MA32297B1 - Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxylique - Google Patents

Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxylique

Info

Publication number
MA32297B1
MA32297B1 MA33338A MA33338A MA32297B1 MA 32297 B1 MA32297 B1 MA 32297B1 MA 33338 A MA33338 A MA 33338A MA 33338 A MA33338 A MA 33338A MA 32297 B1 MA32297 B1 MA 32297B1
Authority
MA
Morocco
Prior art keywords
halobiphenyl
preparation
carboxylic acid
acid derivatives
cyclopropane carboxylic
Prior art date
Application number
MA33338A
Other languages
Arabic (ar)
English (en)
Inventor
Benoit Folleas
Hubert Botte
Thomas Delacroix
Fausto Pivetti
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of MA32297B1 publication Critical patent/MA32297B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

La présente invention concerne un procédé permettant de préparer un composé selon la formule (i). L'invention concerne également des intermédiaires utiles dans le procédé.
MA33338A 2008-06-11 2010-11-11 Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxylique MA32297B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08158022A EP2133322A1 (fr) 2008-06-11 2008-06-11 Procédé de préparation de dérivés d'acide 1-(2-halobiphényl-4-yl)-cyclopropanecardxylique
PCT/EP2009/003288 WO2009149797A1 (fr) 2008-06-11 2009-05-08 Procédé de préparation de dérivés d’acide 1-(2-halobiphényl-4-yl)-cyclopropane carboxylique

Publications (1)

Publication Number Publication Date
MA32297B1 true MA32297B1 (fr) 2011-05-02

Family

ID=40120119

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33338A MA32297B1 (fr) 2008-06-11 2010-11-11 Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxylique

Country Status (28)

Country Link
US (1) US8076505B2 (fr)
EP (2) EP2133322A1 (fr)
JP (1) JP5642067B2 (fr)
KR (1) KR101257217B1 (fr)
CN (1) CN102046576B (fr)
AT (1) ATE552230T1 (fr)
AU (1) AU2009256959B2 (fr)
BR (1) BRPI0909560A2 (fr)
CA (1) CA2723878C (fr)
CO (1) CO6331461A2 (fr)
DK (1) DK2285765T3 (fr)
ES (1) ES2384368T3 (fr)
GE (1) GEP20135800B (fr)
HK (1) HK1152292A1 (fr)
HR (1) HRP20120517T1 (fr)
IL (1) IL209209A (fr)
MA (1) MA32297B1 (fr)
ME (1) ME01160B (fr)
MX (1) MX2010012285A (fr)
MY (1) MY150280A (fr)
NZ (1) NZ589087A (fr)
PL (1) PL2285765T3 (fr)
PT (1) PT2285765E (fr)
RU (1) RU2502721C2 (fr)
SI (1) SI2285765T1 (fr)
UA (1) UA101835C2 (fr)
WO (1) WO2009149797A1 (fr)
ZA (1) ZA201007977B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004016729D1 (de) * 2003-02-21 2008-11-06 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
MY152980A (en) * 2009-08-04 2014-12-15 Chiesi Farma Spa Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
CN102869643A (zh) * 2010-04-01 2013-01-09 奇斯药制品公司 新的多晶型物和盐
BR112012026803A2 (pt) * 2010-04-21 2016-07-12 Chiesi Farma Spa composto
CA2801449A1 (fr) 2010-06-04 2011-12-08 Chiesi Farmaceutici S.P.A. Derives de l'acide 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylique destines au traitement de maladies a prions
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
BR112014023670A8 (pt) 2012-04-04 2017-07-25 Chiesi Farm Spa Composto, composição farmacêutica e suo de um composto
RU2015153818A (ru) * 2013-06-24 2017-06-21 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Усовершенствованный способ получения производных 1-(2-фтор[1, 1-бифенил]-4-ил)-циклопропанкарбоновой кислоты
EP2818460A1 (fr) 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation de phénylacétonitriles substitués ou acétates de phényle
US20150335596A1 (en) 2014-05-26 2015-11-26 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
CN107698462A (zh) * 2017-10-10 2018-02-16 重庆科脉生物化工有限公司 一种1‑氨基‑1‑环丙腈盐酸盐的制备方法
US20230113097A1 (en) 2021-08-31 2023-04-13 Cerespir Incorporated Co-crystals

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4507294B2 (ja) * 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
JP4502293B2 (ja) * 1999-06-04 2010-07-14 長瀬産業株式会社 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用
JP2004091342A (ja) * 2002-08-29 2004-03-25 Matsushita Electric Ind Co Ltd 芳香族メチリデン化合物、それを製造するための化合物、それらの製造方法、及び芳香族メチリデン化合物を用いた有機電界発光素子
DE602004016729D1 (de) 2003-02-21 2008-11-06 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
ITMI20030311A1 (it) * 2003-02-21 2004-08-22 Chiesi Farma Spa Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
EP1650183A1 (fr) * 2004-10-21 2006-04-26 Cellzome Ag L'acides acétiques (de benzyloxy-biphenyle) et de leurs derives ainsi que leurs utilisation en thérapie
US7524870B2 (en) * 2004-12-03 2009-04-28 Hoffmann-La Roche Inc. Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
WO2006133559A1 (fr) * 2005-06-14 2006-12-21 Merck Frosst Canada Ltd. Inhibiteurs reversibles des monoamines oxydases a et b
JP5272345B2 (ja) * 2006-08-28 2013-08-28 東ソー株式会社 ヘテロアセン誘導体、テトラハロターフェニル誘導体及びそれらの製造方法
MY152980A (en) * 2009-08-04 2014-12-15 Chiesi Farma Spa Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Also Published As

Publication number Publication date
RU2502721C2 (ru) 2013-12-27
HRP20120517T1 (hr) 2012-07-31
CA2723878A1 (fr) 2009-12-17
IL209209A (en) 2014-05-28
JP2011523953A (ja) 2011-08-25
ES2384368T3 (es) 2012-07-04
PL2285765T3 (pl) 2012-08-31
US8076505B2 (en) 2011-12-13
NZ589087A (en) 2012-03-30
US20090312426A1 (en) 2009-12-17
JP5642067B2 (ja) 2014-12-17
CN102046576A (zh) 2011-05-04
EP2285765A1 (fr) 2011-02-23
CO6331461A2 (es) 2011-10-20
AU2009256959A1 (en) 2009-12-17
ATE552230T1 (de) 2012-04-15
ME01160B (fr) 2013-03-20
WO2009149797A1 (fr) 2009-12-17
SI2285765T1 (sl) 2012-08-31
IL209209A0 (en) 2011-01-31
EP2285765B1 (fr) 2012-04-04
DK2285765T3 (da) 2012-06-04
CA2723878C (fr) 2016-06-28
CN102046576B (zh) 2013-08-21
MY150280A (en) 2013-12-31
BRPI0909560A2 (pt) 2015-09-22
PT2285765E (pt) 2012-06-21
ZA201007977B (en) 2012-02-29
HK1152292A1 (en) 2012-02-24
MX2010012285A (es) 2010-12-01
GEP20135800B (en) 2013-04-10
UA101835C2 (uk) 2013-05-13
EP2133322A1 (fr) 2009-12-16
RU2010146299A (ru) 2012-07-20
KR20110010633A (ko) 2011-02-01
KR101257217B1 (ko) 2013-04-22
AU2009256959B2 (en) 2014-03-27

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