RS50704A - Method for the preparation of escitalopram - Google Patents

Method for the preparation of escitalopram

Info

Publication number
RS50704A
RS50704A YUP-507/04A YUP50704A RS50704A RS 50704 A RS50704 A RS 50704A YU P50704 A YUP50704 A YU P50704A RS 50704 A RS50704 A RS 50704A
Authority
RS
Serbia
Prior art keywords
preparation
escitalopram
intermediates
cyanation
formulas
Prior art date
Application number
YUP-507/04A
Other languages
English (en)
Inventor
Haleh Ahmadian
Hans Petersen
Original Assignee
H.Lundbeck A/S.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S., filed Critical H.Lundbeck A/S.,
Publication of RS50704A publication Critical patent/RS50704A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Amplifiers (AREA)

Abstract

Pronalazak se odnosi na postupak za pripremanje escitalorpama cijanizacijom optički aktivnih intermedijarnih proizvoda sa donjim formulama (III) i (II), i pripremanje takvih intermedijarnih proizvoda putem optičkog razdvajanja.
YUP-507/04A 2001-12-14 2002-12-09 Method for the preparation of escitalopram RS50704A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34045001P 2001-12-14 2001-12-14
DKPA200101881 2001-12-14
PCT/DK2002/000837 WO2003051861A1 (en) 2001-12-14 2002-12-09 Method for the preparation of escitalopram

Publications (1)

Publication Number Publication Date
RS50704A true RS50704A (en) 2007-02-05

Family

ID=34072369

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-507/04A RS50704A (en) 2001-12-14 2002-12-09 Method for the preparation of escitalopram

Country Status (22)

Country Link
US (1) US20050154051A1 (sr)
EP (1) EP1458701A1 (sr)
JP (1) JP2005513069A (sr)
KR (1) KR20040073463A (sr)
CN (1) CN1602305A (sr)
AR (1) AR037795A1 (sr)
AU (1) AU2002351726A1 (sr)
BR (1) BR0214327A (sr)
CA (1) CA2470225A1 (sr)
CO (1) CO5590910A2 (sr)
EA (1) EA200400809A1 (sr)
HR (1) HRP20040390A2 (sr)
HU (1) HUP0402252A3 (sr)
IL (1) IL161714A0 (sr)
IS (1) IS7239A (sr)
MX (1) MXPA04005766A (sr)
NO (1) NO20042667L (sr)
PL (1) PL368986A1 (sr)
RS (1) RS50704A (sr)
TW (1) TW200409625A (sr)
WO (1) WO2003051861A1 (sr)
ZA (1) ZA200403432B (sr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
ES2228274B1 (es) * 2003-09-24 2006-06-01 Astur Pharma, S.A. Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram.
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
EP2141156A1 (en) 2004-08-23 2010-01-06 Sun Pharma Global FZE Process for Preparation of Citalopram and Enantiomers
US7989645B2 (en) 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
WO2006025071A1 (en) * 2004-09-02 2006-03-09 Natco Pharma Limited A process for the preparation of escitalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
WO2007012954A1 (en) * 2005-07-27 2007-02-01 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
WO2007053796A2 (en) 2005-10-14 2007-05-10 Forest Laboratories, Inc. Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
FI121570B (fi) * 2007-09-11 2011-01-14 Lundbeck & Co As H Menetelmä essitalopraamin valmistamiseksi
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JP3813820B2 (ja) * 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
EP1123284B1 (en) * 1998-10-20 2003-01-08 H. Lundbeck A/S Method for the preparation of citalopram
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
DK1281707T3 (da) * 2001-08-02 2005-05-02 Infosint Sa Fremgangsmåde til fremstilling af 5-substituerede isobenzenfuraner

Also Published As

Publication number Publication date
TW200409625A (en) 2004-06-16
IS7239A (is) 2004-04-29
HRP20040390A2 (en) 2004-08-31
PL368986A1 (en) 2005-04-04
CN1602305A (zh) 2005-03-30
CO5590910A2 (es) 2005-12-30
WO2003051861A1 (en) 2003-06-26
US20050154051A1 (en) 2005-07-14
EP1458701A1 (en) 2004-09-22
KR20040073463A (ko) 2004-08-19
IL161714A0 (en) 2004-09-27
ZA200403432B (en) 2005-05-06
JP2005513069A (ja) 2005-05-12
BR0214327A (pt) 2004-11-03
HUP0402252A2 (hu) 2005-02-28
NO20042667L (no) 2004-06-24
AR037795A1 (es) 2004-12-01
MXPA04005766A (es) 2004-09-10
AU2002351726A1 (en) 2003-06-30
CA2470225A1 (en) 2003-06-26
HUP0402252A3 (en) 2007-05-29
EA200400809A1 (ru) 2004-12-30

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