IN2015DN00910A - - Google Patents

Info

Publication number
IN2015DN00910A
IN2015DN00910A IN910DEN2015A IN2015DN00910A IN 2015DN00910 A IN2015DN00910 A IN 2015DN00910A IN 910DEN2015 A IN910DEN2015 A IN 910DEN2015A IN 2015DN00910 A IN2015DN00910 A IN 2015DN00910A
Authority
IN
India
Prior art keywords
methyl
indol
phenyl
eythl
laminomethyl
Prior art date
Application number
Inventor
Murat Acemoglu
Joginder S Bajwa
David John Parker
Joel Slade
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2015DN00910(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2015DN00910A publication Critical patent/IN2015DN00910A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefor (E)-3-[4-[2-(2-methyl-1H-indol-3--eythl)y laminomethyl] -phenyl] -acrylic acid methyl ester hydrochloride salt and 2- methyltryptamine are prepared by new synthetic methods.
IN910DEN2015 2006-06-12 2007-06-07 IN2015DN00910A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80452706P 2006-06-12 2006-06-12
US86787806P 2006-11-30 2006-11-30
PCT/US2007/070564 WO2007146718A2 (en) 2006-06-12 2007-06-07 Process for making n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino] methyl]phenyl]-2e-2-propenamide and starting materials therefor

Publications (1)

Publication Number Publication Date
IN2015DN00910A true IN2015DN00910A (en) 2015-07-10

Family

ID=38832681

Family Applications (1)

Application Number Title Priority Date Filing Date
IN910DEN2015 IN2015DN00910A (en) 2006-06-12 2007-06-07

Country Status (32)

Country Link
US (2) US20090306405A1 (en)
EP (2) EP2394991B1 (en)
JP (2) JP5431926B2 (en)
KR (2) KR101540194B1 (en)
CN (4) CN101466674A (en)
AR (1) AR061296A1 (en)
AU (1) AU2007257883B2 (en)
BR (1) BRPI0712847A2 (en)
CA (1) CA2653657C (en)
CL (2) CL2007001691A1 (en)
DK (1) DK2032533T3 (en)
EC (1) ECSP088978A (en)
ES (2) ES2553255T3 (en)
GT (1) GT200800282A (en)
HK (2) HK1162029A1 (en)
HR (1) HRP20130798T1 (en)
IL (2) IL195211A (en)
IN (1) IN2015DN00910A (en)
JO (1) JO2900B1 (en)
MA (1) MA30513B1 (en)
MX (2) MX366213B (en)
MY (1) MY147576A (en)
NO (1) NO341870B1 (en)
NZ (1) NZ572707A (en)
PE (2) PE20120221A1 (en)
PL (1) PL2032533T3 (en)
PT (1) PT2032533E (en)
RU (1) RU2448090C2 (en)
TN (1) TNSN08507A1 (en)
TW (1) TWI395734B (en)
WO (1) WO2007146718A2 (en)
ZA (1) ZA200809490B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000004075A1 (en) 2020-02-27 2021-08-27 Flamma Spa PROCESS FOR THE PREPARATION OF PANOBINOSTAT

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB146260A (en) 1918-07-11 1921-08-11 Elektro Osmose Ag A process for preparing proteids charged with immune substances
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
PE20020354A1 (en) * 2000-09-01 2002-06-12 Novartis Ag HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS
AU2002237261A1 (en) 2001-01-09 2002-07-24 Novartis Pharma Gmbh Rapid method for screening compounds for in vivo activity
NZ544689A (en) 2001-11-06 2007-08-31 Novartis Ag Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination
JP2009540007A (en) * 2006-06-12 2009-11-19 ノバルティス アクチエンゲゼルシャフト Process for producing a salt of N-hydroxy-3- [4-[[[2- (2-methyl-1H-indol-3-yl) ethyl] amino] methyl] phenyl] -2E-2-propenamide

Also Published As

Publication number Publication date
WO2007146718A3 (en) 2008-06-19
AU2007257883B2 (en) 2011-09-29
CA2653657C (en) 2015-10-27
MX2008015898A (en) 2009-01-12
US20120010418A1 (en) 2012-01-12
IL233836A (en) 2017-05-29
NO20090137L (en) 2009-03-03
EP2032533B8 (en) 2013-12-11
HK1126759A1 (en) 2009-09-11
JP2009540008A (en) 2009-11-19
TW200815345A (en) 2008-04-01
CL2010000973A1 (en) 2011-07-01
CN102167678A (en) 2011-08-31
MY147576A (en) 2012-12-31
CN103086944A (en) 2013-05-08
KR20090015969A (en) 2009-02-12
NZ572707A (en) 2011-12-22
JP5809223B2 (en) 2015-11-10
PL2032533T3 (en) 2013-08-30
DK2032533T3 (en) 2013-07-01
TWI395734B (en) 2013-05-11
KR101493530B1 (en) 2015-02-13
BRPI0712847A2 (en) 2012-08-07
HK1162029A1 (en) 2012-08-17
US20090306405A1 (en) 2009-12-10
TNSN08507A1 (en) 2010-04-14
CN102167678B (en) 2013-08-28
AU2007257883A1 (en) 2007-12-21
KR20140117703A (en) 2014-10-07
HRP20130798T1 (en) 2013-09-30
JP5431926B2 (en) 2014-03-05
MA30513B1 (en) 2009-06-01
CN102174008A (en) 2011-09-07
PE20120221A1 (en) 2012-03-21
CA2653657A1 (en) 2007-12-21
IL195211A0 (en) 2009-08-03
ECSP088978A (en) 2009-01-30
CL2007001691A1 (en) 2008-05-16
ZA200809490B (en) 2009-10-28
EP2032533A2 (en) 2009-03-11
RU2008151726A (en) 2010-07-20
EP2394991A1 (en) 2011-12-14
EP2394991B1 (en) 2015-09-23
NO341870B1 (en) 2018-02-12
WO2007146718A2 (en) 2007-12-21
JP2014058532A (en) 2014-04-03
EP2032533B1 (en) 2013-04-03
ES2416286T3 (en) 2013-07-31
GT200800282A (en) 2009-03-09
MX366213B (en) 2019-07-01
IL233836A0 (en) 2014-09-30
PE20080851A1 (en) 2008-08-18
IL195211A (en) 2014-08-31
JO2900B1 (en) 2015-09-15
CN101466674A (en) 2009-06-24
KR101540194B1 (en) 2015-07-28
RU2448090C2 (en) 2012-04-20
ES2553255T3 (en) 2015-12-07
US8536346B2 (en) 2013-09-17
PT2032533E (en) 2013-06-28
AR061296A1 (en) 2008-08-20

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