ES2636692T3 - Formulación de anticuerpos humanos para tratar trastornos asociados con TNF-alfa - Google Patents

Formulación de anticuerpos humanos para tratar trastornos asociados con TNF-alfa Download PDF

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ES2636692T3
ES2636692T3 ES10182610.5T ES10182610T ES2636692T3 ES 2636692 T3 ES2636692 T3 ES 2636692T3 ES 10182610 T ES10182610 T ES 10182610T ES 2636692 T3 ES2636692 T3 ES 2636692T3
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formulation
tnf
alpha
human antibodies
disorders associated
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Hans-Juergen Krause
Lisa Baust
Michael Dickes
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AbbVie Biotechnology Ltd
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AbbVie Biotechnology Ltd
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Abstract

Formulación farmacéutica acuosa líquida en forma de una disolución de 0,8 ml que comprende a) 40,0 mg del anticuerpo anti-factor de necrosis tumoral alfa humano D2E7 b) 9,6 mg de manitol c) 1,044 mg de ácido cítrico monohidratado d) 0,244 mg de citrato de sodio e) 1,224 mg de fosfato de disodio dihidratado f) 0,688 mg de dihidrogenofosfato de sodio dihidratado g) 4,932 mg de cloruro de sodio h) 0,8 mg de polisorbato 80 i) 759,028 - 759,048 mg de agua j) 0,02 - 0,04 mg de hidróxido de sodio, lo que da un total de 817,6 mg por 0,8 ml de disolución.

Description

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Claims (1)

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ES10182610.5T 2002-08-16 2003-08-15 Formulación de anticuerpos humanos para tratar trastornos asociados con TNF-alfa Expired - Lifetime ES2636692T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US222140 2002-08-16
US10/222,140 US20040033228A1 (en) 2002-08-16 2002-08-16 Formulation of human antibodies for treating TNF-alpha associated disorders

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