NO20052912L - Metode for fremstilling av krystallinske former for optiske enantiomerer av modafinil - Google Patents

Metode for fremstilling av krystallinske former for optiske enantiomerer av modafinil

Info

Publication number
NO20052912L
NO20052912L NO20052912A NO20052912A NO20052912L NO 20052912 L NO20052912 L NO 20052912L NO 20052912 A NO20052912 A NO 20052912A NO 20052912 A NO20052912 A NO 20052912A NO 20052912 L NO20052912 L NO 20052912L
Authority
NO
Norway
Prior art keywords
modafinil
optical enantiomers
crystalline forms
preparing crystalline
crystalline
Prior art date
Application number
NO20052912A
Other languages
English (en)
Other versions
NO20052912D0 (no
NO335724B1 (no
Inventor
Gerard Coquerel
Adriaan Jan Van Langevelde
Laurent Courvoisier
Stephanie Graf
Gilles Serrure
Olivier Neckerbrock
Sebastien Rose
Christine Besselievre
Original Assignee
Organisation De Synthese Monof
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32406320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20052912(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organisation De Synthese Monof filed Critical Organisation De Synthese Monof
Publication of NO20052912D0 publication Critical patent/NO20052912D0/no
Publication of NO20052912L publication Critical patent/NO20052912L/no
Publication of NO335724B1 publication Critical patent/NO335724B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Oppfinnelsen vedrører en fremgangsmåte for fremstilling av krystallinske former av de optiske enantiomerer av modafinil, omfattende de følgende trinn: i) oppløsning av en av de optiske enantiomerer av modafinil i et annet løsningsmiddel enn etanol, ii) modafinilenantiomeren krystalliseres, iii) den krystallinske form av modafinilenantiomeren oppnådd på denne måte utvinnes. Oppfinnelsen vedrører o gså en fremgangsmåte for fremstilling av de optiske enantiomerer av modafinil.
NO20052912A 2002-12-20 2005-06-15 Krystallinske former av optiske enantiomerer av modafinil, farmasøytiske blandinger omfattende slike, fremgangsmåte for fremstilling av slike samt deres anvendelse NO335724B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0216412A FR2849029B1 (fr) 2002-12-20 2002-12-20 Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
PCT/FR2003/003799 WO2004060858A1 (fr) 2002-12-20 2003-12-18 Procede de preparation et formes cristallines des enantiomeres optiques du modafinil

Publications (3)

Publication Number Publication Date
NO20052912D0 NO20052912D0 (no) 2005-06-15
NO20052912L true NO20052912L (no) 2005-07-19
NO335724B1 NO335724B1 (no) 2015-02-02

Family

ID=32406320

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052912A NO335724B1 (no) 2002-12-20 2005-06-15 Krystallinske former av optiske enantiomerer av modafinil, farmasøytiske blandinger omfattende slike, fremgangsmåte for fremstilling av slike samt deres anvendelse

Country Status (29)

Country Link
US (10) US7132570B2 (no)
EP (6) EP2343275B1 (no)
JP (2) JP4719471B2 (no)
KR (1) KR101050565B1 (no)
CN (5) CN101654423A (no)
AR (1) AR042546A1 (no)
AU (2) AU2003299349C1 (no)
CA (2) CA2724305A1 (no)
CL (2) CL2007002450A1 (no)
CY (1) CY1114291T1 (no)
DK (1) DK2343275T3 (no)
EA (1) EA009592B1 (no)
EG (1) EG24849A (no)
ES (3) ES2575018T3 (no)
FR (1) FR2849029B1 (no)
HK (2) HK1192222A1 (no)
IL (1) IL169205A (no)
IS (1) IS7947A (no)
MX (1) MXPA05006525A (no)
MY (1) MY142926A (no)
NO (1) NO335724B1 (no)
NZ (2) NZ571235A (no)
PL (1) PL377196A1 (no)
PT (1) PT2343275E (no)
SI (1) SI2343275T1 (no)
TW (1) TWI344952B (no)
UA (1) UA100964C2 (no)
WO (1) WO2004060858A1 (no)
ZA (1) ZA200504805B (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
JP4906233B2 (ja) 2002-03-01 2012-03-28 ユニバーシティー オブ サウス フロリダ 少なくとも１種の有効薬剤成分を含有する多構成要素固相
JP2006500377A (ja) 2002-06-21 2006-01-05 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 改善された溶解性を有する医薬組成物
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
AU2003217437A1 (en) * 2003-03-17 2004-10-11 Hetero Drugs Limited Novel crystalline forms of lamotrigine
CA2519117C (en) * 2003-03-17 2010-03-02 Neurohealing Pharmaceuticals, Inc. High potency dopaminergic treatment of neurological impairment associated with brain injury
JP4842819B2 (ja) * 2003-09-04 2011-12-21 セフアロン・インコーポレーテツド モダフィニル組成物
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
CA2556106A1 (en) * 2004-02-06 2005-08-25 Cephalon, Inc. Modafinil compositions
US20090018202A1 (en) * 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
EP2292213A1 (en) * 2004-02-06 2011-03-09 Cephalon, Inc. Compositions comprising a polymorphic form of armodafinil
MX2007000765A (es) 2004-07-20 2007-03-28 Warner Lambert Co Formas cristalinas de sal de calcio del acido (r-(r*, r*))-2- (4-fluorofenil)- beta,gama- dihidroxi-5- (1-metiletil)-3 -fenil-4-((fenilamino) (carbonil)-1ih -pirrol-1- heptanoico (2:1).
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
EP1702915A1 (en) * 2005-03-14 2006-09-20 Cephalon France Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
CA2614777C (en) * 2005-07-21 2012-04-17 Neurohealing Pharmaceuticals, Inc. Rapid onset and short term modafinil compositions and methods of use thereof
US20070293702A1 (en) * 2006-02-21 2007-12-20 Viviana Braude Novel crystalline forms of armodafinil and preparation thereof
EP2159219A3 (en) 2006-03-01 2010-12-15 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of armodafinil
KR20090031618A (ko) * 2006-07-12 2009-03-26 엘란 코포레이션, 피엘씨 나노입자형 모다피닐 제제
CA2660565C (en) * 2006-08-14 2012-10-09 Neurohealing Pharmaceuticals, Inc. Modafinil-based treatment for premature ejaculation
US20080214862A1 (en) * 2006-12-06 2008-09-04 Ben-Zion Dolitzky Processes for preparing armodafinil intermediate
WO2008077127A2 (en) * 2006-12-19 2008-06-26 Lavin Thomas N Use of modafinil to treat restless leg syndrome
CA2688430A1 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
WO2009024863A2 (en) * 2007-06-26 2009-02-26 Actavis Group Ptc Ehf Process for the preparation of modafinil enantiomers
US7960586B2 (en) * 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
US20090082462A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched armodafinil
US20090105346A1 (en) * 2007-10-02 2009-04-23 Alexandr Jegorov Novel crystalline forms of armodafinil and preparation thereof
WO2009090663A1 (en) * 2008-01-15 2009-07-23 Lupin Limited Novel crystalline polymorph of armodafinil and an improved process for preparation thereof
US20090325999A1 (en) * 2008-06-27 2009-12-31 Jie Du Personalized pharmaceutical kits, packaging and compositions for the treatment of allergic conditions
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
EP2292306B1 (en) * 2009-09-02 2013-05-01 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for separation of racemic compound-forming chiral substances by a cyclic crystallization process and a crystallization device
EP2501674A2 (en) * 2009-11-19 2012-09-26 Ranbaxy Laboratories Limited Processes for preparation of polymorphic forms of lacosamide
KR20120101588A (ko) * 2010-01-07 2012-09-13 비버스 인크. 탄산탈수효소 억제제 및 추가적인 활성제의 조합에 의한 폐쇄 수면 무호흡 증후군의 치료
US9267159B2 (en) 2010-12-08 2016-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
JP6116847B2 (ja) * 2012-10-01 2017-04-19 アムビト バイオサイエンシス コーポレーションＡｍｂｉｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ シクロデキストリンとの混合体を含有する錠剤
US10466776B2 (en) * 2014-06-24 2019-11-05 Paypal, Inc. Surfacing related content based on user interaction with currently presented content
US10609267B2 (en) * 2014-07-23 2020-03-31 Orcam Technologies Ltd. Systems and methods for analyzing advertisement effectiveness using wearable camera systems
US20170304034A1 (en) * 2014-11-27 2017-10-26 Gc Corporation Surface treatment agent for wax pattern and method of manufacturing dental prosthesis
WO2017064723A1 (en) * 2015-10-12 2017-04-20 Natco Pharma Ltd An improved process for the preparation of armodafinil

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1905990A (en) 1931-01-02 1933-04-25 Hoffmann La Roche Disubstituted carbamic acid esters of phenols containing a basic constituent
GB1197809A (en) 1968-02-13 1970-07-08 Inst Noguchi Method for Continuous Optical Resolution of Organic Racemates.
GB1584462A (en) 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
FR2597864B1 (fr) 1986-04-28 1990-11-16 Lafon Labor Nouveaux derives de la n-((trimethoxy-2,4,6-benzoyl)-3 propyl) piperidine, leurs procedes de preparation et leur application en therapeutique
FR2626881B1 (fr) 1988-02-10 1990-07-27 Lafon Labor 1-(4-aminophenyl)-2-hexamethyleneiminopropanone, procede de preparation et utilisation en therapeutique
FR2663225B1 (fr) * 1990-06-14 1994-11-04 Lafon Labor Nouvelle utilisation du modafinil.
FR2671349B1 (fr) 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
FR2710337B1 (fr) * 1993-09-23 1995-12-08 Gerard Coquerel Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé.
US6894171B1 (en) 1998-07-20 2005-05-17 Abbott Laboratories Polymorph of a pharmaceutical
CN1249932A (zh) 1999-09-29 2000-04-12 付俊昌 一种莫达芬尼及其光学对映体l及d异构体的新用途
CA2396079A1 (en) 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
US20010036640A1 (en) 2000-04-25 2001-11-01 D'amico Kevin L. System and methods for the high throughput screening of polymorphs
US6670358B2 (en) 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
DE10025756C2 (de) * 2000-05-25 2003-02-20 Cognis Deutschland Gmbh Lösungsvermittler
AU2001283008A1 (en) * 2000-07-27 2002-02-13 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
US6835307B2 (en) * 2000-08-04 2004-12-28 Battelle Memorial Institute Thermal water treatment
US6489363B2 (en) * 2000-10-11 2002-12-03 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
US6919378B2 (en) * 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
WO2002041834A2 (en) 2000-11-03 2002-05-30 Teva Pharmaceutical Industries, Ltd. Atorvastatin hemi-calcium form vii
MXPA03010705A (es) * 2001-05-25 2004-05-27 Cephalon Inc Formulaciones farmaceuticas solidas que comprenden modafinil.
JP2005502861A (ja) 2001-08-10 2005-01-27 サイミックス テクノロジーズ， インコーポレイテッド 事前処方物を作製および試験するための装置および方法ならびにそのためのシステム
ATE329254T1 (de) 2002-01-15 2006-06-15 Avantium Int Bv Verfahren zur durchführung einer leistungsbeugungsanalyse
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US6875893B2 (en) * 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
US20040048931A1 (en) * 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
ATE366137T1 (de) 2002-08-02 2007-07-15 Avantium Int Bv Vorrichtung und verfahren zur parallelen durchführung chemischer experimente, insbesondere kristallisationsexperimente
US6992219B2 (en) * 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
JP4903385B2 (ja) 2002-12-06 2012-03-28 パーデュー・リサーチ・ファウンデーション 損傷した哺乳類神経組織を治療するためのピリジン類
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
MXPA06002507A (es) 2003-09-04 2006-06-20 Cephalon Inc Composiciones de modafinil.
US7566805B2 (en) * 2003-09-04 2009-07-28 Cephalon, Inc. Modafinil compositions
US20090018202A1 (en) * 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
CA2556106A1 (en) 2004-02-06 2005-08-25 Cephalon, Inc. Modafinil compositions
CN101039921A (zh) 2004-10-13 2007-09-19 法玛西雅厄普约翰有限责任公司 3－[5－氯－4－[(2,4－二氟苄基)氧基]－6－氧代嘧啶－1(6h)－基]－n－(2－羟乙基)－4－甲基苯甲酰胺的晶形
CA2614777C (en) * 2005-07-21 2012-04-17 Neurohealing Pharmaceuticals, Inc. Rapid onset and short term modafinil compositions and methods of use thereof
US20070293702A1 (en) * 2006-02-21 2007-12-20 Viviana Braude Novel crystalline forms of armodafinil and preparation thereof
EP2159219A3 (en) 2006-03-01 2010-12-15 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of armodafinil
CA2688430A1 (en) 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
WO2009024863A2 (en) 2007-06-26 2009-02-26 Actavis Group Ptc Ehf Process for the preparation of modafinil enantiomers
US7960586B2 (en) 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
US20090105346A1 (en) * 2007-10-02 2009-04-23 Alexandr Jegorov Novel crystalline forms of armodafinil and preparation thereof
EP1911739A3 (en) * 2007-11-05 2008-09-17 Dipharma Francis S.r.l. Crystalline form of (S)-2-phenylethylammonium (R)-diphenyl-methanesulphinyl-acetate
WO2009090663A1 (en) 2008-01-15 2009-07-23 Lupin Limited Novel crystalline polymorph of armodafinil and an improved process for preparation thereof

Also Published As

Publication number Publication date
CA2510096C (fr) 2011-02-22
EP2679578A3 (fr) 2014-03-19
EP2679576A3 (fr) 2014-02-12
EP2676952A3 (fr) 2014-02-12
CL2016002640A1 (es) 2017-03-24
US20100048719A1 (en) 2010-02-25
EP1572635B1 (fr) 2017-04-12
SI2343275T1 (sl) 2013-10-30
EG24849A (en) 2010-10-27
AU2003299349A8 (en) 2004-07-29
EP2679578A2 (fr) 2014-01-01
EA009592B1 (ru) 2008-02-28
PL377196A1 (pl) 2006-01-23
US20100022653A1 (en) 2010-01-28
US20100048720A1 (en) 2010-02-25
AU2003299349C1 (en) 2011-01-20
NO20052912D0 (no) 2005-06-15
US20060135621A1 (en) 2006-06-22
AU2003299349B2 (en) 2010-06-03
DK2343275T3 (da) 2013-07-01
CY1114291T1 (el) 2016-08-31
HK1192222A1 (zh) 2014-08-15
CN101914044A (zh) 2010-12-15
NZ571235A (en) 2010-01-29
IL169205A (en) 2013-11-28
EP2679577A2 (fr) 2014-01-01
US20090281192A1 (en) 2009-11-12
NZ540733A (en) 2008-10-31
JP2011102330A (ja) 2011-05-26
CN1751021A (zh) 2006-03-22
EP2676952A2 (fr) 2013-12-25
US8975442B2 (en) 2015-03-10
CA2510096A1 (fr) 2004-07-22
AU2010212462A1 (en) 2010-09-16
CN101654423A (zh) 2010-02-24
US9382200B2 (en) 2016-07-05
EP1572635A1 (fr) 2005-09-14
US7132570B2 (en) 2006-11-07
US20140031589A1 (en) 2014-01-30
PT2343275E (pt) 2013-07-30
CN106065007A (zh) 2016-11-02
CN100540533C (zh) 2009-09-16
NO335724B1 (no) 2015-02-02
TWI344952B (en) 2011-07-11
US20130274521A1 (en) 2013-10-17
JP4719471B2 (ja) 2011-07-06
KR20050085847A (ko) 2005-08-29
ES2575018T3 (es) 2016-06-23
EP2343275B1 (fr) 2013-04-24
US20060241320A1 (en) 2006-10-26
US20090281193A1 (en) 2009-11-12
BR0316916A (pt) 2005-10-18
JP5497680B2 (ja) 2014-05-21
CN101012189A (zh) 2007-08-08
IS7947A (is) 2005-07-19
TW200419175A (en) 2004-10-01
JP2006511588A (ja) 2006-04-06
EP2343275A2 (fr) 2011-07-13
US8729305B2 (en) 2014-05-20
AR042546A1 (es) 2005-06-22
KR101050565B1 (ko) 2011-07-19
MY142926A (en) 2011-01-31
EP2679577A3 (fr) 2014-02-12
BRPI0316916A8 (pt) 2015-09-22
EP2679578B1 (fr) 2016-03-09
FR2849029B1 (fr) 2005-03-18
CN101012189B (zh) 2013-03-13
ES2627808T3 (es) 2017-07-31
EA200501016A1 (ru) 2005-12-29
FR2849029A1 (fr) 2004-06-25
ES2425023T3 (es) 2013-10-10
ZA200504805B (en) 2006-07-26
HK1225371A1 (zh) 2017-09-08
UA100964C2 (ru) 2013-02-25
EP2343275A3 (fr) 2011-08-17
CA2724305A1 (fr) 2004-07-22
AU2003299349A1 (en) 2004-07-29
CL2007002450A1 (es) 2009-01-16
US20100048718A1 (en) 2010-02-25
EP2679576A2 (fr) 2014-01-01
MXPA05006525A (es) 2005-12-05
WO2004060858A1 (fr) 2004-07-22

Similar Documents

Publication Publication Date Title
NO20052912L (no) Metode for fremstilling av krystallinske former for optiske enantiomerer av modafinil
DE60316688D1 (de) Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon
EA200900536A1 (ru) Способ получения хиральных 8-(3-аминопиперидин-1-ил) ксантинов
NO20054614L (no) Fremgangsmate til fremstilling av 68Ga
ATE417036T1 (de) Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen
ATE515496T1 (de) Verfahren zur herstellung von enantiomerenangereicherter indolin-2-carbonsäure
EA200600485A1 (ru) Способ получения производных 2-оксо-1-пирролидина
DE60326341D1 (de) Verfahren zur herstellung von anthranilsäurederivat-hydrat
EA200602169A1 (ru) Способ получения производных 2-оксо-1-пирролидина внутримолекулярным аллилированием
ATE445601T1 (de) Verfahren zur herstellung von carvedilol und seinen enantiomeren
ATE526312T1 (de) Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitoren
ATE291006T1 (de) Verfahren zur herstellung von salbutamolisomeren
BRPI0513881A (pt) processo para a preparação de compostos opticamente ativos
ATE469149T1 (de) Verfahren zur herstellung von cabergolin
WO2006034812A3 (de) Verfahren zur herstellung von optisch aktiven 2-methylalkan-1-ols aus dem entsprechenden 2-methylalk-2-en-1-al, umfassend eine carbonylselektive reduktion, eine enantioselektive hydrierung und eine lipase-katalysierte, stereoselektive acylierung zwecks anreicherung des gewünschten enatiomers
DE60015563D1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
ATE297933T1 (de) Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil
ATE549315T1 (de) Verfahren zur herstellung von kristallinem perindopril
MX2007011274A (es) Procesos y metodos para la preparacion de cis-2-hidroximetil-4-(ci tosin-1-il)-1,3-oxatiolano opticamente activas o sales aceptables farmaceuticamente del mismo.
DE50307171D1 (de) Verfahren zur herstellung von 3-amidinophenylalanin-derivaten
ATE370950T1 (de) Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol
ATE318815T1 (de) Verfahren zur herstellung von enantiomeren von indol-2,3-dion-3-oximderivaten
ATE502045T1 (de) Verfahren zur herstellung von perindoprilerbumin
ATE496038T1 (de) Verfahren zur herstellung von quetiapin
ATE375355T1 (de) Verfahren zur herstellung von cefpodoxim-proxetil

Legal Events

Date Code Title Description
MK1K Patent expired