SI2407451T1 - N,N-substituirane 3-aminopirolidinske spojine, uporabne kot inhibitorji ponovnega privzema monoaminov - Google Patents
N,N-substituirane 3-aminopirolidinske spojine, uporabne kot inhibitorji ponovnega privzema monoaminovInfo
- Publication number
- SI2407451T1 SI2407451T1 SI200631727T SI200631727T SI2407451T1 SI 2407451 T1 SI2407451 T1 SI 2407451T1 SI 200631727 T SI200631727 T SI 200631727T SI 200631727 T SI200631727 T SI 200631727T SI 2407451 T1 SI2407451 T1 SI 2407451T1
- Authority
- SI
- Slovenia
- Prior art keywords
- substituted
- compounds useful
- reuptake inhibitors
- monoamines
- aminopyrrolidine compounds
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical class NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Diabetes (AREA)
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- Addiction (AREA)
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- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Child & Adolescent Psychology (AREA)
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- Dermatology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005141230 | 2005-05-13 | ||
EP11185205.9A EP2407451B1 (en) | 2005-05-13 | 2006-05-12 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2407451T1 true SI2407451T1 (sl) | 2014-02-28 |
Family
ID=36693623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200631727T SI2407451T1 (sl) | 2005-05-13 | 2006-05-12 | N,N-substituirane 3-aminopirolidinske spojine, uporabne kot inhibitorji ponovnega privzema monoaminov |
Country Status (25)
Country | Link |
---|---|
US (6) | US8084442B2 (sl) |
EP (2) | EP1881975B8 (sl) |
JP (1) | JP4776631B2 (sl) |
KR (2) | KR20100038453A (sl) |
CN (3) | CN103613587A (sl) |
AR (1) | AR054191A1 (sl) |
AU (2) | AU2006244851B2 (sl) |
BR (1) | BRPI0610279A2 (sl) |
CA (1) | CA2608184C (sl) |
CY (1) | CY1114767T1 (sl) |
DK (1) | DK2407451T3 (sl) |
ES (2) | ES2451523T3 (sl) |
HK (1) | HK1193094A1 (sl) |
IL (1) | IL187311A (sl) |
IN (1) | IN2012DN00758A (sl) |
MX (1) | MX2007014252A (sl) |
MY (1) | MY148653A (sl) |
PL (1) | PL2407451T3 (sl) |
PT (1) | PT2407451E (sl) |
RU (1) | RU2414454C2 (sl) |
SG (1) | SG162722A1 (sl) |
SI (1) | SI2407451T1 (sl) |
TW (3) | TWI410406B (sl) |
WO (1) | WO2006121218A1 (sl) |
ZA (1) | ZA200709691B (sl) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004050024A2 (en) | 2002-11-27 | 2004-06-17 | Incyte Corporation | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
TWI410406B (zh) * | 2005-05-13 | 2013-10-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物 |
AU2006319231A1 (en) * | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles and aza-substituted indoles |
US20100216813A1 (en) * | 2005-11-30 | 2010-08-26 | Smithkline Beecham Corporation | Pyrrolidineanilines |
JP5219465B2 (ja) * | 2006-11-10 | 2013-06-26 | 大塚製薬株式会社 | 医薬 |
CA2718736A1 (en) * | 2008-03-20 | 2009-09-24 | F. Hoffmann-La Roche Ag | Pyrrolidinyl derivatives and uses thereof |
WO2011054433A1 (en) | 2009-11-07 | 2011-05-12 | Merck Patent Gmbh | Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors |
WO2011131748A2 (en) * | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
CN102766079B (zh) * | 2011-05-06 | 2015-04-08 | 上海医药工业研究院 | 一类吡咯烷衍生物、其制备方法及应用 |
US9353078B2 (en) | 2013-10-01 | 2016-05-31 | New York University | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof |
KR20160148871A (ko) | 2015-06-17 | 2016-12-27 | 양순구 | 일방향 클러치 제동장치 |
EP3371154A4 (en) | 2015-10-30 | 2019-06-05 | Trillium Therapeutics Inc. | HETEROCYCLIC DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS |
US12030875B2 (en) | 2018-09-07 | 2024-07-09 | PIC Therapeutics, Inc. | EIF4E inhibitors and uses thereof |
RU2698400C1 (ru) * | 2018-12-17 | 2019-08-26 | Георгий Сергеевич Немов | Способ лечения депрессии у собак и кошек |
CN113024517A (zh) * | 2019-12-09 | 2021-06-25 | 武汉九州钰民医药科技有限公司 | 一种制备厄达替尼的方法 |
CN113024518A (zh) * | 2019-12-09 | 2021-06-25 | 武汉九州钰民医药科技有限公司 | 一种厄达替尼的制备方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1164828A (en) | 1965-10-23 | 1969-09-24 | Robins Co Inc A H | 3-(2-Substituted Ethyl)Indoles and their Manufacture and Use |
GB1173373A (en) * | 1966-03-22 | 1969-12-10 | Robins Co Inc A H | Substituted 3-Aminopyrrolidines |
US3509171A (en) | 1967-09-14 | 1970-04-28 | Robins Co Inc A H | 3-amino-1-carbamyl and thiocarbamyl pyrrolidines |
US3433802A (en) | 1968-06-25 | 1969-03-18 | Robins Co Inc A H | 3-(n-lower-alkylanilino)pyrrolidines |
US3577440A (en) | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-amido-pyrrolidines |
GB1523631A (en) | 1975-07-08 | 1978-09-06 | Leo Pharm Prod Ltd | Sulphonamide derivatives |
US4254135A (en) | 1979-10-16 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Amino-4-hydroxypyrrolidines |
GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
SE9604786D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
EP1138672A1 (en) | 1998-01-12 | 2001-10-04 | Basilea Pharmaceutica AG | Process for the preparation of 3-amino-pyrrolidine derivatives |
US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
AU6589801A (en) * | 2000-04-28 | 2001-11-12 | F. Hoffmann-La Roche Ag | P-(sulfonyl)aryl and heteroaryls |
JP4549024B2 (ja) | 2001-05-18 | 2010-09-22 | アストラゼネカ・アクチエボラーグ | 4(フェニル−ピペラジニル−メチル)ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
ES2298782T3 (es) * | 2003-06-11 | 2008-05-16 | Eli Lilly And Company | 3-aminopirrolidinas como inhibidores de la reabsorcion de monoaminas. |
GB0314054D0 (en) | 2003-06-17 | 2003-07-23 | Pfizer Ltd | Amide derivatives as selective serotonin re-uptake inhibitors |
ES2305776T3 (es) * | 2003-06-17 | 2008-11-01 | Pfizer Inc. | Derivados de n-pirrolidin-3-il-amida como inhibidores de la re-captacion de serotonina y noradrenalina. |
EP1638560A1 (en) | 2003-06-20 | 2006-03-29 | Eli Lilly And Company | 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake |
CA2545644C (en) | 2003-11-12 | 2011-11-01 | Lg Life Sciences Ltd. | Melanocortin receptor agonists |
KR20060121178A (ko) | 2003-12-12 | 2006-11-28 | 일라이 릴리 앤드 캄파니 | 일과성 전신 열감, 충동 조절 장애 및 일반적인 의학상태로 인한 인격 변화 치료용 선택적 노르에피네프린재흡수 억제제 |
WO2006113704A2 (en) | 2005-04-18 | 2006-10-26 | Neurogen Corporation | Subtituted heteroaryl cb1 antagonists |
TWI410406B (zh) * | 2005-05-13 | 2013-10-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物 |
EP2035763A1 (en) * | 2006-06-30 | 2009-03-18 | Arcelik Anonim Sirketi | A cooling device |
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