DK2407451T3 - N,N-substituerede 3-aminopyrrolidin-forbindelser anvendelige som monoamin-genoptagelseshæmmere - Google Patents

N,N-substituerede 3-aminopyrrolidin-forbindelser anvendelige som monoamin-genoptagelseshæmmere

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Publication number
DK2407451T3
DK2407451T3 DK11185205.9T DK11185205T DK2407451T3 DK 2407451 T3 DK2407451 T3 DK 2407451T3 DK 11185205 T DK11185205 T DK 11185205T DK 2407451 T3 DK2407451 T3 DK 2407451T3
Authority
DK
Denmark
Prior art keywords
substituted
compounds useful
reuptake inhibitors
monoamine reuptake
aminopyrrolidine compounds
Prior art date
Application number
DK11185205.9T
Other languages
English (en)
Inventor
Muneaki Kurimura
Shinichi Taira
Takahiro Tomoyasu
Nobuaki Ito
Kuninori Tai
Noriaki Takemura
Takayuki Matsuzaki
Yasuhiro Menjo
Shin Miyamura
Yohji Sakurai
Akihito Watanabe
Yasuyo Sakata
Takumi Masumoto
Kohei Akazawa
Haruhiko Sugino
Naoki Amada
Satoshi Ohashi
Tomoichi Shinohara
Hirofumi Sasaki
Chisako Morita
Junko Yamashita
Satoko Nakajima
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36693623&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2407451(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of DK2407451T3 publication Critical patent/DK2407451T3/da

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Organic Chemistry (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
  • Hematology (AREA)
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  • Psychology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK11185205.9T 2005-05-13 2006-05-12 N,N-substituerede 3-aminopyrrolidin-forbindelser anvendelige som monoamin-genoptagelseshæmmere DK2407451T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005141230 2005-05-13
EP06756356.9A EP1881975B8 (en) 2005-05-13 2006-05-12 N,n-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors

Publications (1)

Publication Number Publication Date
DK2407451T3 true DK2407451T3 (da) 2013-12-16

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ID=36693623

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DK11185205.9T DK2407451T3 (da) 2005-05-13 2006-05-12 N,N-substituerede 3-aminopyrrolidin-forbindelser anvendelige som monoamin-genoptagelseshæmmere

Country Status (25)

Country Link
US (6) US8084442B2 (da)
EP (2) EP1881975B8 (da)
JP (1) JP4776631B2 (da)
KR (2) KR20100038453A (da)
CN (3) CN103613587A (da)
AR (1) AR054191A1 (da)
AU (2) AU2006244851B2 (da)
BR (1) BRPI0610279A2 (da)
CA (1) CA2608184C (da)
CY (1) CY1114767T1 (da)
DK (1) DK2407451T3 (da)
ES (2) ES2446375T3 (da)
HK (1) HK1193094A1 (da)
IL (1) IL187311A (da)
IN (1) IN2012DN00758A (da)
MX (1) MX2007014252A (da)
MY (1) MY148653A (da)
PL (1) PL2407451T3 (da)
PT (1) PT2407451E (da)
RU (1) RU2414454C2 (da)
SG (1) SG162722A1 (da)
SI (1) SI2407451T1 (da)
TW (3) TWI449692B (da)
WO (1) WO2006121218A1 (da)
ZA (1) ZA200709691B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE555087T1 (de) 2002-11-27 2012-05-15 Incyte Corp 3-aminopyrrolidinderivate als modulatoren von chemokinrezeptoren
TWI449692B (zh) 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物（三）
JP2009517430A (ja) * 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ３−アミノ−１−アリールプロピルインドール類及びアザ置換インドール類
JP2009518313A (ja) * 2005-11-30 2009-05-07 スミスクライン・ビーチャム・コーポレイション ピロリジンアニリン
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬
ATE522519T1 (de) 2008-03-20 2011-09-15 Hoffmann La Roche Pyrrolidinylderivate und anwendungen davon
JP5827627B2 (ja) * 2009-11-07 2015-12-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ＴＧＦ−β受容体キナーゼ阻害剤としてのヘテロアリールアミノキノリン
EP2560953B1 (en) * 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
CN102766079B (zh) * 2011-05-06 2015-04-08 上海医药工业研究院 一类吡咯烷衍生物、其制备方法及应用
WO2015050984A1 (en) 2013-10-01 2015-04-09 New York University Amino, amido, and heterocyclic compounds as modulators of rage activity and uses thereof
KR20160148871A (ko) 2015-06-17 2016-12-27 양순구 일방향 클러치 제동장치
US10428030B2 (en) 2015-10-30 2019-10-01 Trillium Therapeutics Heterocycle derivatives and their use for the treatment of CNS disorders
RU2698400C1 (ru) * 2018-12-17 2019-08-26 Георгий Сергеевич Немов Способ лечения депрессии у собак и кошек
CN113024517A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种制备厄达替尼的方法
CN113024518A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种厄达替尼的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164828A (en) 1965-10-23 1969-09-24 Robins Co Inc A H 3-(2-Substituted Ethyl)Indoles and their Manufacture and Use
GB1173373A (en) * 1966-03-22 1969-12-10 Robins Co Inc A H Substituted 3-Aminopyrrolidines
US3509171A (en) 1967-09-14 1970-04-28 Robins Co Inc A H 3-amino-1-carbamyl and thiocarbamyl pyrrolidines
US3433802A (en) 1968-06-25 1969-03-18 Robins Co Inc A H 3-(n-lower-alkylanilino)pyrrolidines
US3577440A (en) 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-amido-pyrrolidines
GB1523631A (en) 1975-07-08 1978-09-06 Leo Pharm Prod Ltd Sulphonamide derivatives
US4254135A (en) 1979-10-16 1981-03-03 A. H. Robins Company, Inc. 3-Amino-4-hydroxypyrrolidines
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
EP1138672A1 (en) 1998-01-12 2001-10-04 Basilea Pharmaceutica AG Process for the preparation of 3-amino-pyrrolidine derivatives
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
ATE303360T1 (de) * 2000-04-28 2005-09-15 Hoffmann La Roche P-(sulfonyl)-aryl- and -heteroaryl-amine
DE60230869D1 (de) 2001-05-18 2009-03-05 Astrazeneca Ab 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
ES2298782T3 (es) * 2003-06-11 2008-05-16 Eli Lilly And Company 3-aminopirrolidinas como inhibidores de la reabsorcion de monoaminas.
WO2004110995A1 (en) * 2003-06-17 2004-12-23 Pfizer Limited N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
GB0314054D0 (en) 2003-06-17 2003-07-23 Pfizer Ltd Amide derivatives as selective serotonin re-uptake inhibitors
EP1638560A1 (en) 2003-06-20 2006-03-29 Eli Lilly And Company 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
TWI341835B (en) 2003-11-12 2011-05-11 Lg Life Sciences Ltd Melanocortin receptor agonists
JP2007513945A (ja) * 2003-12-12 2007-05-31 イーライ リリー アンド カンパニー 体熱感、衝動調節障害および一般的な病状による人格変化の治療
US20070078135A1 (en) 2005-04-18 2007-04-05 Neurogen Corporation Substituted heteroaryl CB1 antagonists
TWI449692B (zh) * 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物（三）
WO2008000811A1 (en) * 2006-06-30 2008-01-03 Arcelik Anonim Sirketi A cooling device

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