WO2008059514A3 - Process for preparing escitalopram - Google Patents

Process for preparing escitalopram Download PDF

Info

Publication number
WO2008059514A3
WO2008059514A3 PCT/IN2007/000323 IN2007000323W WO2008059514A3 WO 2008059514 A3 WO2008059514 A3 WO 2008059514A3 IN 2007000323 W IN2007000323 W IN 2007000323W WO 2008059514 A3 WO2008059514 A3 WO 2008059514A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
iii
escitalopram
preparing escitalopram
preparing
Prior art date
Application number
PCT/IN2007/000323
Other languages
French (fr)
Other versions
WO2008059514A2 (en
Inventor
Dhimant Jasubhai Patel
Rajiv Kumar
Shriprakash Dhar Dwivedi
Original Assignee
Cadila Healthcare Ltd
Dhimant Jasubhai Patel
Rajiv Kumar
Shriprakash Dhar Dwivedi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Dhimant Jasubhai Patel, Rajiv Kumar, Shriprakash Dhar Dwivedi filed Critical Cadila Healthcare Ltd
Publication of WO2008059514A2 publication Critical patent/WO2008059514A2/en
Publication of WO2008059514A3 publication Critical patent/WO2008059514A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an improved process for preparation of Escitalopram of formula (I) or its pharmaceutically acceptable salt, solvates or hydrates thereof formula (I), (III): via formation of hydrobromide salt of 4-(4-(dimethylamino)-l-(4-fluorophenyl)-l- hydroxybutyl)-3-(hydroxymethyl) benzonitrile of formula (III) to purify the compound of formula (III).
PCT/IN2007/000323 2006-07-31 2007-07-31 Process for preparing escitalopram WO2008059514A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1210MU2006 2006-07-31
IN1210/MUM/2006 2006-07-31

Publications (2)

Publication Number Publication Date
WO2008059514A2 WO2008059514A2 (en) 2008-05-22
WO2008059514A3 true WO2008059514A3 (en) 2009-04-02

Family

ID=39337393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000323 WO2008059514A2 (en) 2006-07-31 2007-07-31 Process for preparing escitalopram

Country Status (1)

Country Link
WO (1) WO2008059514A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007012954A1 (en) 2005-07-27 2007-02-01 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN104119248A (en) * 2014-08-08 2014-10-29 广东东阳光药业有限公司 Method for preparing S-citalopram
WO2016074225A1 (en) 2014-11-14 2016-05-19 浙江华海药业股份有限公司 Method for resolution of citalopram intermediate 5-cyanogen diol
CN109212045A (en) * 2017-07-04 2019-01-15 万全万特制药（厦门）有限公司 The method of separating and assaying of escitalopram oxalate residual solvent and impurity
KR102134179B1 (en) * 2018-09-17 2020-07-16 (주)유케이케미팜 A New method for the production of citalopram and escitalopram using carbonates
CN115368327A (en) * 2022-09-07 2022-11-22 无锡积大制药有限公司 Escitalopram oxalate resolution process

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136193A (en) * 1976-01-14 1979-01-23 Kefalas A/S Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
WO2003000672A1 (en) * 2001-06-25 2003-01-03 H. Lundbeck A/S Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram
WO2003072565A1 (en) * 2002-02-27 2003-09-04 Matrix Laboratories Limited Process for the production of citalopram
WO2004014821A1 (en) * 2002-08-12 2004-02-19 H. Lundbeck A/S Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1414435A1 (en) * 2001-07-31 2004-05-06 H. Lundbeck A/S Crystalline composition containing escitalopram
WO2004056791A1 (en) * 2002-12-23 2004-07-08 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
WO2004080988A1 (en) * 2003-03-13 2004-09-23 Adorkem Technology Spa Process for the preparation of a cyano-isobenzofuran
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
WO2005049596A1 (en) * 2003-11-20 2005-06-02 Natco Pharma Limited A process for the preparation of high purity escitalopram
WO2006021971A2 (en) * 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited 'process for preparation of citalopram and enantiomers'
WO2006025071A1 (en) * 2004-09-02 2006-03-09 Natco Pharma Limited A process for the preparation of escitalopram
WO2006037714A2 (en) * 2004-10-01 2006-04-13 Adorkem Technology Spa Process for the preparation of citalopram and escitalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts
WO2006136169A2 (en) * 2005-06-22 2006-12-28 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136193A (en) * 1976-01-14 1979-01-23 Kefalas A/S Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
WO2003000672A1 (en) * 2001-06-25 2003-01-03 H. Lundbeck A/S Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram
EP1414435A1 (en) * 2001-07-31 2004-05-06 H. Lundbeck A/S Crystalline composition containing escitalopram
WO2003072565A1 (en) * 2002-02-27 2003-09-04 Matrix Laboratories Limited Process for the production of citalopram
WO2004014821A1 (en) * 2002-08-12 2004-02-19 H. Lundbeck A/S Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2004056791A1 (en) * 2002-12-23 2004-07-08 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
WO2004080988A1 (en) * 2003-03-13 2004-09-23 Adorkem Technology Spa Process for the preparation of a cyano-isobenzofuran
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
WO2005049596A1 (en) * 2003-11-20 2005-06-02 Natco Pharma Limited A process for the preparation of high purity escitalopram
WO2006021971A2 (en) * 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited 'process for preparation of citalopram and enantiomers'
WO2006025071A1 (en) * 2004-09-02 2006-03-09 Natco Pharma Limited A process for the preparation of escitalopram
WO2006037714A2 (en) * 2004-10-01 2006-04-13 Adorkem Technology Spa Process for the preparation of citalopram and escitalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts
WO2006136169A2 (en) * 2005-06-22 2006-12-28 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SOLARES LAURA F ET AL: "Enzymatic resolution of a quaternary stereogenic centre as the key step in the synthesis of (S)-(+)-citalopram", 20040101, vol. 15, 1 January 2004 (2004-01-01), pages 341 - 345, XP002330867 *

Also Published As

Publication number Publication date
WO2008059514A2 (en) 2008-05-22

Similar Documents

Publication Publication Date Title
WO2008059514A3 (en) Process for preparing escitalopram
WO2009023844A3 (en) 3' substituted compounds having 5-ht6 receptor affinity
UA94833C2 (en) Substituted bicyclolactams
GB0510143D0 (en) Novel compounds A1
WO2005070890A3 (en) Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
WO2007079163A3 (en) Prokineticin 1 receptor antagonists
TW200621739A (en) Asymmetric synthesis of substituted dihydrobenzofurans
WO2007032028A8 (en) Thiazolinones and oxazolinones and their use as ptp1b inhibitors
WO2010014666A3 (en) Processes and intermediates for making sweet taste enhancers
WO2008035212A3 (en) Processes for preparing intermediate compounds useful for the preparation of cinacalcet
TW200716566A (en) Prokineticin 2 receptor antagonists
WO2012002741A3 (en) Process for the preparation of hmg-coa reductase inhibitors and intermediates thereof
WO2006057922A3 (en) Niacin receptor agonists, compositions containing such compounds and methods of treatment
HK1080088A1 (en) Processes for preparing c-7 substituted 5-androstenes
PL1831152T3 (en) Tetralin and indane derivatives and uses thereof as 5-ht antagonists
MY178894A (en) Therapeutic compositions containing macitentan
WO2009068463A9 (en) Process for the preparation of isoindole derivatives as well as a process for the preparation of their intermediates
WO2008053334A3 (en) An improved process for preparing rosuvastatin calcium
WO2010011811A3 (en) 3-(phenoxyphenylmethyl)pyrrolidine compounds
TW200420541A (en) Crystalline forms
WO2006127815A3 (en) Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
PL1831191T3 (en) Chroman derivatives and their use as 5-ht receptor ligands
WO2006066044A3 (en) Processes for producing 4-aminoquinazolines
WO2008101247A3 (en) 6 ' substituted indole and indazole derivatives having 5-ht6 receptor affinity
WO2009097515A3 (en) [a]-fused indole compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses

Legal Events

Date Code Title Description
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07866670

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 07866670

Country of ref document: EP

Kind code of ref document: A2