ATE453634T1 - Regioselektives verfahren zur zubereitung von benzimidazol-thiophenen - Google Patents
Regioselektives verfahren zur zubereitung von benzimidazol-thiophenenInfo
- Publication number
- ATE453634T1 ATE453634T1 AT06813938T AT06813938T ATE453634T1 AT E453634 T1 ATE453634 T1 AT E453634T1 AT 06813938 T AT06813938 T AT 06813938T AT 06813938 T AT06813938 T AT 06813938T AT E453634 T1 ATE453634 T1 AT E453634T1
- Authority
- AT
- Austria
- Prior art keywords
- thiophenes
- preparing benzimidazole
- regioselective process
- preparing
- benzimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71430105P | 2005-09-06 | 2005-09-06 | |
| PCT/US2006/033793 WO2007030366A1 (en) | 2005-09-06 | 2006-08-28 | Regioselective process for preparing benzimidazole thiophenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453634T1 true ATE453634T1 (de) | 2010-01-15 |
Family
ID=37605702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06813938T ATE453634T1 (de) | 2005-09-06 | 2006-08-28 | Regioselektives verfahren zur zubereitung von benzimidazol-thiophenen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20080249301A1 (de) |
| EP (1) | EP1924572B1 (de) |
| JP (1) | JP2009507022A (de) |
| KR (1) | KR20080045266A (de) |
| CN (1) | CN101304986A (de) |
| AT (1) | ATE453634T1 (de) |
| AU (1) | AU2006287771A1 (de) |
| BR (1) | BRPI0615705A2 (de) |
| CA (1) | CA2621073A1 (de) |
| DE (1) | DE602006011482D1 (de) |
| EA (1) | EA200800549A1 (de) |
| ES (1) | ES2338590T3 (de) |
| IL (1) | IL189769A0 (de) |
| MA (1) | MA29781B1 (de) |
| MX (1) | MX2008003172A (de) |
| NO (1) | NO20081101L (de) |
| WO (1) | WO2007030366A1 (de) |
| ZA (1) | ZA200801950B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20070518A1 (es) * | 2005-09-06 | 2007-06-12 | Smithkline Beecham Corp | Compuestos de tiofeno bencimidazol como agentes inhibidores de plk |
| CN101331126A (zh) * | 2005-09-06 | 2008-12-24 | 史密丝克莱恩比彻姆公司 | 作为plk调节剂的苯并咪唑噻吩化合物 |
| WO2007087283A2 (en) * | 2006-01-23 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| EP2007757B1 (de) | 2006-04-13 | 2012-10-03 | Vertex Pharmceuticals Incorporated | Als protein-kinase-inhibitoren nutzbare thiophen-carboxamide |
| US8853244B2 (en) | 2006-05-23 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| US7851495B2 (en) | 2006-05-23 | 2010-12-14 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
| EP2170871A2 (de) * | 2007-06-26 | 2010-04-07 | GlaxoSmithKline LLC | Verfahren zur herstellung von benzimidazolthiophenen |
| EP2100894A1 (de) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinone verwendbar als Plk1 (polo-like kinase) Hemmen |
| WO2011130194A2 (en) * | 2010-04-12 | 2011-10-20 | Supernus Pharmaceuticals Inc. | Methods for producing viloxazine salts and novel polymorphs thereof |
| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| EP2565186A1 (de) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Spezifische und reversible Inhibitoren von ubiquitinspezifischer Protease 7 |
| BR112014025201A2 (pt) | 2012-04-10 | 2017-07-11 | Sumitomo Dainippon Pharma Co Ltd | derivado de indazol 1-substituído |
| CN107652289B (zh) | 2012-06-13 | 2020-07-21 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| JP6449244B2 (ja) | 2013-04-19 | 2019-01-09 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｆｇｆｒ抑制剤としての二環式複素環 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134320A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EP3728228A1 (de) | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Aminopyridinderivate als phosphatidylinositol-phosphatkinase-inhibitoren |
| SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
| DK3788047T3 (da) | 2018-05-04 | 2024-09-16 | Incyte Corp | Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| CN109988098A (zh) * | 2019-05-23 | 2019-07-09 | 常州工程职业技术学院 | 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法 |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| MX2022004513A (es) | 2019-10-14 | 2022-07-19 | Incyte Corp | Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4323405A1 (de) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Kombinationstherapie mit einem fgfr-inhibitor und einem auf nectin-4 abzielenden mittel |
| CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| GB0005642D0 (en) * | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| CA2465328C (en) * | 2001-11-01 | 2011-06-14 | Michael Francis Gross | Piperidines |
| US20060074119A1 (en) * | 2002-08-08 | 2006-04-06 | Andrews Clarence W Iii | Thiophene compounds |
| US7491737B2 (en) * | 2002-10-30 | 2009-02-17 | Merck & Co., Inc. | Heterarylpiperidine modulators of chemokine receptor activity |
| JP2007509070A (ja) * | 2003-10-16 | 2007-04-12 | スミスクライン ビーチャム コーポレーション | チオフェン化合物 |
-
2006
- 2006-08-28 EP EP06813938A patent/EP1924572B1/de active Active
- 2006-08-28 MX MX2008003172A patent/MX2008003172A/es not_active Application Discontinuation
- 2006-08-28 WO PCT/US2006/033793 patent/WO2007030366A1/en active Application Filing
- 2006-08-28 AT AT06813938T patent/ATE453634T1/de not_active IP Right Cessation
- 2006-08-28 CA CA002621073A patent/CA2621073A1/en not_active Abandoned
- 2006-08-28 CN CNA2006800413629A patent/CN101304986A/zh active Pending
- 2006-08-28 JP JP2008529214A patent/JP2009507022A/ja not_active Ceased
- 2006-08-28 DE DE602006011482T patent/DE602006011482D1/de active Active
- 2006-08-28 EA EA200800549A patent/EA200800549A1/ru unknown
- 2006-08-28 AU AU2006287771A patent/AU2006287771A1/en not_active Abandoned
- 2006-08-28 ES ES06813938T patent/ES2338590T3/es active Active
- 2006-08-28 KR KR1020087008167A patent/KR20080045266A/ko not_active Application Discontinuation
- 2006-08-28 BR BRPI0615705A patent/BRPI0615705A2/pt not_active IP Right Cessation
- 2006-08-28 US US12/065,655 patent/US20080249301A1/en not_active Abandoned
-
2008
- 2008-02-26 IL IL189769A patent/IL189769A0/en unknown
- 2008-02-29 ZA ZA200801950A patent/ZA200801950B/xx unknown
- 2008-03-03 NO NO20081101A patent/NO20081101L/no not_active Application Discontinuation
- 2008-03-17 MA MA30750A patent/MA29781B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080249301A1 (en) | 2008-10-09 |
| EP1924572A1 (de) | 2008-05-28 |
| EA200800549A1 (ru) | 2008-08-29 |
| EP1924572B1 (de) | 2009-12-30 |
| DE602006011482D1 (de) | 2010-02-11 |
| JP2009507022A (ja) | 2009-02-19 |
| IL189769A0 (en) | 2008-08-07 |
| WO2007030366A1 (en) | 2007-03-15 |
| MA29781B1 (fr) | 2008-09-01 |
| BRPI0615705A2 (pt) | 2016-08-23 |
| NO20081101L (no) | 2008-04-04 |
| CN101304986A (zh) | 2008-11-12 |
| KR20080045266A (ko) | 2008-05-22 |
| ES2338590T3 (es) | 2010-05-10 |
| AU2006287771A1 (en) | 2007-03-15 |
| CA2621073A1 (en) | 2007-03-15 |
| ZA200801950B (en) | 2009-09-30 |
| MX2008003172A (es) | 2008-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE453634T1 (de) | Regioselektives verfahren zur zubereitung von benzimidazol-thiophenen | |
| UY33981A (es) | ?método para preparar compuestos macrocíclicos inhibidores de serina proteasas de hepatitis c?. | |
| DE602005015174D1 (de) | Verfahren zur herstellung von montelukast-natrium | |
| DE502006001614D1 (de) | Verfahren zur herstellung von 1-alkyl-3-phenyluracilen | |
| EA201001359A1 (ru) | Гетероциклические соединения в качестве ингибиторов cxcr2 | |
| CY1110010T1 (el) | Πυριδιναμινοσουλφονυλ υποκατεστημενα βενζαμιδια ως αναστολεις κυτοχρωματος ρ450 3α4 (cyp3a4) | |
| HRP20090213A2 (en) | Process and intermediates for preparing integrase inhibitors | |
| DE602006014670D1 (de) | Verfahren zur doppelbindungs-hydroisomerisierung von butenen | |
| ATE522518T1 (de) | Indazol- und isoindolderivate als glucokinaseaktivierende stoffe | |
| ATE485279T1 (de) | Verbessertes verfahren zur herstellung der salze von 4-(benzimidazolylmethylamin)-benzamiden | |
| DE502005004141D1 (de) | Verfahren zur kompensation von thermischen verlagerungen | |
| DE602007009096D1 (de) | Verfahren zur herstellung von benzopyran-2-olderivaten | |
| CY1118173T1 (el) | 5-[(3,3,3-τριφθορο-2-υδροξυ-1-αρυλπροπυλ)αμινο]-1h-κινολιν-2-ονες, μια διεργασια για την παραγωγη τους και η χρηση τους ως αντι-φλεγμονωδων παραγοντων | |
| EA200900945A1 (ru) | Новый способ синтеза агомелатина | |
| CY1112520T1 (el) | Βενζυλαμινες, μια διαδικασια για την παραγωγη τους και η χρηση τους ως αντι-φλεγμονωδεις παραγοντες | |
| TNSN06260A1 (en) | Process for the preparation of tryptase inhibitors | |
| DE502005007702D1 (de) | Verfahren zur herstellung von terrylen-3,4:11,12-t | |
| EA200801549A1 (ru) | Новые производные фенантридина в качестве антагонистов брадикинина | |
| ATE519722T1 (de) | Verfahren zur palladiumkatalysierten kopplung von terminalalkynen mit aryltosylaten | |
| DE502007003531D1 (de) | Verfahren zum herstellen von alkylaniliden aus halogenbenzolderivaten | |
| DE502007000339D1 (de) | Verfahren zur Herstellung von Urethangruppen aufweisenden Organosiliciumverbindungen | |
| DE602006017671D1 (de) | Verfahren zur herstellung von tricarbonsäuretris(alkylsubstituiertes cyclohexylamid) | |
| DE602006017011D1 (de) | Verfahren zur Herstellung von Mannich Kondensationsprodukte zur Verwendung als Chelatbildner | |
| DE112009000076A5 (de) | Verfahren zur Herstellung von Urethanen | |
| DE602006018331D1 (de) | 4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |