BR112012012908A2 - processo de preparo de um derivado de combretastatina - Google Patents

processo de preparo de um derivado de combretastatina

Info

Publication number
BR112012012908A2
BR112012012908A2 BR112012012908A BR112012012908A BR112012012908A2 BR 112012012908 A2 BR112012012908 A2 BR 112012012908A2 BR 112012012908 A BR112012012908 A BR 112012012908A BR 112012012908 A BR112012012908 A BR 112012012908A BR 112012012908 A2 BR112012012908 A2 BR 112012012908A2
Authority
BR
Brazil
Prior art keywords
preparing
compound
formula
combretastatin derivative
combretastatin
Prior art date
Application number
BR112012012908A
Other languages
English (en)
Inventor
Eric Didier
Nicolas Tremaudeux
Pascoal Besse
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112012012908A2 publication Critical patent/BR112012012908A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated

Abstract

patente de invenção: processo de preparo de um derivado de combretastatina. a presente invenção refere-se a um processo de preparo de um derivado de combretastatina (i) ou (ii): compreendendo as seguintes etapas: faz-se reagir a halogeneto triatril (3,4,5-trimetóxi benzil) fosfênio p ~3~ (iii) na qual ar designa um grupo arila escolhido dentre fenila ou tienila, com p ~2~ de fórmula (v), de forma se obter respectivamente o composto p ~4~ ou bem p´ ~4~: (vi), (vii); depois, no decorrer de uma etapa de desproteção em presença de um ácido e/ou de uma base, composto de fórmula p ~4~ ou p ´ ~4~ conduz, após uma eventual etapa de purificação, ao composto de fórmula (i) ou (ii).
BR112012012908A 2009-12-03 2010-12-02 processo de preparo de um derivado de combretastatina BR112012012908A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0905837A FR2953518B1 (fr) 2009-12-03 2009-12-03 Procede de preparation d'un derive de combretastatine
PCT/FR2010/052592 WO2011067538A1 (fr) 2009-12-03 2010-12-02 Procede de preparation d'un derive de combretastatine

Publications (1)

Publication Number Publication Date
BR112012012908A2 true BR112012012908A2 (pt) 2015-09-08

Family

ID=42165674

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012012908A BR112012012908A2 (pt) 2009-12-03 2010-12-02 processo de preparo de um derivado de combretastatina

Country Status (17)

Country Link
US (1) US20120302759A1 (pt)
EP (1) EP2507218A1 (pt)
JP (1) JP2013512883A (pt)
KR (1) KR20120104988A (pt)
CN (1) CN102906076A (pt)
AR (1) AR079300A1 (pt)
AU (1) AU2010326423A1 (pt)
BR (1) BR112012012908A2 (pt)
CA (1) CA2782701A1 (pt)
FR (1) FR2953518B1 (pt)
IL (1) IL220059A0 (pt)
MX (1) MX2012006388A (pt)
RU (1) RU2012127575A (pt)
SG (1) SG181467A1 (pt)
TW (1) TW201127790A (pt)
UY (1) UY33080A (pt)
WO (1) WO2011067538A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2805705B1 (en) 2013-05-23 2016-11-09 IP Gesellschaft für Management mbH Packaging with one or more administration units comprising a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1 H-imidazol-4-yl)-propionic acid
CN104817519B (zh) * 2015-05-11 2016-11-16 中国药科大学 一类ca-4的衍生物、其制法及其医药用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW325458B (en) * 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
PT1068870E (pt) 1998-04-03 2006-10-31 Ajinomoto Kk Agentes antitumorais
GB9903403D0 (en) 1999-02-16 1999-04-07 Angiogene Pharm Ltd Substituted stilbene compounds with vascular damaging activity
JP4826051B2 (ja) 2000-03-17 2011-11-30 味の素株式会社 スチルベン誘導体の新規結晶及びその製造方法
US6743937B2 (en) * 2000-07-17 2004-06-01 Oxigene, Inc. Efficient method of synthesizing combretastatin A-4 prodrugs
DK1407784T3 (da) 2001-06-25 2011-02-28 Ajinomoto Kk Antitumormidler
FR2838437B1 (fr) * 2002-04-11 2004-06-04 Aventis Pharma Sa Procedes de preparation de combretastatines
US6759555B2 (en) * 2002-04-11 2004-07-06 Aventis Pharma S.A. Process for the preparation of combretastatins
AU2005295016A1 (en) 2004-10-08 2006-04-20 Janssen Pharmaceutica, N.V. 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives
FR2928148B1 (fr) 2008-02-28 2013-01-18 Sanofi Aventis Procede de preparation de combretastatine

Also Published As

Publication number Publication date
US20120302759A1 (en) 2012-11-29
AU2010326423A1 (en) 2012-06-21
FR2953518A1 (fr) 2011-06-10
CN102906076A (zh) 2013-01-30
KR20120104988A (ko) 2012-09-24
IL220059A0 (en) 2012-09-24
WO2011067538A1 (fr) 2011-06-09
MX2012006388A (es) 2012-06-19
TW201127790A (en) 2011-08-16
UY33080A (es) 2011-06-01
SG181467A1 (en) 2012-07-30
CA2782701A1 (fr) 2011-06-09
RU2012127575A (ru) 2014-01-10
EP2507218A1 (fr) 2012-10-10
AR079300A1 (es) 2012-01-18
JP2013512883A (ja) 2013-04-18
FR2953518B1 (fr) 2012-01-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A E 5A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.