MA29781B1 - Procede regioselectif de preparation de benzimidazole thiophenes - Google Patents
Procede regioselectif de preparation de benzimidazole thiophenesInfo
- Publication number
- MA29781B1 MA29781B1 MA30750A MA30750A MA29781B1 MA 29781 B1 MA29781 B1 MA 29781B1 MA 30750 A MA30750 A MA 30750A MA 30750 A MA30750 A MA 30750A MA 29781 B1 MA29781 B1 MA 29781B1
- Authority
- MA
- Morocco
- Prior art keywords
- thiophenes
- preparing benzimidazole
- regioselective process
- preparing
- benzimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'INVENTION CONCERNE UN PROCÉDÉ DE PRÉPARATION DE COMPOSÉS DE BENZIMIDAZOLE THIOPHÈNE DE FORMULE I. L'INVENTION CONCERNE EN OUTRE DES PRODUITS INTERMÉDIAIRES UTILISÉS DANS CE PROCÉDÉ.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71430105P | 2005-09-06 | 2005-09-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29781B1 true MA29781B1 (fr) | 2008-09-01 |
Family
ID=37605702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30750A MA29781B1 (fr) | 2005-09-06 | 2008-03-17 | Procede regioselectif de preparation de benzimidazole thiophenes |
Country Status (18)
Country | Link |
---|---|
US (1) | US20080249301A1 (fr) |
EP (1) | EP1924572B1 (fr) |
JP (1) | JP2009507022A (fr) |
KR (1) | KR20080045266A (fr) |
CN (1) | CN101304986A (fr) |
AT (1) | ATE453634T1 (fr) |
AU (1) | AU2006287771A1 (fr) |
BR (1) | BRPI0615705A2 (fr) |
CA (1) | CA2621073A1 (fr) |
DE (1) | DE602006011482D1 (fr) |
EA (1) | EA200800549A1 (fr) |
ES (1) | ES2338590T3 (fr) |
IL (1) | IL189769A0 (fr) |
MA (1) | MA29781B1 (fr) |
MX (1) | MX2008003172A (fr) |
NO (1) | NO20081101L (fr) |
WO (1) | WO2007030366A1 (fr) |
ZA (1) | ZA200801950B (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20070518A1 (es) * | 2005-09-06 | 2007-06-12 | Smithkline Beecham Corp | Compuestos de tiofeno bencimidazol como agentes inhibidores de plk |
CN101331126A (zh) * | 2005-09-06 | 2008-12-24 | 史密丝克莱恩比彻姆公司 | 作为plk调节剂的苯并咪唑噻吩化合物 |
WO2007087283A2 (fr) * | 2006-01-23 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides utiles en tant qu'inhibiteurs de proteines kinases |
EP2007757B1 (fr) | 2006-04-13 | 2012-10-03 | Vertex Pharmceuticals Incorporated | Thiophène-carboxamides servant d'inhibiteurs de protéines kinases |
US8853244B2 (en) | 2006-05-23 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
US7851495B2 (en) | 2006-05-23 | 2010-12-14 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
EP2170871A2 (fr) * | 2007-06-26 | 2010-04-07 | GlaxoSmithKline LLC | Procédés de préparation de thiophènes de benzimidazole |
EP2100894A1 (fr) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinones utilisés comme inhibiteurs de la kinase de type Plk1 (polo-like kinase) |
WO2011130194A2 (fr) * | 2010-04-12 | 2011-10-20 | Supernus Pharmaceuticals Inc. | Procédés de fabrication de sels de viloxazine et leurs nouveaux polymorphes |
US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
WO2012088266A2 (fr) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3 |
EP2565186A1 (fr) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Inhibiteurs sélectifs et réversibles de la protéase 7 spécifique de l'ubiquitine |
BR112014025201A2 (pt) | 2012-04-10 | 2017-07-11 | Sumitomo Dainippon Pharma Co Ltd | derivado de indazol 1-substituído |
CN107652289B (zh) | 2012-06-13 | 2020-07-21 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
WO2014026125A1 (fr) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Dérivés de pyrazine en tant qu'inhibiteurs de fgfr |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
JP6449244B2 (ja) | 2013-04-19 | 2019-01-09 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Fgfr抑制剤としての二環式複素環 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
WO2016134320A1 (fr) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
EP3728228A1 (fr) | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Dérivés d'aminopyridine utilisés en tant qu'inhibiteurs de la phosphatidylinositol phosphate kinase |
SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
DK3788047T3 (da) | 2018-05-04 | 2024-09-16 | Incyte Corp | Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
CN109988098A (zh) * | 2019-05-23 | 2019-07-09 | 常州工程职业技术学院 | 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法 |
TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
WO2021007269A1 (fr) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
MX2022004513A (es) | 2019-10-14 | 2022-07-19 | Incyte Corp | Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
WO2021076728A1 (fr) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
EP4323405A1 (fr) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Polythérapie comprenant un inhibiteur de fgfr et un agent de ciblage de nectine-4 |
CA3220274A1 (fr) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Heterocycles tricycliques en tant qu'inhibiteurs de fgfr |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
GB0005642D0 (en) * | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
CA2465328C (fr) * | 2001-11-01 | 2011-06-14 | Michael Francis Gross | Piperidines |
US20060074119A1 (en) * | 2002-08-08 | 2006-04-06 | Andrews Clarence W Iii | Thiophene compounds |
US7491737B2 (en) * | 2002-10-30 | 2009-02-17 | Merck & Co., Inc. | Heterarylpiperidine modulators of chemokine receptor activity |
JP2007509070A (ja) * | 2003-10-16 | 2007-04-12 | スミスクライン ビーチャム コーポレーション | チオフェン化合物 |
-
2006
- 2006-08-28 EP EP06813938A patent/EP1924572B1/fr active Active
- 2006-08-28 MX MX2008003172A patent/MX2008003172A/es not_active Application Discontinuation
- 2006-08-28 WO PCT/US2006/033793 patent/WO2007030366A1/fr active Application Filing
- 2006-08-28 AT AT06813938T patent/ATE453634T1/de not_active IP Right Cessation
- 2006-08-28 CA CA002621073A patent/CA2621073A1/fr not_active Abandoned
- 2006-08-28 CN CNA2006800413629A patent/CN101304986A/zh active Pending
- 2006-08-28 JP JP2008529214A patent/JP2009507022A/ja not_active Ceased
- 2006-08-28 DE DE602006011482T patent/DE602006011482D1/de active Active
- 2006-08-28 EA EA200800549A patent/EA200800549A1/ru unknown
- 2006-08-28 AU AU2006287771A patent/AU2006287771A1/en not_active Abandoned
- 2006-08-28 ES ES06813938T patent/ES2338590T3/es active Active
- 2006-08-28 KR KR1020087008167A patent/KR20080045266A/ko not_active Application Discontinuation
- 2006-08-28 BR BRPI0615705A patent/BRPI0615705A2/pt not_active IP Right Cessation
- 2006-08-28 US US12/065,655 patent/US20080249301A1/en not_active Abandoned
-
2008
- 2008-02-26 IL IL189769A patent/IL189769A0/en unknown
- 2008-02-29 ZA ZA200801950A patent/ZA200801950B/xx unknown
- 2008-03-03 NO NO20081101A patent/NO20081101L/no not_active Application Discontinuation
- 2008-03-17 MA MA30750A patent/MA29781B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
US20080249301A1 (en) | 2008-10-09 |
ATE453634T1 (de) | 2010-01-15 |
EP1924572A1 (fr) | 2008-05-28 |
EA200800549A1 (ru) | 2008-08-29 |
EP1924572B1 (fr) | 2009-12-30 |
DE602006011482D1 (de) | 2010-02-11 |
JP2009507022A (ja) | 2009-02-19 |
IL189769A0 (en) | 2008-08-07 |
WO2007030366A1 (fr) | 2007-03-15 |
BRPI0615705A2 (pt) | 2016-08-23 |
NO20081101L (no) | 2008-04-04 |
CN101304986A (zh) | 2008-11-12 |
KR20080045266A (ko) | 2008-05-22 |
ES2338590T3 (es) | 2010-05-10 |
AU2006287771A1 (en) | 2007-03-15 |
CA2621073A1 (fr) | 2007-03-15 |
ZA200801950B (en) | 2009-09-30 |
MX2008003172A (es) | 2008-03-18 |
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