PT2407451E - Compostos de 3-aminopirrolidina substituído nos dois átomos de n, úteis como inibidores da absorção de monoaminas - Google Patents

Compostos de 3-aminopirrolidina substituído nos dois átomos de n, úteis como inibidores da absorção de monoaminas Download PDF

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Publication number
PT2407451E
PT2407451E PT111852059T PT11185205T PT2407451E PT 2407451 E PT2407451 E PT 2407451E PT 111852059 T PT111852059 T PT 111852059T PT 11185205 T PT11185205 T PT 11185205T PT 2407451 E PT2407451 E PT 2407451E
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PT
Portugal
Prior art keywords
substituted
compounds useful
reuptake inhibitors
monoamines
aminopyrrolidine compounds
Prior art date
Application number
PT111852059T
Other languages
English (en)
Inventor
Nobuaki Ito
Shin Miyamura
Shinichi Taira
Muneaki Kurimura
Takahiro Tomoyasu
Kuninori Tai
Noriaki Takemura
Takayuki Matsuzaki
Yasuhiro Menjo
Yohji Sakurai
Akihito Watanabe
Yasuyo Sakata
Takumi Masumoto
Kohei Akazawa
Haruhiko Sugino
Naoki Amada
Satoshi Ohashi
Tomoichi Shinohara
Hirofumi Sasaki
Chisako Morita
Junko Yamashita
Satoko Nakajima
Original Assignee
Otsuka Pharma Co Ltd
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Publication date
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Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of PT2407451E publication Critical patent/PT2407451E/pt

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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
PT111852059T 2005-05-13 2006-05-12 Compostos de 3-aminopirrolidina substituído nos dois átomos de n, úteis como inibidores da absorção de monoaminas PT2407451E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005141230 2005-05-13

Publications (1)

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PT2407451E true PT2407451E (pt) 2014-01-13

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ID=36693623

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PT111852059T PT2407451E (pt) 2005-05-13 2006-05-12 Compostos de 3-aminopirrolidina substituído nos dois átomos de n, úteis como inibidores da absorção de monoaminas

Country Status (25)

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US (6) US8084442B2 (pt)
EP (2) EP2407451B1 (pt)
JP (1) JP4776631B2 (pt)
KR (2) KR100971850B1 (pt)
CN (3) CN103613527B (pt)
AR (1) AR054191A1 (pt)
AU (2) AU2006244851B2 (pt)
BR (1) BRPI0610279A2 (pt)
CA (1) CA2608184C (pt)
CY (1) CY1114767T1 (pt)
DK (1) DK2407451T3 (pt)
ES (2) ES2451523T3 (pt)
HK (1) HK1193094A1 (pt)
IL (1) IL187311A (pt)
IN (1) IN2012DN00758A (pt)
MX (1) MX2007014252A (pt)
MY (1) MY148653A (pt)
PL (1) PL2407451T3 (pt)
PT (1) PT2407451E (pt)
RU (1) RU2414454C2 (pt)
SG (1) SG162722A1 (pt)
SI (1) SI2407451T1 (pt)
TW (3) TWI439452B (pt)
WO (1) WO2006121218A1 (pt)
ZA (1) ZA200709691B (pt)

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BRPI0316732B8 (pt) 2002-11-27 2021-05-25 Incyte Corp composto derivado de 3-aminopirrolidina e sua composição farmacêutica
TWI439452B (zh) 2005-05-13 2014-06-01 Otsuka Pharma Co Ltd 吡咯烷化合物（二）
JP2009518313A (ja) * 2005-11-30 2009-05-07 スミスクライン・ビーチャム・コーポレイション ピロリジンアニリン
WO2007062996A1 (en) * 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬
JP2011515355A (ja) * 2008-03-20 2011-05-19 エフ．ホフマン−ラ ロシュ アーゲー ピロリジニル誘導体およびその使用
EP2496234A1 (en) * 2009-11-07 2012-09-12 Merck Patent GmbH Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors
JP5945532B2 (ja) * 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
CN102766079B (zh) * 2011-05-06 2015-04-08 上海医药工业研究院 一类吡咯烷衍生物、其制备方法及应用
US9353078B2 (en) 2013-10-01 2016-05-31 New York University Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof
KR20160148871A (ko) 2015-06-17 2016-12-27 양순구 일방향 클러치 제동장치
US10428030B2 (en) 2015-10-30 2019-10-01 Trillium Therapeutics Heterocycle derivatives and their use for the treatment of CNS disorders
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