MX2007006082A - Tetrahidroisoquinolinas aril- y heteroaril-sustituidas, y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina. - Google Patents
Tetrahidroisoquinolinas aril- y heteroaril-sustituidas, y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina.Info
- Publication number
- MX2007006082A MX2007006082A MX2007006082A MX2007006082A MX2007006082A MX 2007006082 A MX2007006082 A MX 2007006082A MX 2007006082 A MX2007006082 A MX 2007006082A MX 2007006082 A MX2007006082 A MX 2007006082A MX 2007006082 A MX2007006082 A MX 2007006082A
- Authority
- MX
- Mexico
- Prior art keywords
- heteroaryl
- aryl
- norepinephrine
- serotonin
- dopamine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invencion se refiere a un metodo para tratar trastornos al administrarle a un paciente en necesidad de tal tratamiento, una cantidad terapeuticamente efectiva de un compuesto de la formula (I): en donde R1-R8 son como se describen en la presente, siendo R4 arilo o heteroarilo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/994,956 US20060111394A1 (en) | 2004-11-22 | 2004-11-22 | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
PCT/US2005/042347 WO2006058016A2 (en) | 2004-11-22 | 2005-11-21 | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007006082A true MX2007006082A (es) | 2007-07-11 |
Family
ID=36461731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007006082A MX2007006082A (es) | 2004-11-22 | 2005-11-21 | Tetrahidroisoquinolinas aril- y heteroaril-sustituidas, y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina. |
Country Status (13)
Country | Link |
---|---|
US (2) | US20060111394A1 (es) |
EP (1) | EP1819337A4 (es) |
JP (1) | JP2008524118A (es) |
KR (1) | KR20070086598A (es) |
CN (1) | CN101443008A (es) |
AU (1) | AU2005309651A1 (es) |
BR (1) | BRPI0518000A (es) |
CA (1) | CA2588036A1 (es) |
IL (1) | IL183382A0 (es) |
MX (1) | MX2007006082A (es) |
NO (1) | NO20073207L (es) |
RU (1) | RU2007123391A (es) |
WO (1) | WO2006058016A2 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1414953A (zh) * | 1999-11-03 | 2003-04-30 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途 |
AU7334901A (en) * | 2000-07-11 | 2002-01-21 | Du Pont Pharm Co | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
MX2007000428A (es) | 2004-07-15 | 2008-03-05 | Amr Technology Inc | Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina. |
US20060111385A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
KR20060059728A (ko) * | 2004-11-29 | 2006-06-02 | 삼성에스디아이 주식회사 | 액정 표시 장치 및 그 제조 방법 |
CA2615403C (en) | 2005-07-15 | 2015-06-16 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
WO2009005459A1 (en) * | 2007-06-29 | 2009-01-08 | Astrazeneca Ab | Phenyl-1,2, 3,4-tetrahydroisoquinolinone derivatives and their use in the treatment of a pain disorder |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
KR20120034644A (ko) * | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도 |
ES2662072T3 (es) * | 2009-05-12 | 2018-04-05 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma |
EP2429293B1 (en) * | 2009-05-12 | 2014-10-29 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF |
EP2606049A4 (en) | 2010-08-17 | 2014-01-08 | Albany Molecular Res Inc | 2,5-METHANO- AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USES THEREOF FOR BLOCKING NOREPINEPHRINE, DOPAMINE, AND SEROTONIN REUPTAKE |
CN104245674B (zh) * | 2012-04-17 | 2017-07-11 | 霍夫曼-拉罗奇有限公司 | 苯基‑四氢异喹啉衍生物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3666763A (en) * | 1970-01-06 | 1972-05-30 | Hoffmann La Roche | 4-phenyl isoquinolines and process for preparing same |
US3947456A (en) * | 1970-01-06 | 1976-03-30 | Hoffman-La Roche Inc. | Substituted 4-phenyl isoquinolines |
GB1504424A (en) * | 1975-08-09 | 1978-03-22 | Beecham Group Ltd | Isoquinoline-derived aminoethers |
DE3333994A1 (de) * | 1983-09-21 | 1985-04-04 | Troponwerke GmbH & Co KG, 5000 Köln | Neue pyridoindolderivate, verfahren zu ihrer herstellung und ihre verwendung |
US4843071A (en) * | 1986-12-05 | 1989-06-27 | Serotonin Industries Of Charleston | Method and composition for treating obesity, drug abuse, and narcolepsy |
CA1327795C (en) * | 1987-08-14 | 1994-03-15 | Jules Freedman | Antidepressants which are aryloxy inadanamines |
US4902710A (en) * | 1988-12-14 | 1990-02-20 | Eli Lilly And Company | Serotonin and norepinephrine uptake inhibitors |
US5114976A (en) * | 1989-01-06 | 1992-05-19 | Norden Michael J | Method for treating certain psychiatric disorders and certain psychiatric symptoms |
DK154192D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Heterocycliske forbindelser |
US5607939A (en) * | 1994-04-28 | 1997-03-04 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
CA2134038C (en) * | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
US6121261A (en) * | 1997-11-19 | 2000-09-19 | Merck & Co., Inc. | Method for treating attention deficit disorder |
CN1414953A (zh) * | 1999-11-03 | 2003-04-30 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途 |
EP1246805A1 (en) * | 1999-11-03 | 2002-10-09 | Albany Molecular Research, Inc. | 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
AU7334901A (en) * | 2000-07-11 | 2002-01-21 | Du Pont Pharm Co | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
US6911453B2 (en) * | 2001-12-05 | 2005-06-28 | Aventis Pharma Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them |
MX2007000428A (es) * | 2004-07-15 | 2008-03-05 | Amr Technology Inc | Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina. |
US20060111385A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
-
2004
- 2004-11-22 US US10/994,956 patent/US20060111394A1/en not_active Abandoned
-
2005
- 2005-11-21 RU RU2007123391/04A patent/RU2007123391A/ru not_active Application Discontinuation
- 2005-11-21 CA CA002588036A patent/CA2588036A1/en not_active Abandoned
- 2005-11-21 BR BRPI0518000-7A patent/BRPI0518000A/pt not_active Application Discontinuation
- 2005-11-21 JP JP2007543407A patent/JP2008524118A/ja active Pending
- 2005-11-21 KR KR1020077014350A patent/KR20070086598A/ko not_active Application Discontinuation
- 2005-11-21 MX MX2007006082A patent/MX2007006082A/es not_active Application Discontinuation
- 2005-11-21 AU AU2005309651A patent/AU2005309651A1/en not_active Abandoned
- 2005-11-21 EP EP05824750A patent/EP1819337A4/en not_active Withdrawn
- 2005-11-21 US US11/284,264 patent/US20060111395A1/en not_active Abandoned
- 2005-11-21 CN CNA2005800471070A patent/CN101443008A/zh active Pending
- 2005-11-21 WO PCT/US2005/042347 patent/WO2006058016A2/en active Application Filing
-
2007
- 2007-05-22 IL IL183382A patent/IL183382A0/en unknown
- 2007-06-22 NO NO20073207A patent/NO20073207L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2006058016A2 (en) | 2006-06-01 |
AU2005309651A1 (en) | 2006-06-01 |
JP2008524118A (ja) | 2008-07-10 |
EP1819337A4 (en) | 2009-11-04 |
IL183382A0 (en) | 2007-10-31 |
CN101443008A (zh) | 2009-05-27 |
RU2007123391A (ru) | 2008-12-27 |
US20060111394A1 (en) | 2006-05-25 |
BRPI0518000A (pt) | 2008-10-21 |
KR20070086598A (ko) | 2007-08-27 |
CA2588036A1 (en) | 2006-06-01 |
US20060111395A1 (en) | 2006-05-25 |
NO20073207L (no) | 2007-06-22 |
EP1819337A2 (en) | 2007-08-22 |
WO2006058016A3 (en) | 2009-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2007006082A (es) | Tetrahidroisoquinolinas aril- y heteroaril-sustituidas, y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina. | |
GEP20125566B (en) | Aryl-and heteroaryl-substituded tetrahydro-benzazepines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | |
EA201101308A1 (ru) | Применение ралфинамида для лечения биполярного расстройства | |
TW200806299A (en) | Treatment of pain | |
ZA200600343B (en) | Substituted 2-aminotetralin for the treatment of depression | |
MX2007006081A (es) | Tetrahidroisoquinolinas 4-fenil-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina. | |
EA200601746A1 (ru) | Применение ротиготина для лечения и предупреждения синдрома "паркинсонизм-плюс" | |
MX2012000488A (es) | Terapia de combinacion para el tratamiento de la diabetes. | |
MX338338B (es) | Composiciones y metodos utiles para el tratamiento de enfermedades respiratorias. | |
CY1108081T1 (el) | Αρυλο-και ετεροαρυλο υποκατεστημενες τετραυδροισοκινολινες και χρησις αυτων προς αποκλεισμον επαναπροσληψεως νορεπινεφρινης ντοπαμινης και σεροτονινης | |
EA200700851A1 (ru) | Получение и применение бифенил-4-илкарбониламинокислотных производных для лечения ожирения | |
TW200639159A (en) | Treatment of pain | |
BRPI0514841A (pt) | inibidores de piridila da sinalização de hedgehog, processo de preparação dos mesmos e composição compreendendo os referidos inibidores | |
DK1933833T3 (da) | Terapi til behandling af overaktiv blære | |
EA200971107A1 (ru) | Катехоламиновые производные, полезные для лечения болезни паркинсона | |
EA201071038A1 (ru) | Производные 1-бензил-3-гидроксиметилиндазола и их применение для лечения заболеваний, основанных на экспрессии mcp-1, cx3cr1 и p40 | |
EA201070477A1 (ru) | Транс-кломифен для лечения метаболического синдрома | |
MA30620B1 (fr) | Carboxamides substitues | |
SE0401465D0 (sv) | New substituted piperdines as modulators of dopamine neurotransmission | |
MX2009004770A (es) | Compuestos de carbamato para usarse en el tratamiento de la depresion. | |
MXPA05010020A (es) | Derivados de oxamida. | |
HK1141019A1 (en) | Carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound | |
TW200616637A (en) | Novel quinoxalinone norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | |
RS20060049A (en) | Novel n-substituted indolyl-3-glycoxylic acid amides, use thereof as a medicament and method for the production thereof | |
NZ622993A (en) | Combination therapy for the treatment of diabetes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |