CY1111924T1 - Μεθοδος για την βιομηχανικη παρασκευη της εσκιταλοπραμης - Google Patents

Μεθοδος για την βιομηχανικη παρασκευη της εσκιταλοπραμης

Info

Publication number
CY1111924T1
CY1111924T1 CY20111100963T CY111100963T CY1111924T1 CY 1111924 T1 CY1111924 T1 CY 1111924T1 CY 20111100963 T CY20111100963 T CY 20111100963T CY 111100963 T CY111100963 T CY 111100963T CY 1111924 T1 CY1111924 T1 CY 1111924T1
Authority
CY
Cyprus
Prior art keywords
excitalopram
industrial preparation
benzonitrile
hydroxybutyl
racemic
Prior art date
Application number
CY20111100963T
Other languages
English (en)
Inventor
Faveri Carla De
Florian Anton Martin Huber
Robert James Dancer
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735675&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1111924(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1111924T1 publication Critical patent/CY1111924T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Abstract

Αυτή η ευρεσιτεχνία αποκαλύπτει μία μέθοδο για τον διαχωρισμό σε οπτικούς αντίποδες του 4-[4-(διμεθυλαμινο)-1-(4’-φθοροφαινυλ)-1-υδροξυβουτυλ]-3-(υδροξυμεθυλ)-βενζονιτριλίου ως ένα ρακεμικό ή μη-ρακεμικό μείγμα εναντιομερών στα απομονωμένα εναντιομερή αυτού, η εν λόγω μέθοδος περιλαμβάνουσα το βήμα της κατά κλασματικό τρόπο κρυστάλλωσης του 4-[4-(διμεθυλαμινο)-1-(4’-φθορο-φαινυλ)-1-υδροξυβουτυλ]-3-(υδροξυμεθυλ)-βενζονιτριλίου ως ένα άλας με το(+)-(S,S)- ή το (-)-(R,R)-εναντιομερές του Ο,Ο’-δι-p-τολουοϋλ-τρυγικό οξύ σε ένα σύστημα διαλυτών περιλαμβάνοντας 1-προπανόλη, αιθανόλη ή ακετονιτρίλιο.
CY20111100963T 2007-09-11 2011-10-07 Μεθοδος για την βιομηχανικη παρασκευη της εσκιταλοπραμης CY1111924T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200701314 2007-09-11
EP08801398A EP2061753B1 (en) 2007-09-11 2008-09-10 Method for manufacture of escitalopram

Publications (1)

Publication Number Publication Date
CY1111924T1 true CY1111924T1 (el) 2015-11-04

Family

ID=39735675

Family Applications (2)

Application Number Title Priority Date Filing Date
CY0800015A CY2600B1 (en) 2007-09-11 2008-09-10 Method for manufacture of escitalopram
CY20111100963T CY1111924T1 (el) 2007-09-11 2011-10-07 Μεθοδος για την βιομηχανικη παρασκευη της εσκιταλοπραμης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY0800015A CY2600B1 (en) 2007-09-11 2008-09-10 Method for manufacture of escitalopram

Country Status (52)

Country Link
EP (2) EP2397461A1 (el)
JP (1) JP4966933B2 (el)
KR (1) KR101054224B1 (el)
CN (1) CN101386583A (el)
AR (2) AR068174A1 (el)
AT (2) ATE518829T1 (el)
AU (1) AU2008212055C1 (el)
BE (1) BE1017548A6 (el)
BG (1) BG110206A (el)
BR (1) BRPI0804121B1 (el)
CA (1) CA2638499C (el)
CH (1) CH697885B1 (el)
CL (1) CL2008002686A1 (el)
CO (1) CO6140012A1 (el)
CY (2) CY2600B1 (el)
CZ (1) CZ2008537A3 (el)
DE (1) DE102008046530A1 (el)
DK (2) DK2061753T3 (el)
EA (1) EA012787B1 (el)
EE (1) EE00864U1 (el)
ES (2) ES2368294T3 (el)
FI (1) FI121570B (el)
FR (1) FR2920766A1 (el)
GB (1) GB2448848B (el)
GR (1) GR1006595B (el)
HR (2) HRP20080425A2 (el)
HU (1) HUP0800549A2 (el)
IE (1) IES20080708A2 (el)
IL (1) IL193845A (el)
IS (1) IS8758A (el)
LT (1) LT5577B (el)
LU (1) LU91479B1 (el)
LV (1) LV13813B (el)
ME (1) ME00176B (el)
MX (1) MX2008011451A (el)
MY (1) MY144210A (el)
NL (1) NL2001953C2 (el)
NO (1) NO20083756L (el)
NZ (1) NZ570884A (el)
PL (2) PL386026A1 (el)
PT (2) PT104169A (el)
RO (1) RO125301A2 (el)
RS (2) RS20080401A (el)
SE (1) SE533041C2 (el)
SG (1) SG151195A1 (el)
SI (2) SI22567A2 (el)
SK (1) SK500302008A3 (el)
TR (2) TR200806903A2 (el)
TW (1) TWI391383B (el)
UA (2) UA41919U (el)
WO (1) WO2009033488A1 (el)
ZA (1) ZA200807753B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007012954A1 (en) 2005-07-27 2007-02-01 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
CN102796065A (zh) * 2011-05-27 2012-11-28 江苏豪森医药集团连云港宏创医药有限公司 一种制备光学纯度高的艾司西酞普兰的方法
CN104119240A (zh) * 2013-04-23 2014-10-29 中国人民解放军军事医学科学院毒物药物研究所 (S)-(-)-α-甲胺基苯丙酮的制备方法
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
CN104119248A (zh) * 2014-08-08 2014-10-29 广东东阳光药业有限公司 S-西酞普兰的制备方法
US10287240B2 (en) 2014-11-14 2019-05-14 Zhejiang Hushai Pharmaceuticals Co., Ltd. Method for resolution of citalopram intermediate 5-cyano diol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AR034612A1 (es) 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
CA2511143C (en) 2002-12-23 2011-06-28 H. Lundbeck A/S Preparation of racemic and/or s- or r-citalopram diols and their use for the preparation racemic and/or s- or r-citalopram
WO2004065375A1 (en) * 2003-01-17 2004-08-05 Natco Pharma Limited Processes for the preparation of escitalopram and its precursor
WO2005047274A1 (en) * 2003-11-12 2005-05-26 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts
WO2007012954A1 (en) * 2005-07-27 2007-02-01 Aurobindo Pharma Limited An improved process for the preparation of escitalopram

Also Published As

Publication number Publication date
SI22567A2 (sl) 2008-12-31
ES2334875A1 (es) 2010-03-16
HRP20110636T1 (hr) 2011-10-31
PT2061753E (pt) 2011-09-14
RS20080401A (en) 2010-03-02
PT104169A (pt) 2009-02-02
RO125301A2 (ro) 2010-03-30
ZA200807753B (en) 2009-04-29
FI20085807A (fi) 2009-03-12
AT10984U1 (de) 2010-02-15
KR101054224B1 (ko) 2011-08-08
EP2397461A1 (en) 2011-12-21
EP2061753A1 (en) 2009-05-27
GR20080100581A (el) 2009-04-30
TR200806903A2 (tr) 2009-03-23
DK2061753T3 (da) 2011-09-26
LT2008068A (en) 2009-03-25
LT5577B (lt) 2009-06-25
JP2009149600A (ja) 2009-07-09
RS51909B (en) 2012-02-29
FI20085807A0 (fi) 2008-08-29
SI2061753T1 (sl) 2011-10-28
BRPI0804121A8 (pt) 2021-04-13
GB0815773D0 (en) 2008-10-08
MEP10108A (en) 2010-10-10
CZ2008537A3 (cs) 2009-03-18
GB2448848B (en) 2011-01-26
CA2638499C (en) 2010-09-28
TW200906814A (en) 2009-02-16
WO2009033488A1 (en) 2009-03-19
BG110206A (en) 2009-03-31
HU0800549D0 (en) 2008-10-28
MY144210A (en) 2011-08-15
JP4966933B2 (ja) 2012-07-04
GR1006595B (el) 2009-11-16
NL2001953A1 (nl) 2008-12-22
AR108885A2 (es) 2018-10-03
NZ570884A (en) 2010-03-26
UA41919U (uk) 2009-06-10
EA200801797A2 (ru) 2008-12-30
IES20080708A2 (en) 2009-03-18
HUP0800549A2 (en) 2009-03-02
AR068174A1 (es) 2009-11-11
GB2448848A (en) 2008-10-29
ES2368294T3 (es) 2011-11-16
EP2061753B1 (en) 2011-08-03
LU91479B1 (fr) 2010-03-11
SG151195A1 (en) 2009-04-30
AU2008212055C1 (en) 2011-06-02
DK200801265A (en) 2009-03-12
AU2008212055A1 (en) 2009-03-26
PL386026A1 (pl) 2009-02-16
CA2638499A1 (en) 2008-11-21
PL2061753T3 (pl) 2011-12-30
EE00864U1 (et) 2009-10-15
SE533041C2 (sv) 2010-06-15
AU2008212055B2 (en) 2010-08-12
ME00176B (me) 2011-02-10
SE0801929L (sv) 2009-03-12
ATE518829T1 (de) 2011-08-15
NO20083756L (no) 2009-03-12
EA012787B1 (ru) 2009-12-30
LV13813B (en) 2008-11-20
EA200801797A3 (ru) 2009-02-27
HRP20080425A2 (hr) 2010-04-30
IS8758A (is) 2009-03-12
CO6140012A1 (es) 2010-03-19
CY2600B1 (en) 2010-03-03
BRPI0804121B1 (pt) 2022-04-12
ES2334875B1 (es) 2010-10-27
CN101386583A (zh) 2009-03-18
IL193845A (en) 2011-03-31
DE102008046530A1 (de) 2009-03-19
BE1017548A6 (fr) 2008-11-04
DK177075B1 (da) 2011-06-14
CL2008002686A1 (es) 2009-01-02
TWI391383B (zh) 2013-04-01
TR200907629A2 (tr) 2009-11-23
SK500302008A3 (sk) 2009-04-06
NL2001953C2 (en) 2009-05-07
KR20090027185A (ko) 2009-03-16
UA43461U (uk) 2009-08-25
BRPI0804121A2 (pt) 2009-09-29
MX2008011451A (es) 2009-03-10
FR2920766A1 (fr) 2009-03-13
FI121570B (fi) 2011-01-14
CH697885B1 (de) 2009-03-13

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