ES2149141T3 - Metodo para la preparacion de citalopram. - Google Patents

Metodo para la preparacion de citalopram.

Info

Publication number
ES2149141T3
ES2149141T3 ES97945798T ES97945798T ES2149141T3 ES 2149141 T3 ES2149141 T3 ES 2149141T3 ES 97945798 T ES97945798 T ES 97945798T ES 97945798 T ES97945798 T ES 97945798T ES 2149141 T3 ES2149141 T3 ES 2149141T3
Authority
ES
Spain
Prior art keywords
compound
formula
citalopram
alkyl
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97945798T
Other languages
English (en)
Other versions
ES2149141T1 (es
ES2149141T4 (es
Inventor
Hans Petersen
Klaus Peter Bogeso
Sommer Michael Bech
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37709809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2149141(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2149141T1 publication Critical patent/ES2149141T1/es
Publication of ES2149141T3 publication Critical patent/ES2149141T3/es
Application granted granted Critical
Publication of ES2149141T4 publication Critical patent/ES2149141T4/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un método para la preparación de citalopram, que comprende las etapas de: a) reducir un compuesto de **fórmula** en la que R1 es CN, alquil C1-6-oxicarbonilo o alquil C1-6-aminocarbonilo; b) efectuar el cierre del compuesto resultante de **fórmula** en la que R1 se define como antes, obteniéndose un compuesto de **fórmula** en la que R1 se define como antes, c) después, si R1 es ciano, utilizar el compuesto de **fórmula** directamente en la siguiente etapa y si R1 es alquil C1-6-oxicarbonilo, o alquil C1-6-aminocarbonilo, convertir el compuesto de **fórmula** en el compuesto correspondiente, en el que R1 es ciano; y d) alquilar el compuesto 5-ciano resultante de **fórmula** (R1=CN) con halogenuro de 3-dimetilaminopropilo en condiciones básicas, por lo cual se obtiene citalopram, que se aísla como la base o como una de sus sales farmacéuticamente aceptables.
ES97945798T 1997-11-10 1997-11-10 Metodo para la preparacion de citalopram. Expired - Lifetime ES2149141T4 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1997/000511 WO1998019511A2 (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram
CNB971825017A CN100338051C (zh) 1997-11-10 1997-11-10 西酞普兰的制备方法

Publications (3)

Publication Number Publication Date
ES2149141T1 ES2149141T1 (es) 2000-11-01
ES2149141T3 true ES2149141T3 (es) 2003-10-01
ES2149141T4 ES2149141T4 (es) 2004-11-16

Family

ID=37709809

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97945798T Expired - Lifetime ES2149141T4 (es) 1997-11-10 1997-11-10 Metodo para la preparacion de citalopram.

Country Status (21)

Country Link
US (1) US6291689B1 (es)
EP (1) EP1032566B9 (es)
JP (1) JP2002530296A (es)
CN (1) CN100338051C (es)
AR (1) AR029604A2 (es)
AT (1) ATE232524T1 (es)
AU (1) AU738526C (es)
BR (1) BR9714924A (es)
CA (1) CA2291068C (es)
CZ (1) CZ296533B6 (es)
DE (2) DE1032566T1 (es)
DK (1) DK1032566T5 (es)
EA (1) EA003132B1 (es)
ES (1) ES2149141T4 (es)
IL (1) IL135813A (es)
IS (1) IS5473A (es)
SK (1) SK6812000A3 (es)
TR (1) TR200001314T2 (es)
UA (1) UA62985C2 (es)
WO (1) WO1998019511A2 (es)
ZA (1) ZA9810059B (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (en) 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
IL142346A0 (en) * 1998-10-20 2002-03-10 Lundbeck & Co As H Method for the preparation of citalopram
CZ300408B6 (cs) 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
DK1298124T3 (da) * 1999-10-25 2007-07-09 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
AU742554B2 (en) * 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IL150335A0 (en) 1999-12-28 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
PT1246813E (pt) * 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
KR100660802B1 (ko) 2000-01-14 2006-12-26 하. 룬트벡 아크티에 셀스카브 5-시아노프탈리드의 제조 방법
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017417C1 (nl) * 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
HUP0300274A2 (hu) 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás citalopram előállítására
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
GR1004072B (el) * 2000-03-13 2002-12-02 H.Lundbeck A/S Μεθοδος παρασκευης της σιταλοπραμης
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) * 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
PL360107A1 (en) * 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
ES2159271B1 (es) * 2000-03-16 2002-05-01 Lundbeck & Co As H Metodo para la preparacion de 5-ciano-1-(4-fluorofenil)-1,3-dihidroisobenzofuranos
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
US6491947B2 (en) 2000-11-03 2002-12-10 Chemlink Laboratories, Llc Expanded perborate salt, use, and method of production
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
KR100439329B1 (ko) 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
PL353369A1 (en) * 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
RS8304A (en) 2001-07-31 2006-12-15 H.Lundbeck A/S. Crystalline composition containing escitalopram
CN100402489C (zh) * 2002-03-27 2008-07-16 坂东化学株式会社 新型1,3,5-三(芳氨基)苯类
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
WO2004026855A1 (en) * 2002-09-20 2004-04-01 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
ITMI20030479A1 (it) * 2003-03-13 2004-09-14 Adorkem Technology S P A Procedimento per la preparazione di un ciano-isobenzofurano.
WO2004083197A2 (en) 2003-03-21 2004-09-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
AU2003238676A1 (en) * 2003-04-21 2004-11-19 Podile Khadgapathi An improved process for the preparation of citalopram hydrobromide
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram
DE60300502T2 (de) * 2003-10-28 2006-02-23 Adorkem Technology S.P.A., Costa Volpino Verfahren zur Herstellung von Citalopram
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
EP1723133A1 (en) * 2004-02-16 2006-11-22 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
EP2141156A1 (en) 2004-08-23 2010-01-06 Sun Pharma Global FZE Process for Preparation of Citalopram and Enantiomers
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
WO2009111031A2 (en) * 2008-03-04 2009-09-11 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (es) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
CA2171850A1 (en) * 1994-07-15 1996-02-01 Kiyoaki Katano Novel compound having platelet aggregation inhibitor effect
CA2291067C (en) 1997-07-08 2002-07-30 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (en) 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Also Published As

Publication number Publication date
US6291689B1 (en) 2001-09-18
ZA9810059B (en) 1999-05-05
EP1032566B1 (en) 2003-02-12
SK6812000A3 (en) 2000-10-09
AR029604A2 (es) 2003-07-10
DE69719098D1 (de) 2003-03-20
UA62985C2 (en) 2004-01-15
ES2149141T1 (es) 2000-11-01
TR200001314T2 (tr) 2000-11-21
CZ296533B6 (cs) 2006-04-12
AU738526B2 (en) 2001-09-20
EA003132B1 (ru) 2003-02-27
DK1032566T3 (da) 2003-06-10
IS5473A (is) 2000-04-26
JP2002530296A (ja) 2002-09-17
ES2149141T4 (es) 2004-11-16
AU5116798A (en) 1998-05-29
CN1286688A (zh) 2001-03-07
CZ20001713A3 (cs) 2000-10-11
DE1032566T1 (de) 2001-03-15
BR9714924A (pt) 2000-09-26
ATE232524T1 (de) 2003-02-15
IL135813A (en) 2003-07-31
CA2291068C (en) 2002-10-29
AU738526C (en) 2004-03-25
WO1998019511A3 (en) 1998-08-06
EP1032566A2 (en) 2000-09-06
DE69719098T2 (de) 2004-02-12
IL135813A0 (en) 2001-05-20
DK1032566T5 (da) 2004-06-28
WO1998019511A2 (en) 1998-05-14
EP1032566B9 (en) 2003-10-22
CN100338051C (zh) 2007-09-19
CA2291068A1 (en) 1998-05-14
EA200000509A1 (ru) 2000-10-30

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