AR030938A1 - Proceso de obtencion de los enantiomeros de la cetamina racemica; proceso de obtencion de sales farmaceuticamente aceptables de enantiomeros de la cetamina racemica y utilizacion de las sales farmaceuticamente aceptables obtenidas por el referido proceso - Google Patents

Proceso de obtencion de los enantiomeros de la cetamina racemica; proceso de obtencion de sales farmaceuticamente aceptables de enantiomeros de la cetamina racemica y utilizacion de las sales farmaceuticamente aceptables obtenidas por el referido proceso

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Publication number
AR030938A1
AR030938A1 ARP010102913A ARP010102913A AR030938A1 AR 030938 A1 AR030938 A1 AR 030938A1 AR P010102913 A ARP010102913 A AR P010102913A AR P010102913 A ARP010102913 A AR P010102913A AR 030938 A1 AR030938 A1 AR 030938A1
Authority
AR
Argentina
Prior art keywords
pharmaceutically acceptable
obtaining
acceptable salts
racemic
ketamine
Prior art date
Application number
ARP010102913A
Other languages
English (en)
Inventor
Russo Valter Freire Torres
De Souza Russo Elisa Mannochio
Original Assignee
Cristalia Prod Quimicos Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cristalia Prod Quimicos Farm filed Critical Cristalia Prod Quimicos Farm
Publication of AR030938A1 publication Critical patent/AR030938A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente describe un proceso de obtencion de los enantiomeros de la cetamina, a partir de la resolucion de la cetamina racémica con auxilio de un agente de resolucion asimétrico, que proporciona la cristalizacion selectiva de sus enantiomeros. El agente de resolucion es empleado en condiciones especiales de concentracion que confieren estabilidad, reproductibilidad y elevada pureza enantiomérica a la sal diastereoisomera precipitada, haciendo viable la produccion industrial de la S-cetamina y sus sales farmacéuticamente aceptables. La cetamina es (R,S)-2-(2-clorofenil)-2-metilamino ciclohexanona.
ARP010102913A 2000-06-19 2001-06-19 Proceso de obtencion de los enantiomeros de la cetamina racemica; proceso de obtencion de sales farmaceuticamente aceptables de enantiomeros de la cetamina racemica y utilizacion de las sales farmaceuticamente aceptables obtenidas por el referido proceso AR030938A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0002693A BRPI0002693B8 (pt) 2000-06-19 2000-06-19 processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis

Publications (1)

Publication Number Publication Date
AR030938A1 true AR030938A1 (es) 2003-09-03

Family

ID=37515961

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102913A AR030938A1 (es) 2000-06-19 2001-06-19 Proceso de obtencion de los enantiomeros de la cetamina racemica; proceso de obtencion de sales farmaceuticamente aceptables de enantiomeros de la cetamina racemica y utilizacion de las sales farmaceuticamente aceptables obtenidas por el referido proceso

Country Status (11)

Country Link
US (1) US6743949B2 (es)
EP (1) EP1294659B1 (es)
AR (1) AR030938A1 (es)
AT (1) ATE378307T1 (es)
AU (1) AU7374401A (es)
BR (1) BRPI0002693B8 (es)
DE (1) DE60131397T2 (es)
DK (1) DK1294659T3 (es)
ES (1) ES2296757T3 (es)
PT (1) PT1294659E (es)
WO (1) WO2001098265A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063802A1 (en) 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US9072662B2 (en) 2004-03-29 2015-07-07 Auris Medical Ag Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US8268866B2 (en) 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US20090246255A1 (en) 2005-09-28 2009-10-01 Thomas Meyer Pharmaceutical Compositions for the Treatment of Inner Ear Disorders
US8808263B2 (en) * 2010-01-14 2014-08-19 The Procter & Gamble Company Article of commerce including two-piece wearable absorbent article
BRPI1003620A2 (pt) 2010-09-03 2012-06-05 Ouro Fino Participacoes E Empreendimentos S A associação anestésica, composição anestésica, e, medicamento anestésico de uso veterinário
US20150044200A1 (en) 2011-12-12 2015-02-12 Otolanum Ag Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system
US9872841B2 (en) 2013-09-13 2018-01-23 National University Corporation Chiba University Application of R-ketamine and salt thereof as pharmaceuticals
US20160332962A1 (en) * 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
CN111936127A (zh) 2018-02-15 2020-11-13 国立大学法人千叶大学 炎症性疾病或骨病的预防或治疗剂及医药组合物
CN110218157B (zh) * 2018-03-01 2022-08-23 江苏恒瑞医药股份有限公司 一种r-氯胺酮及其可药用盐的制备方法
MX2020011653A (es) 2018-05-04 2021-02-09 Perception Neuroscience Inc Métodos de tratamiento para el abuso de sustancias.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH535201A (de) * 1969-12-19 1973-03-31 Bristol Myers Co Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren
CA2202911A1 (en) * 1994-10-17 1996-04-25 Cor Peter Mathilde Gerard A'campo Process for separating enantiomers from a racemic mixture
DE19619665C2 (de) * 1996-05-15 2001-03-08 Goedecke Ag Racemattrennung von Ketamin

Also Published As

Publication number Publication date
BR0002693B1 (pt) 2013-12-24
EP1294659A4 (en) 2005-06-22
ES2296757T3 (es) 2008-05-01
ATE378307T1 (de) 2007-11-15
PT1294659E (pt) 2008-02-19
DE60131397D1 (de) 2007-12-27
WO2001098265A3 (en) 2002-08-15
WO2001098265B1 (en) 2002-10-24
WO2001098265A2 (en) 2001-12-27
DK1294659T3 (da) 2008-03-17
EP1294659A2 (en) 2003-03-26
BRPI0002693B8 (pt) 2021-05-25
EP1294659B1 (en) 2007-11-14
AU7374401A (en) 2002-01-02
DE60131397T2 (de) 2008-09-18
US20030212143A1 (en) 2003-11-13
BR0002693A (pt) 2004-07-06
US6743949B2 (en) 2004-06-01

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