ATE453634T1 - Regioselektives verfahren zur zubereitung von benzimidazol-thiophenen - Google Patents
Regioselektives verfahren zur zubereitung von benzimidazol-thiophenenInfo
- Publication number
- ATE453634T1 ATE453634T1 AT06813938T AT06813938T ATE453634T1 AT E453634 T1 ATE453634 T1 AT E453634T1 AT 06813938 T AT06813938 T AT 06813938T AT 06813938 T AT06813938 T AT 06813938T AT E453634 T1 ATE453634 T1 AT E453634T1
- Authority
- AT
- Austria
- Prior art keywords
- thiophenes
- preparing benzimidazole
- regioselective process
- preparing
- benzimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71430105P | 2005-09-06 | 2005-09-06 | |
| PCT/US2006/033793 WO2007030366A1 (en) | 2005-09-06 | 2006-08-28 | Regioselective process for preparing benzimidazole thiophenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453634T1 true ATE453634T1 (de) | 2010-01-15 |
Family
ID=37605702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06813938T ATE453634T1 (de) | 2005-09-06 | 2006-08-28 | Regioselektives verfahren zur zubereitung von benzimidazol-thiophenen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20080249301A1 (de) |
| EP (1) | EP1924572B1 (de) |
| JP (1) | JP2009507022A (de) |
| KR (1) | KR20080045266A (de) |
| CN (1) | CN101304986A (de) |
| AT (1) | ATE453634T1 (de) |
| AU (1) | AU2006287771A1 (de) |
| BR (1) | BRPI0615705A2 (de) |
| CA (1) | CA2621073A1 (de) |
| DE (1) | DE602006011482D1 (de) |
| EA (1) | EA200800549A1 (de) |
| ES (1) | ES2338590T3 (de) |
| IL (1) | IL189769A0 (de) |
| MA (1) | MA29781B1 (de) |
| MX (1) | MX2008003172A (de) |
| NO (1) | NO20081101L (de) |
| WO (1) | WO2007030366A1 (de) |
| ZA (1) | ZA200801950B (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7595330B2 (en) * | 2005-09-06 | 2009-09-29 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
| JP2009507020A (ja) * | 2005-09-06 | 2009-02-19 | スミスクライン ビーチャム コーポレーション | Ｐｌｋ調節物質としてのルベンゾイミダゾールチオフェン化合物 |
| WO2007087283A2 (en) * | 2006-01-23 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| CN101466708A (zh) | 2006-04-13 | 2009-06-24 | 弗特克斯药品有限公司 | 可用作蛋白激酶抑制剂的噻吩甲酰胺 |
| AU2007268056A1 (en) | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| AU2007267986A1 (en) | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
| WO2009002916A2 (en) * | 2007-06-26 | 2008-12-31 | Smithkline Beecham Corporation | Processes for preparing benzimidazole thiophenes |
| EP2100894A1 (de) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinone verwendbar als Plk1 (polo-like kinase) Hemmen |
| MX357614B (es) * | 2010-04-12 | 2018-07-17 | Supernus Pharmaceuticals Inc | Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas. |
| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| EP2565186A1 (de) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Spezifische und reversible Inhibitoren von ubiquitinspezifischer Protease 7 |
| RU2014144951A (ru) | 2012-04-10 | 2016-06-10 | Сумитомо Дайниппон Фарма Ко., Лтд. | Новое 1-замещенное производное индазола |
| EA036592B1 (ru) | 2012-06-13 | 2020-11-26 | Инсайт Холдингс Корпорейшн | Замещенные трициклические соединения как ингибиторы fgfr |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| WO2014172644A2 (en) | 2013-04-19 | 2014-10-23 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| ES2895769T3 (es) | 2015-02-20 | 2022-02-22 | Incyte Corp | Heterociclos bicíclicos como inhibidores de FGFR |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| BR112020012635A2 (pt) | 2017-12-22 | 2020-12-01 | Ravenna Pharmaceuticals, Inc. | derivados de aminopiridina como inibidores de fosfatidilinositol fosfato quinase |
| US11174257B2 (en) | 2018-05-04 | 2021-11-16 | Incyte Corporation | Salts of an FGFR inhibitor |
| CA3099287A1 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| CN109988098A (zh) * | 2019-05-23 | 2019-07-09 | 常州工程职业技术学院 | 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法 |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| EP4069696A1 (de) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclische heterocyclen als fgfr-inhibitoren |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| EP4352059A1 (de) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclische heterocyclen als fgfr-inhibitoren |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| GB0005642D0 (en) * | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| US7244744B2 (en) * | 2001-11-01 | 2007-07-17 | Icagen, Inc. | Piperidines |
| KR20050071471A (ko) * | 2002-08-08 | 2005-07-07 | 스미스클라인 비참 코포레이션 | 티오펜 화합물 |
| CA2502178A1 (en) * | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Heteroarylpiperidine modulators of chemokine receptor activity |
| JP2007509070A (ja) * | 2003-10-16 | 2007-04-12 | スミスクライン ビーチャム コーポレーション | チオフェン化合物 |
-
2006
- 2006-08-28 KR KR1020087008167A patent/KR20080045266A/ko not_active Application Discontinuation
- 2006-08-28 AT AT06813938T patent/ATE453634T1/de not_active IP Right Cessation
- 2006-08-28 ES ES06813938T patent/ES2338590T3/es active Active
- 2006-08-28 JP JP2008529214A patent/JP2009507022A/ja not_active Ceased
- 2006-08-28 DE DE602006011482T patent/DE602006011482D1/de active Active
- 2006-08-28 CN CNA2006800413629A patent/CN101304986A/zh active Pending
- 2006-08-28 CA CA002621073A patent/CA2621073A1/en not_active Abandoned
- 2006-08-28 MX MX2008003172A patent/MX2008003172A/es not_active Application Discontinuation
- 2006-08-28 AU AU2006287771A patent/AU2006287771A1/en not_active Abandoned
- 2006-08-28 BR BRPI0615705A patent/BRPI0615705A2/pt not_active IP Right Cessation
- 2006-08-28 WO PCT/US2006/033793 patent/WO2007030366A1/en active Application Filing
- 2006-08-28 EA EA200800549A patent/EA200800549A1/ru unknown
- 2006-08-28 EP EP06813938A patent/EP1924572B1/de active Active
- 2006-08-28 US US12/065,655 patent/US20080249301A1/en not_active Abandoned
-
2008
- 2008-02-26 IL IL189769A patent/IL189769A0/en unknown
- 2008-02-29 ZA ZA200801950A patent/ZA200801950B/xx unknown
- 2008-03-03 NO NO20081101A patent/NO20081101L/no not_active Application Discontinuation
- 2008-03-17 MA MA30750A patent/MA29781B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006287771A1 (en) | 2007-03-15 |
| ES2338590T3 (es) | 2010-05-10 |
| ZA200801950B (en) | 2009-09-30 |
| CA2621073A1 (en) | 2007-03-15 |
| EP1924572B1 (de) | 2009-12-30 |
| EP1924572A1 (de) | 2008-05-28 |
| JP2009507022A (ja) | 2009-02-19 |
| MX2008003172A (es) | 2008-03-18 |
| WO2007030366A1 (en) | 2007-03-15 |
| NO20081101L (no) | 2008-04-04 |
| EA200800549A1 (ru) | 2008-08-29 |
| IL189769A0 (en) | 2008-08-07 |
| MA29781B1 (fr) | 2008-09-01 |
| KR20080045266A (ko) | 2008-05-22 |
| DE602006011482D1 (de) | 2010-02-11 |
| BRPI0615705A2 (pt) | 2016-08-23 |
| CN101304986A (zh) | 2008-11-12 |
| US20080249301A1 (en) | 2008-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |