BRPI0508808A - processo quimio-enzimático para preparar escitalopram - Google Patents

processo quimio-enzimático para preparar escitalopram

Info

Publication number
BRPI0508808A
BRPI0508808A BRPI0508808-9A BRPI0508808A BRPI0508808A BR PI0508808 A BRPI0508808 A BR PI0508808A BR PI0508808 A BRPI0508808 A BR PI0508808A BR PI0508808 A BRPI0508808 A BR PI0508808A
Authority
BR
Brazil
Prior art keywords
chemo
escitalopram
enzymatic process
enzymatic
prepare
Prior art date
Application number
BRPI0508808-9A
Other languages
English (en)
Inventor
Giovanni Cotticelli
Silvia Rocchietti
Marco Terreni
Massimo Pregnolato
Raul Salvetti
Original Assignee
Adorkem Technology Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adorkem Technology Spa filed Critical Adorkem Technology Spa
Publication of BRPI0508808A publication Critical patent/BRPI0508808A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Processo quimio-enzimático para preparar Escitalopram. O presente invento descreve um processo para preparar o intermediário para sintetizar escitalopram e os sais farmaceuticamente aceitáveis a partir de 4-(4-dimetilamino)-1-(4'-fluorofenil)-1-(hidroxibutil)-3-(aciloximetil) benzonitrila que, por meio de resolução enantiomérica enzimática, é sintetizada em um dos seus enantiómeros.
BRPI0508808-9A 2004-04-09 2005-04-07 processo quimio-enzimático para preparar escitalopram BRPI0508808A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000717A ITMI20040717A1 (it) 2004-04-09 2004-04-09 Procedimento chemo-enzimatico per la preparazione dell'escitalopram
PCT/IB2005/001067 WO2005098018A1 (en) 2004-04-09 2005-04-07 Chemo-enzymatic process for preparing escitalopram

Publications (1)

Publication Number Publication Date
BRPI0508808A true BRPI0508808A (pt) 2007-08-07

Family

ID=34967756

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508808-9A BRPI0508808A (pt) 2004-04-09 2005-04-07 processo quimio-enzimático para preparar escitalopram

Country Status (17)

Country Link
US (1) US7470526B2 (pt)
EP (1) EP1733042B1 (pt)
JP (1) JP2007532106A (pt)
CN (1) CN1946854A (pt)
AT (1) ATE395429T1 (pt)
BR (1) BRPI0508808A (pt)
CA (1) CA2561888A1 (pt)
DE (1) DE602005006770D1 (pt)
DK (1) DK1733042T3 (pt)
ES (1) ES2308465T3 (pt)
HK (1) HK1101827A1 (pt)
IT (1) ITMI20040717A1 (pt)
MX (1) MXPA06011609A (pt)
PL (1) PL1733042T3 (pt)
PT (1) PT1733042E (pt)
SI (1) SI1733042T1 (pt)
WO (1) WO2005098018A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20041872A1 (it) * 2004-10-01 2005-01-01 Adorkem Technology Spa Processo per la preparazione di citalopram e di scitalopram
EP1736550A1 (en) * 2005-06-22 2006-12-27 Adorkem Technology SpA Chemoenzymatic process for the synthesis of escitalopram
JP6680690B2 (ja) * 2014-04-10 2020-04-15 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 有機化合物の半合成経路
JP6925258B2 (ja) 2014-07-18 2021-08-25 ジェノマティカ， インコーポレイテッド 脂肪ジオールの微生物による産生

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
JPS62151196A (ja) * 1985-09-26 1987-07-06 Nitto Electric Ind Co Ltd ｌ−プロプラノロ−ルの生化学的分離法
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JP3097145B2 (ja) * 1991-02-27 2000-10-10 日産化学工業株式会社 コーリーラクトンジオールの光学分割方法
AU746665B2 (en) 1998-10-20 2002-05-02 H. Lundbeck A/S Method for the preparation of citalopram
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
AR034612A1 (es) 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IS7239A (is) 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
PE20040991A1 (es) * 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram

Also Published As

Publication number Publication date
PL1733042T3 (pl) 2008-10-31
ES2308465T3 (es) 2008-12-01
MXPA06011609A (es) 2007-01-23
CA2561888A1 (en) 2005-10-20
JP2007532106A (ja) 2007-11-15
US7470526B2 (en) 2008-12-30
PT1733042E (pt) 2008-07-29
EP1733042B1 (en) 2008-05-14
HK1101827A1 (en) 2007-10-26
DK1733042T3 (da) 2008-09-08
DE602005006770D1 (de) 2008-06-26
EP1733042A1 (en) 2006-12-20
SI1733042T1 (sl) 2008-10-31
WO2005098018A1 (en) 2005-10-20
ITMI20040717A1 (it) 2004-07-09
CN1946854A (zh) 2007-04-11
US20070238887A1 (en) 2007-10-11
ATE395429T1 (de) 2008-05-15

Similar Documents

Publication Publication Date Title
CO5251411A1 (es) Sintesis asimetrica de pregabalin
NO20090166L (no) Amino-imidazoloner og deres anvendelse som et medikament for behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerering og demens
BRPI0514865A (pt) processo para preparar um composto
BRPI0519496A2 (pt) processo para preparar um composto ou uma composiÇço, e, composiÇço
MA27781A1 (fr) 3-fluoro-piperidines comme antagonistes de nmda/nr2b.
NO20082481L (no) Nye 2-aminoheterosykluser som er nyttige ved behandling av ABETA-relaterte patologier
BRPI0618379A2 (pt) processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico
BRPI0411268A (pt) processo para a preparação de um composto 3-aril butil-amina substituìdo
ATE416766T1 (de) Verfahren zur herstellung von 4-(2- dipropylaminoethyl)-1,3-dihydro-2h-indol-2-on- hydrochlorid
BRPI0606639A2 (pt) novo processo para a preparação de indóis substituìdos
BR0317005A (pt) Processo para a preparação de compostos ativos opticamente puros
BRPI0508808A (pt) processo quimio-enzimático para preparar escitalopram
WO2006085118A3 (en) Dihydroimidazothiazole derivatives
WO2008059514A3 (en) Process for preparing escitalopram
TR200806903A2 (tr) Escitalopram'ın üretimi için yöntem
DK1853241T3 (da) Anvendelse af 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyclohexandion ved behandling af Parkinson's sygdom
BR0316702A (pt) xprocesso para preparação de (s)-pantoprazol
DK1289527T3 (da) (+)-alfa.(2,3-dimethoxyphenyl)-1-(2-(4-fluorphenyl)-ethyl)-4-piperodonmethanol eller dets prolægemiddel til behandling af demens eller kognitiv svækkelse
WO2008104880A3 (en) Stable solid dosage forms of an antidepressant
BR0313246A (pt) Processo de preparação de fenilamida do ácido 5-(4-fluorfenil)-1-[2-((2r,4r)-4-hidróxi-6-oxo-tetrahidr o-piran-2-il)etil]-2-isopropil-4-fenil-1h-pirrol-3-carbo xìlico
WO2008029257A3 (en) Improved method for preparing 1,3-disubstituted pyrrolidine compounds
BRPI0409333A (pt) processo para a preparação de fenilamida do ácido 5-(4-fluorofenil)-1-[2-((2r,4r)-4-hidróxi-6-oxo-tetrahid ro-piran-2-il)etil]-2-isopropil-4-fenil-1h-pirrol-3-carb oxìlico
HUP0004667A2 (hu) Új, optikailag aktív aminopentán-származékok
BRPI0514313A (pt) processo para sintetizar um composto, e, composto
BR0101630A (pt) Processo para a preparação do trihidrato do salmesilato de1-(4-hidroxifenil)-2(4-hidróxi-4fenilpiperidin-1-il)-1-propanol

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE A 8.6 NA RPI 2099 DE 29/03/2011.