ATE523503T1 - Verfahren zur herstellung von (s)-n-methyl-3-(1- naphthyloxy)-3-(2-thienyl)propylaminhydrochlori (duloxetin) - Google Patents

Verfahren zur herstellung von (s)-n-methyl-3-(1- naphthyloxy)-3-(2-thienyl)propylaminhydrochlori (duloxetin)

Info

Publication number
ATE523503T1
ATE523503T1 AT06840860T AT06840860T ATE523503T1 AT E523503 T1 ATE523503 T1 AT E523503T1 AT 06840860 T AT06840860 T AT 06840860T AT 06840860 T AT06840860 T AT 06840860T AT E523503 T1 ATE523503 T1 AT E523503T1
Authority
AT
Austria
Prior art keywords
naphthyloxy
thienyl
base
propylamine
dimethyl
Prior art date
Application number
AT06840860T
Other languages
English (en)
Inventor
Ludek Ridvan
Kamal Jarrah
Josef Cinibulk
Monika Zatopkova
Lukas Placek
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Application granted granted Critical
Publication of ATE523503T1 publication Critical patent/ATE523503T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06840860T 2006-01-04 2006-12-22 Verfahren zur herstellung von (s)-n-methyl-3-(1- naphthyloxy)-3-(2-thienyl)propylaminhydrochlori (duloxetin) ATE523503T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20060007A CZ299270B6 (cs) 2006-01-04 2006-01-04 Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
PCT/CZ2006/000096 WO2007076733A2 (en) 2006-01-04 2006-12-22 A METHOD FOR THE PREPARATION OF (S)-N-METΗYL-3-(l-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE HYDROCHLORIDE (DULOXETINE)

Publications (1)

Publication Number Publication Date
ATE523503T1 true ATE523503T1 (de) 2011-09-15

Family

ID=38042666

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06840860T ATE523503T1 (de) 2006-01-04 2006-12-22 Verfahren zur herstellung von (s)-n-methyl-3-(1- naphthyloxy)-3-(2-thienyl)propylaminhydrochlori (duloxetin)

Country Status (9)

Country Link
US (2) US8071791B2 (de)
EP (2) EP2172464B1 (de)
AT (1) ATE523503T1 (de)
CZ (1) CZ299270B6 (de)
EA (1) EA014559B1 (de)
PL (1) PL1968965T3 (de)
PT (1) PT1968965E (de)
UA (1) UA94931C2 (de)
WO (1) WO2007076733A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006021628D1 (de) * 2005-12-12 2011-06-09 Medichem Sa Verbesserte synthese und zubereitungen von duloxetinsalzen
EP2107057A1 (de) 2008-04-04 2009-10-07 Ranbaxy Laboratories Limited Verfahren zur Herstellung von reinem Duloxetin
WO2016137667A1 (en) * 2015-02-24 2016-09-01 Coiled Tubing Specialties, Llc Steerable hydraulic jetting nozzle, and guidance system for downhole boring device
EP3356562A4 (de) * 2015-10-02 2019-06-12 Phylagen, Inc. Produktauthentifizierung und -verfolgung
CN114163415B (zh) * 2021-12-01 2023-03-03 珠海润都制药股份有限公司 一种盐酸度洛西汀中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007433A (ko) 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
DE10212301A1 (de) 2002-03-20 2003-10-02 Bayer Ag Verfahren zur Herstellung von Aryl-aminopropanolen
CN103058986A (zh) 2002-07-09 2013-04-24 隆萨股份公司 N-单取代β-氨基醇的制备方法
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
GB0410470D0 (en) 2004-05-11 2004-06-16 Cipla Ltd Pharmaceutical compound and polymorphs thereof
CZ297560B6 (cs) * 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
CZ297555B6 (cs) * 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
WO2006099459A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Process for the preparation of optically active (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
WO2006126213A1 (en) 2005-05-24 2006-11-30 Matrix Laboratories Ltd An improved process for the preparation of duloxetine

Also Published As

Publication number Publication date
CZ299270B6 (cs) 2008-06-04
EP2172464A3 (de) 2010-05-12
EP2172464A2 (de) 2010-04-07
US8207356B2 (en) 2012-06-26
WO2007076733A2 (en) 2007-07-12
UA94931C2 (ru) 2011-06-25
EA200801635A1 (ru) 2008-10-30
US8071791B2 (en) 2011-12-06
PT1968965E (pt) 2011-11-10
US20120029212A1 (en) 2012-02-02
CZ20067A3 (cs) 2007-07-11
EP1968965A2 (de) 2008-09-17
EP2172464B1 (de) 2015-08-26
WO2007076733A3 (en) 2007-08-23
EA014559B1 (ru) 2010-12-30
EP1968965B1 (de) 2011-09-07
PL1968965T3 (pl) 2011-12-30
US20080293952A1 (en) 2008-11-27

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