CY1113261T1 - Διαδικασια για την παρασκευη εναντιομερικως καθαρων 1- υποκατεστημενων-3-αμινοαλκοολων - Google Patents
Διαδικασια για την παρασκευη εναντιομερικως καθαρων 1- υποκατεστημενων-3-αμινοαλκοολωνInfo
- Publication number
- CY1113261T1 CY1113261T1 CY20121100937T CY121100937T CY1113261T1 CY 1113261 T1 CY1113261 T1 CY 1113261T1 CY 20121100937 T CY20121100937 T CY 20121100937T CY 121100937 T CY121100937 T CY 121100937T CY 1113261 T1 CY1113261 T1 CY 1113261T1
- Authority
- CY
- Cyprus
- Prior art keywords
- aminocoloses
- substitutes
- procedure
- amino
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
Abstract
Παρέχεται μία διαδικασία για την παρασκευή εναντιομερικώς καθαρών 1-υποκατεστημένων-3-αμινοαλκοολών, ειδικότερα της S)-(-)- και (R)-(+)-3-Ν-μεθυλαμινο-1-(2-θειενυλο)-1-προπανόλης, με ασύμμετρη υδρογόνωση αλάτων ενός καρβοξυλικού οξέος με μια αμινοκετόνη του τύπου (II), όπου R1 επιλέγεται από την ομάδα η οποία αποτελείται από 2-θειενύλιο, 2-φουρανύλιο και φαινύλιο, έκαστο κατ' επιλογή υποκατεστημένο με ένα ή περισσότερα άτομα αλογόνου και/ή μία ή περισσότερες C1-4 αλκοξυ ομάδες, και όπου R2 είναι C1-4 αλκύλιο ή φαινύλιο, έκαστο κατ' επιλογή υποκατεστημένο με ένα ή περισσότερα άτομα αλογόνου και/ή μία ή περισσότερες C1-4 αλκυλικές ή C1-4-αλκοξυ ομάδες, και όπου οι αντίστοιχες αμινοαλκοόλες λαμβάνονται με επακόλουθη υδρόλυση των αλάτων τους. Επιπροσθέτως παρέχονται άλατα ενός καρβοξυλικού οξέος με τις εν λόγω αμινοκετόνες και τις αμινοαλκοόλες που λαμβάνονται με ασύμμετρη υδρογόνωση των εν λόγω αμινοκετονών, αντίστοιχα.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04003809A EP1566383A1 (en) | 2004-02-19 | 2004-02-19 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols |
| EP04010043 | 2004-04-28 | ||
| EP05715425A EP1720852B1 (en) | 2004-02-19 | 2005-02-21 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113261T1 true CY1113261T1 (el) | 2016-04-13 |
Family
ID=34889010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100937T CY1113261T1 (el) | 2004-02-19 | 2012-10-10 | Διαδικασια για την παρασκευη εναντιομερικως καθαρων 1- υποκατεστημενων-3-αμινοαλκοολων |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7973182B2 (el) |
| EP (1) | EP1720852B1 (el) |
| JP (2) | JP2007523124A (el) |
| KR (1) | KR101160502B1 (el) |
| CN (1) | CN102627572A (el) |
| AU (1) | AU2005215906C1 (el) |
| BR (1) | BRPI0506796A (el) |
| CA (1) | CA2556891C (el) |
| CY (1) | CY1113261T1 (el) |
| DK (1) | DK1720852T3 (el) |
| EA (1) | EA200601513A1 (el) |
| ES (1) | ES2391399T3 (el) |
| IL (1) | IL177561A (el) |
| NO (1) | NO20064017L (el) |
| NZ (1) | NZ549381A (el) |
| PL (1) | PL1720852T3 (el) |
| PT (1) | PT1720852E (el) |
| SG (1) | SG135196A1 (el) |
| SI (1) | SI1720852T1 (el) |
| WO (1) | WO2005080370A1 (el) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1720852B1 (en) | 2004-02-19 | 2012-07-11 | Lonza AG | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols |
| KR20070104942A (ko) * | 2005-02-21 | 2007-10-29 | 론자 아게 | 거울상적으로 순수한 1-치환-3-아미노알코올의 제조 방법 |
| CA2656128A1 (en) | 2006-07-03 | 2008-01-10 | Ranbaxy Laboratories Limited | Process for the preparation of enantiomerically pure salts of n-methyl-3(1-naphthaleneoxy)-3-(2-thienyl)propanamine |
| US8288141B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| ES2560459T3 (es) | 2008-08-27 | 2016-02-19 | Codexis, Inc. | Polipéptidos cetorreductasa para la producción de una 3-aril-3-hidroxipropanamina a partir de una 3-aril-3-cetopropanamina |
| SI2558455T1 (sl) | 2010-04-13 | 2017-12-29 | Krka, D.D., Novo Mesto | Sinteza duloksetina in/ali njegovih farmacevtsko sprejemljivih soli |
| CN104056663B (zh) * | 2013-03-22 | 2016-12-28 | 上海交通大学 | 一种面手性双反应中心钌催化剂及其合成与应用 |
| CN110054563A (zh) * | 2019-06-10 | 2019-07-26 | 江西隆莱生物制药有限公司 | 丁内酯类化合物的制备方法及其中间体 |
| CN111793056A (zh) * | 2020-07-27 | 2020-10-20 | 广州康瑞泰药业有限公司 | 一种度洛西汀中间体的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3031248A1 (de) | 1980-08-19 | 1982-04-01 | Ruhrchemie Ag, 4200 Oberhausen | Verfahren zur herstellung von 3-dimethylamino-2,2-dimethylpropanal |
| US5362866A (en) | 1983-09-02 | 1994-11-08 | Molecular Biosystems, Inc. | Oligonucleotide polymeric support system with an oxidation cleavable link |
| KR880007433A (ko) * | 1986-12-22 | 1988-08-27 | 메리 앤 터커 | 3-아릴옥시-3-치환된 프로판아민 |
| US4948813A (en) | 1987-11-30 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Benzylketone phospholipase A2 inhibitors |
| CA2042346A1 (en) * | 1990-05-17 | 1991-11-18 | Michael Alexander Staszak | Chiral synthesis of 1-aryl-3-aminopropan-1-ols |
| JPH0570412A (ja) * | 1991-09-13 | 1993-03-23 | Fuji Yakuhin Kogyo Kk | 光学活性なβ−アミノアルコールの製造方法 |
| US5491234A (en) * | 1992-03-30 | 1996-02-13 | Pfizer Inc. | Pyrimidine derivatives for enhancing antitumor activity |
| ES2130321T3 (es) | 1993-10-08 | 1999-07-01 | Hoffmann La Roche | Compuestos de fosforo opticamente activos. |
| US5362886A (en) | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| IT1270082B (it) * | 1994-07-12 | 1997-04-28 | Univ Degli Studi Milano | Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali |
| US6008412A (en) * | 1997-10-14 | 1999-12-28 | Eli Lilly And Company | Process to make chiral compounds |
| TW514634B (en) * | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
| US6162929A (en) | 1997-12-23 | 2000-12-19 | Hoffmann-La Roche Inc. | Process for the manufacture of bisphosphine oxide and bisphosphonate compounds |
| JP3549390B2 (ja) | 1998-03-23 | 2004-08-04 | 高砂香料工業株式会社 | ルテニウム−ホスフィン錯体及びその製造方法 |
| EP0955303B1 (en) | 1998-05-08 | 2006-11-08 | Takasago International Corporation | Ruthenium-iodo-optically active phosphine complex |
| FR2816946B1 (fr) | 2000-11-17 | 2004-04-02 | Ppg Sipsy | Diphosphines chirales dissymetriques, leurs utilisations pour la preparation de complexes diphosphino-metalliques, et les complexes diphosphino-metalliques ainsi obtenus |
| DE10207586A1 (de) * | 2002-02-22 | 2003-09-11 | Degussa | Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte |
| FR2841899A1 (fr) | 2002-07-05 | 2004-01-09 | Ppg Sipsy | Procede de resolution asymetrique d'un racemique faisant intervenir l'acide diprogulique et utilisation dudit acide comme agent de resolution asymetrique |
| WO2004005307A1 (en) * | 2002-07-09 | 2004-01-15 | Lonza Ag | Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol |
| ES2293029T3 (es) * | 2002-07-09 | 2008-03-16 | Lonza Ag | Proceso para la preparacion de beta-amino alcoholes n-monosustituidos. |
| EP1720852B1 (en) | 2004-02-19 | 2012-07-11 | Lonza AG | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols |
-
2005
- 2005-02-21 EP EP05715425A patent/EP1720852B1/en not_active Not-in-force
- 2005-02-21 ES ES05715425T patent/ES2391399T3/es active Active
- 2005-02-21 SG SG200706103-9A patent/SG135196A1/en unknown
- 2005-02-21 KR KR1020067018840A patent/KR101160502B1/ko not_active IP Right Cessation
- 2005-02-21 PL PL05715425T patent/PL1720852T3/pl unknown
- 2005-02-21 SI SI200531602T patent/SI1720852T1/sl unknown
- 2005-02-21 AU AU2005215906A patent/AU2005215906C1/en not_active Ceased
- 2005-02-21 EA EA200601513A patent/EA200601513A1/ru unknown
- 2005-02-21 WO PCT/EP2005/001781 patent/WO2005080370A1/en active Application Filing
- 2005-02-21 CA CA2556891A patent/CA2556891C/en not_active Expired - Fee Related
- 2005-02-21 BR BRPI0506796-0A patent/BRPI0506796A/pt not_active IP Right Cessation
- 2005-02-21 CN CN2012100464149A patent/CN102627572A/zh active Pending
- 2005-02-21 PT PT05715425T patent/PT1720852E/pt unknown
- 2005-02-21 DK DK05715425.4T patent/DK1720852T3/da active
- 2005-02-21 US US10/590,140 patent/US7973182B2/en not_active Expired - Fee Related
- 2005-02-21 NZ NZ549381A patent/NZ549381A/en not_active IP Right Cessation
- 2005-02-21 JP JP2006553562A patent/JP2007523124A/ja active Pending
-
2006
- 2006-08-17 IL IL177561A patent/IL177561A/en not_active IP Right Cessation
- 2006-09-06 NO NO20064017A patent/NO20064017L/no not_active Application Discontinuation
-
2011
- 2011-03-08 US US13/064,146 patent/US8198468B2/en not_active Expired - Fee Related
- 2011-03-08 US US13/064,147 patent/US8193380B2/en not_active Expired - Fee Related
-
2012
- 2012-06-14 JP JP2012134968A patent/JP2012229223A/ja not_active Withdrawn
- 2012-10-10 CY CY20121100937T patent/CY1113261T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005080370A1 (en) | 2005-09-01 |
| ES2391399T3 (es) | 2012-11-26 |
| EP1720852B1 (en) | 2012-07-11 |
| NO20064017L (no) | 2006-09-15 |
| CA2556891A1 (en) | 2005-09-01 |
| SI1720852T1 (sl) | 2012-11-30 |
| JP2007523124A (ja) | 2007-08-16 |
| US20110207946A1 (en) | 2011-08-25 |
| EP1720852A1 (en) | 2006-11-15 |
| IL177561A (en) | 2011-12-29 |
| CA2556891C (en) | 2012-12-18 |
| AU2005215906B2 (en) | 2011-08-18 |
| PL1720852T3 (pl) | 2012-12-31 |
| KR20070009587A (ko) | 2007-01-18 |
| EA200601513A1 (ru) | 2007-02-27 |
| US20110207945A1 (en) | 2011-08-25 |
| IL177561A0 (en) | 2006-12-10 |
| JP2012229223A (ja) | 2012-11-22 |
| US8198468B2 (en) | 2012-06-12 |
| NZ549381A (en) | 2010-05-28 |
| US20080154047A1 (en) | 2008-06-26 |
| AU2005215906A1 (en) | 2005-09-01 |
| US8193380B2 (en) | 2012-06-05 |
| KR101160502B1 (ko) | 2012-06-28 |
| US7973182B2 (en) | 2011-07-05 |
| DK1720852T3 (da) | 2012-10-22 |
| PT1720852E (pt) | 2012-10-22 |
| AU2005215906C1 (en) | 2012-03-01 |
| BRPI0506796A (pt) | 2007-05-22 |
| CN102627572A (zh) | 2012-08-08 |
| SG135196A1 (en) | 2007-09-28 |
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