EA201170016A1 - Новые производные (пиперазинил мостиковый)-1-алканона и их применение в качестве ингибиторов р75 - Google Patents

Новые производные (пиперазинил мостиковый)-1-алканона и их применение в качестве ингибиторов р75

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Publication number
EA201170016A1
EA201170016A1 EA201170016A EA201170016A EA201170016A1 EA 201170016 A1 EA201170016 A1 EA 201170016A1 EA 201170016 A EA201170016 A EA 201170016A EA 201170016 A EA201170016 A EA 201170016A EA 201170016 A1 EA201170016 A1 EA 201170016A1
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EA
Eurasian Patent Office
Prior art keywords
mostic
alkanona
piperazinil
inhibitors
new derivatives
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EA201170016A
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English (en)
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EA019074B1 (ru
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Марко Барони
Франсуаз Боно
Сандрин Дельбари-Госсар
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Санофи-Авентис
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Publication of EA201170016A1 publication Critical patent/EA201170016A1/ru
Publication of EA019074B1 publication Critical patent/EA019074B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Transplantation (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Изобретение относится к производным ((фенил)-3,6-дигидропиридин-1-ил)-(мостиковый пиперазинил)-1-алканона и ((фенил)-2,5-дигидропиррол-1-ил)-(мостиковый пиперазинил)-1-алканона общей формулы (I), где А, В, m, W, n и R5 имеют те же значения, что по п.1, а также к способу получения и их применению в медицине.
EA201170016A 2008-06-13 2009-06-12 Производные (пиперазинил мостиковый)-1-алканона и их применение в качестве ингибиторов р75 EA019074B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0803299A FR2932482B1 (fr) 2008-06-13 2008-06-13 Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75
PCT/FR2009/051118 WO2009150388A1 (fr) 2008-06-13 2009-06-12 NOUVEAUX DERIVES DE (PIPERAZINYL PONTE)-1-ALCANONE ET LEUR UTILISATION COMME INHIBITEURS DE p75

Publications (2)

Publication Number Publication Date
EA201170016A1 true EA201170016A1 (ru) 2011-08-30
EA019074B1 EA019074B1 (ru) 2013-12-30

Family

ID=40305395

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170016A EA019074B1 (ru) 2008-06-13 2009-06-12 Производные (пиперазинил мостиковый)-1-алканона и их применение в качестве ингибиторов р75

Country Status (39)

Country Link
US (2) US8193190B2 (ru)
EP (1) EP2297148B8 (ru)
JP (1) JP5476373B2 (ru)
KR (1) KR101642526B1 (ru)
CN (1) CN102124006B (ru)
AR (1) AR072103A1 (ru)
AT (1) ATE540039T1 (ru)
AU (1) AU2009259121B2 (ru)
BR (1) BRPI0915126B8 (ru)
CA (1) CA2727669C (ru)
CL (1) CL2010001429A1 (ru)
CO (1) CO6280535A2 (ru)
CR (1) CR11832A (ru)
CY (1) CY1112610T1 (ru)
DK (1) DK2297148T3 (ru)
DO (2) DOP2010000380A (ru)
EA (1) EA019074B1 (ru)
EC (1) ECSP10010672A (ru)
ES (1) ES2379685T3 (ru)
FR (1) FR2932482B1 (ru)
HK (1) HK1158631A1 (ru)
HR (1) HRP20120290T1 (ru)
IL (1) IL209902A (ru)
JO (1) JO2774B1 (ru)
MA (1) MA32474B1 (ru)
MX (1) MX2010013695A (ru)
MY (1) MY150988A (ru)
NI (1) NI201000215A (ru)
NZ (1) NZ589840A (ru)
PE (1) PE20110154A1 (ru)
PL (1) PL2297148T3 (ru)
PT (1) PT2297148E (ru)
RS (1) RS52262B (ru)
SI (1) SI2297148T1 (ru)
SV (1) SV2010003755A (ru)
TW (1) TWI432433B (ru)
UA (1) UA101979C2 (ru)
UY (1) UY31893A (ru)
WO (1) WO2009150388A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2931223B1 (fr) 2008-05-16 2010-08-20 Air Liquide Dispositif distributeur de gaz sous pression, ensemble comprenant un tel dispositif et dispositif de commande, recipient pourvu d'un tel dispositif distributeur
FR2932481B1 (fr) * 2008-06-13 2010-10-08 Sanofi Aventis Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique.
FR2953836B1 (fr) 2009-12-14 2012-03-16 Sanofi Aventis Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75
FR2953839A1 (fr) 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75
EP2606894A1 (en) * 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3236243A1 (de) * 1982-09-30 1984-04-05 Merck Patent Gmbh, 6100 Darmstadt Schwefelhaltige indolderivate
FR2744448B1 (fr) * 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
US6613942B1 (en) * 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
WO1999001423A1 (en) * 1997-07-01 1999-01-14 Novo Nordisk A/S Glucagon antagonists/inverse agonists
AU4198400A (en) 1999-04-06 2000-10-23 Krenitsky Pharmaceuticals Inc. Neurotrophic thio substituted pyrimidines
UA77526C2 (en) * 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862967B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
FR2862968B1 (fr) 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
FR2932481B1 (fr) 2008-06-13 2010-10-08 Sanofi Aventis Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
CO6280535A2 (es) 2011-05-20
ES2379685T3 (es) 2012-04-30
HK1158631A1 (en) 2012-07-20
NZ589840A (en) 2012-11-30
BRPI0915126B8 (pt) 2021-05-25
FR2932482A1 (fr) 2009-12-18
JO2774B1 (en) 2014-03-15
AR072103A1 (es) 2010-08-04
DOP2010000380A (es) 2011-01-15
US20120232280A1 (en) 2012-09-13
KR101642526B1 (ko) 2016-07-25
CN102124006B (zh) 2014-06-11
AU2009259121A1 (en) 2009-12-17
HRP20120290T1 (hr) 2012-04-30
KR20110018435A (ko) 2011-02-23
UA101979C2 (ru) 2013-05-27
WO2009150388A1 (fr) 2009-12-17
PE20110154A1 (es) 2011-03-14
MX2010013695A (es) 2011-03-04
NI201000215A (es) 2011-05-04
ECSP10010672A (es) 2011-01-31
EA019074B1 (ru) 2013-12-30
EP2297148A1 (fr) 2011-03-23
CA2727669C (fr) 2016-08-23
US8519143B2 (en) 2013-08-27
IL209902A0 (en) 2011-02-28
JP5476373B2 (ja) 2014-04-23
DOP2013000124A (es) 2013-12-31
IL209902A (en) 2014-09-30
TW201002710A (en) 2010-01-16
UY31893A (es) 2010-01-29
ATE540039T1 (de) 2012-01-15
EP2297148B8 (fr) 2012-03-28
TWI432433B (zh) 2014-04-01
MA32474B1 (fr) 2011-07-03
US20110144116A1 (en) 2011-06-16
MY150988A (en) 2014-03-31
AU2009259121B2 (en) 2013-12-19
SV2010003755A (es) 2011-03-15
FR2932482B1 (fr) 2010-10-08
EP2297148B1 (fr) 2012-01-04
CR11832A (es) 2011-02-04
PT2297148E (pt) 2012-04-03
CL2010001429A1 (es) 2011-07-29
PL2297148T3 (pl) 2012-05-31
CA2727669A1 (fr) 2009-12-17
CN102124006A (zh) 2011-07-13
SI2297148T1 (sl) 2012-05-31
CY1112610T1 (el) 2016-02-10
BRPI0915126A2 (pt) 2016-02-16
BRPI0915126B1 (pt) 2019-09-24
US8193190B2 (en) 2012-06-05
DK2297148T3 (da) 2012-05-07
RS52262B (en) 2012-10-31
JP2011522869A (ja) 2011-08-04

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