DK1289527T3 - (+)-alfa.(2,3-dimethoxyphenyl)-1-(2-(4-fluorphenyl)-ethyl)-4-piperodonmethanol eller dets prolægemiddel til behandling af demens eller kognitiv svækkelse - Google Patents
(+)-alfa.(2,3-dimethoxyphenyl)-1-(2-(4-fluorphenyl)-ethyl)-4-piperodonmethanol eller dets prolægemiddel til behandling af demens eller kognitiv svækkelseInfo
- Publication number
- DK1289527T3 DK1289527T3 DK01939312T DK01939312T DK1289527T3 DK 1289527 T3 DK1289527 T3 DK 1289527T3 DK 01939312 T DK01939312 T DK 01939312T DK 01939312 T DK01939312 T DK 01939312T DK 1289527 T3 DK1289527 T3 DK 1289527T3
- Authority
- DK
- Denmark
- Prior art keywords
- piperodone
- dimethoxyphenyl
- dementia
- prodrug
- fluorophenyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20694300P | 2000-05-25 | 2000-05-25 | |
PCT/US2001/016653 WO2001089498A2 (en) | 2000-05-25 | 2001-05-23 | USE OF (+)-α -(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL OR ITS PRODRUG IN THE TREATMENT OF SYMPTOMS OF DEMENTIA AND DOPAMINE INDUCED PSYCHOSIS |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1289527T3 true DK1289527T3 (da) | 2008-07-14 |
Family
ID=22768607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01939312T DK1289527T3 (da) | 2000-05-25 | 2001-05-23 | (+)-alfa.(2,3-dimethoxyphenyl)-1-(2-(4-fluorphenyl)-ethyl)-4-piperodonmethanol eller dets prolægemiddel til behandling af demens eller kognitiv svækkelse |
Country Status (20)
Country | Link |
---|---|
US (3) | US20020099076A1 (da) |
EP (1) | EP1289527B1 (da) |
JP (1) | JP2003535058A (da) |
KR (1) | KR100784655B1 (da) |
CN (1) | CN1436078A (da) |
AR (1) | AR029666A1 (da) |
AT (1) | ATE390134T1 (da) |
AU (2) | AU6484201A (da) |
BR (1) | BR0111102A (da) |
CA (1) | CA2410554C (da) |
DE (1) | DE60133385T2 (da) |
DK (1) | DK1289527T3 (da) |
ES (1) | ES2300333T3 (da) |
IL (1) | IL152908A0 (da) |
MX (1) | MXPA02011511A (da) |
NO (1) | NO20025630L (da) |
NZ (1) | NZ522659A (da) |
PT (1) | PT1289527E (da) |
TW (1) | TWI299001B (da) |
WO (1) | WO2001089498A2 (da) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1534391T3 (da) | 2002-07-19 | 2007-06-11 | Biovitrum Ab | Nye piperazinyl-pyrazinonderivater til behandling af 5-HT2A-recptor-relaterede forstyrrelser |
US7713954B2 (en) | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
ES2359725T3 (es) * | 2004-09-30 | 2011-05-26 | F. Hoffmann-La Roche Ag | Composiciones y métodos para el tratamiento de trastornos cognitivos. |
DE102006040278A1 (de) * | 2006-08-21 | 2008-03-20 | Technische Universität Dresden | Arzneimittel zur Behandlung des Charles-Bonnet-Syndroms |
CA2992728A1 (en) | 2015-07-20 | 2017-01-26 | Acadia Pharmaceuticals Inc. | Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c |
US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
WO2017172757A1 (en) * | 2016-03-29 | 2017-10-05 | Acadia Pharmaceuticals Inc. | 5-ht2a serotonin receptor inverse agonists or antagonists for use in reducing amyloid-beta peptides and accumulation of amyloid plaques |
US11464768B2 (en) | 2016-12-20 | 2022-10-11 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis |
US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
EP3675827A1 (en) | 2017-08-30 | 2020-07-08 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5021428A (en) * | 1985-07-02 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Novel chemical compounds for the prophylactic treatment of migraine |
US4783471A (en) * | 1985-07-02 | 1988-11-08 | Merrell Dow Pharmaceuticals Inc. | N-aralkyl piperidine methanol derivatives and the uses thereof |
US4912117A (en) * | 1985-07-02 | 1990-03-27 | Merrell Dow Pharmaceuticals Inc. | Novel chemical compounds |
US5169096A (en) * | 1985-07-02 | 1992-12-08 | Merrell Dow Pharmaceuticals Inc. | N-aralkyl-piperidine-methanol derivatives |
US4877798A (en) * | 1987-11-23 | 1989-10-31 | Merrell Dow Pharmaceuticals Inc. | Treatment of fibromyalgia |
DE3888340T2 (de) * | 1988-01-21 | 1994-06-30 | Merrell Dow Pharma | Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit. |
US5106855A (en) * | 1989-12-20 | 1992-04-21 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of glaucoma |
US6004980A (en) * | 1990-06-01 | 1999-12-21 | Merrell Pharmaceuticals, Inc. | (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
JP2869512B2 (ja) * | 1990-06-01 | 1999-03-10 | メレルダウファーマスーティカルズ インコーポレイテッド | (+)―α―(2,3―ジメトキシフェニル)―1―[2―(4―フルオロフェニル)エチル]―4―ピペリジンメタノール |
US5618824A (en) * | 1994-03-09 | 1997-04-08 | Merrell Pharmaceuticals Inc. | Treatment of obsessive-compulsive disorders with 5-HT2 antagonists |
FR2738819B1 (fr) * | 1995-09-14 | 1997-12-05 | Sanofi Sa | Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant |
EP0796619A1 (en) * | 1996-03-21 | 1997-09-24 | Merrell Pharmaceuticals Inc. | Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders |
US6028083A (en) * | 1997-07-25 | 2000-02-22 | Hoechst Marion Roussel, Inc. | Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
WO1999020315A1 (en) * | 1997-10-23 | 1999-04-29 | The Research Foundation Of State University Of New York | Methods of screening potential atypical antipsychotic drugs |
ATE249830T1 (de) | 1998-08-28 | 2003-10-15 | Aventis Pharma Inc | Die verwendung von r (+)- g(a)-(2,3- dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4- piperidinemethanol zur behandlung von obstruktive schlafapnoe |
UA57859C2 (uk) * | 1998-10-14 | 2003-07-15 | Авентіс Фармасьютікалз Інк. | СКЛАДНІ ЕФІРИ (+)-АЛЬФА-(2,3-ДИМЕТОКСИФЕНІЛ)-1-[2-(4-ФТОРФЕНІЛ)ЕТИЛ]-4-ПІПЕРИДИНМЕТАНОЛУ, СПОСІБ ЇХ ОТРИМАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, СПОСІБ ІНГІБУВАННЯ ДІЇ СЕРОТОНІНУ НА 5HT<sub>2A</sub> РЕЦЕПТОР, СПОСІБ ЛІКУВАННЯ |
US6455526B1 (en) * | 1998-12-16 | 2002-09-24 | Aventis Pharmaceuticals, Inc. | Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same |
-
2001
- 2001-05-18 US US09/861,980 patent/US20020099076A1/en not_active Abandoned
- 2001-05-23 PT PT01939312T patent/PT1289527E/pt unknown
- 2001-05-23 JP JP2001585743A patent/JP2003535058A/ja active Pending
- 2001-05-23 KR KR1020027015968A patent/KR100784655B1/ko not_active IP Right Cessation
- 2001-05-23 BR BR0111102-7A patent/BR0111102A/pt not_active Application Discontinuation
- 2001-05-23 AR ARP010102464A patent/AR029666A1/es unknown
- 2001-05-23 CN CN01810983A patent/CN1436078A/zh active Pending
- 2001-05-23 TW TW090112318A patent/TWI299001B/zh not_active IP Right Cessation
- 2001-05-23 CA CA002410554A patent/CA2410554C/en not_active Expired - Fee Related
- 2001-05-23 WO PCT/US2001/016653 patent/WO2001089498A2/en active IP Right Grant
- 2001-05-23 DE DE60133385T patent/DE60133385T2/de not_active Expired - Fee Related
- 2001-05-23 NZ NZ522659A patent/NZ522659A/en unknown
- 2001-05-23 IL IL15290801A patent/IL152908A0/xx unknown
- 2001-05-23 AU AU6484201A patent/AU6484201A/xx active Pending
- 2001-05-23 AU AU2001264842A patent/AU2001264842B2/en not_active Ceased
- 2001-05-23 MX MXPA02011511A patent/MXPA02011511A/es active IP Right Grant
- 2001-05-23 AT AT01939312T patent/ATE390134T1/de not_active IP Right Cessation
- 2001-05-23 EP EP01939312A patent/EP1289527B1/en not_active Expired - Lifetime
- 2001-05-23 DK DK01939312T patent/DK1289527T3/da active
- 2001-05-23 ES ES01939312T patent/ES2300333T3/es not_active Expired - Lifetime
-
2002
- 2002-08-13 US US10/217,843 patent/US20030036553A1/en not_active Abandoned
- 2002-11-22 NO NO20025630A patent/NO20025630L/no not_active Application Discontinuation
-
2004
- 2004-05-03 US US10/838,035 patent/US7132433B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR100784655B1 (ko) | 2007-12-12 |
EP1289527A2 (en) | 2003-03-12 |
EP1289527B1 (en) | 2008-03-26 |
PT1289527E (pt) | 2008-05-13 |
NO20025630D0 (no) | 2002-11-22 |
JP2003535058A (ja) | 2003-11-25 |
NO20025630L (no) | 2003-01-24 |
BR0111102A (pt) | 2003-03-11 |
US20020099076A1 (en) | 2002-07-25 |
DE60133385T2 (de) | 2009-04-23 |
ES2300333T3 (es) | 2008-06-16 |
CA2410554C (en) | 2009-02-03 |
IL152908A0 (en) | 2003-06-24 |
AU2001264842B2 (en) | 2005-01-27 |
US20040204457A1 (en) | 2004-10-14 |
US20030036553A1 (en) | 2003-02-20 |
AU6484201A (en) | 2001-12-03 |
TWI299001B (en) | 2008-07-21 |
PL359176A1 (en) | 2004-08-23 |
WO2001089498A2 (en) | 2001-11-29 |
ATE390134T1 (de) | 2008-04-15 |
CA2410554A1 (en) | 2001-11-29 |
WO2001089498A3 (en) | 2002-05-10 |
AR029666A1 (es) | 2003-07-10 |
KR20030034078A (ko) | 2003-05-01 |
NZ522659A (en) | 2004-06-25 |
CN1436078A (zh) | 2003-08-13 |
DE60133385D1 (de) | 2008-05-08 |
MXPA02011511A (es) | 2003-04-25 |
US7132433B2 (en) | 2006-11-07 |
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