CN101208347B - 制备氯吡格雷的方法和其中使用的中间体 - Google Patents
制备氯吡格雷的方法和其中使用的中间体 Download PDFInfo
- Publication number
- CN101208347B CN101208347B CN2005800502327A CN200580050232A CN101208347B CN 101208347 B CN101208347 B CN 101208347B CN 2005800502327 A CN2005800502327 A CN 2005800502327A CN 200580050232 A CN200580050232 A CN 200580050232A CN 101208347 B CN101208347 B CN 101208347B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- acid
- salt
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (19)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020050054303A KR100678287B1 (ko) | 2005-06-23 | 2005-06-23 | 클로피도그렐의 제조방법 및 이에 사용되는 중간체 |
KR10-2005-0054303 | 2005-06-23 | ||
KR1020050054303 | 2005-06-23 | ||
PCT/KR2005/004017 WO2006137628A1 (en) | 2005-06-23 | 2005-11-28 | Method of preparing clopidogrel and intermediates used therein |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101208347A CN101208347A (zh) | 2008-06-25 |
CN101208347B true CN101208347B (zh) | 2011-01-12 |
Family
ID=37570622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800502327A Expired - Fee Related CN101208347B (zh) | 2005-06-23 | 2005-11-28 | 制备氯吡格雷的方法和其中使用的中间体 |
Country Status (12)
Country | Link |
---|---|
US (2) | US7652140B2 (zh) |
EP (1) | EP1907397B1 (zh) |
JP (1) | JP2008546761A (zh) |
KR (1) | KR100678287B1 (zh) |
CN (1) | CN101208347B (zh) |
AT (1) | ATE514702T1 (zh) |
AU (1) | AU2005333309B2 (zh) |
CA (1) | CA2612996A1 (zh) |
ES (1) | ES2366334T3 (zh) |
IL (1) | IL187640A0 (zh) |
RU (1) | RU2357970C1 (zh) |
WO (1) | WO2006137628A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI22383A (sl) * | 2006-09-22 | 2008-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli |
BRPI0803101A2 (pt) * | 2007-04-18 | 2014-04-22 | Teva Pharma | Processos melhores para preparação de clopidogrel |
KR100848936B1 (ko) * | 2007-05-17 | 2008-07-29 | 주식회사 대희화학 | 클로피도그렐 이성질체의 제조방법 및 이의 제조에사용되는 신규 중간체 화합물 |
KR100990949B1 (ko) | 2008-06-09 | 2010-10-29 | 엔자이텍 주식회사 | 클로피도그렐 및 그의 유도체의 제조방법 |
WO2012007019A1 (en) | 2010-07-13 | 2012-01-19 | Pharmathen S.A. | Process for the preparation of clopidogrel and salts thereof |
WO2012123958A1 (en) | 2011-02-14 | 2012-09-20 | Cadila Healthcare Limited | Highly pure salts of clopidogrel free of genotoxic impurities |
CN102336767A (zh) * | 2011-07-11 | 2012-02-01 | 华东理工大学 | 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4847265A (en) * | 1987-02-17 | 1989-07-11 | Sanofi | Dextro-rotatory enantiomer of methyl alpha-5 (4,5,6,7-tetrahydro (3,2-c) thieno pyridyl) (2-chlorophenyl)-acetate and the pharmaceutical compositions containing it |
US6635763B2 (en) * | 2001-01-24 | 2003-10-21 | Cadila Health Care Limited | Process to prepare clopidogrel |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH15674A (en) * | 1979-07-06 | 1983-03-11 | Syntex Corp | Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid |
JP3030780B2 (ja) * | 1988-12-29 | 2000-04-10 | 日本農薬株式会社 | 光学活性なケテンジチオアセタール誘導体及びその製造方法 |
JPH10237013A (ja) * | 1996-12-28 | 1998-09-08 | Fuji Yakuhin Kogyo Kk | 光学活性2−ベンジルコハク酸の製造法 |
IT1311921B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
CA2436323C (en) | 2001-01-24 | 2012-02-21 | Cadila Healthcare Ltd. | Process for preparing clopidogrel |
HU230004B1 (en) * | 2001-06-21 | 2015-04-28 | Sanofi Aventis | Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid |
CA2352520C (en) | 2001-07-06 | 2007-10-02 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
JP4319847B2 (ja) * | 2002-02-13 | 2009-08-26 | 第一三共株式会社 | (1s,2s)−2−フルオロシクロプロパンカルボン酸誘導体の製造方法 |
US20050059696A1 (en) | 2003-05-08 | 2005-03-17 | Dr. Reddy's Laboratories Limited | Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers |
CA2529774C (en) * | 2003-06-20 | 2014-05-27 | Metabolex, Inc. | Resolution of .alpha.-(phenoxy)phenylacetic acid derivatives |
JP2005023055A (ja) * | 2003-07-04 | 2005-01-27 | Mitsubishi Gas Chem Co Inc | 新規光学活性アミン |
JPWO2005040099A1 (ja) * | 2003-10-23 | 2007-03-08 | 小野薬品工業株式会社 | 3−置換−(2r,3r)−2−保護されたアミノ−3−ヒドロキシプロピオン酸誘導体の製造方法およびその中間体 |
-
2005
- 2005-06-23 KR KR1020050054303A patent/KR100678287B1/ko active IP Right Grant
- 2005-11-28 AT AT05818892T patent/ATE514702T1/de not_active IP Right Cessation
- 2005-11-28 ES ES05818892T patent/ES2366334T3/es active Active
- 2005-11-28 US US11/917,794 patent/US7652140B2/en not_active Expired - Fee Related
- 2005-11-28 CA CA002612996A patent/CA2612996A1/en not_active Abandoned
- 2005-11-28 EP EP05818892A patent/EP1907397B1/en not_active Not-in-force
- 2005-11-28 RU RU2008102389/04A patent/RU2357970C1/ru not_active IP Right Cessation
- 2005-11-28 JP JP2008518011A patent/JP2008546761A/ja active Pending
- 2005-11-28 CN CN2005800502327A patent/CN101208347B/zh not_active Expired - Fee Related
- 2005-11-28 WO PCT/KR2005/004017 patent/WO2006137628A1/en active Application Filing
- 2005-11-28 AU AU2005333309A patent/AU2005333309B2/en not_active Ceased
-
2007
- 2007-11-26 IL IL187640A patent/IL187640A0/en unknown
-
2009
- 2009-08-28 US US12/549,850 patent/US7763730B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4847265A (en) * | 1987-02-17 | 1989-07-11 | Sanofi | Dextro-rotatory enantiomer of methyl alpha-5 (4,5,6,7-tetrahydro (3,2-c) thieno pyridyl) (2-chlorophenyl)-acetate and the pharmaceutical compositions containing it |
US6635763B2 (en) * | 2001-01-24 | 2003-10-21 | Cadila Health Care Limited | Process to prepare clopidogrel |
Non-Patent Citations (4)
Title |
---|
张青山等.新型抗血小管药氯吡格雷研究进展.化工进展22 7.2003,22(7),689-693. |
张青山等.新型抗血小管药氯吡格雷研究进展.化工进展22 7.2003,22(7),689-693. * |
陈子明等.氯吡格雷合成路线图解.中国医药工业杂志33 4.2002,33(4),206-208. |
陈子明等.氯吡格雷合成路线图解.中国医药工业杂志33 4.2002,33(4),206-208. * |
Also Published As
Publication number | Publication date |
---|---|
IL187640A0 (en) | 2008-03-20 |
JP2008546761A (ja) | 2008-12-25 |
US20090318701A1 (en) | 2009-12-24 |
AU2005333309A1 (en) | 2006-12-28 |
US7652140B2 (en) | 2010-01-26 |
ES2366334T3 (es) | 2011-10-19 |
US20080214821A1 (en) | 2008-09-04 |
EP1907397A1 (en) | 2008-04-09 |
KR100678287B1 (ko) | 2007-02-02 |
US7763730B2 (en) | 2010-07-27 |
EP1907397A4 (en) | 2009-05-27 |
WO2006137628A1 (en) | 2006-12-28 |
KR20060134541A (ko) | 2006-12-28 |
ATE514702T1 (de) | 2011-07-15 |
CA2612996A1 (en) | 2006-12-28 |
CN101208347A (zh) | 2008-06-25 |
AU2005333309B2 (en) | 2009-04-23 |
EP1907397B1 (en) | 2011-06-29 |
RU2357970C1 (ru) | 2009-06-10 |
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Owner name: HANMI HOLDINGS CO., LTD. Free format text: FORMER OWNER: HANMI PHARM. CO., LTD. Effective date: 20110318 |
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Free format text: CORRECT: ADDRESS; FROM: GYEONGGI-DO, SOUTH KOREA TO: SEOUL, SOUTH KOREA |
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Effective date of registration: 20110318 Address after: Seoul, South Kerean Patentee after: Hanmi Pharm Ind Co.,Ltd. Address before: Gyeonggi Do, South Korea Patentee before: Hanmi Pharm. Co., Ltd. |
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