MEP10108A - Metod za proizvodnju escitaloprama - Google Patents

Metod za proizvodnju escitaloprama

Info

Publication number
MEP10108A
MEP10108A MEP-101/08A MEP10108A MEP10108A ME P10108 A MEP10108 A ME P10108A ME P10108 A MEP10108 A ME P10108A ME P10108 A MEP10108 A ME P10108A
Authority
ME
Montenegro
Prior art keywords
escitalopram
production method
benzonitrile
hydroxybutyl
fluorophenyl
Prior art date
Application number
MEP-101/08A
Other languages
English (en)
Inventor
De Faveri Carla
Anton Martin Huber Florian
James Dancer Robert
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735675&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP10108(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of MEP10108A publication Critical patent/MEP10108A/bs
Publication of ME00176B publication Critical patent/ME00176B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ovaj patent otkriva postupak za razdvajanje 4-[4-(dimeti lamino)-1-(4’-fl uorofenil)-1-hidroksibuti l]-3-(hidroksimeti l)-benzonitrila kao racemske ili neracemske enanti omerne smješe u njegove izolovane enanti omere, pri čemu navedeni postupak sadrži korak frakcione kristalizacije 4-[4-(dimeti lamino)-1-(4’-fl uorofenil)-1-hidroksibuti l]-3-(hidroksimeti l)-benzonitrila kao soli sa (+)-(S,S)- ili (-)-(R,R)-enanti omera O,O’-di-p-toluoil-vinske kisjeline u sistemu rastvarača koji sadrži 1-propanol, etanol ili acetonitril.
MEP-2008-101A 2007-09-11 2008-09-03 Postupak za proizvodnju escitaloprama ME00176B (me)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200701314 2007-09-11

Publications (2)

Publication Number Publication Date
MEP10108A true MEP10108A (bs) 2010-10-10
ME00176B ME00176B (me) 2011-02-10

Family

ID=39735675

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-101A ME00176B (me) 2007-09-11 2008-09-03 Postupak za proizvodnju escitaloprama

Country Status (52)

Country Link
EP (2) EP2061753B1 (bs)
JP (1) JP4966933B2 (bs)
KR (1) KR101054224B1 (bs)
CN (1) CN101386583A (bs)
AR (2) AR068174A1 (bs)
AT (2) ATE518829T1 (bs)
AU (1) AU2008212055C1 (bs)
BE (1) BE1017548A6 (bs)
BG (1) BG110206A (bs)
BR (1) BRPI0804121B1 (bs)
CA (1) CA2638499C (bs)
CH (1) CH697885B1 (bs)
CL (1) CL2008002686A1 (bs)
CO (1) CO6140012A1 (bs)
CY (2) CY2600B1 (bs)
CZ (1) CZ2008537A3 (bs)
DE (1) DE102008046530A1 (bs)
DK (2) DK2061753T3 (bs)
EA (1) EA012787B1 (bs)
EE (1) EE00864U1 (bs)
ES (2) ES2334875B1 (bs)
FI (1) FI121570B (bs)
FR (1) FR2920766A1 (bs)
GB (1) GB2448848B (bs)
GR (1) GR1006595B (bs)
HR (2) HRP20080425A2 (bs)
HU (1) HUP0800549A2 (bs)
IE (1) IES20080708A2 (bs)
IL (1) IL193845A (bs)
IS (1) IS8758A (bs)
LT (1) LT5577B (bs)
LU (1) LU91479B1 (bs)
LV (1) LV13813B (bs)
ME (1) ME00176B (bs)
MX (1) MX2008011451A (bs)
MY (1) MY144210A (bs)
NL (1) NL2001953C2 (bs)
NO (1) NO20083756L (bs)
NZ (1) NZ570884A (bs)
PL (2) PL386026A1 (bs)
PT (2) PT104169A (bs)
RO (1) RO125301A2 (bs)
RS (2) RS20080401A (bs)
SE (1) SE533041C2 (bs)
SG (1) SG151195A1 (bs)
SI (2) SI22567A2 (bs)
SK (1) SK500302008A3 (bs)
TR (2) TR200907629A2 (bs)
TW (1) TWI391383B (bs)
UA (2) UA41919U (bs)
WO (1) WO2009033488A1 (bs)
ZA (1) ZA200807753B (bs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939680B2 (en) 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram
CN102796065A (zh) * 2011-05-27 2012-11-28 江苏豪森医药集团连云港宏创医药有限公司 一种制备光学纯度高的艾司西酞普兰的方法
CN104119240A (zh) * 2013-04-23 2014-10-29 中国人民解放军军事医学科学院毒物药物研究所 (S)-(-)-α-甲胺基苯丙酮的制备方法
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
CN104119248A (zh) * 2014-08-08 2014-10-29 广东东阳光药业有限公司 S-西酞普兰的制备方法
ES2881105T3 (es) * 2014-11-14 2021-11-26 Zhejiang Huahai Pharm Co Ltd Método para la resolución del producto intermedio de citalopram 5-cianodiol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AR034612A1 (es) 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
WO2004056754A1 (en) 2002-12-23 2004-07-08 H. Lundbeck A/S A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, r-citalopram and/or s-citalopram
WO2004065375A1 (en) * 2003-01-17 2004-08-05 Natco Pharma Limited Processes for the preparation of escitalopram and its precursor
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
EP1877394A1 (en) * 2005-04-04 2008-01-16 Jubilant Organosys Limited Process for the preparation of escitalopram or its acid addition salts
US7939680B2 (en) * 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram

Also Published As

Publication number Publication date
AU2008212055A1 (en) 2009-03-26
EE00864U1 (et) 2009-10-15
CA2638499C (en) 2010-09-28
PL2061753T3 (pl) 2011-12-30
DK2061753T3 (da) 2011-09-26
SE0801929L (sv) 2009-03-12
IL193845A (en) 2011-03-31
TR200907629A2 (tr) 2009-11-23
PT104169A (pt) 2009-02-02
CN101386583A (zh) 2009-03-18
HRP20110636T1 (hr) 2011-10-31
FI20085807L (fi) 2009-03-12
BE1017548A6 (fr) 2008-11-04
IES20080708A2 (en) 2009-03-18
CY1111924T1 (el) 2015-11-04
BG110206A (en) 2009-03-31
NL2001953A1 (nl) 2008-12-22
GR20080100581A (el) 2009-04-30
GB2448848B (en) 2011-01-26
SK500302008A3 (sk) 2009-04-06
SE533041C2 (sv) 2010-06-15
SI22567A2 (sl) 2008-12-31
EA012787B1 (ru) 2009-12-30
ES2334875A1 (es) 2010-03-16
TR200806903A2 (tr) 2009-03-23
SG151195A1 (en) 2009-04-30
PL386026A1 (pl) 2009-02-16
BRPI0804121A2 (pt) 2009-09-29
JP2009149600A (ja) 2009-07-09
FI121570B (fi) 2011-01-14
HRP20080425A2 (hr) 2010-04-30
WO2009033488A1 (en) 2009-03-19
ES2368294T3 (es) 2011-11-16
LU91479B1 (fr) 2010-03-11
BRPI0804121B1 (pt) 2022-04-12
KR20090027185A (ko) 2009-03-16
HU0800549D0 (en) 2008-10-28
AU2008212055C1 (en) 2011-06-02
EA200801797A2 (ru) 2008-12-30
AT10984U1 (de) 2010-02-15
RS20080401A (sr) 2010-03-02
RO125301A2 (ro) 2010-03-30
IS8758A (is) 2009-03-12
HUP0800549A2 (en) 2009-03-02
ZA200807753B (en) 2009-04-29
GR1006595B (el) 2009-11-16
BRPI0804121A8 (pt) 2021-04-13
ATE518829T1 (de) 2011-08-15
CA2638499A1 (en) 2008-11-21
TWI391383B (zh) 2013-04-01
ME00176B (me) 2011-02-10
NO20083756L (no) 2009-03-12
GB0815773D0 (en) 2008-10-08
EP2061753B1 (en) 2011-08-03
PT2061753E (pt) 2011-09-14
TW200906814A (en) 2009-02-16
KR101054224B1 (ko) 2011-08-08
EP2397461A1 (en) 2011-12-21
NL2001953C2 (en) 2009-05-07
EP2061753A1 (en) 2009-05-27
DE102008046530A1 (de) 2009-03-19
CZ2008537A3 (cs) 2009-03-18
DK200801265A (en) 2009-03-12
CH697885B1 (de) 2009-03-13
EA200801797A3 (ru) 2009-02-27
SI2061753T1 (sl) 2011-10-28
JP4966933B2 (ja) 2012-07-04
DK177075B1 (da) 2011-06-14
ES2334875B1 (es) 2010-10-27
CL2008002686A1 (es) 2009-01-02
LV13813B (en) 2008-11-20
MY144210A (en) 2011-08-15
LT5577B (lt) 2009-06-25
NZ570884A (en) 2010-03-26
MX2008011451A (es) 2009-03-10
UA43461U (uk) 2009-08-25
AR068174A1 (es) 2009-11-11
LT2008068A (en) 2009-03-25
FI20085807A0 (fi) 2008-08-29
CY2600B1 (en) 2010-03-03
GB2448848A (en) 2008-10-29
FR2920766A1 (fr) 2009-03-13
UA41919U (uk) 2009-06-10
AU2008212055B2 (en) 2010-08-12
AR108885A2 (es) 2018-10-03
CO6140012A1 (es) 2010-03-19
RS51909B (sr) 2012-02-29

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