DE602004030239D1 - Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon - Google Patents

Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon

Info

Publication number
DE602004030239D1
DE602004030239D1 DE602004030239T DE602004030239T DE602004030239D1 DE 602004030239 D1 DE602004030239 D1 DE 602004030239D1 DE 602004030239 T DE602004030239 T DE 602004030239T DE 602004030239 T DE602004030239 T DE 602004030239T DE 602004030239 D1 DE602004030239 D1 DE 602004030239D1
Authority
DE
Germany
Prior art keywords
ühexan
carboxylate
dimethyl
salts
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004030239T
Other languages
English (en)
Inventor
Jeonghan Park
Anantha Sudhakar
George S Wong
Minzhang Chen
Juergen Weber
Xiaojing Yang
Daw-Iong Kwok
Ingyu Jeon
Ramani R Raghavan
Maria Tamarez
Weidong Tong
Eugene J Vater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE602004030239D1 publication Critical patent/DE602004030239D1/de
Anticipated expiration legal-status Critical
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE602004030239T 2003-06-17 2004-06-15 Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon Active DE602004030239D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47951603P 2003-06-17 2003-06-17
PCT/US2004/019135 WO2004113295A1 (en) 2003-06-17 2004-06-15 Process and intermediates for the preparation of (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof

Publications (1)

Publication Number Publication Date
DE602004030239D1 true DE602004030239D1 (de) 2011-01-05

Family

ID=33539184

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004030239T Active DE602004030239D1 (de) 2003-06-17 2004-06-15 Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon

Country Status (13)

Country Link
US (3) US7309717B2 (de)
EP (1) EP1633711B1 (de)
JP (1) JP4825129B2 (de)
CN (2) CN101823965B (de)
AT (1) ATE489365T1 (de)
CA (1) CA2526635C (de)
DE (1) DE602004030239D1 (de)
ES (1) ES2354817T3 (de)
HK (1) HK1081199A1 (de)
MX (1) MXPA05013752A (de)
SG (1) SG180022A1 (de)
WO (1) WO2004113295A1 (de)
ZA (1) ZA201006378B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20060309A1 (es) * 2004-05-06 2006-04-13 Schering Corp (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil]-3-[(2s)-2[[[(1,1-dimetiletil)amino]carbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3.1.o]hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de l
US20060276406A1 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis C virus
WO2006130686A2 (en) 2005-06-02 2006-12-07 Schering Corporation Hcv protease inhibitors in combination with food
US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
WO2006130666A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Medicaments and methods combining a hcv protease inhibitor and an akr competitor
EP1898941A2 (de) * 2005-06-02 2008-03-19 Schering Corporation Formulierungen mit kontrollierter freisetzung zur behandlung von erkrankungen im zusammenhang mit hepatitis-c-virus
US20060281689A1 (en) * 2005-06-02 2006-12-14 Schering Corporation Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
CA2611155A1 (en) * 2005-06-02 2006-12-07 Schering Corporation Pharmaceutical formulations and methods of treatment using the same
US20070021351A1 (en) * 2005-06-02 2007-01-25 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor
WO2006130554A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
AR056805A1 (es) * 2005-11-14 2007-10-24 Schering Corp Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
CA2634397A1 (en) * 2005-12-22 2007-07-05 Schering Corporation Process for the preparation of 6,6-dimethyl-3-azabicyclo[3.1.0|-hexane compounds and enantiomeric salts thereof
WO2007074391A2 (en) * 2005-12-28 2007-07-05 Bakulesh Mafatlal Khamar Preparation of a key intermediate in the synthesis of rosuvastatin
KR101059593B1 (ko) 2006-04-11 2011-08-25 노파르티스 아게 Ｈｃｖ/ｈｉｖ 억제제 및 이들의 용도
WO2007122744A1 (ja) 2006-04-17 2007-11-01 Sumitomo Chemical Company, Limited 多環式プロリン誘導体又はその酸付加塩の製造方法
JP5272324B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 Ｎ−ｔｅｒｔ−ブトキシカルボニル−２−ピロリジノン類およびその製造方法
WO2007122743A1 (ja) 2006-04-17 2007-11-01 Sumitomo Chemical Company, Limited 多環式ラクタム類の製造方法
WO2007122745A1 (ja) 2006-04-17 2007-11-01 Sumitomo Chemical Company, Limited Ｎ−ｔｅｒｔ−ブトキシカルボニル−２−ピロリジノン類およびその製造方法
JP5272325B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 多環式プロリン誘導体またはその酸付加塩の製造方法
JP2010513492A (ja) * 2006-12-19 2010-04-30 シェーリング コーポレイション ３−（アミノ）−３−（シクロブチルメチル）−２−（ヒドロキシ）−プロピオンアミド塩酸塩の調製
CN101868452B (zh) * 2007-10-10 2014-08-06 诺华股份有限公司 螺环吡咯烷类与其对抗hcv和hiv感染的应用
EP2225203A1 (de) * 2007-11-28 2010-09-08 Schering Corporation Dehydrohalogenierungsverfahren zur herstellung von für die bereitstellung von 6,6-dimethyl-3-azabicyclo[3.1.0]hexanverbindungen nützlichen zwischenprodukten
CN102282135A (zh) * 2008-06-05 2011-12-14 帝斯曼知识产权资产管理有限公司 一种(4s，5r)-半酯的制备方法
CN102131813B (zh) 2008-06-24 2014-07-30 科德克希思公司 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
EP2365753B1 (de) * 2008-11-17 2013-07-17 Anadys Pharmaceuticals, Inc. Verfahren zur herstellung von desoxyribofuranoseverbindungen
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
CN101863866B (zh) * 2009-04-16 2012-07-04 上海联友制药技术有限公司 3,3-二甲基环丙烷-1,2-二甲酸酐的合成方法
AU2010276490B2 (en) 2009-07-29 2013-11-14 Merck Sharp & Dohme Corp. Enantio- and stereo-specific syntheses of beta-amino-alpha- hydroxy amides
CN102070575B (zh) * 2010-12-28 2012-10-17 上海北卡医药技术有限公司 卡隆酸酐的合成方法
CN102127040B (zh) * 2010-12-30 2013-05-01 西安彩晶光电科技股份有限公司 6,6-二甲基-3-氧杂双环[3.1.0]己烷-2,4-二酮的制备方法
FR2972453B1 (fr) * 2011-03-09 2013-11-29 Minakem Nouveau procede de synthese du (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate de methyle ou de l'un de ses sels
JP2013010738A (ja) * 2011-05-31 2013-01-17 Sumitomo Chemical Co Ltd エステル化合物の製造方法
JP2013010732A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd プロリン化合物の製造方法
JP2013010734A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd Ｎ−置換ラクタム化合物の製造方法
JP2013010733A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd ヘミアミナール化合物の製造方法及びシアノアミン化合物の製造方法
WO2013178682A2 (en) 2012-05-30 2013-12-05 Chemo Ibérica, S.A. Multicomponent process for the preparation of bicyclic compounds
CN103435532B (zh) * 2013-09-02 2015-07-08 苏州永健生物医药有限公司 波普瑞韦中间体的合成方法
CN104151279A (zh) * 2014-08-26 2014-11-19 广西梧松林化集团有限公司 卡龙酸酐的合成方法
CN114539125B (zh) * 2022-03-07 2024-02-09 杭州国瑞生物科技有限公司 一种帕西洛韦中间体的合成方法
CN114478690B (zh) * 2022-03-08 2024-01-02 新发药业有限公司 一种6,6-二甲基-3-氮杂双环[3.1.0]己烷衍生物的制备方法
WO2023175526A1 (en) * 2022-03-16 2023-09-21 Laurus Labs Limited Process for preparation of azabicyclo [3.1.0] hexane intermediates
CN114605309B (zh) * 2022-03-23 2023-07-21 浙江新和成股份有限公司 一种氮杂双环衍生物的合成方法
CN114989067B (zh) * 2022-07-18 2022-10-28 苏州奥普拓新材料有限公司 一种帕罗韦德中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2376120A1 (fr) * 1976-12-30 1978-07-28 Roussel Uclaf Procede de preparation d'esters d'alcoyle inferieur d'acides cis ou trans 3-formyl cyclopropane 1-carboxyliques 2,2-disubstitues racemiques
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
CA1117128A (en) * 1978-10-27 1982-01-26 Derek A. Wood 2-cyano-3-azabicyclo(3.1.0)hexane
CN102372764A (zh) 2000-07-21 2012-03-14 先灵公司 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
IL144815A (en) * 2000-08-11 2005-07-25 Sumitomo Chemical Co Process for producing carbonyl or hydroxy compound

Also Published As

Publication number Publication date
JP4825129B2 (ja) 2011-11-30
CN1805931A (zh) 2006-07-19
CN1805931B (zh) 2010-06-23
US7728165B2 (en) 2010-06-01
US7309717B2 (en) 2007-12-18
US20090247784A1 (en) 2009-10-01
JP2007520434A (ja) 2007-07-26
MXPA05013752A (es) 2006-03-08
EP1633711B1 (de) 2010-11-24
SG180022A1 (en) 2012-05-30
CN101823965B (zh) 2012-12-19
WO2004113295A1 (en) 2004-12-29
ATE489365T1 (de) 2010-12-15
US20080114179A1 (en) 2008-05-15
ZA201006378B (en) 2011-05-25
ES2354817T3 (es) 2011-03-18
HK1081199A1 (en) 2006-05-12
CA2526635C (en) 2012-06-05
US7569705B2 (en) 2009-08-04
EP1633711A1 (de) 2006-03-15
CA2526635A1 (en) 2004-12-29
CN101823965A (zh) 2010-09-08
US20050059648A1 (en) 2005-03-17

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