EA201101308A1 - Применение ралфинамида для лечения биполярного расстройства - Google Patents
Применение ралфинамида для лечения биполярного расстройстваInfo
- Publication number
- EA201101308A1 EA201101308A1 EA201101308A EA201101308A EA201101308A1 EA 201101308 A1 EA201101308 A1 EA 201101308A1 EA 201101308 A EA201101308 A EA 201101308A EA 201101308 A EA201101308 A EA 201101308A EA 201101308 A1 EA201101308 A1 EA 201101308A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bipolar disorder
- treatment
- ralfinamide
- application
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/08—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к применению ралфинамида высокой степени чистоты или его соли фармацевтически приемлемой кислоты, где содержание соответствующей примеси (S)-2-[3-(2-фторбензил)-4-(2-фторбензилокси)бензиламино]пропанамида (IIb) или его соли фармацевтически приемлемой кислоты ниже 0,03 мас.%, для производства лекарственного препарата для лечения биполярного расстройства. Изобретение также относится к способу лечения биполярного расстройства с использованием упомянутого выше соединения.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06012565 | 2006-06-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201101308A1 true EA201101308A1 (ru) | 2012-02-28 |
EA025326B1 EA025326B1 (ru) | 2016-12-30 |
Family
ID=37101658
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201101308A EA025326B1 (ru) | 2006-06-19 | 2007-06-08 | Применение сафинамида и ралфинамида высокой степени чистоты для лечения заболеваний и болезненных состояний в условиях, не препятствующих активности цитохромов системы cyp450 и не проявляющих блокирующих свойств в отношении herg канала |
EA200970028A EA017123B1 (ru) | 2006-06-19 | 2007-06-08 | Способ получения 2-[4-(3- и 2-фторбензилокси)бензиламино]пропанамидов |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970028A EA017123B1 (ru) | 2006-06-19 | 2007-06-08 | Способ получения 2-[4-(3- и 2-фторбензилокси)бензиламино]пропанамидов |
Country Status (27)
Country | Link |
---|---|
US (2) | US8076515B2 (ru) |
EP (2) | EP2474521B1 (ru) |
JP (2) | JP5240476B2 (ru) |
KR (2) | KR101491541B1 (ru) |
CN (2) | CN103284984B (ru) |
AR (1) | AR061510A1 (ru) |
AU (1) | AU2007263328C1 (ru) |
BR (1) | BRPI0712936B8 (ru) |
CA (1) | CA2653012C (ru) |
CY (2) | CY1115951T1 (ru) |
DK (2) | DK2029524T3 (ru) |
EA (2) | EA025326B1 (ru) |
ES (2) | ES2602069T3 (ru) |
HK (1) | HK1130245A1 (ru) |
HR (2) | HRP20150136T1 (ru) |
HU (1) | HUE030233T2 (ru) |
IL (1) | IL195294A (ru) |
LT (1) | LT2474521T (ru) |
MX (2) | MX2008015704A (ru) |
NO (2) | NO342018B1 (ru) |
NZ (2) | NZ595737A (ru) |
PL (2) | PL2029524T3 (ru) |
PT (2) | PT2029524E (ru) |
RS (2) | RS53824B1 (ru) |
SI (2) | SI2029524T1 (ru) |
TW (2) | TWI393700B (ru) |
WO (1) | WO2007147491A1 (ru) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1658062B1 (en) * | 2003-08-25 | 2010-02-17 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as anti-inflammatory agents |
RS53824B1 (en) * | 2006-06-19 | 2015-06-30 | Newron Pharmaceuticals S.P.A. | PROCESS FOR OBTAINING 2- [4- (3-AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDE |
DK2229351T3 (en) * | 2007-12-11 | 2018-01-22 | Newron Pharm Spa | PROCEDURE FOR THE PREPARATION OF 2- [4- (3- OR 2-FLUORBENZYLOXY) BENZYLAMINO] PROPANAMIDS WITH HIGH PURITY |
EP2314569A1 (en) * | 2009-10-22 | 2011-04-27 | Merck Patent GmbH | Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof |
LT2563355T (lt) * | 2010-04-27 | 2016-09-26 | Newron Pharmaceuticals S.P.A. | Ralfinamido metansulfonato druskų arba jų r-enentiomerų gavimo būdas |
RU2015122615A (ru) | 2012-12-03 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Замещенные соединения амида изоксазола в качестве ингибиторов стеароил-коа-десатуразы 1 (скд1) |
WO2014178083A1 (en) | 2013-05-03 | 2014-11-06 | Council Of Scientific & Industrial Research | An improved synthesis of anti-parkinson agent |
CN104292128A (zh) * | 2014-07-01 | 2015-01-21 | 南京正科制药有限公司 | 一种沙芬酰胺晶型a |
JP6466109B2 (ja) * | 2014-09-09 | 2019-02-06 | 東ソー・ファインケム株式会社 | 2−ベンジルオキシ−5−(トリフルオロメチル)ピリミジン誘導体及びその製造方法 |
CN105017060B (zh) * | 2015-07-03 | 2017-06-16 | 南京正大天晴制药有限公司 | 一种沙芬酰胺新晶型及其制备方法 |
CN113072436A (zh) * | 2015-07-24 | 2021-07-06 | 上海医药集团股份有限公司 | 一种苄基芳基醚的制备方法 |
CN105061245A (zh) * | 2015-08-25 | 2015-11-18 | 成都维恒医药科技有限公司 | 一种高纯度沙芬酰胺的制备方法 |
CN106220525A (zh) * | 2016-07-31 | 2016-12-14 | 合肥远志医药科技开发有限公司 | 一种工业化沙芬酰胺甲磺酸盐的制备方法 |
CN106336363B (zh) * | 2016-08-22 | 2018-10-30 | 上海医药集团股份有限公司 | 一种沙芬酰胺甲磺酸盐晶型c及其制备方法 |
CN106565521B (zh) * | 2016-08-24 | 2019-03-08 | 浙江美诺华药物化学有限公司 | (s)-2-[3-(3-氟苄基)-4-(3-氟苄氧基)苄氨基]丙酰胺及其盐的制备方法 |
CN106596828B (zh) * | 2016-12-15 | 2018-09-25 | 扬子江药业集团有限公司 | 一种甲磺酸沙芬酰胺有关物质的检测方法 |
CN107271600B (zh) * | 2017-07-28 | 2019-01-25 | 成都百裕制药股份有限公司 | 一种4-(3-氟苄氧基)苯甲醛中异构体杂质含量的检测方法 |
CN107857713A (zh) * | 2017-11-23 | 2018-03-30 | 江苏恒盛药业有限公司 | 一种沙芬酰胺氢溴酸盐及其一种晶型 |
CN107759487A (zh) * | 2017-11-23 | 2018-03-06 | 江苏恒盛药业有限公司 | 一种沙芬酰胺盐酸盐及其一种晶型以及制备方法 |
WO2019167085A1 (en) * | 2018-03-01 | 2019-09-06 | Msn Laboratories Private Limited, R&D Center | Process for the preparation of (s)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino propanamide methanesulfonate |
US11111208B2 (en) | 2019-06-17 | 2021-09-07 | RK Pharma Solutions LLC | Process for the preparation of safinamide mesylate intermediate |
ES2977486T3 (es) * | 2019-08-06 | 2024-08-26 | Medichem Sa | Proceso para preparar safinamida |
CN111122736B (zh) * | 2019-12-30 | 2021-03-12 | 北京鑫开元医药科技有限公司海南分公司 | 一种用于检测布瓦西坦中间体中对映异构体的方法 |
CN113214097B (zh) * | 2020-01-21 | 2022-08-30 | 厦门大学 | 治疗阿尔茨海默病的化合物 |
CN112028754A (zh) * | 2020-06-17 | 2020-12-04 | 浙江美诺华药物化学有限公司 | 一种甲磺酸沙芬酰胺中间体的制备方法 |
CN114088830B (zh) * | 2021-11-10 | 2022-09-23 | 石家庄四药有限公司 | 一种4-(3-氟苄氧基)苯甲醛中异构体的检测方法 |
CN116008439B (zh) * | 2023-02-20 | 2023-10-27 | 山东绿叶制药有限公司 | 一种检测2,6-二氧杂螺[4,5]癸烷类化合物或其盐中杂质的方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL94466A (en) | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
EP0974351A3 (en) * | 1998-04-24 | 2000-12-13 | Jouveinal | Medicament for preventing and treating gastrointestinal damage |
AU2001249610B2 (en) | 2000-03-31 | 2005-03-24 | Euro-Celtique S.A. | Aminopyridines and their use as anticonvulsants and sodium channel blockers |
AU2002333374B2 (en) | 2001-09-03 | 2007-03-22 | Newron Pharmaceuticals S.P.A. | Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use |
EP1438956A1 (en) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
EP1589959A2 (en) * | 2003-01-30 | 2005-11-02 | Dynogen Pharmaceuticals Inc. | Methods of treating lower urinary tract disorders using sodium channel modulators |
JP2006515326A (ja) * | 2003-01-30 | 2006-05-25 | ダイノジェン ファーマシューティカルズ, インコーポレイテッド | 胃腸管障害を処置するためのナトリウムチャネルモジュレーターの使用 |
AR044007A1 (es) | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
TW200507850A (en) * | 2003-07-25 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Pharmaceutical composition |
EP1658062B1 (en) * | 2003-08-25 | 2010-02-17 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as anti-inflammatory agents |
EP1524267A1 (en) | 2003-10-15 | 2005-04-20 | Newron Pharmaceuticals S.p.A. | Substituted benzylaminoalkylene heterocycles |
EP1557166A1 (en) * | 2004-01-21 | 2005-07-27 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders |
EP1588704A1 (en) | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
SI1809271T1 (sl) * | 2004-09-10 | 2010-10-29 | Newron Pharm Spa | Uporaba (R)-(halobenziloksi) benzilamino propanamidov kot selektivnih modulatorjev natrijevih in/ali kalcijevih kanalov |
EP1870097A1 (en) * | 2006-06-15 | 2007-12-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of cognitive disorders |
RS53824B1 (en) * | 2006-06-19 | 2015-06-30 | Newron Pharmaceuticals S.P.A. | PROCESS FOR OBTAINING 2- [4- (3-AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDE |
DK2229351T3 (en) * | 2007-12-11 | 2018-01-22 | Newron Pharm Spa | PROCEDURE FOR THE PREPARATION OF 2- [4- (3- OR 2-FLUORBENZYLOXY) BENZYLAMINO] PROPANAMIDS WITH HIGH PURITY |
JP5736175B2 (ja) * | 2007-12-19 | 2015-06-17 | ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー | 精神障害の治療に有用なα−アミノアミド誘導体 |
-
2007
- 2007-06-08 RS RS20150114A patent/RS53824B1/en unknown
- 2007-06-08 ES ES12163085.9T patent/ES2602069T3/es active Active
- 2007-06-08 NZ NZ595737A patent/NZ595737A/xx unknown
- 2007-06-08 PT PT07764601T patent/PT2029524E/pt unknown
- 2007-06-08 ES ES07764601.6T patent/ES2527437T3/es active Active
- 2007-06-08 RS RS20160965A patent/RS55464B1/sr unknown
- 2007-06-08 LT LTEP12163085.9T patent/LT2474521T/lt unknown
- 2007-06-08 BR BRPI0712936A patent/BRPI0712936B8/pt active IP Right Grant
- 2007-06-08 EP EP12163085.9A patent/EP2474521B1/en active Active
- 2007-06-08 CA CA2653012A patent/CA2653012C/en active Active
- 2007-06-08 PL PL07764601T patent/PL2029524T3/pl unknown
- 2007-06-08 MX MX2008015704A patent/MX2008015704A/es active IP Right Grant
- 2007-06-08 PT PT121630859T patent/PT2474521T/pt unknown
- 2007-06-08 NZ NZ572798A patent/NZ572798A/en unknown
- 2007-06-08 AU AU2007263328A patent/AU2007263328C1/en active Active
- 2007-06-08 CN CN201310142245.3A patent/CN103284984B/zh active Active
- 2007-06-08 MX MX2012005094A patent/MX342698B/es unknown
- 2007-06-08 EA EA201101308A patent/EA025326B1/ru unknown
- 2007-06-08 KR KR20147003965A patent/KR101491541B1/ko active Protection Beyond IP Right Term
- 2007-06-08 DK DK07764601.6T patent/DK2029524T3/da active
- 2007-06-08 CN CN2007800228798A patent/CN101472880B/zh not_active Ceased
- 2007-06-08 SI SI200731603T patent/SI2029524T1/sl unknown
- 2007-06-08 EA EA200970028A patent/EA017123B1/ru unknown
- 2007-06-08 KR KR1020097001124A patent/KR101410291B1/ko active Protection Beyond IP Right Term
- 2007-06-08 SI SI200731854A patent/SI2474521T1/sl unknown
- 2007-06-08 HU HUE12163085A patent/HUE030233T2/en unknown
- 2007-06-08 PL PL12163085T patent/PL2474521T3/pl unknown
- 2007-06-08 JP JP2009515731A patent/JP5240476B2/ja active Active
- 2007-06-08 DK DK12163085.9T patent/DK2474521T3/en active
- 2007-06-08 EP EP07764601.6A patent/EP2029524B1/en active Active
- 2007-06-08 WO PCT/EP2007/005105 patent/WO2007147491A1/en active Application Filing
- 2007-06-15 TW TW096121879A patent/TWI393700B/zh active
- 2007-06-15 TW TW101148004A patent/TWI412512B/zh active
- 2007-06-19 AR ARP070102674A patent/AR061510A1/es active IP Right Grant
-
2008
- 2008-11-13 IL IL195294A patent/IL195294A/en active Protection Beyond IP Right Term
- 2008-12-18 US US12/338,825 patent/US8076515B2/en active Active
-
2009
- 2009-01-14 NO NO20090231A patent/NO342018B1/no unknown
- 2009-09-04 HK HK09108103.8A patent/HK1130245A1/xx unknown
-
2011
- 2011-11-03 US US13/288,891 patent/US8278485B2/en active Active
-
2013
- 2013-01-10 JP JP2013002429A patent/JP5795342B2/ja active Active
-
2015
- 2015-01-23 CY CY20151100072T patent/CY1115951T1/el unknown
- 2015-02-04 HR HRP20150136TT patent/HRP20150136T1/hr unknown
-
2016
- 2016-10-18 CY CY20161101038T patent/CY1118113T1/el unknown
- 2016-11-03 HR HRP20161456TT patent/HRP20161456T1/hr unknown
-
2017
- 2017-11-30 NO NO20171916A patent/NO342644B1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201101308A1 (ru) | Применение ралфинамида для лечения биполярного расстройства | |
IS2533B (is) | (S)-2-N-própýlamínó-5-hýdroxýetralín sem D3-gerandefni | |
GEP20156366B (en) | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use | |
GEP20125566B (en) | Aryl-and heteroaryl-substituded tetrahydro-benzazepines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | |
MX2007006082A (es) | Tetrahidroisoquinolinas aril- y heteroaril-sustituidas, y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina. | |
ATE450514T1 (de) | Piperazinylalkylpyrazol-derivate zur verwendung als selektive calciumkanalblocker des t-typs und verfahren zu ihrer herstellung | |
TW201000473A (en) | Benzene or thiophene derivative and use thereof as VAP-1 inhibitor | |
AU2018236805B2 (en) | Glutarimide derivatives, use thereof, pharmaceutical composition based thereon and methods for producing glutarimide derivatives | |
MXPA03011484A (es) | Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades. | |
TW200744586A (en) | Therapeutic compounds | |
EA201270560A1 (ru) | Спиропиперидиновые соединения и их фармацевтическое применение для лечения диабета | |
EA201391486A1 (ru) | Способы и композиции для лечения болезни паркинсона | |
WO2009066041A3 (fr) | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
TW200806299A (en) | Treatment of pain | |
WO2012018534A3 (en) | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases | |
TW200639159A (en) | Treatment of pain | |
UA114405C2 (uk) | Феніл-3-азабіцикло[3.1.0]гекс-3-илметанони та їх застосування як лікарського засобу | |
EA201070442A1 (ru) | НОВЫЕ ИНГИБИТОРЫ sEH И ИХ ПРИМЕНЕНИЕ | |
MX2011009709A (es) | Compuestos para el tratamiento de la inflamacion y del dolor. | |
MX2021010046A (es) | Nueva composicion terapeutica que contiene ingrediente activo de apomorfinas. | |
EP1627635A3 (en) | Benzothiazolium compounds for use in methods of inhibiting NO production and TNF alpha and treating coronaviral infection | |
UA107562C2 (uk) | Спосіб лікування псоріазу | |
MY149058A (en) | N-(2-aminophenyl)-4-[n-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (ms-275) polymorph b | |
EA201391026A1 (ru) | Кристаллическое производное оксазина и его применение в качестве ингибитора bace | |
MX2010010595A (es) | Proceso para la preparacion de sulfamatos de heteroarilo benzofusionado y la forma cristalina de n-(((2s)-6-cloro-2,3-dihid ro-1,4-benzodioxin-2il)metil-sulfamida. |