ATE514702T1 - Verfahren zur herstellung von clopidogrel und dabei verwendete zwischenprodukte - Google Patents

Verfahren zur herstellung von clopidogrel und dabei verwendete zwischenprodukte

Info

Publication number
ATE514702T1
ATE514702T1 AT05818892T AT05818892T ATE514702T1 AT E514702 T1 ATE514702 T1 AT E514702T1 AT 05818892 T AT05818892 T AT 05818892T AT 05818892 T AT05818892 T AT 05818892T AT E514702 T1 ATE514702 T1 AT E514702T1
Authority
AT
Austria
Prior art keywords
intermediate products
products used
compound
formula
producing clopidogrel
Prior art date
Application number
AT05818892T
Other languages
English (en)
Inventor
Eun Sook Kim
Hee Cheol Kim
Bo Sung Kwon
Sangmin Yun
Mi Young Ko
Cheol Kyung Kim
Kwee Hyun Suh
Original Assignee
Hanmi Holdings Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Holdings Co Ltd filed Critical Hanmi Holdings Co Ltd
Application granted granted Critical
Publication of ATE514702T1 publication Critical patent/ATE514702T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT05818892T 2005-06-23 2005-11-28 Verfahren zur herstellung von clopidogrel und dabei verwendete zwischenprodukte ATE514702T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020050054303A KR100678287B1 (ko) 2005-06-23 2005-06-23 클로피도그렐의 제조방법 및 이에 사용되는 중간체
PCT/KR2005/004017 WO2006137628A1 (en) 2005-06-23 2005-11-28 Method of preparing clopidogrel and intermediates used therein

Publications (1)

Publication Number Publication Date
ATE514702T1 true ATE514702T1 (de) 2011-07-15

Family

ID=37570622

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05818892T ATE514702T1 (de) 2005-06-23 2005-11-28 Verfahren zur herstellung von clopidogrel und dabei verwendete zwischenprodukte

Country Status (12)

Country Link
US (2) US7652140B2 (de)
EP (1) EP1907397B1 (de)
JP (1) JP2008546761A (de)
KR (1) KR100678287B1 (de)
CN (1) CN101208347B (de)
AT (1) ATE514702T1 (de)
AU (1) AU2005333309B2 (de)
CA (1) CA2612996A1 (de)
ES (1) ES2366334T3 (de)
IL (1) IL187640A0 (de)
RU (1) RU2357970C1 (de)
WO (1) WO2006137628A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI22383A (sl) * 2006-09-22 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
KR20090086903A (ko) * 2007-04-18 2009-08-14 테바 파마슈티컬 인더스트리즈 리미티드 개선된 클로피도그렐의 제조 방법
KR100848936B1 (ko) * 2007-05-17 2008-07-29 주식회사 대희화학 클로피도그렐 이성질체의 제조방법 및 이의 제조에사용되는 신규 중간체 화합물
KR100990949B1 (ko) 2008-06-09 2010-10-29 엔자이텍 주식회사 클로피도그렐 및 그의 유도체의 제조방법
WO2012007019A1 (en) 2010-07-13 2012-01-19 Pharmathen S.A. Process for the preparation of clopidogrel and salts thereof
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102336767A (zh) * 2011-07-11 2012-02-01 华东理工大学 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH15674A (en) * 1979-07-06 1983-03-11 Syntex Corp Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
JP3030780B2 (ja) * 1988-12-29 2000-04-10 日本農薬株式会社 光学活性なケテンジチオアセタール誘導体及びその製造方法
JPH10237013A (ja) * 1996-12-28 1998-09-08 Fuji Yakuhin Kogyo Kk 光学活性２−ベンジルコハク酸の製造法
IT1311921B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
MXPA03006133A (es) * 2001-01-24 2004-05-04 Cadila Healthcare Ltd Proceso para preparar clopidogrel.
IN191030B (de) * 2001-01-24 2003-09-13 Cadila Healthcare Ltd
HU230004B1 (en) * 2001-06-21 2015-04-28 Sanofi Aventis Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid
CA2352520C (en) 2001-07-06 2007-10-02 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
JP4319847B2 (ja) * 2002-02-13 2009-08-26 第一三共株式会社 （１ｓ，２ｓ）−２−フルオロシクロプロパンカルボン酸誘導体の製造方法
US20050059696A1 (en) * 2003-05-08 2005-03-17 Dr. Reddy's Laboratories Limited Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers
MXPA05013981A (es) * 2003-06-20 2006-03-02 Metabolex Inc Resolucion de derivados de acido a- (fenoxi) fenilacetico.
JP2005023055A (ja) * 2003-07-04 2005-01-27 Mitsubishi Gas Chem Co Inc 新規光学活性アミン
JPWO2005040099A1 (ja) * 2003-10-23 2007-03-08 小野薬品工業株式会社 ３−置換−（２ｒ，３ｒ）−２−保護されたアミノ−３−ヒドロキシプロピオン酸誘導体の製造方法およびその中間体

Also Published As

Publication number Publication date
AU2005333309B2 (en) 2009-04-23
IL187640A0 (en) 2008-03-20
CA2612996A1 (en) 2006-12-28
US7763730B2 (en) 2010-07-27
JP2008546761A (ja) 2008-12-25
AU2005333309A1 (en) 2006-12-28
US7652140B2 (en) 2010-01-26
US20090318701A1 (en) 2009-12-24
US20080214821A1 (en) 2008-09-04
EP1907397A4 (de) 2009-05-27
EP1907397A1 (de) 2008-04-09
WO2006137628A1 (en) 2006-12-28
KR100678287B1 (ko) 2007-02-02
EP1907397B1 (de) 2011-06-29
CN101208347A (zh) 2008-06-25
CN101208347B (zh) 2011-01-12
ES2366334T3 (es) 2011-10-19
KR20060134541A (ko) 2006-12-28
RU2357970C1 (ru) 2009-06-10

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