MXPA05001841A - Formulacion de anticuerpos humanos para tratar trastornos asociados con tnfa. - Google Patents
Formulacion de anticuerpos humanos para tratar trastornos asociados con tnfa.Info
- Publication number
- MXPA05001841A MXPA05001841A MXPA05001841A MXPA05001841A MXPA05001841A MX PA05001841 A MXPA05001841 A MX PA05001841A MX PA05001841 A MXPA05001841 A MX PA05001841A MX PA05001841 A MXPA05001841 A MX PA05001841A MX PA05001841 A MXPA05001841 A MX PA05001841A
- Authority
- MX
- Mexico
- Prior art keywords
- tnf
- antibody formulation
- alpha antibody
- pharmaceutical anti
- pharmaceutical
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Se describe una formulacion farmaceutica liquida, acuosa, que tiene una concentracion elevada de proteina, un pH de entre alrededor de 4 y alrededor de 8, y estabilidad incrementada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/222,140 US20040033228A1 (en) | 2002-08-16 | 2002-08-16 | Formulation of human antibodies for treating TNF-alpha associated disorders |
PCT/IB2003/004502 WO2004016286A2 (en) | 2002-08-16 | 2003-08-15 | Pharmaceutical anti-tnf-alpha antibody formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05001841A true MXPA05001841A (es) | 2005-09-30 |
Family
ID=31714885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05001841A MXPA05001841A (es) | 2002-08-16 | 2003-08-15 | Formulacion de anticuerpos humanos para tratar trastornos asociados con tnfa. |
Country Status (27)
Country | Link |
---|---|
US (27) | US20040033228A1 (es) |
EP (5) | EP2361637A1 (es) |
JP (5) | JP4925582B2 (es) |
KR (4) | KR101367743B1 (es) |
CN (4) | CN102078608B (es) |
AR (2) | AR040881A1 (es) |
AT (1) | ATE555809T1 (es) |
AU (1) | AU2003267744C1 (es) |
BR (1) | BR0313492A (es) |
CA (9) | CA2882907C (es) |
CL (1) | CL2010000603A1 (es) |
CY (2) | CY1113353T1 (es) |
DK (2) | DK2359856T3 (es) |
ES (2) | ES2636692T3 (es) |
HK (1) | HK1074008A1 (es) |
IL (2) | IL166809A (es) |
MX (1) | MXPA05001841A (es) |
MY (3) | MY162068A (es) |
NZ (1) | NZ538030A (es) |
PE (1) | PE20040994A1 (es) |
PL (3) | PL218834B1 (es) |
PT (2) | PT2359856T (es) |
SI (2) | SI2359856T1 (es) |
TW (1) | TWI331532B (es) |
UY (1) | UY27940A1 (es) |
WO (1) | WO2004016286A2 (es) |
ZA (1) | ZA200501032B (es) |
Families Citing this family (229)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
HU221984B1 (hu) * | 1996-02-09 | 2003-03-28 | Basf Ag | Humán TNFalfa-t kötő antitestek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
CA2817619A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
US8658773B2 (en) | 2011-05-02 | 2014-02-25 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
US20040002451A1 (en) * | 2002-06-20 | 2004-01-01 | Bruce Kerwin | Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing |
US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
DK1944322T3 (da) * | 2002-07-19 | 2015-06-22 | Abbvie Biotechnology Ltd | Behandling af TNFalfa-relaterede sygdomme |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
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