FR2849029B1 - Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. - Google Patents

Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.

Info

Publication number
FR2849029B1
FR2849029B1 FR0216412A FR0216412A FR2849029B1 FR 2849029 B1 FR2849029 B1 FR 2849029B1 FR 0216412 A FR0216412 A FR 0216412A FR 0216412 A FR0216412 A FR 0216412A FR 2849029 B1 FR2849029 B1 FR 2849029B1
Authority
FR
France
Prior art keywords
enantiomer
ray diffraction
diffraction pattern
interplanar spacings
maxima corresponding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0216412A
Other languages
English (en)
French (fr)
Other versions
FR2849029A1 (fr
Inventor
Olivier Neckebrock
Laurent Courvoisier
Stephanie Graf
Gilles Serrure
Gerard Coquerel
Sebastien Rose
Christine Besselievre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Sante SAS
Original Assignee
Organisation de Synthese Mondiale Orsymonde SA
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32406320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2849029(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organisation de Synthese Mondiale Orsymonde SA, Laboratoire L Lafon SA filed Critical Organisation de Synthese Mondiale Orsymonde SA
Priority to FR0216412A priority Critical patent/FR2849029B1/fr
Priority to CN200910152177A priority patent/CN101654423A/zh
Priority to EP13177648.6A priority patent/EP2679576A3/fr
Priority to ES03799631.1T priority patent/ES2627808T3/es
Priority to CA2510096A priority patent/CA2510096C/fr
Priority to CA2724305A priority patent/CA2724305A1/fr
Priority to PCT/FR2003/003799 priority patent/WO2004060858A1/fr
Priority to PL377196A priority patent/PL377196A1/pl
Priority to MXPA05006525A priority patent/MXPA05006525A/es
Priority to UAA200507106A priority patent/UA100964C2/ru
Priority to CN2010101503175A priority patent/CN101914044A/zh
Priority to KR1020057011619A priority patent/KR101050565B1/ko
Priority to SI200332281T priority patent/SI2343275T1/sl
Priority to EP13177660.1A priority patent/EP2679578B1/fr
Priority to NZ540733A priority patent/NZ540733A/en
Priority to EP11163602.3A priority patent/EP2343275B1/fr
Priority to DK11163602.3T priority patent/DK2343275T3/da
Priority to EP13177658.5A priority patent/EP2679577A3/fr
Priority to EP13177661.9A priority patent/EP2676952A3/fr
Priority to ES11163602T priority patent/ES2425023T3/es
Priority to JP2004564285A priority patent/JP4719471B2/ja
Priority to AU2003299349A priority patent/AU2003299349C1/en
Priority to EA200501016A priority patent/EA009592B1/ru
Priority to PT111636023T priority patent/PT2343275E/pt
Priority to BRPI0316916-2A priority patent/BRPI0316916B1/pt
Priority to US10/539,918 priority patent/US7132570B2/en
Priority to NZ571235A priority patent/NZ571235A/en
Priority to ES13177660.1T priority patent/ES2575018T3/es
Priority to CNB2003801098134A priority patent/CN100540533C/zh
Priority to CN201610461501.9A priority patent/CN106065007A/zh
Priority to CN2007100017638A priority patent/CN101012189B/zh
Priority to EP03799631.1A priority patent/EP1572635B1/fr
Priority to ARP030104730A priority patent/AR042546A1/es
Priority to TW092136443A priority patent/TWI344952B/zh
Priority to MYPI20034935A priority patent/MY142926A/en
Publication of FR2849029A1 publication Critical patent/FR2849029A1/fr
Application granted granted Critical
Publication of FR2849029B1 publication Critical patent/FR2849029B1/fr
Priority to ZA200504805A priority patent/ZA200504805B/en
Priority to NO20052912A priority patent/NO335724B1/no
Priority to IL169205A priority patent/IL169205A/en
Priority to EGNA2005000326 priority patent/EG24849A/xx
Priority to IS7947A priority patent/IS7947A/is
Priority to HK11112662.9A priority patent/HK1158171A1/xx
Priority to US11/474,859 priority patent/US20060241320A1/en
Priority to CL2007002450A priority patent/CL2007002450A1/es
Priority to US12/507,594 priority patent/US20090281192A1/en
Priority to US12/507,610 priority patent/US20100048719A1/en
Priority to US12/507,602 priority patent/US20100048718A1/en
Priority to US12/507,584 priority patent/US9382200B2/en
Priority to US12/507,631 priority patent/US20100048720A1/en
Priority to US12/507,623 priority patent/US20090281193A1/en
Priority to AU2010212462A priority patent/AU2010212462A1/en
Priority to JP2011032155A priority patent/JP5497680B2/ja
Priority to US13/858,483 priority patent/US8729305B2/en
Priority to CY20131100573T priority patent/CY1114291T1/el
Priority to US14/012,363 priority patent/US8975442B2/en
Priority to HK14105599.8A priority patent/HK1192222A1/zh
Priority to CL2016002640A priority patent/CL2016002640A1/es
Priority to HK16113750A priority patent/HK1225371A1/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0216412A 2002-12-20 2002-12-20 Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. Expired - Fee Related FR2849029B1 (fr)

Priority Applications (57)

Application Number Priority Date Filing Date Title
FR0216412A FR2849029B1 (fr) 2002-12-20 2002-12-20 Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
CN200910152177A CN101654423A (zh) 2002-12-20 2003-12-18 莫达非尼旋光对映异构体的晶形及其制备方法
EP13177648.6A EP2679576A3 (fr) 2002-12-20 2003-12-18 Procédé de préparation de formes cristallines des énantiomeres optiques du modafinil et leur composition pharmaceutique
ES03799631.1T ES2627808T3 (es) 2002-12-20 2003-12-18 Método para la producción de formas cristalinas y formas cristalinas de Enantiomeros ópticos de modafinil
CA2510096A CA2510096C (fr) 2002-12-20 2003-12-18 Procede de preparation et formes cristallines des enantiomeres optiques du modafinil
CA2724305A CA2724305A1 (fr) 2002-12-20 2003-12-18 Procede de preparation et formes cristallines des enantiomeres optiques du modafinil
PCT/FR2003/003799 WO2004060858A1 (fr) 2002-12-20 2003-12-18 Procede de preparation et formes cristallines des enantiomeres optiques du modafinil
PL377196A PL377196A1 (pl) 2002-12-20 2003-12-18 Sposób przygotowania i postacie krystaliczne enancjomerów optycznych modafinilu
MXPA05006525A MXPA05006525A (es) 2002-12-20 2003-12-18 Procedimiento de preparacion de formas cristalinas de enantiomeros opticos de modafinil.
UAA200507106A UA100964C2 (ru) 2002-12-20 2003-12-18 Способ получения кристаллических форм и кристаллические формы оптических энантиомеров модафинила
CN2010101503175A CN101914044A (zh) 2002-12-20 2003-12-18 莫达非尼旋光对映异构体的晶形及其制备方法
KR1020057011619A KR101050565B1 (ko) 2002-12-20 2003-12-18 모다피닐의 광학 거울상 이성질체들의 결정체 형태 및결정체 형태의 제조방법
SI200332281T SI2343275T1 (sl) 2002-12-20 2003-12-18 Kristaliniäśna oblika optiäśnih enantiomerov modafinila
EP13177660.1A EP2679578B1 (fr) 2002-12-20 2003-12-18 Procédé de préparation et une forme cristalline des énantiomères optiques du modafinil
NZ540733A NZ540733A (en) 2002-12-20 2003-12-18 Method for the production of crystalline forms and crystalline forms of optical enantiomers of modafinil
EP11163602.3A EP2343275B1 (fr) 2002-12-20 2003-12-18 Forme cristalline des énantiomères optiques du modafinil.
DK11163602.3T DK2343275T3 (da) 2002-12-20 2003-12-18 Krystallinsk form af optiske enantiomerer af modafinil
EP13177658.5A EP2679577A3 (fr) 2002-12-20 2003-12-18 Procédé de préparation de formes cristallines des énantiomeres optiques du modafinil et leur composition pharmaceutique
EP13177661.9A EP2676952A3 (fr) 2002-12-20 2003-12-18 Procédé de préparation et formes cristallines IV des énantiomères optiques du modafinil
ES11163602T ES2425023T3 (es) 2002-12-20 2003-12-18 Forma cristalina de los enantiómeros ópticos de modafinilo
JP2004564285A JP4719471B2 (ja) 2002-12-20 2003-12-18 モダフィニルの光学異性体の調製方法及び結晶形
AU2003299349A AU2003299349C1 (en) 2002-12-20 2003-12-18 Method for the production of crystalline forms and crystalline forms of optical enantiomers of modafinil
EA200501016A EA009592B1 (ru) 2002-12-20 2003-12-18 Способ получения кристаллических форм и кристаллические формы оптических энантиомеров модафинила
PT111636023T PT2343275E (pt) 2002-12-20 2003-12-18 Forma cristalina dos enantiómeros ópticos de modafinil
BRPI0316916-2A BRPI0316916B1 (pt) 2002-12-20 2003-12-18 Processo para a preparação de formas cristalinas polimórficas de enantiômeros óticos levógiro de modafinila
US10/539,918 US7132570B2 (en) 2002-12-20 2003-12-18 Method for the production of crystalline forms and crystalline forms of optical enantiomers of modafinil
NZ571235A NZ571235A (en) 2002-12-20 2003-12-18 Process for the preparation of optically active 2-benzhydrylsulfinylacetamide
ES13177660.1T ES2575018T3 (es) 2002-12-20 2003-12-18 Forma cristalina de los enantiómeros ópticos de modafinilo
CNB2003801098134A CN100540533C (zh) 2002-12-20 2003-12-18 莫达非尼旋光对映异构体的晶形及其制备方法
CN201610461501.9A CN106065007A (zh) 2002-12-20 2003-12-18 莫达非尼旋光对映异构体的晶形及其制备方法
CN2007100017638A CN101012189B (zh) 2002-12-20 2003-12-18 莫达非尼旋光对映异构体的晶形及其制备方法
EP03799631.1A EP1572635B1 (fr) 2002-12-20 2003-12-18 Procede de preparation et formes cristallines des enantiomeres optiques du modafinil
ARP030104730A AR042546A1 (es) 2002-12-20 2003-12-19 Procedimiento de preparacion y formas cristalinas de los enantiomeros de modafinil, composiciones farmaceuticas y medicamentos que los contienen
TW092136443A TWI344952B (en) 2002-12-20 2003-12-22 Process for the preparation of and crystalline forms of optical enantiomers of modafinil
MYPI20034935A MY142926A (en) 2002-12-20 2003-12-22 Method of the production of crystalline forms and crystalline forms of optical enantiomers of modafinil
ZA200504805A ZA200504805B (en) 2002-12-20 2005-06-13 Method for the procution of crystalline forms and crystalline forms of optical enantiomers of modafinil
NO20052912A NO335724B1 (no) 2002-12-20 2005-06-15 Krystallinske former av optiske enantiomerer av modafinil, farmasøytiske blandinger omfattende slike, fremgangsmåte for fremstilling av slike samt deres anvendelse
IL169205A IL169205A (en) 2002-12-20 2005-06-16 Polymorphically modulating abortifacient enantiomer, (i) form (i) of (-) - modafinil, pharmaceutical preparation and process for the preparation of (-) form (i) - modafinil polymorph
EGNA2005000326 EG24849A (en) 2002-12-20 2005-06-19 Method for the production of crystalline forms andcrystalline forms of optical enantiomers of modaf inil
IS7947A IS7947A (is) 2002-12-20 2005-07-19 Aðferð til að framleiða kristölluð form ljósfræðilegra handhverfa módafíníls
HK11112662.9A HK1158171A1 (en) 2002-12-20 2005-12-15 Crystalline form of the optical enantiomers of modafinil
US11/474,859 US20060241320A1 (en) 2002-12-20 2006-06-26 Process for the preparation of and crystalline forms of optical enantiomers of modafinil
CL2007002450A CL2007002450A1 (es) 2002-12-20 2007-08-22 Forma polimorfica i del enantiomero levogiro o dextrogiro de modafinilo; su procedimiento de preparacion; y composicion farmaceutica que los comprende (divisional solicitud 2693-03).
US12/507,594 US20090281192A1 (en) 2002-12-20 2009-07-22 Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
US12/507,610 US20100048719A1 (en) 2002-12-20 2009-07-22 Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
US12/507,602 US20100048718A1 (en) 2002-12-20 2009-07-22 Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
US12/507,584 US9382200B2 (en) 2002-12-20 2009-07-22 Process for the preparation of and crystalline forms of optical enantiomers of modafinil
US12/507,631 US20100048720A1 (en) 2002-12-20 2009-07-22 Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
US12/507,623 US20090281193A1 (en) 2002-12-20 2009-07-22 Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
AU2010212462A AU2010212462A1 (en) 2002-12-20 2010-08-20 Method for the production of crystalline forms and crystalline forms of optical enantiomers of modafinil
JP2011032155A JP5497680B2 (ja) 2002-12-20 2011-02-17 モダフィニルの異性体の調製方法及び結晶形
US13/858,483 US8729305B2 (en) 2002-12-20 2013-04-08 Process for the preparation of and crystalline forms of optical enantiomers of modafinil
CY20131100573T CY1114291T1 (el) 2002-12-20 2013-07-08 Κρυσταλλικη μορφη των οπτικων εναντιομερων της μοδαφινιλης
US14/012,363 US8975442B2 (en) 2002-12-20 2013-08-28 Process for the preparation of and crystalline forms of optical enantiomers of modafinil
HK14105599.8A HK1192222A1 (zh) 2002-12-20 2014-06-13 莫達非尼光學對映異構體的晶形及其製備方法
CL2016002640A CL2016002640A1 (es) 2002-12-20 2016-10-17 Procedimiento de preparación y formas cristalinas de los enantiómeros ópticos de modafinilo (divisional solicitud de origen 2693-2003).
HK16113750A HK1225371A1 (zh) 2002-12-20 2016-12-01 莫達非尼旋光對映異構體的晶形及其製備方法

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US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US8492423B2 (en) 2002-12-30 2013-07-23 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions

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