ATE396189T1 - Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung - Google Patents
Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellungInfo
- Publication number
- ATE396189T1 ATE396189T1 AT05740218T AT05740218T ATE396189T1 AT E396189 T1 ATE396189 T1 AT E396189T1 AT 05740218 T AT05740218 T AT 05740218T AT 05740218 T AT05740218 T AT 05740218T AT E396189 T1 ATE396189 T1 AT E396189T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- methyl
- alkyl
- cyanopyrrole
- aminoalkyl
- Prior art date
Links
- BQMPGKPTOHKYHS-UHFFFAOYSA-N 1h-pyrrole-2-carbonitrile Chemical compound N#CC1=CC=CN1 BQMPGKPTOHKYHS-UHFFFAOYSA-N 0.000 title abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- 150000005347 biaryls Chemical class 0.000 title 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 3
- JDCAVWLLZCSPTB-UHFFFAOYSA-N 5-(3-acetyl-4-aminophenyl)-1-methylpyrrole-2-carbonitrile Chemical compound C1=C(N)C(C(=O)C)=CC(C=2N(C(C#N)=CC=2)C)=C1 JDCAVWLLZCSPTB-UHFFFAOYSA-N 0.000 abstract 1
- AKWXTECOJTWHIU-UHFFFAOYSA-N 5-[4-amino-3-(2-hydroxypropan-2-yl)phenyl]-1-methylpyrrole-2-carbonitrile Chemical compound CN1C(C#N)=CC=C1C1=CC=C(N)C(C(C)(C)O)=C1 AKWXTECOJTWHIU-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 1
- 241000347391 Umbrina cirrosa Species 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyclic carbamates Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- IVBWMGBBBAVXRJ-UHFFFAOYSA-N methyl 2-amino-5-(5-cyano-1-methylpyrrol-2-yl)benzoate Chemical compound C1=C(N)C(C(=O)OC)=CC(C=2N(C(C#N)=CC=2)C)=C1 IVBWMGBBBAVXRJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56561604P | 2004-04-27 | 2004-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE396189T1 true ATE396189T1 (de) | 2008-06-15 |
Family
ID=35242253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05740218T ATE396189T1 (de) | 2004-04-27 | 2005-04-25 | Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7582755B2 (de) |
| EP (1) | EP1756095B1 (de) |
| JP (2) | JP5108506B2 (de) |
| CN (1) | CN1946716B (de) |
| AT (1) | ATE396189T1 (de) |
| AU (1) | AU2005238520B2 (de) |
| BR (1) | BRPI0510278A (de) |
| CA (1) | CA2562160C (de) |
| DE (1) | DE602005007021D1 (de) |
| DK (1) | DK1756095T3 (de) |
| ES (1) | ES2306140T3 (de) |
| MX (1) | MXPA06012402A (de) |
| PL (1) | PL1756095T3 (de) |
| WO (1) | WO2005105739A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| DE602005007021D1 (de) | 2004-04-27 | 2008-07-03 | Wyeth Corp | Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung |
| ES2340610T3 (es) * | 2005-04-28 | 2010-06-07 | Wyeth Llc | Composiciones de tanaproget micronizado y procedimientos de preparacion de las mismas. |
| ES2340518T3 (es) * | 2005-04-28 | 2010-06-04 | Wyeth Llc | Tanaproget micronizado y composiciones que lo contienen. |
| WO2007030153A2 (en) * | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
| PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
| PE20070404A1 (es) * | 2005-07-29 | 2007-05-10 | Wyeth Corp | Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona |
| PE20070220A1 (es) * | 2005-07-29 | 2007-03-19 | Wyeth Corp | Proceso para la sintesis de moduladores del receptor de progesterona |
| PE20070182A1 (es) * | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
| US20070213526A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Purification of progesterone receptor modulators |
| US20080319204A1 (en) * | 2007-06-25 | 2008-12-25 | Wyeth | Process for the synthesis of progesterone receptor modulators |
| BRPI0819571A2 (pt) * | 2007-12-20 | 2019-09-24 | Teva Womenss Health Inc | "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica" |
| GB0817578D0 (en) * | 2008-09-25 | 2008-11-05 | 3M Innovative Properties Co | Method for treating wheel rims and composition for use therein |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194628A (en) * | 1988-03-18 | 1993-03-16 | Ciba-Geigy Corporation | Process for the preparation of substituted difluorobenzo-1,3-dioxoles |
| JPH09502432A (ja) | 1993-09-10 | 1997-03-11 | チバ−ガイギー アクチエンゲゼルシャフト | フォトクロミック化合物、その製造方法および製造のための中間生成物、ならびにそれらの用法 |
| CN1347423A (zh) | 1999-02-22 | 2002-05-01 | 伊斯曼化学公司 | 含有n－吡咯基取代的氮给电体的催化剂 |
| US6545108B1 (en) | 1999-02-22 | 2003-04-08 | Eastman Chemical Company | Catalysts containing N-pyrrolyl substituted nitrogen donors |
| HUP0201609A3 (en) * | 1999-05-04 | 2002-12-28 | Wyeth Five Giralda Farms Madis | Benzoxazine derivatives as progesterone receptor modulators |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| WO2000066560A1 (en) * | 1999-05-04 | 2000-11-09 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| MXPA01011310A (es) * | 1999-05-04 | 2003-07-14 | American Home Prod | Derivados de quinazolinona y benzoxazina como moduladores del receptor de progesterona. |
| US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| CZ20013952A3 (cs) * | 1999-05-04 | 2002-05-15 | American Home Products Corporation | Deriváty cyklothiokarbamátu jako modulátory receptoru pro progesteron |
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US20020065192A1 (en) * | 2000-02-18 | 2002-05-30 | Mackenzie Peter Borden | Productivity catalysts and microstructure control |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| US6350837B1 (en) | 2000-06-09 | 2002-02-26 | Eastman Chemical Company | Copolymerization of norbornene and functional norbornene monomers |
| EP1404723A2 (de) | 2000-11-06 | 2004-04-07 | Eastman Chemical Company | Olefinpolymerisationsverfahren unter verwendung von geträgerten katalysatoren |
| WO2002036641A2 (en) | 2000-11-06 | 2002-05-10 | Eastman Chemical Company | Improved productivity catalysts and microstructure control |
| US6387992B1 (en) * | 2000-11-27 | 2002-05-14 | Ciba Specialty Chemicals Corporation | Substituted 5-heteroaryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, a process for preparation thereof and compositions stabilized therewith |
| WO2002042281A1 (en) | 2000-11-27 | 2002-05-30 | Ciba Specialty Chemicals Holding Inc. | Substituted 5-aryl and 5-heteroaryl-2-(2-hydroxyphenyl)-2h-benzotriazole derivatives as uv absorbers |
| DE10111262A1 (de) | 2001-03-09 | 2002-09-12 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von Vinyl- Aryl- und Heteroarylessigsäuren und ihrer Devivate |
| JP2005194190A (ja) | 2001-10-05 | 2005-07-21 | Fumie Satou | １９−ノル−ビタミンｄ誘導体の製造法 |
| DE10152989A1 (de) * | 2001-10-26 | 2003-05-08 | Bayer Ag | Komplexe N-heterocyslischer Carbene und ihre Verwendung |
| AU2003223930A1 (en) | 2002-06-14 | 2003-12-31 | Novo Nordisk A/S | Pharmaceutical use of boronic acids and esters thereof |
| AR040644A1 (es) * | 2002-06-25 | 2005-04-13 | Wyeth Corp | Un moduladores del receptor de progesterona benzoxazina-2-tiona, una composicion farmaceutica, uso del compuesto para preparar un dedicamento para tratar una enfermedad neoplasica-hormona-dependiente y el uso de un compuesto benzoxazina-2-tiona, benzoxazina-2-ilideno cianamida o benzoxazina-2-iliden |
| TW200404548A (en) * | 2002-06-25 | 2004-04-01 | Wyeth Corp | Pharmaceutical composition containing cyclothiocarbamate derivatives in treatment of hormone-related conditions |
| PE20060331A1 (es) | 2004-04-27 | 2006-05-16 | Wyeth Corp | Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos |
| WO2005104711A2 (en) | 2004-04-27 | 2005-11-10 | Wyeth | Purification of progesterone receptor modulators |
| DE602005007021D1 (de) | 2004-04-27 | 2008-07-03 | Wyeth Corp | Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung |
-
2005
- 2005-04-25 DE DE602005007021T patent/DE602005007021D1/de not_active Expired - Lifetime
- 2005-04-25 CN CN200580013271XA patent/CN1946716B/zh not_active Expired - Fee Related
- 2005-04-25 WO PCT/US2005/014342 patent/WO2005105739A2/en not_active Ceased
- 2005-04-25 CA CA2562160A patent/CA2562160C/en not_active Expired - Fee Related
- 2005-04-25 DK DK05740218T patent/DK1756095T3/da active
- 2005-04-25 EP EP05740218A patent/EP1756095B1/de not_active Expired - Lifetime
- 2005-04-25 AT AT05740218T patent/ATE396189T1/de not_active IP Right Cessation
- 2005-04-25 US US11/113,795 patent/US7582755B2/en not_active Expired - Fee Related
- 2005-04-25 ES ES05740218T patent/ES2306140T3/es not_active Expired - Lifetime
- 2005-04-25 AU AU2005238520A patent/AU2005238520B2/en not_active Ceased
- 2005-04-25 MX MXPA06012402A patent/MXPA06012402A/es active IP Right Grant
- 2005-04-25 BR BRPI0510278-2A patent/BRPI0510278A/pt not_active IP Right Cessation
- 2005-04-25 PL PL05740218T patent/PL1756095T3/pl unknown
- 2005-04-25 JP JP2007510902A patent/JP5108506B2/ja not_active Expired - Fee Related
-
2009
- 2009-07-24 US US12/508,679 patent/US8003784B2/en not_active Expired - Fee Related
-
2011
- 2011-07-11 US US13/179,730 patent/US8129524B2/en not_active Expired - Fee Related
-
2012
- 2012-08-28 JP JP2012187513A patent/JP2013006853A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007534767A (ja) | 2007-11-29 |
| DE602005007021D1 (de) | 2008-07-03 |
| EP1756095B1 (de) | 2008-05-21 |
| ES2306140T3 (es) | 2008-11-01 |
| US20050239779A1 (en) | 2005-10-27 |
| AU2005238520A1 (en) | 2005-11-10 |
| WO2005105739A2 (en) | 2005-11-10 |
| EP1756095A2 (de) | 2007-02-28 |
| US8003784B2 (en) | 2011-08-23 |
| PL1756095T3 (pl) | 2008-10-31 |
| US20120016118A1 (en) | 2012-01-19 |
| CN1946716A (zh) | 2007-04-11 |
| US7582755B2 (en) | 2009-09-01 |
| AU2005238520B2 (en) | 2011-09-08 |
| CN1946716B (zh) | 2011-12-21 |
| CA2562160A1 (en) | 2005-11-10 |
| JP5108506B2 (ja) | 2012-12-26 |
| MXPA06012402A (es) | 2007-01-17 |
| BRPI0510278A (pt) | 2007-10-30 |
| WO2005105739A3 (en) | 2006-02-16 |
| US8129524B2 (en) | 2012-03-06 |
| CA2562160C (en) | 2013-05-28 |
| DK1756095T3 (da) | 2008-08-11 |
| JP2013006853A (ja) | 2013-01-10 |
| US20090306371A1 (en) | 2009-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |