ATE517086T1 - Verfahren zur synthese von 3-amino-1- arylpropylindolen - Google Patents
Verfahren zur synthese von 3-amino-1- arylpropylindolenInfo
- Publication number
- ATE517086T1 ATE517086T1 AT06819599T AT06819599T ATE517086T1 AT E517086 T1 ATE517086 T1 AT E517086T1 AT 06819599 T AT06819599 T AT 06819599T AT 06819599 T AT06819599 T AT 06819599T AT E517086 T1 ATE517086 T1 AT E517086T1
- Authority
- AT
- Austria
- Prior art keywords
- arylpropylindoles
- synthesis
- amino
- formula
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 indole propionamide compound Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000000407 monoamine reuptake Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74151605P | 2005-11-30 | 2005-11-30 | |
| PCT/EP2006/068644 WO2007062994A1 (en) | 2005-11-30 | 2006-11-20 | Methods for synthesis of 3-amino-1-arylpropyl indoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517086T1 true ATE517086T1 (de) | 2011-08-15 |
Family
ID=37887751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06819599T ATE517086T1 (de) | 2005-11-30 | 2006-11-20 | Verfahren zur synthese von 3-amino-1- arylpropylindolen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7598399B2 (de) |
| EP (1) | EP1957454B1 (de) |
| JP (1) | JP2009523705A (de) |
| KR (1) | KR20080080593A (de) |
| CN (1) | CN101316819B (de) |
| AT (1) | ATE517086T1 (de) |
| AU (1) | AU2006319229B2 (de) |
| BR (1) | BRPI0619247A2 (de) |
| CA (1) | CA2631048A1 (de) |
| ES (1) | ES2368416T3 (de) |
| WO (1) | WO2007062994A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7632540B2 (en) * | 2003-07-01 | 2009-12-15 | Transitions Optical, Inc. | Alignment facilities for optical dyes |
| DE102008030206A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung |
| DE102008030207A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung |
| CA2732278C (en) * | 2008-07-31 | 2017-12-19 | The Lubrizol Corporation | Copolymers and lubricating compositions thereof |
| CA2774616A1 (en) * | 2009-09-23 | 2011-03-31 | Biokier, Inc. | Composition and method for treatment of diabetes |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB705652A (en) | 1948-10-01 | 1954-03-17 | Farbewerke Hoechst Ag | Manufacture of 3-aminopropane compounds |
| DE849108C (de) | 1948-10-01 | 1952-09-11 | Hoechst Ag | Verfahren zur Herstellung von 1-disubstituierten 3-Aminopropanen |
| NL82464C (de) | 1952-01-05 | |||
| US2708197A (en) | 1952-05-24 | 1955-05-10 | Upjohn Co | Preparation of (hydroxy-3-indole)-alkylamines |
| US2984670A (en) | 1959-05-22 | 1961-05-16 | Upjohn Co | Novel 3-(1-hydroxy-1-phenyl-3-aminopropyl) indoles |
| GB992731A (en) | 1962-09-28 | 1965-05-19 | Koninklijke Pharma Fab Nv | Aminoalkyl-indolyl-benzyl alcohols |
| JPH0314562A (ja) | 1988-04-11 | 1991-01-23 | Nippon Chemiphar Co Ltd | 新規なアルキレンジアミン誘導体およびグルタミン酸遮断剤 |
| EP0600830A1 (de) | 1992-11-27 | 1994-06-08 | Ciba-Geigy Ag | Substituierte Derivate von Diaminophthalimid als Protein-Tyrosin-Kinase-Hemmer |
| GB9225141D0 (en) | 1992-12-01 | 1993-01-20 | Smithkline Beecham Corp | Chemical compounds |
| US6071970A (en) | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| GB9518552D0 (en) | 1995-09-11 | 1995-11-08 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
| GB9523948D0 (en) | 1995-11-23 | 1996-01-24 | Univ East Anglia | Process for preparing n-benzyl indoles |
| JP2002511835A (ja) | 1996-06-07 | 2002-04-16 | エヌピーエス・ファーマシウティカルズ・インコーポレイテッド | 神経障害および神経病の治療に有用な受容体作動性カルシウムチャネル上の新規部位で活性な化合物 |
| SE9701144D0 (sv) | 1997-03-27 | 1997-03-27 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
| EP0887348A1 (de) | 1997-06-25 | 1998-12-30 | Boehringer Mannheim Italia S.p.A. | Bis-Indolderivative mit antimetastatischer Wirkung, Verfahren für deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| CA2303830A1 (en) | 1997-09-26 | 1999-04-08 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| WO1999021553A1 (en) | 1997-10-28 | 1999-05-06 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP1049472A4 (de) | 1997-10-28 | 2002-04-03 | Merck & Co Inc | Antagonisten des gonadotropin freisetzenden hormons |
| WO2000002551A2 (en) | 1998-07-13 | 2000-01-20 | Nps Pharmaceuticals, Inc. | Methods and compounds for treating depression |
| SE9903998D0 (sv) | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
| FR2814073B1 (fr) | 2000-09-21 | 2005-06-24 | Yang Ji Chemical Company Ltd | Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition |
| JP2004523565A (ja) | 2001-03-05 | 2004-08-05 | トランス テック ファーマ，インコーポレイテッド | 治療因子としてのベンゾイミダゾール誘導体 |
| CN1314673C (zh) * | 2002-07-02 | 2007-05-09 | 中国科学院上海有机化学研究所 | 具有手性的多齿噁唑啉配体及其与主族金属或过渡金属的配合物、合成方法及其用途 |
| US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| WO2005118539A1 (en) * | 2004-06-01 | 2005-12-15 | F.Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitor |
-
2006
- 2006-11-20 CA CA002631048A patent/CA2631048A1/en not_active Abandoned
- 2006-11-20 AT AT06819599T patent/ATE517086T1/de not_active IP Right Cessation
- 2006-11-20 BR BRPI0619247-5A patent/BRPI0619247A2/pt not_active IP Right Cessation
- 2006-11-20 WO PCT/EP2006/068644 patent/WO2007062994A1/en not_active Ceased
- 2006-11-20 CN CN2006800448079A patent/CN101316819B/zh not_active Expired - Fee Related
- 2006-11-20 ES ES06819599T patent/ES2368416T3/es active Active
- 2006-11-20 KR KR1020087015757A patent/KR20080080593A/ko not_active Ceased
- 2006-11-20 JP JP2008542711A patent/JP2009523705A/ja active Pending
- 2006-11-20 AU AU2006319229A patent/AU2006319229B2/en not_active Expired - Fee Related
- 2006-11-20 EP EP06819599A patent/EP1957454B1/de not_active Not-in-force
- 2006-11-29 US US11/605,648 patent/US7598399B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070135647A1 (en) | 2007-06-14 |
| EP1957454B1 (de) | 2011-07-20 |
| KR20080080593A (ko) | 2008-09-04 |
| AU2006319229A1 (en) | 2007-06-07 |
| US7598399B2 (en) | 2009-10-06 |
| AU2006319229B2 (en) | 2011-09-15 |
| ES2368416T3 (es) | 2011-11-17 |
| CN101316819A (zh) | 2008-12-03 |
| CN101316819B (zh) | 2011-05-18 |
| WO2007062994A1 (en) | 2007-06-07 |
| CA2631048A1 (en) | 2007-06-07 |
| EP1957454A1 (de) | 2008-08-20 |
| JP2009523705A (ja) | 2009-06-25 |
| BRPI0619247A2 (pt) | 2011-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |