CL2008002686A1 - Metodo para resolver una mezcla racemica de un diol intermediario en la sintesis de escitalopram usando acido tartarico ocupando al menos un 50% de 1-propanolol como solvente. - Google Patents
Metodo para resolver una mezcla racemica de un diol intermediario en la sintesis de escitalopram usando acido tartarico ocupando al menos un 50% de 1-propanolol como solvente.Info
- Publication number
- CL2008002686A1 CL2008002686A1 CL2008002686A CL2008002686A CL2008002686A1 CL 2008002686 A1 CL2008002686 A1 CL 2008002686A1 CL 2008002686 A CL2008002686 A CL 2008002686A CL 2008002686 A CL2008002686 A CL 2008002686A CL 2008002686 A1 CL2008002686 A1 CL 2008002686A1
- Authority
- CL
- Chile
- Prior art keywords
- escitalopram
- tartaric acid
- propanolol
- solvent
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
Abstract
ESTA PATENTE REVELA UN METODO PARA LA ELABORACIÓN DE ESCITALOPRAM A PARTIR DE UN METODO PARA LA RESOLUCIÓN DE 4-[4-(DIMETILAMINOH -(4'- FLUORFENILH - HIDROXI BUTIL}-3-{HIDROXIMETIL}-BENZONITRILO COMO UNA MEZCLA RACÉMICA O NO RACÉMICA DE ENANTIÓMEROS, EN SUS ENANTIÓMEROS AISLADOS, DONDE DICHO METODA<br /> COMPRENDE LA ETAPA DE LA CRISTALIZACIÓN FRACCIONAL DE 4-[4-(DIMETILAMINO}-1 -(4'-FLUORFENIL}-1-HIDROXIBUTILJ-3- (HIDROXIMETIL}-BENZONITRILO COMO UNA SAL, CON EL ENANTIÓMERO (+H S,S}- 0 (-H R.R}- DE ÁCIDO O,O'-DI-P- TOLUOIL-TARTARICO. EN UN SISTEMA DE SOLVENTE QUE COMPRENDE 1- PROPANOL, ETANOL O ACETONITRILO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200701314 | 2007-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008002686A1 true CL2008002686A1 (es) | 2009-01-02 |
Family
ID=39735675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008002686A CL2008002686A1 (es) | 2007-09-11 | 2008-09-10 | Metodo para resolver una mezcla racemica de un diol intermediario en la sintesis de escitalopram usando acido tartarico ocupando al menos un 50% de 1-propanolol como solvente. |
Country Status (52)
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007012954A1 (en) | 2005-07-27 | 2007-02-01 | Aurobindo Pharma Limited | An improved process for the preparation of escitalopram |
CN102796065A (zh) * | 2011-05-27 | 2012-11-28 | 江苏豪森医药集团连云港宏创医药有限公司 | 一种制备光学纯度高的艾司西酞普兰的方法 |
CN104119240A (zh) * | 2013-04-23 | 2014-10-29 | 中国人民解放军军事医学科学院毒物药物研究所 | (S)-(-)-α-甲胺基苯丙酮的制备方法 |
CN103497145B (zh) * | 2013-10-10 | 2016-01-27 | 南昌大学 | 一种光学纯多奈哌齐的制备工艺 |
CN104119248A (zh) * | 2014-08-08 | 2014-10-29 | 广东东阳光药业有限公司 | S-西酞普兰的制备方法 |
US10287240B2 (en) | 2014-11-14 | 2019-05-14 | Zhejiang Hushai Pharmaceuticals Co., Ltd. | Method for resolution of citalopram intermediate 5-cyano diol |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
AR034612A1 (es) | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram |
AR034759A1 (es) * | 2001-07-13 | 2004-03-17 | Lundbeck & Co As H | Metodo para la preparacion de escitalopram |
IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
CA2511143C (en) | 2002-12-23 | 2011-06-28 | H. Lundbeck A/S | Preparation of racemic and/or s- or r-citalopram diols and their use for the preparation racemic and/or s- or r-citalopram |
WO2004065375A1 (en) * | 2003-01-17 | 2004-08-05 | Natco Pharma Limited | Processes for the preparation of escitalopram and its precursor |
WO2005047274A1 (en) * | 2003-11-12 | 2005-05-26 | Dr. Reddy's Laboratories, Inc. | Preparation of escitalopram |
WO2006106531A1 (en) * | 2005-04-04 | 2006-10-12 | Jubilant Organosys Ltd | Process for the preparation of escitalopram or its acid addition salts |
WO2007012954A1 (en) * | 2005-07-27 | 2007-02-01 | Aurobindo Pharma Limited | An improved process for the preparation of escitalopram |
-
2008
- 2008-08-29 NZ NZ570884A patent/NZ570884A/en not_active IP Right Cessation
- 2008-08-29 FI FI20085807A patent/FI121570B/fi not_active IP Right Cessation
- 2008-09-01 GB GB0815773A patent/GB2448848B/en not_active Expired - Fee Related
- 2008-09-01 IE IE20080708A patent/IES20080708A2/en not_active IP Right Cessation
- 2008-09-01 TW TW097133379A patent/TWI391383B/zh active
- 2008-09-01 NO NO20083756A patent/NO20083756L/no unknown
- 2008-09-02 JP JP2008224435A patent/JP4966933B2/ja active Active
- 2008-09-02 BG BG110206A patent/BG110206A/en unknown
- 2008-09-02 EA EA200801797A patent/EA012787B1/ru not_active IP Right Cessation
- 2008-09-02 HR HR20080425A patent/HRP20080425A2/hr not_active Application Discontinuation
- 2008-09-02 IS IS8758A patent/IS8758A/is unknown
- 2008-09-02 LV LVP-08-154A patent/LV13813B/lv unknown
- 2008-09-02 IL IL193845A patent/IL193845A/en active IP Right Grant
- 2008-09-03 ME MEP-2008-101A patent/ME00176B/me unknown
- 2008-09-03 AR ARP080103832A patent/AR068174A1/es active IP Right Grant
- 2008-09-03 LT LT2008068A patent/LT5577B/lt not_active IP Right Cessation
- 2008-09-04 PL PL386026A patent/PL386026A1/pl unknown
- 2008-09-04 MY MYPI20083415A patent/MY144210A/en unknown
- 2008-09-04 CZ CZ20080537A patent/CZ2008537A3/cs unknown
- 2008-09-04 RS RSP-2008/0401A patent/RS20080401A/sr unknown
- 2008-09-04 NL NL2001953A patent/NL2001953C2/en not_active IP Right Cessation
- 2008-09-05 SI SI200800207A patent/SI22567A2/sl not_active IP Right Cessation
- 2008-09-05 HU HU0800549A patent/HUP0800549A2/hu unknown
- 2008-09-08 AU AU2008212055A patent/AU2008212055C1/en active Active
- 2008-09-08 MX MX2008011451A patent/MX2008011451A/es active IP Right Grant
- 2008-09-09 EE EEU200800091U patent/EE00864U1/xx not_active IP Right Cessation
- 2008-09-09 SE SE0801929A patent/SE533041C2/sv not_active IP Right Cessation
- 2008-09-09 PT PT104169A patent/PT104169A/pt not_active IP Right Cessation
- 2008-09-09 ZA ZA200807753A patent/ZA200807753B/en unknown
- 2008-09-10 PL PL08801398T patent/PL2061753T3/pl unknown
- 2008-09-10 SG SG200806650-8A patent/SG151195A1/en unknown
- 2008-09-10 ES ES08801398T patent/ES2368294T3/es active Active
- 2008-09-10 CA CA2638499A patent/CA2638499C/en not_active Expired - Fee Related
- 2008-09-10 AT AT08801398T patent/ATE518829T1/de active
- 2008-09-10 CL CL2008002686A patent/CL2008002686A1/es unknown
- 2008-09-10 FR FR0856077A patent/FR2920766A1/fr active Pending
- 2008-09-10 CY CY0800015A patent/CY2600B1/xx unknown
- 2008-09-10 EP EP11172640A patent/EP2397461A1/en not_active Withdrawn
- 2008-09-10 RS RS20110394A patent/RS51909B/en unknown
- 2008-09-10 PT PT08801398T patent/PT2061753E/pt unknown
- 2008-09-10 WO PCT/DK2008/050222 patent/WO2009033488A1/en active Application Filing
- 2008-09-10 DK DK08801398.2T patent/DK2061753T3/da active
- 2008-09-10 GR GR20080100581A patent/GR1006595B/el not_active IP Right Cessation
- 2008-09-10 SI SI200830361T patent/SI2061753T1/sl unknown
- 2008-09-10 UA UAU200901635U patent/UA41919U/uk unknown
- 2008-09-10 DE DE102008046530A patent/DE102008046530A1/de not_active Withdrawn
- 2008-09-10 SK SK50030-2008A patent/SK500302008A3/sk unknown
- 2008-09-10 CO CO08095718A patent/CO6140012A1/es not_active Application Discontinuation
- 2008-09-10 EP EP08801398A patent/EP2061753B1/en active Active
- 2008-09-10 ES ES200802582A patent/ES2334875B1/es not_active Expired - Fee Related
- 2008-09-10 DK DKPA200801265A patent/DK177075B1/da not_active IP Right Cessation
- 2008-09-10 CN CNA2008101686272A patent/CN101386583A/zh active Pending
- 2008-09-10 UA UAU200811050U patent/UA43461U/uk unknown
- 2008-09-11 TR TR2008/06903A patent/TR200806903A2/xx unknown
- 2008-09-11 TR TR2009/07629A patent/TR200907629A2/xx unknown
- 2008-09-11 RO ROA200800706A patent/RO125301A2/ro unknown
- 2008-09-11 LU LU91479A patent/LU91479B1/fr active
- 2008-09-11 BR BRPI0804121-0A patent/BRPI0804121B1/pt active IP Right Grant
- 2008-09-11 CH CH01450/08A patent/CH697885B1/de not_active IP Right Cessation
- 2008-09-11 AT AT0048708U patent/AT10984U1/de not_active IP Right Cessation
- 2008-09-11 BE BE2008/0498A patent/BE1017548A6/fr not_active IP Right Cessation
- 2008-09-11 KR KR1020080090058A patent/KR101054224B1/ko active IP Right Grant
-
2011
- 2011-09-07 HR HR20110636T patent/HRP20110636T1/hr unknown
- 2011-10-07 CY CY20111100963T patent/CY1111924T1/el unknown
-
2017
- 2017-06-26 AR ARP170101761A patent/AR108885A2/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2008002686A1 (es) | Metodo para resolver una mezcla racemica de un diol intermediario en la sintesis de escitalopram usando acido tartarico ocupando al menos un 50% de 1-propanolol como solvente. | |
ES2567159T3 (es) | Método para la deshidratación de alcoholes grasos | |
CY1112283T1 (el) | Μεθοδος για την παρασκευη 17-βινυλ-τριφλικων ως ενδιaμεσα | |
HRP20050641A2 (en) | New carboxylic acids and the esters thereof, pharmaceutical compositions containing these compounds and processes for the preparation thereof | |
RS51341B (en) | INTERMEDIATE COMPOUNDS FOR THE TRANS-5-CHLOR-2-METHYL-2,3A, 12B-TETRAHYDRO-1H-DIBENZE [2,3; 6,7] OXEPINO [4,5-C] Pyrrole | |
UY30051A1 (es) | Derivados de pirimidina para el tratamiento del crecimiento celular anormal | |
ATE554086T1 (de) | Scopin-salze und deren verwendung in verfahren zur herstellung von n-demethyl-tiotropium und tiotropiumbromid | |
EA201101672A1 (ru) | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина | |
BRPI0813140C1 (pt) | método para a preparação de ácido desoxicólico (dca) ou um éster desse ou um sal farmaceuticamente aceitável desse e composto intermediário | |
EA201170251A1 (ru) | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 1,2,3,4-ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛ-3-ИЛ)УКСУСНОЙ КИСЛОТЫ, ПРИМЕНИМЫЕ В ЛЕЧЕНИИ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ РАССТРОЙСТВ | |
AR063515A1 (es) | Nuevos derivados piridazina | |
ATE506352T1 (de) | Verfahren zur herstellung von optional 2- substituierten 1,6-dihydro-6-oxo-4- pyrimidincarboxylsäuren | |
PE20061437A1 (es) | Composicion en emulsion que comprende derivados de cicloalqueno, estable en rango acido | |
MA32297B1 (fr) | Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxylique | |
EA201070804A1 (ru) | (аза)индольное производное, замещенное по положению 5, содержащая его фармацевтическая композиция, промежуточные соединения и способ их получения | |
SV2008002512A (es) | Derivados de aminoacidos ref. pc32769a | |
DE602006014001D1 (de) | Herstellung von 2-aminothiazol-5-carbonsäurederivaten | |
DE602006002271D1 (de) | Pyrimidinderivate zur verwendung als antikrebsmittel | |
CL2009000453A1 (es) | Composicion farmaceutica que comprende i) compuesto derivado triciclico nitrogenado, tal como pirido[2,3-b]indol, ii) al menos un derivado de ciclodextrina y iii) agua, util para prevenir o tratar cancer e inflamacion, entre otras; metodo para mejorar la solubilidad y estabilidad en agua de dichos compuestos. | |
BRPI0509360A (pt) | processo para preparação de derivados de diazina | |
IL180571A0 (en) | Method for producing enantiomeric from of 2,3-diaminopropionic acid derivatives | |
ATE380190T1 (de) | Verbessertes verfahren zur herstellung von 5,6 - dihydro -4h-4(s)-ethylamin-6(s)-methylthieno(2,3- b) thiopyran-2-sulfonamid- 7,7 -dioxid und seinen salzen | |
CY1116177T1 (el) | Μεθοδος για την παρασκευη 17-βινυλο-τριφλικων ως ενδιαμεσα | |
DE60302217D1 (de) | Trizyklo-imidazolinen derivaten, verfahren zu deren herstellung und deren verwendung als heilmitteln | |
ITMI20040582A1 (it) | Processo per la semisintesi di deserpidina |