ATE514702T1 - Verfahren zur herstellung von clopidogrel und dabei verwendete zwischenprodukte - Google Patents
Verfahren zur herstellung von clopidogrel und dabei verwendete zwischenprodukteInfo
- Publication number
- ATE514702T1 ATE514702T1 AT05818892T AT05818892T ATE514702T1 AT E514702 T1 ATE514702 T1 AT E514702T1 AT 05818892 T AT05818892 T AT 05818892T AT 05818892 T AT05818892 T AT 05818892T AT E514702 T1 ATE514702 T1 AT E514702T1
- Authority
- AT
- Austria
- Prior art keywords
- intermediate products
- products used
- compound
- formula
- producing clopidogrel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020050054303A KR100678287B1 (ko) | 2005-06-23 | 2005-06-23 | 클로피도그렐의 제조방법 및 이에 사용되는 중간체 |
PCT/KR2005/004017 WO2006137628A1 (en) | 2005-06-23 | 2005-11-28 | Method of preparing clopidogrel and intermediates used therein |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE514702T1 true ATE514702T1 (de) | 2011-07-15 |
Family
ID=37570622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05818892T ATE514702T1 (de) | 2005-06-23 | 2005-11-28 | Verfahren zur herstellung von clopidogrel und dabei verwendete zwischenprodukte |
Country Status (12)
Country | Link |
---|---|
US (2) | US7652140B2 (de) |
EP (1) | EP1907397B1 (de) |
JP (1) | JP2008546761A (de) |
KR (1) | KR100678287B1 (de) |
CN (1) | CN101208347B (de) |
AT (1) | ATE514702T1 (de) |
AU (1) | AU2005333309B2 (de) |
CA (1) | CA2612996A1 (de) |
ES (1) | ES2366334T3 (de) |
IL (1) | IL187640A0 (de) |
RU (1) | RU2357970C1 (de) |
WO (1) | WO2006137628A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI22383A (sl) * | 2006-09-22 | 2008-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli |
EP2084164A2 (de) * | 2007-04-18 | 2009-08-05 | Teva Pharmaceutical Industries Ltd. | Verbessertes verfahren zur herstellung von clopidogrel |
KR100848936B1 (ko) * | 2007-05-17 | 2008-07-29 | 주식회사 대희화학 | 클로피도그렐 이성질체의 제조방법 및 이의 제조에사용되는 신규 중간체 화합물 |
KR100990949B1 (ko) | 2008-06-09 | 2010-10-29 | 엔자이텍 주식회사 | 클로피도그렐 및 그의 유도체의 제조방법 |
WO2012007019A1 (en) | 2010-07-13 | 2012-01-19 | Pharmathen S.A. | Process for the preparation of clopidogrel and salts thereof |
WO2012123958A1 (en) | 2011-02-14 | 2012-09-20 | Cadila Healthcare Limited | Highly pure salts of clopidogrel free of genotoxic impurities |
CN102336767A (zh) * | 2011-07-11 | 2012-02-01 | 华东理工大学 | 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH15674A (en) * | 1979-07-06 | 1983-03-11 | Syntex Corp | Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid |
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
JP3030780B2 (ja) * | 1988-12-29 | 2000-04-10 | 日本農薬株式会社 | 光学活性なケテンジチオアセタール誘導体及びその製造方法 |
JPH10237013A (ja) * | 1996-12-28 | 1998-09-08 | Fuji Yakuhin Kogyo Kk | 光学活性2−ベンジルコハク酸の製造法 |
IT1311921B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
EP1353928B1 (de) * | 2001-01-24 | 2006-12-27 | Cadila Healthcare Ltd. | Verfahren zur herstellung von clopidogrel |
IN191030B (de) * | 2001-01-24 | 2003-09-13 | Cadila Healthcare Ltd | |
HU230004B1 (en) * | 2001-06-21 | 2015-04-28 | Sanofi Aventis | Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid |
CA2352520C (en) * | 2001-07-06 | 2007-10-02 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
JP4319847B2 (ja) * | 2002-02-13 | 2009-08-26 | 第一三共株式会社 | (1s,2s)−2−フルオロシクロプロパンカルボン酸誘導体の製造方法 |
US20050059696A1 (en) * | 2003-05-08 | 2005-03-17 | Dr. Reddy's Laboratories Limited | Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers |
MXPA05013981A (es) * | 2003-06-20 | 2006-03-02 | Metabolex Inc | Resolucion de derivados de acido a- (fenoxi) fenilacetico. |
JP2005023055A (ja) * | 2003-07-04 | 2005-01-27 | Mitsubishi Gas Chem Co Inc | 新規光学活性アミン |
JPWO2005040099A1 (ja) * | 2003-10-23 | 2007-03-08 | 小野薬品工業株式会社 | 3−置換−(2r,3r)−2−保護されたアミノ−3−ヒドロキシプロピオン酸誘導体の製造方法およびその中間体 |
-
2005
- 2005-06-23 KR KR1020050054303A patent/KR100678287B1/ko active IP Right Grant
- 2005-11-28 ES ES05818892T patent/ES2366334T3/es active Active
- 2005-11-28 US US11/917,794 patent/US7652140B2/en not_active Expired - Fee Related
- 2005-11-28 CN CN2005800502327A patent/CN101208347B/zh not_active Expired - Fee Related
- 2005-11-28 WO PCT/KR2005/004017 patent/WO2006137628A1/en active Application Filing
- 2005-11-28 AU AU2005333309A patent/AU2005333309B2/en not_active Ceased
- 2005-11-28 AT AT05818892T patent/ATE514702T1/de not_active IP Right Cessation
- 2005-11-28 RU RU2008102389/04A patent/RU2357970C1/ru not_active IP Right Cessation
- 2005-11-28 JP JP2008518011A patent/JP2008546761A/ja active Pending
- 2005-11-28 EP EP05818892A patent/EP1907397B1/de not_active Not-in-force
- 2005-11-28 CA CA002612996A patent/CA2612996A1/en not_active Abandoned
-
2007
- 2007-11-26 IL IL187640A patent/IL187640A0/en unknown
-
2009
- 2009-08-28 US US12/549,850 patent/US7763730B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20060134541A (ko) | 2006-12-28 |
US7763730B2 (en) | 2010-07-27 |
WO2006137628A1 (en) | 2006-12-28 |
IL187640A0 (en) | 2008-03-20 |
US20090318701A1 (en) | 2009-12-24 |
CA2612996A1 (en) | 2006-12-28 |
RU2357970C1 (ru) | 2009-06-10 |
AU2005333309A1 (en) | 2006-12-28 |
AU2005333309B2 (en) | 2009-04-23 |
ES2366334T3 (es) | 2011-10-19 |
KR100678287B1 (ko) | 2007-02-02 |
EP1907397B1 (de) | 2011-06-29 |
CN101208347A (zh) | 2008-06-25 |
JP2008546761A (ja) | 2008-12-25 |
EP1907397A4 (de) | 2009-05-27 |
CN101208347B (zh) | 2011-01-12 |
US7652140B2 (en) | 2010-01-26 |
US20080214821A1 (en) | 2008-09-04 |
EP1907397A1 (de) | 2008-04-09 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |