CY1112283T1 - Μεθοδος για την παρασκευη 17-βινυλ-τριφλικων ως ενδιaμεσα - Google Patents

Μεθοδος για την παρασκευη 17-βινυλ-τριφλικων ως ενδιaμεσα

Info

Publication number
CY1112283T1
CY1112283T1 CY20121100095T CY121100095T CY1112283T1 CY 1112283 T1 CY1112283 T1 CY 1112283T1 CY 20121100095 T CY20121100095 T CY 20121100095T CY 121100095 T CY121100095 T CY 121100095T CY 1112283 T1 CY1112283 T1 CY 1112283T1
Authority
CY
Cyprus
Prior art keywords
triflates
intermediates
vinyl
preparing
formula
Prior art date
Application number
CY20121100095T
Other languages
English (en)
Inventor
Paul Stanley Bury
Original Assignee
Btg International Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35311370&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1112283(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0418901A external-priority patent/GB0418901D0/en
Priority claimed from GBGB0418900.7A external-priority patent/GB0418900D0/en
Application filed by Btg International Limited filed Critical Btg International Limited
Publication of CY1112283T1 publication Critical patent/CY1112283T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Μια ένωση του τύπου (Ι) ή φαρμακευτικώς αποδεκτό άλας αυτής μπορεί να γίνει με μια μέθοδο που συμπεριλαμβάνει στάδιο τριφλίωσης με το οποίο μια κετόνη του τύπου (II) μετατρέπεται σε τριφλικό του τύπου (III) παρουσία μιας βάσης που περιλαμβάνει τριτοταγή ή ετεροκυκλική αμίνη, έτσι ώστε το pΚa του συζυγούς οξέος στους 25°C βρίσκεται εντός της περιοχής 5,21 έως 12.
CY20121100095T 2004-08-24 2012-01-27 Μεθοδος για την παρασκευη 17-βινυλ-τριφλικων ως ενδιaμεσα CY1112283T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60355804P 2004-08-24 2004-08-24
GB0418901A GB0418901D0 (en) 2004-08-24 2004-08-24 Synthetic method
GBGB0418900.7A GB0418900D0 (en) 2004-08-24 2004-08-24 Novel salt forms
EP05781067A EP1781683B1 (en) 2004-08-24 2005-08-23 Process for the preparation of 17-vinyl- triflates as intermediates

Publications (1)

Publication Number Publication Date
CY1112283T1 true CY1112283T1 (el) 2015-12-09

Family

ID=35311370

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100095T CY1112283T1 (el) 2004-08-24 2012-01-27 Μεθοδος για την παρασκευη 17-βινυλ-τριφλικων ως ενδιaμεσα

Country Status (12)

Country Link
US (2) US8236946B2 (el)
EP (2) EP1781683B1 (el)
JP (1) JP5199667B2 (el)
AT (1) ATE533775T1 (el)
CY (1) CY1112283T1 (el)
DK (2) DK1781683T3 (el)
ES (2) ES2377074T3 (el)
HK (1) HK1167658A1 (el)
PL (2) PL1781683T3 (el)
PT (2) PT2428519E (el)
SI (2) SI2428519T1 (el)
WO (1) WO2006021777A1 (el)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102030798B (zh) * 2010-12-17 2012-10-17 深圳万乐药业有限公司 一种醋酸阿比特龙的纯化方法
PL2766381T3 (pl) 2011-10-10 2016-12-30 Sposób wytwarzania steroidów podstawionych w pozycji 17
CN103172690B (zh) * 2011-12-23 2016-08-24 重庆医药工业研究院有限责任公司 醋酸阿比特龙及其中间体的制备方法
EP2607371A1 (en) 2011-12-23 2013-06-26 Crystal Pharma, S.A.U. Processes for the preparation of abiraterone and related compouds
CN103193849B (zh) * 2012-01-04 2016-05-04 连云港润众制药有限公司 一种高纯度醋酸阿比特龙的制备方法
CN103254265B (zh) 2012-02-21 2016-07-13 上海希迈医药科技有限公司 醋酸阿比特龙三氟乙酸盐及其制备方法和应用
US9511152B2 (en) * 2012-04-05 2016-12-06 The Board Of Regents Of The University Of Texas System Multicolored pH-activatable fluorescence nanoplatform
WO2014009436A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Nanosuspension of abiraterone acetate
WO2014009434A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate
WO2014009437A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Oxidation stability of abiraterone acetate
WO2014016830A1 (en) * 2012-07-25 2014-01-30 Mapi Pharma Ltd. Process and intermediates for the preparation of abiraterone acetate
CN102816200B (zh) * 2012-09-05 2015-04-15 中山大学 一种醋酸阿比特龙的制备方法
ITMI20121788A1 (it) 2012-10-22 2014-04-23 Olon Spa Procedimento per la purificazione di abiraterone acetato
EP2917225A1 (en) 2012-11-09 2015-09-16 Synthon BV Process for making abiraterone-3-acetate
EP2917226A1 (en) 2012-11-09 2015-09-16 Synthon BV Process for making the 17-triflate intermediate of abiraterone-3-acetate
WO2014075978A1 (en) 2012-11-16 2014-05-22 Synthon B.V. Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound
WO2014095833A1 (en) 2012-12-19 2014-06-26 Bayer Pharma Aktiengesellschaft Combination comprising radium-223 for the treatment of cancer
WO2014102833A2 (en) * 2012-12-31 2014-07-03 Hetero Research Foundation Process for abiraterone acetate
RS55673B1 (sr) 2013-04-19 2017-06-30 Zach System Postupak za dobijanje čvrstog oblika abirateron acetata
CN103242410B (zh) * 2013-05-09 2015-08-26 苏州明锐医药科技有限公司 醋酸阿比特龙的制备方法
IN2013MU02133A (el) * 2013-06-24 2015-06-05 Sun Pharmaceutical Ind Ltd
CA2914305A1 (en) * 2013-06-28 2014-12-31 Scinopharm Taiwan, Ltd. Process for the preparation of abiraterone and intermediates thereof
ES2581317T3 (es) 2013-07-29 2016-09-05 Industriale Chimica S.R.L. Proceso de preparación de abiraterona o acetato de abiraterona
ITMI20131861A1 (it) * 2013-11-08 2015-05-09 Ind Chimica Srl Processo per la preparazione di abiraterone e abiraterone acetato
EP3027638B1 (en) 2013-07-29 2017-12-27 Industriale Chimica S.R.L. Process for the preparation of abiraterone and abiraterone acetate
CN104418930B (zh) * 2013-08-23 2018-01-12 四川海思科制药有限公司 一种高纯度醋酸乌利司他
CA2938023C (en) 2014-01-28 2022-03-08 Olon S.P.A. Procedure for the preparation of abiraterone acetate and intermediates thereof
CN103965282B (zh) 2014-04-21 2016-01-20 武汉百科药物开发有限公司 一种醋酸阿比特龙的制备方法
US9315541B2 (en) * 2014-05-20 2016-04-19 Olon S.P.A. Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives
EP3160450A1 (en) 2014-06-30 2017-05-03 Galenicum Health S.L. Stable pharmaceutical compositions in the form of immediate release tablets
CZ2014475A3 (cs) 2014-07-09 2016-01-20 Zentiva, K.S. Způsob přípravy Abirateron acetátu o vysoké čistotě aplikovatelný v průmyslovém měřítku
CN105622703B (zh) * 2014-11-05 2019-09-27 兰州大学 一种制备醋酸阿比特龙的方法
CN104447934B (zh) * 2014-12-08 2017-03-15 深圳科兴生物工程有限公司 一种醋酸阿比特龙的纯化方法
HU231297B1 (hu) 2018-07-31 2022-09-28 Richter Gedeon Nyrt Stabil gyógyszerkészítmények és eljárás az előállításukra
CN112812147A (zh) * 2019-11-15 2021-05-18 江苏佳尔科药业集团股份有限公司 一种醋酸阿比特龙的合成方法及其中间体
EP3944860A1 (en) 2020-07-30 2022-02-02 Galenicum Health S.L.U. Abiraterone for use in a method of treating cancer

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4207851A1 (de) * 1992-03-12 1993-09-16 Bayer Ag Mittel und verfahren zur ausruestung von textilien
GB2265624B (en) * 1992-03-31 1995-04-19 British Tech Group 17-substituted steroids useful in cancer treatment
US5338875A (en) 1992-11-19 1994-08-16 Merck & Co., Inc. Boron containing intermediates useful in the preparation of carbapenems
DK0721461T3 (da) 1993-09-30 1999-09-20 Btg Int Ltd Syntese af 17-(3-pyridyl)-steroider
US5466770A (en) * 1994-05-26 1995-11-14 Minnesota Mining And Manufacturing Company Fluorine-efficient oil- and water-repellent compositions
JP3982012B2 (ja) * 1997-01-30 2007-09-26 ダイキン工業株式会社 新規組成物および処理剤
US5994334A (en) 1997-02-05 1999-11-30 University Of Maryland Androgen synthesis inhibitors
JP3399286B2 (ja) * 1997-04-11 2003-04-21 ダイキン工業株式会社 防汚加工剤組成物
JPH10316719A (ja) * 1997-05-20 1998-12-02 Daikin Ind Ltd 新規重合体およびそれを含む防汚加工剤組成物
US6059868A (en) * 1998-10-29 2000-05-09 Hewlett-Packard Company Ink-jet inks with improved performance
US6753376B1 (en) * 1998-12-22 2004-06-22 Daikin Industries Ltd. Aqueous water-and oil-repellent dispersion
JP2000212549A (ja) * 1999-01-25 2000-08-02 Asahi Glass Co Ltd 撥水撥油剤組成物およびその製造方法
US6274060B1 (en) * 1999-02-04 2001-08-14 Daikin Industries, Ltd. Water- and oil-repellent
JP5298399B2 (ja) * 2000-09-21 2013-09-25 ダイキン工業株式会社 撥水撥油剤水性分散液組成物およびその製造方法
EP1365000B1 (en) * 2001-01-30 2012-09-26 Daikin Industries, Ltd. Water- and oil-repellent composition, process for producing the same and use thereof
EP1380628A4 (en) * 2001-03-09 2006-09-13 Daikin Ind Ltd BETTER CALCULATED HYDROGEN AND OLEOPHOBIC AGENT
JPWO2002083809A1 (ja) * 2001-04-13 2004-08-05 旭硝子株式会社 撥水撥油剤組成物
KR100605415B1 (ko) * 2002-01-21 2006-08-02 다이킨 고교 가부시키가이샤 발수 발유제 수성 분산액
AU2003244320A1 (en) * 2002-06-20 2004-01-06 Kyowa Hakko Kogyo Co., Ltd. Process for production of vinyl perfluoroalkanesulfonate derivatives
JP4483582B2 (ja) * 2002-10-15 2010-06-16 旭硝子株式会社 撥水撥油剤組成物
GB0418900D0 (en) * 2004-08-24 2004-09-29 Btg Int Ltd Novel salt forms

Also Published As

Publication number Publication date
JP5199667B2 (ja) 2013-05-15
ATE533775T1 (de) 2011-12-15
EP2428519A3 (en) 2014-01-15
PL1781683T3 (pl) 2012-04-30
SI1781683T1 (sl) 2012-06-29
WO2006021777A1 (en) 2006-03-02
EP2428519A2 (en) 2012-03-14
PL2428519T3 (pl) 2015-09-30
ES2534587T3 (es) 2015-04-24
ES2377074T3 (es) 2012-03-22
US20070282109A1 (en) 2007-12-06
EP1781683A1 (en) 2007-05-09
PT2428519E (pt) 2015-04-29
PT1781683E (pt) 2012-02-13
DK1781683T3 (da) 2012-02-06
HK1167658A1 (en) 2012-12-07
SI2428519T1 (sl) 2015-07-31
EP1781683B1 (en) 2011-11-16
JP2008510781A (ja) 2008-04-10
US8236946B2 (en) 2012-08-07
EP2428519B1 (en) 2015-01-21
US20110288288A1 (en) 2011-11-24
US8389714B2 (en) 2013-03-05
DK2428519T3 (en) 2015-04-13

Similar Documents

Publication Publication Date Title
CY1112283T1 (el) Μεθοδος για την παρασκευη 17-βινυλ-τριφλικων ως ενδιaμεσα
CY1113029T1 (el) Παραγωγα αζαδικυκλο [3.1.0] εξανιου χρησιμα ως ρυθμιστες υποδοχεων d3 ντοπαμινης
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
DK1678119T3 (da) Fremgangsmåde til fremstilling af 2-dihalogenacyl-3-amino-acrylsyreestere og 3-dihalogenmethyl-pyrazol-4-carboxylsyreestere
CY1112914T1 (el) Υποκατεστημενα παραγωγα ινδολυλ αλκυλ αμινης ως νεοι αναστολεις των αποακετυλασων ιστονης
RS51341B (en) INTERMEDIATE COMPOUNDS FOR THE TRANS-5-CHLOR-2-METHYL-2,3A, 12B-TETRAHYDRO-1H-DIBENZE [2,3; 6,7] OXEPINO [4,5-C] Pyrrole
JP2015524409A5 (el)
CO5550450A2 (es) Derivados de 1-acil-pirrolidina para el tratamiento de infec ciones virales
EA200601364A1 (ru) Производные хинолина и их применение в качестве ингибиторов микобактерий
RU2011108663A (ru) Способы получения метилового эфира 4-оксооктагидроиндол-1-карбоновой кислоты и ее производные
RS52108B (en) 3-SUBSTITUTED [1,2,3] -BENZOTRIAZINONE UNIT TO INCREASE GLUTAMATERGIC SYNAPTIC ANSWERS
EA200700550A1 (ru) Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
DK1606276T3 (da) Fremstilling og anvendelse af 2-substituerede 5-oxo-3-pyrazolidincarboxylater
CY1112176T1 (el) Υποκατεστημενα παραγωγα οξαζολης με αναλγητικη δραση
ATE526312T1 (de) Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitoren
IL187640A0 (en) Method for preparing clopidogrel and intermediates used therein
EA200700767A1 (ru) Способ получения пиразолов
DE602006014001D1 (de) Herstellung von 2-aminothiazol-5-carbonsäurederivaten
EA200800633A1 (ru) Способ получения производных сартана и промежуточных соединений, пригодных для этого способа
DE602006005230D1 (de) Verfahren zur herstellung von 2-azabicycloä3.3.0üoctan-3-carbonsäurederivaten
RS53062B (en) PREPARATION PROCESS 4 - [(1,6-Dihydro-6-oxo-2-pyrimidinyl) AMINO BENZONITRILA
CY1107193T1 (el) Παραγωγα πιπεραζινης και η χρηση τους ως αναστολεων της επανασυλληψης της σεροτονινης ή ως ανταγωνιστων της νευροκινινης
ATE517086T1 (de) Verfahren zur synthese von 3-amino-1- arylpropylindolen
DE602006015241D1 (de) Verbessertes verfahren zur herstellung von rivastigmin
CY1116177T1 (el) Μεθοδος για την παρασκευη 17-βινυλο-τριφλικων ως ενδιαμεσα