ATE415388T1 - Verfahren zur herstellung von enantiomerenreinen 4-pyrrolidinophenyl- benzyletherderivaten - Google Patents
Verfahren zur herstellung von enantiomerenreinen 4-pyrrolidinophenyl- benzyletherderivatenInfo
- Publication number
- ATE415388T1 ATE415388T1 AT06707355T AT06707355T ATE415388T1 AT E415388 T1 ATE415388 T1 AT E415388T1 AT 06707355 T AT06707355 T AT 06707355T AT 06707355 T AT06707355 T AT 06707355T AT E415388 T1 ATE415388 T1 AT E415388T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidinophenyl
- ether derivatives
- benzyl ether
- enantiomer pure
- producing enantiomer
- Prior art date
Links
- YOVMEQZKFWKEAI-UHFFFAOYSA-N 1-[4-[phenyl-[phenyl-(4-pyrrolidin-1-ylphenyl)methoxy]methyl]phenyl]pyrrolidine Chemical class C1CCCN1C1=CC=C(C(OC(C=2C=CC=CC=2)C=2C=CC(=CC=2)N2CCCC2)C=2C=CC=CC=2)C=C1 YOVMEQZKFWKEAI-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05102028 | 2005-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE415388T1 true ATE415388T1 (de) | 2008-12-15 |
Family
ID=36218379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06707355T ATE415388T1 (de) | 2005-03-15 | 2006-03-02 | Verfahren zur herstellung von enantiomerenreinen 4-pyrrolidinophenyl- benzyletherderivaten |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7485731B2 (de) |
| EP (1) | EP1861362B1 (de) |
| JP (1) | JP4796620B2 (de) |
| KR (1) | KR100915736B1 (de) |
| CN (1) | CN101142181B (de) |
| AT (1) | ATE415388T1 (de) |
| AU (1) | AU2006224878B2 (de) |
| BR (1) | BRPI0608466A2 (de) |
| CA (1) | CA2601416C (de) |
| DE (1) | DE602006003879D1 (de) |
| ES (1) | ES2314877T3 (de) |
| IL (1) | IL185635A (de) |
| MX (1) | MX2007011154A (de) |
| TW (1) | TW200640856A (de) |
| WO (1) | WO2006097197A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105705487A (zh) * | 2013-10-29 | 2016-06-22 | 豪夫迈·罗氏有限公司 | 可用于治疗阿尔茨海默病的吡咯烷酮衍生物的晶形及其制备 |
| JP2018509400A (ja) | 2015-03-27 | 2018-04-05 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | セムブラギリンを含む医薬製剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997033572A1 (en) | 1996-03-15 | 1997-09-18 | Somerset Pharmaceuticals, Inc. | Method for preventing and treating peripheral neurophathy by administering selegiline |
| AU1359801A (en) | 1999-11-05 | 2001-06-06 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
| TWI286132B (en) * | 2002-09-20 | 2007-09-01 | Hoffmann La Roche | 4-pyrrolidino-phenyl-benzyl ether derivatives |
-
2006
- 2006-03-02 EP EP06707355A patent/EP1861362B1/de not_active Expired - Lifetime
- 2006-03-02 BR BRPI0608466-4A patent/BRPI0608466A2/pt not_active Application Discontinuation
- 2006-03-02 DE DE602006003879T patent/DE602006003879D1/de not_active Expired - Lifetime
- 2006-03-02 AU AU2006224878A patent/AU2006224878B2/en not_active Ceased
- 2006-03-02 CA CA2601416A patent/CA2601416C/en not_active Expired - Fee Related
- 2006-03-02 KR KR1020077020948A patent/KR100915736B1/ko not_active Expired - Fee Related
- 2006-03-02 ES ES06707355T patent/ES2314877T3/es not_active Expired - Lifetime
- 2006-03-02 CN CN2006800082128A patent/CN101142181B/zh not_active Expired - Fee Related
- 2006-03-02 MX MX2007011154A patent/MX2007011154A/es active IP Right Grant
- 2006-03-02 AT AT06707355T patent/ATE415388T1/de active
- 2006-03-02 JP JP2008501182A patent/JP4796620B2/ja not_active Expired - Fee Related
- 2006-03-02 WO PCT/EP2006/001878 patent/WO2006097197A1/en not_active Ceased
- 2006-03-08 US US11/370,450 patent/US7485731B2/en not_active Expired - Fee Related
- 2006-03-13 TW TW095108442A patent/TW200640856A/zh unknown
-
2007
- 2007-08-30 IL IL185635A patent/IL185635A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070103494A (ko) | 2007-10-23 |
| CA2601416C (en) | 2013-07-09 |
| CN101142181A (zh) | 2008-03-12 |
| IL185635A (en) | 2011-07-31 |
| TW200640856A (en) | 2006-12-01 |
| CA2601416A1 (en) | 2006-09-21 |
| IL185635A0 (en) | 2008-01-06 |
| US7485731B2 (en) | 2009-02-03 |
| DE602006003879D1 (de) | 2009-01-08 |
| EP1861362A1 (de) | 2007-12-05 |
| JP4796620B2 (ja) | 2011-10-19 |
| BRPI0608466A2 (pt) | 2010-01-05 |
| CN101142181B (zh) | 2011-05-04 |
| MX2007011154A (es) | 2007-10-17 |
| AU2006224878B2 (en) | 2011-02-17 |
| US20060211869A1 (en) | 2006-09-21 |
| JP2008533061A (ja) | 2008-08-21 |
| AU2006224878A1 (en) | 2006-09-21 |
| EP1861362B1 (de) | 2008-11-26 |
| KR100915736B1 (ko) | 2009-09-04 |
| WO2006097197A1 (en) | 2006-09-21 |
| ES2314877T3 (es) | 2009-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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