CO5590910A2 - Metodo para la preparacion del escitalopram - Google Patents
Metodo para la preparacion del escitalopramInfo
- Publication number
- CO5590910A2 CO5590910A2 CO04067002A CO04067002A CO5590910A2 CO 5590910 A2 CO5590910 A2 CO 5590910A2 CO 04067002 A CO04067002 A CO 04067002A CO 04067002 A CO04067002 A CO 04067002A CO 5590910 A2 CO5590910 A2 CO 5590910A2
- Authority
- CO
- Colombia
- Prior art keywords
- compound
- group
- following formula
- formula
- escitalopram
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Amplifiers (AREA)
Abstract
1.- Un método para la preparación del escitalopram que tiene la siguiente Fórmula: que comprende:a).- la resolución óptica del compuesto racémico que tiene la siguiente Fórmula: En la cual X es como definido anteriormente y Z es OH o un grupo saliente, mediante la cristalización fraccionada de una sal diastereomérica del mismo, o por formación y separación de los ésteres diasteroméricos del mismo opcionalmente seguido por hidrólisis del éster diasteromérico correcto, de manera de formar un compuesto de la siguiente Fórmula: en la cual X es como anteriormente definido y Z es OH o un grupo saliente, y cuando Z es OH, mediante la conversión de Z en un grupo saliente, seguido por cierre de anillo del compuesto de la Fórmula (III) de manera de formar un compuesto de la Fórmula: (ll) en la cual X es halógeno o cualquier otro grupo que puede ser convertido en un grupo ciano, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101881 | 2001-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5590910A2 true CO5590910A2 (es) | 2005-12-30 |
Family
ID=34072369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04067002A CO5590910A2 (es) | 2001-12-14 | 2004-07-14 | Metodo para la preparacion del escitalopram |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20050154051A1 (es) |
| EP (1) | EP1458701A1 (es) |
| JP (1) | JP2005513069A (es) |
| KR (1) | KR20040073463A (es) |
| CN (1) | CN1602305A (es) |
| AR (1) | AR037795A1 (es) |
| AU (1) | AU2002351726A1 (es) |
| BR (1) | BR0214327A (es) |
| CA (1) | CA2470225A1 (es) |
| CO (1) | CO5590910A2 (es) |
| EA (1) | EA200400809A1 (es) |
| HR (1) | HRP20040390A2 (es) |
| HU (1) | HUP0402252A3 (es) |
| IL (1) | IL161714A0 (es) |
| IS (1) | IS7239A (es) |
| MX (1) | MXPA04005766A (es) |
| NO (1) | NO20042667L (es) |
| PL (1) | PL368986A1 (es) |
| RS (1) | RS50704A (es) |
| TW (1) | TW200409625A (es) |
| WO (1) | WO2003051861A1 (es) |
| ZA (1) | ZA200403432B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20040991A1 (es) | 2002-08-12 | 2004-12-27 | Lundbeck & Co As H | Separacion de intermediarios para la preparacion de escitalopram |
| ES2228274B1 (es) * | 2003-09-24 | 2006-06-01 | Astur Pharma, S.A. | Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram. |
| WO2005047274A1 (en) * | 2003-11-12 | 2005-05-26 | Dr. Reddy's Laboratories, Inc. | Preparation of escitalopram |
| CN100569765C (zh) * | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| ITMI20040717A1 (it) | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| JP2006008603A (ja) * | 2004-06-25 | 2006-01-12 | Sumitomo Chemical Co Ltd | 光学活性シタロプラムの製造方法、その中間体およびその製造方法 |
| US7989645B2 (en) | 2004-08-23 | 2011-08-02 | Sun Pharma Global Fze | Process for preparation of citalopram and enantiomers |
| US7790935B2 (en) | 2004-08-23 | 2010-09-07 | Sun Pharma Global Fze | Process for preparation of citalopram and enantiomers |
| WO2006025071A1 (en) * | 2004-09-02 | 2006-03-09 | Natco Pharma Limited | A process for the preparation of escitalopram |
| WO2006106531A1 (en) * | 2005-04-04 | 2006-10-12 | Jubilant Organosys Ltd | Process for the preparation of escitalopram or its acid addition salts |
| US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| TWI358407B (en) | 2005-06-22 | 2012-02-21 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersibl |
| EP1987016A1 (en) * | 2005-07-27 | 2008-11-05 | Aurobindo Pharma Limited | An improved process for the preparation of escitalopram |
| EA200801081A1 (ru) | 2005-10-14 | 2008-10-30 | Х. Лундбекк А/С | Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона |
| EP2017271A1 (en) | 2007-07-06 | 2009-01-21 | Aurobindo Pharma Limited | Process for the preparation of escitalopram |
| US8022232B2 (en) | 2007-09-11 | 2011-09-20 | H. Lundbeck A/S | Method for manufacture of escitalopram |
| NZ570884A (en) * | 2007-09-11 | 2010-03-26 | Lundbeck & Co As H | Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| JP3813820B2 (ja) * | 1997-11-11 | 2006-08-23 | ハー・ルンドベック・アクチエゼルスカベット | シタロプラムの製造方法 |
| WO2000023431A1 (en) * | 1998-10-20 | 2000-04-27 | H. Lundbeck A/S | Method for the preparation of citalopram |
| CN1142926C (zh) * | 1999-04-14 | 2004-03-24 | H·隆德贝克有限公司 | 制备西酞普兰的方法 |
| IT1319686B1 (it) * | 2000-12-12 | 2003-10-23 | C D Farmasint S R L | Procedimento di preparazione di citalopram. |
| ES2234797T3 (es) * | 2001-08-02 | 2005-07-01 | Infosint Sa | Procedimiento para la preparacion de citalopram partiendo de 5-formilftalida. |
-
2002
- 2002-04-29 IS IS7239A patent/IS7239A/is unknown
- 2002-12-06 TW TW091135380A patent/TW200409625A/zh unknown
- 2002-12-09 EA EA200400809A patent/EA200400809A1/ru unknown
- 2002-12-09 IL IL16171402A patent/IL161714A0/xx unknown
- 2002-12-09 CN CNA028248880A patent/CN1602305A/zh active Pending
- 2002-12-09 CA CA002470225A patent/CA2470225A1/en not_active Abandoned
- 2002-12-09 PL PL02368986A patent/PL368986A1/xx not_active Application Discontinuation
- 2002-12-09 RS YUP-507/04A patent/RS50704A/sr unknown
- 2002-12-09 BR BR0214327-5A patent/BR0214327A/pt not_active IP Right Cessation
- 2002-12-09 JP JP2003552745A patent/JP2005513069A/ja active Pending
- 2002-12-09 MX MXPA04005766A patent/MXPA04005766A/es not_active Application Discontinuation
- 2002-12-09 EP EP02787443A patent/EP1458701A1/en not_active Withdrawn
- 2002-12-09 WO PCT/DK2002/000837 patent/WO2003051861A1/en not_active Application Discontinuation
- 2002-12-09 US US10/498,747 patent/US20050154051A1/en not_active Abandoned
- 2002-12-09 KR KR10-2004-7008809A patent/KR20040073463A/ko not_active Application Discontinuation
- 2002-12-09 HU HU0402252A patent/HUP0402252A3/hu unknown
- 2002-12-09 AU AU2002351726A patent/AU2002351726A1/en not_active Abandoned
- 2002-12-11 AR ARP020104803A patent/AR037795A1/es not_active Application Discontinuation
-
2004
- 2004-05-04 HR HR20040390A patent/HRP20040390A2/hr not_active Application Discontinuation
- 2004-05-06 ZA ZA200403432A patent/ZA200403432B/xx unknown
- 2004-06-24 NO NO20042667A patent/NO20042667L/no not_active Application Discontinuation
- 2004-07-14 CO CO04067002A patent/CO5590910A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200403432B (en) | 2005-05-06 |
| EP1458701A1 (en) | 2004-09-22 |
| WO2003051861A1 (en) | 2003-06-26 |
| IS7239A (is) | 2004-04-29 |
| NO20042667L (no) | 2004-06-24 |
| HUP0402252A3 (en) | 2007-05-29 |
| RS50704A (en) | 2007-02-05 |
| TW200409625A (en) | 2004-06-16 |
| EA200400809A1 (ru) | 2004-12-30 |
| BR0214327A (pt) | 2004-11-03 |
| IL161714A0 (en) | 2004-09-27 |
| JP2005513069A (ja) | 2005-05-12 |
| HUP0402252A2 (hu) | 2005-02-28 |
| MXPA04005766A (es) | 2004-09-10 |
| PL368986A1 (en) | 2005-04-04 |
| HRP20040390A2 (en) | 2004-08-31 |
| AU2002351726A1 (en) | 2003-06-30 |
| CN1602305A (zh) | 2005-03-30 |
| CA2470225A1 (en) | 2003-06-26 |
| US20050154051A1 (en) | 2005-07-14 |
| KR20040073463A (ko) | 2004-08-19 |
| AR037795A1 (es) | 2004-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |