EA200601513A1 - Способ получения энантиомерно чистых 1-замещённых 3-аминоспиртов - Google Patents

Способ получения энантиомерно чистых 1-замещённых 3-аминоспиртов

Info

Publication number
EA200601513A1
EA200601513A1 EA200601513A EA200601513A EA200601513A1 EA 200601513 A1 EA200601513 A1 EA 200601513A1 EA 200601513 A EA200601513 A EA 200601513A EA 200601513 A EA200601513 A EA 200601513A EA 200601513 A1 EA200601513 A1 EA 200601513A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
alkyl
salts
aminospirants
thienyl
Prior art date
Application number
EA200601513A
Other languages
English (en)
Inventor
Доминик Мишель
Ханспетер Меттлер
Джон Макгаррити
Original Assignee
Лонца Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04003809A external-priority patent/EP1566383A1/en
Application filed by Лонца Аг filed Critical Лонца Аг
Publication of EA200601513A1 publication Critical patent/EA200601513A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)

Abstract

В заявке описан способ получения энантиомерно чистых 1-замещенных-3-аминоспиртов, в особенности (S)-(-)- и (R)-(+)-3-N-метиламино-1-(2-тиенил)-1-пропанола с помощью асимметрического гидрирования солей карбоновых кислот с аминокетоном формулыв которой Rвыбран из группы, включающей 2-тиенил, 2-фуранил и фенил, каждый из которых необязательно замещен одним или большим количеством атомов галогена и/или одной или большим количеством С-С-алкильных или С-С-алкоксигрупп, и в которой Rобозначает С-С-алкил или фенил, каждый из которых необязательно замещен одним или большим количеством атомов галогена и/или одной или большим количеством С-С-алкильных или C-С-алкоксигрупп, и в котором соответствующие аминоспирты получают последующим гидролизом их солей. Кроме того, описаны соли карбоновой кислоты с указанными аминокетонами и аминоспиртами, полученные с помощью асимметрического гидрирования указанных аминокетонов, соответственно.
EA200601513A 2004-02-19 2005-02-21 Способ получения энантиомерно чистых 1-замещённых 3-аминоспиртов EA200601513A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04003809A EP1566383A1 (en) 2004-02-19 2004-02-19 Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
EP04010043 2004-04-28
PCT/EP2005/001781 WO2005080370A1 (en) 2004-02-19 2005-02-21 Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols

Publications (1)

Publication Number Publication Date
EA200601513A1 true EA200601513A1 (ru) 2007-02-27

Family

ID=34889010

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601513A EA200601513A1 (ru) 2004-02-19 2005-02-21 Способ получения энантиомерно чистых 1-замещённых 3-аминоспиртов

Country Status (20)

Country Link
US (3) US7973182B2 (ru)
EP (1) EP1720852B1 (ru)
JP (2) JP2007523124A (ru)
KR (1) KR101160502B1 (ru)
CN (1) CN102627572A (ru)
AU (1) AU2005215906C1 (ru)
BR (1) BRPI0506796A (ru)
CA (1) CA2556891C (ru)
CY (1) CY1113261T1 (ru)
DK (1) DK1720852T3 (ru)
EA (1) EA200601513A1 (ru)
ES (1) ES2391399T3 (ru)
IL (1) IL177561A (ru)
NO (1) NO20064017L (ru)
NZ (1) NZ549381A (ru)
PL (1) PL1720852T3 (ru)
PT (1) PT1720852E (ru)
SG (1) SG135196A1 (ru)
SI (1) SI1720852T1 (ru)
WO (1) WO2005080370A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1720852B1 (en) 2004-02-19 2012-07-11 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
EP1868983A1 (en) * 2005-02-21 2007-12-26 Lonza Ag Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
EP2044049A2 (en) 2006-07-03 2009-04-08 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl- 3 -( 1-naph-thaleneoxy)- 3 - (-2-thienyl) propanamine
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SI2329013T1 (sl) 2008-08-27 2016-03-31 Codexis, Inc. Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina
SI2558455T1 (sl) 2010-04-13 2017-12-29 Krka, D.D., Novo Mesto Sinteza duloksetina in/ali njegovih farmacevtsko sprejemljivih soli
CN104056663B (zh) * 2013-03-22 2016-12-28 上海交通大学 一种面手性双反应中心钌催化剂及其合成与应用
CN110054563A (zh) * 2019-06-10 2019-07-26 江西隆莱生物制药有限公司 丁内酯类化合物的制备方法及其中间体
CN111793056A (zh) * 2020-07-27 2020-10-20 广州康瑞泰药业有限公司 一种度洛西汀中间体的制备方法

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DE3031248A1 (de) * 1980-08-19 1982-04-01 Ruhrchemie Ag, 4200 Oberhausen Verfahren zur herstellung von 3-dimethylamino-2,2-dimethylpropanal
US5362866A (en) 1983-09-02 1994-11-08 Molecular Biosystems, Inc. Oligonucleotide polymeric support system with an oxidation cleavable link
KR880007433A (ko) * 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
US4948813A (en) 1987-11-30 1990-08-14 E. I. Du Pont De Nemours And Company Benzylketone phospholipase A2 inhibitors
IL98108A0 (en) * 1990-05-17 1992-06-21 Lilly Co Eli Chiral synthesis of 1-aryl-3-aminopropan-1-ols
JPH0570412A (ja) * 1991-09-13 1993-03-23 Fuji Yakuhin Kogyo Kk 光学活性なβ−アミノアルコールの製造方法
US5491234A (en) * 1992-03-30 1996-02-13 Pfizer Inc. Pyrimidine derivatives for enhancing antitumor activity
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IT1270082B (it) * 1994-07-12 1997-04-28 Univ Degli Studi Milano Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali
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JP3549390B2 (ja) 1998-03-23 2004-08-04 高砂香料工業株式会社 ルテニウム−ホスフィン錯体及びその製造方法
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DE10207586A1 (de) * 2002-02-22 2003-09-11 Degussa Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte
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Also Published As

Publication number Publication date
JP2012229223A (ja) 2012-11-22
AU2005215906B2 (en) 2011-08-18
BRPI0506796A (pt) 2007-05-22
IL177561A (en) 2011-12-29
CY1113261T1 (el) 2016-04-13
WO2005080370A1 (en) 2005-09-01
US20110207946A1 (en) 2011-08-25
CN102627572A (zh) 2012-08-08
SI1720852T1 (sl) 2012-11-30
ES2391399T3 (es) 2012-11-26
NZ549381A (en) 2010-05-28
JP2007523124A (ja) 2007-08-16
EP1720852A1 (en) 2006-11-15
US8198468B2 (en) 2012-06-12
KR20070009587A (ko) 2007-01-18
US20080154047A1 (en) 2008-06-26
DK1720852T3 (da) 2012-10-22
IL177561A0 (en) 2006-12-10
CA2556891C (en) 2012-12-18
CA2556891A1 (en) 2005-09-01
NO20064017L (no) 2006-09-15
SG135196A1 (en) 2007-09-28
KR101160502B1 (ko) 2012-06-28
AU2005215906C1 (en) 2012-03-01
US8193380B2 (en) 2012-06-05
AU2005215906A1 (en) 2005-09-01
PT1720852E (pt) 2012-10-22
EP1720852B1 (en) 2012-07-11
PL1720852T3 (pl) 2012-12-31
US20110207945A1 (en) 2011-08-25
US7973182B2 (en) 2011-07-05

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