer
CA2516056C (en) * 2003-01-06 2012-05-29 Angiochem Inc. Aprotinin and analogs as carriers across the blood-brain barrier
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
US7902156B2 (en) * 2005-02-18 2011-03-08 Angiochem Inc. Aprotinin polypeptides for transporting a compound across the blood-brain barrier
EP1907009A4 (en) * 2005-07-15 2009-09-02 Angiochem Inc USE OF APROTININ POLYPEPTIDES AS CARRIER IN PHARMACEUTICAL CONJUGATES
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) * 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
WO2009036106A1 (en) * 2007-09-13 2009-03-19 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
CA2705152C (en) 2007-11-09 2016-10-11 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
UY31545A1 (es) 2007-12-20 2009-08-03 Nuevos derivados de 2-carboxamida cianoaminourea, sus sales y profarmacos farmacéuticamente aceptables, procesos de preparacion y aplicaciones
US8710013B2 (en) * 2008-04-18 2014-04-29 Angiochem Inc. Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use
JP2012505637A (ja) 2008-10-15 2012-03-08 アンジオケム，インコーポレーテッド Ｇｌｐ−１アゴニストのコンジュゲート及びその使用
US8828925B2 (en) 2008-10-15 2014-09-09 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
BRPI0922689A2 (pt) * 2008-12-05 2018-11-06 Angiochem Inc. conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos
EP2373789A4 (en) 2008-12-17 2012-08-29 Angiochem Inc MEMBRANTYP-1 MATRIX METALLOPROTEINASE INHIBITORS AND THEIR USE
WO2010121379A1 (en) 2009-04-20 2010-10-28 Angiochem Inc Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
IN2012DN00248A (cs) 2009-07-02 2015-05-01 Angiochem Inc
KR101498774B1 (ko) 2010-02-22 2015-03-04 에프. 호프만-라 로슈 아게 피리도［3,2-ｄ］피리미딘 ｐｉ3ｋ 델타 억제제 화합물 및 이의 용도
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
EP2670753B1 (en) 2011-01-31 2016-10-19 Novartis AG Novel heterocyclic derivatives
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
EA023935B1 (ru) 2011-10-28 2016-07-29 Новартис Аг Производные пурина и их применение для лечения заболевания
EP2788003A4 (en) * 2011-12-09 2015-05-27 Demerx Inc PHOSPHATESTER OF NORIBOGAIN
US10213432B2 (en) 2012-05-16 2019-02-26 Novartis Ag Dosage regimen for a PI-3 kinase inhibitor
WO2014098877A1 (en) 2012-12-20 2014-06-26 Demerx, Inc. Substituted noribogaine
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CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
CN108472289A (zh) 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案
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Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (cs) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481913A (de) * 1966-12-13 1969-11-30 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
NO883299L (no) 1989-02-24
GR880100512A (en) 1989-05-25
YU10490A (en) 1990-06-30
YU143688A (en) 1990-04-30
HU211960A9 (en) 1996-01-29
IE882378L (en) 1989-02-04
DD299067A5 (de) 1992-03-26
NO920665D0 (no) 1992-02-20
HUT47303A (en) 1989-02-28
LU90138I2 (fr) 1997-11-26
FR2622193B1 (fr) 1993-12-17
DD274423A5 (de) 1989-12-20
IL87290A0 (en) 1989-01-31
IT8821535A0 (it) 1988-07-28
NO170284B (no) 1992-06-22
DE3826562C2 (cs) 1993-04-08
CN1027169C (zh) 1994-12-28
DK169344B1 (da) 1994-10-10
CA1310637C (en) 1992-11-24
KR890003790A (ko) 1989-04-18
PT88186A (pt) 1989-06-30
JPH01100188A (ja) 1989-04-18
IL87290A (en) 1993-01-31
YU10390A (en) 1990-06-30
NO920277L (no) 1989-02-24
HU202547B (en) 1991-03-28
FI883596A7 (fi) 1989-02-05
CH676716A5 (cs) 1991-02-28
GR1000490B (el) 1992-07-30
LU87290A1 (fr) 1990-02-07
NL970042I1 (nl) 1998-03-02
BE1002982A4 (fr) 1991-10-15
NZ225615A (en) 1991-06-25
MX173843B (es) 1994-03-30
NL192683C (nl) 1997-12-02
FI883596A0 (fi) 1988-08-01
NL8801934A (nl) 1989-03-01
NO883299D0 (no) 1988-07-26
FI87790B (fi) 1992-11-13
HU208147B (en) 1993-08-30
SG101291G (en) 1992-01-17
AU610619B2 (en) 1991-05-23
MY104321A (en) 1994-03-31
JPH0699465B2 (ja) 1994-12-07
DE3826562A1 (de) 1989-02-16
US5041424A (en) 1991-08-20
NO170284C (no) 1992-09-30
NL970042I2 (cs) 2005-06-01
SE502214C2 (sv) 1995-09-18
DK11992D0 (da) 1992-01-31
CY1625A (en) 1992-07-10
US4904768A (en) 1990-02-27
DK434088D0 (da) 1988-08-03
CZ286893B6 (cs) 2000-07-12
CN1061225A (zh) 1992-05-20
CZ541288A3 (cs) 1999-12-15
DK11992A (da) 1992-01-31
GB2207674A (en) 1989-02-08
AU2030688A (en) 1989-06-08
GB8818462D0 (en) 1988-09-07
IT1226825B (it) 1991-02-19
NO920665L (no) 1989-02-24
GB2207674B (en) 1991-09-11
SE8802815D0 (sv) 1988-08-03
SK279325B6 (sk) 1998-10-07
ES2010775A6 (es) 1989-12-01
AT398974B (de) 1995-02-27
MX9202851A (es) 1992-06-30
SE8802815L (sv) 1989-02-05
FR2622193A1 (fr) 1989-04-28
NO920277D0 (no) 1992-01-22
IE61040B1 (en) 1994-09-07
HK6392A (en) 1992-01-17
PT88186B (pt) 1995-07-03
SK541288A3 (en) 1998-10-07
ATA195588A (de) 1994-07-15
NO1998002I1 (no) 1998-01-14
DK434088A (da) 1989-02-05
NO172440C (no) 1993-07-21
KR900006230B1 (ko) 1990-08-27
NO172440B (no) 1993-04-13
FI87790C (fi) 1993-02-25
HU905862D0 (en) 1991-03-28
USRE35524E (en) 1997-06-03

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A1A A request for search or an international-type search has been filed
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Free format text: FROM THE TITLE OF THE INVENTION ON THE FRONT PAGE OF PATENT 192683 ISSUED ON FEBRUARY 02, 1998 THE WORD "ALMEDE" SHOULD BE MODIFIED IN: ALSMEDE A CORRECTED FRONT PAGE OF THE ABOVE MENTIONED PATENT HAS BEEN ISSUED.

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Free format text: PRODUCT NAME: ETOPOSIDEFOSFAAT, DESGEWENST IN DE VORM VAN EEN FARMACEUTISCH AANVAARDBAAR ZOUT; NAT.REGISTRATION NO/DATE: RUG 19077 19970701; FIRST REGISTRATION: SE 12512 19960412

Spc suppl protection certif: C970042

Filing date: 19971205

Expiry date: 20080803

Extension date: 20110411