CL2010000973A1 - Procedimiento de preparacion de la sal de clorhidrato de ester metilico del acido (e)-3-(4-{[2-(2-metil-1h-indol-3-il)etilamino]metil}fenil)-acrilico por combinacion de 2-metiltriptamina y el ester metilico del acido (e)-3-(4-formil-fenil)-acrilico, y posterior reduccion de la imina formada ( divisional de la sol. n° 1691-2007). - Google Patents

Procedimiento de preparacion de la sal de clorhidrato de ester metilico del acido (e)-3-(4-{[2-(2-metil-1h-indol-3-il)etilamino]metil}fenil)-acrilico por combinacion de 2-metiltriptamina y el ester metilico del acido (e)-3-(4-formil-fenil)-acrilico, y posterior reduccion de la imina formada ( divisional de la sol. n° 1691-2007).

Info

Publication number
CL2010000973A1
CL2010000973A1 CL2010000973A CL2010000973A CL2010000973A1 CL 2010000973 A1 CL2010000973 A1 CL 2010000973A1 CL 2010000973 A CL2010000973 A CL 2010000973A CL 2010000973 A CL2010000973 A CL 2010000973A CL 2010000973 A1 CL2010000973 A1 CL 2010000973A1
Authority
CL
Chile
Prior art keywords
methyl
phenyl
acrylic
acid
methyl ester
Prior art date
Application number
CL2010000973A
Other languages
English (en)
Inventor
Murat Acemoglu
Joginder S Bajwa
David John Parker
Joel Slade
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2010000973(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2010000973A1 publication Critical patent/CL2010000973A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedimiento para preparar la sal de clorhidrato de ester metílico del ácido (e)-3-(4-{[2-(2-metil-1h-indol-3-il)etilamino]metil}fenil)-acrílico que comprende: a) Combinar 2-metiltriptamina y ester metilico del ácido (e)-3-(4-formil-fenil)-acrílico, b) Agitar para formar un intermediario de imina y c) Reducir este intermediario para formar la sal.
CL2010000973A 2006-06-12 2010-09-13 Procedimiento de preparacion de la sal de clorhidrato de ester metilico del acido (e)-3-(4-{[2-(2-metil-1h-indol-3-il)etilamino]metil}fenil)-acrilico por combinacion de 2-metiltriptamina y el ester metilico del acido (e)-3-(4-formil-fenil)-acrilico, y posterior reduccion de la imina formada ( divisional de la sol. n° 1691-2007). CL2010000973A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80452706P 2006-06-12 2006-06-12
US86787806P 2006-11-30 2006-11-30

Publications (1)

Publication Number Publication Date
CL2010000973A1 true CL2010000973A1 (es) 2011-07-01

Family

ID=38832681

Family Applications (2)

Application Number Title Priority Date Filing Date
CL200701691A CL2007001691A1 (es) 2006-06-12 2007-06-11 Metodo para hacer n-hidroxi-3-(4(((2-(2-metil-1h-indol-3-il)etil)amino)metil)fenil)-2e-2-propenamida.
CL2010000973A CL2010000973A1 (es) 2006-06-12 2010-09-13 Procedimiento de preparacion de la sal de clorhidrato de ester metilico del acido (e)-3-(4-{[2-(2-metil-1h-indol-3-il)etilamino]metil}fenil)-acrilico por combinacion de 2-metiltriptamina y el ester metilico del acido (e)-3-(4-formil-fenil)-acrilico, y posterior reduccion de la imina formada ( divisional de la sol. n° 1691-2007).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL200701691A CL2007001691A1 (es) 2006-06-12 2007-06-11 Metodo para hacer n-hidroxi-3-(4(((2-(2-metil-1h-indol-3-il)etil)amino)metil)fenil)-2e-2-propenamida.

Country Status (32)

Country Link
US (2) US20090306405A1 (es)
EP (2) EP2394991B1 (es)
JP (2) JP5431926B2 (es)
KR (2) KR101493530B1 (es)
CN (4) CN103086944A (es)
AR (1) AR061296A1 (es)
AU (1) AU2007257883B2 (es)
BR (1) BRPI0712847A2 (es)
CA (1) CA2653657C (es)
CL (2) CL2007001691A1 (es)
DK (1) DK2032533T3 (es)
EC (1) ECSP088978A (es)
ES (2) ES2416286T3 (es)
GT (1) GT200800282A (es)
HK (2) HK1126759A1 (es)
HR (1) HRP20130798T1 (es)
IL (2) IL195211A (es)
IN (1) IN2015DN00910A (es)
JO (1) JO2900B1 (es)
MA (1) MA30513B1 (es)
MX (2) MX2008015898A (es)
MY (1) MY147576A (es)
NO (1) NO341870B1 (es)
NZ (1) NZ572707A (es)
PE (2) PE20080851A1 (es)
PL (1) PL2032533T3 (es)
PT (1) PT2032533E (es)
RU (1) RU2448090C2 (es)
TN (1) TNSN08507A1 (es)
TW (1) TWI395734B (es)
WO (1) WO2007146718A2 (es)
ZA (1) ZA200809490B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000004075A1 (it) 2020-02-27 2021-08-27 Flamma Spa Processo per la preparazione di panobinostat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB146260A (en) 1918-07-11 1921-08-11 Elektro Osmose Ag A process for preparing proteids charged with immune substances
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
US20040067540A1 (en) 2001-01-09 2004-04-08 Piotr Lassota Rapid method for screening compounds for in vivo activity
BR0213932A (pt) 2001-11-06 2004-08-31 Novartis Ag Combinação do inibidor da ciclooxigenase-2/inibidor da desacetilase histona
MX2008015899A (es) * 2006-06-12 2009-04-01 Novartis Ag Procedimiento para hacer sales de n-hidroxi-3-[4-[[[2-(2-metil-1h- indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida.

Also Published As

Publication number Publication date
AU2007257883A1 (en) 2007-12-21
BRPI0712847A2 (pt) 2012-08-07
PE20080851A1 (es) 2008-08-18
ZA200809490B (en) 2009-10-28
IL233836A (en) 2017-05-29
JO2900B1 (en) 2015-09-15
EP2394991A1 (en) 2011-12-14
GT200800282A (es) 2009-03-09
KR20140117703A (ko) 2014-10-07
IN2015DN00910A (es) 2015-07-10
KR20090015969A (ko) 2009-02-12
RU2008151726A (ru) 2010-07-20
CN102174008A (zh) 2011-09-07
US8536346B2 (en) 2013-09-17
AU2007257883B2 (en) 2011-09-29
CA2653657C (en) 2015-10-27
IL195211A0 (en) 2009-08-03
EP2032533B8 (en) 2013-12-11
WO2007146718A3 (en) 2008-06-19
MX2008015898A (es) 2009-01-12
HK1126759A1 (en) 2009-09-11
NO341870B1 (no) 2018-02-12
TWI395734B (zh) 2013-05-11
MA30513B1 (fr) 2009-06-01
HK1162029A1 (en) 2012-08-17
IL195211A (en) 2014-08-31
JP5431926B2 (ja) 2014-03-05
MX366213B (es) 2019-07-01
KR101493530B1 (ko) 2015-02-13
ECSP088978A (es) 2009-01-30
CL2007001691A1 (es) 2008-05-16
KR101540194B1 (ko) 2015-07-28
CA2653657A1 (en) 2007-12-21
MY147576A (en) 2012-12-31
PL2032533T3 (pl) 2013-08-30
EP2394991B1 (en) 2015-09-23
RU2448090C2 (ru) 2012-04-20
CN101466674A (zh) 2009-06-24
ES2416286T3 (es) 2013-07-31
CN102167678A (zh) 2011-08-31
CN102167678B (zh) 2013-08-28
IL233836A0 (en) 2014-09-30
EP2032533B1 (en) 2013-04-03
JP2009540008A (ja) 2009-11-19
JP2014058532A (ja) 2014-04-03
HRP20130798T1 (en) 2013-09-30
TNSN08507A1 (en) 2010-04-14
DK2032533T3 (da) 2013-07-01
PE20120221A1 (es) 2012-03-21
US20120010418A1 (en) 2012-01-12
NZ572707A (en) 2011-12-22
PT2032533E (pt) 2013-06-28
EP2032533A2 (en) 2009-03-11
TW200815345A (en) 2008-04-01
JP5809223B2 (ja) 2015-11-10
AR061296A1 (es) 2008-08-20
WO2007146718A2 (en) 2007-12-21
ES2553255T3 (es) 2015-12-07
NO20090137L (no) 2009-03-03
US20090306405A1 (en) 2009-12-10
CN103086944A (zh) 2013-05-08

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