TR200001314T2 - Sitalopram hazırlanması için metod - Google Patents

Sitalopram hazırlanması için metod

Info

Publication number
TR200001314T2
TR200001314T2 TR2000/01314T TR200001314T TR200001314T2 TR 200001314 T2 TR200001314 T2 TR 200001314T2 TR 2000/01314 T TR2000/01314 T TR 2000/01314T TR 200001314 T TR200001314 T TR 200001314T TR 200001314 T2 TR200001314 T2 TR 200001314T2
Authority
TR
Turkey
Prior art keywords
compound
citalopram
cyano
preparation
alkyloxycarbonyl
Prior art date
Application number
TR2000/01314T
Other languages
English (en)
Inventor
Peterson Hans
Peter B�Ges� Klaus
Bech Sommer Michael
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37709809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200001314(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of TR200001314T2 publication Critical patent/TR200001314T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Sitalopram hazirlanmasi için bir metod tarif edilir, metod formül (IV)'ün bir bilesimin okso grubunun, burada R , CN, C1-6 alkiloksikarbonil ya da C1-6 alkilaminokarbonildir, elde edilen hidroksi bilesiminin halka kapanisini ve karsilik gelen 1-(4-florofenil)-1,3- dihidroisobenzofuran elde edilmesi, eger R siyano ise sonraki asamada dogrudan kullanilmasi ve eger R C1-6 alkiloksikarbonil ya da C1-6 alkilaminokarbonil ise bilesimin karsilik gelen bilesime dönüstürülmesi, burada R siyanodur, ve elde edilen 5-siyano bilesiminin bazik sartlar altinda 3-dimetil-aminopropilhalojenid ile alkilasyonunu ve sitalopram elde edilmesini içerir.
TR2000/01314T 1997-11-10 1997-11-10 Sitalopram hazırlanması için metod TR200001314T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB971825017A CN100338051C (zh) 1997-11-10 1997-11-10 西酞普兰的制备方法
PCT/DK1997/000511 WO1998019511A2 (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
TR200001314T2 true TR200001314T2 (tr) 2000-11-21

Family

ID=37709809

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01314T TR200001314T2 (tr) 1997-11-10 1997-11-10 Sitalopram hazırlanması için metod

Country Status (21)

Country Link
US (1) US6291689B1 (tr)
EP (1) EP1032566B9 (tr)
JP (1) JP2002530296A (tr)
CN (1) CN100338051C (tr)
AR (1) AR029604A2 (tr)
AT (1) ATE232524T1 (tr)
AU (1) AU738526C (tr)
BR (1) BR9714924A (tr)
CA (1) CA2291068C (tr)
CZ (1) CZ296533B6 (tr)
DE (2) DE1032566T1 (tr)
DK (1) DK1032566T5 (tr)
EA (1) EA003132B1 (tr)
ES (1) ES2149141T4 (tr)
IL (1) IL135813A (tr)
IS (1) IS5473A (tr)
SK (1) SK6812000A3 (tr)
TR (1) TR200001314T2 (tr)
UA (1) UA62985C2 (tr)
WO (1) WO1998019511A2 (tr)
ZA (1) ZA9810059B (tr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
NZ510858A (en) * 1998-10-20 2003-11-28 H Method for the preparation of citalopram
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DK1173431T4 (da) 1999-04-14 2010-01-04 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
SK287139B6 (sk) * 1999-10-25 2010-01-07 H. Lundbeck A/S Spôsob prípravy citalopramu
ATE277032T1 (de) 1999-10-25 2004-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
WO2001047909A1 (en) 1999-12-28 2001-07-05 H. Lundbeck A/S Method for the preparation of citalopram
DE69912652T2 (de) 1999-12-30 2004-06-09 H. Lundbeck A/S Verfahren zur herstellung von citalopram
PL197821B1 (pl) 2000-01-14 2008-04-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IES20010157A2 (en) * 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL151490A0 (en) 2000-03-13 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
GR1004072B (el) * 2000-03-13 2002-12-02 H.Lundbeck A/S Μεθοδος παρασκευης της σιταλοπραμης
SK14522002A3 (sk) * 2000-03-13 2003-03-04 H. Lundbeck A/S Spôsob prípravy citalopramu a citalopram pripravený týmto spôsobom
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
TR200202155T2 (tr) * 2000-03-14 2002-12-23 H. Lundbeck A/S Sitalopramin preparasyon metodu
PL360115A1 (en) * 2000-03-16 2004-09-06 H.Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
US6491947B2 (en) 2000-11-03 2002-12-10 Chemlink Laboratories, Llc Expanded perborate salt, use, and method of production
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
DK1181713T3 (da) 2000-12-22 2005-01-31 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram
EA003459B1 (ru) 2000-12-28 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
HUP0401946A2 (hu) 2001-07-31 2005-01-28 H. Lundbeck A/S Escitalopramot tartalmazó kristályos gyógyszerkészítmény
KR100903841B1 (ko) * 2002-03-27 2009-06-25 반도 카가쿠 가부시키가이샤 신규의 1,3,5-트리스(아릴아미노)벤젠류
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
AU2003263155A1 (en) * 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
ITMI20030479A1 (it) * 2003-03-13 2004-09-14 Adorkem Technology S P A Procedimento per la preparazione di un ciano-isobenzofurano.
US7687645B2 (en) 2003-03-21 2010-03-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
AU2003238676A1 (en) * 2003-04-21 2004-11-19 Podile Khadgapathi An improved process for the preparation of citalopram hydrobromide
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram
ES2240931T3 (es) * 2003-10-28 2005-10-16 Adorkem Technology Spa Procedimiento para la preparacion de citalopram.
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
EP1723133A1 (en) * 2004-02-16 2006-11-22 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
EP1797060A2 (en) 2004-08-23 2007-06-20 Sun Pharmaceutical Industries Limited "process for preparation of citalopram and enantiomers"
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
WO2009111031A2 (en) * 2008-03-04 2009-09-11 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (tr) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
TW397831B (en) * 1994-07-15 2000-07-11 Meiji Seika Kaisha The anti-platelet-agglutination hexahydrogenated pyridine and its derivatives
ES2148120T3 (es) 1997-07-08 2002-01-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама

Also Published As

Publication number Publication date
AU738526B2 (en) 2001-09-20
ES2149141T3 (es) 2003-10-01
ZA9810059B (en) 1999-05-05
AU738526C (en) 2004-03-25
DK1032566T3 (da) 2003-06-10
DE1032566T1 (de) 2001-03-15
CN100338051C (zh) 2007-09-19
BR9714924A (pt) 2000-09-26
IL135813A0 (en) 2001-05-20
CA2291068A1 (en) 1998-05-14
WO1998019511A2 (en) 1998-05-14
EP1032566B9 (en) 2003-10-22
EP1032566A2 (en) 2000-09-06
IS5473A (is) 2000-04-26
DK1032566T5 (da) 2004-06-28
JP2002530296A (ja) 2002-09-17
CZ296533B6 (cs) 2006-04-12
ES2149141T4 (es) 2004-11-16
AU5116798A (en) 1998-05-29
IL135813A (en) 2003-07-31
DE69719098T2 (de) 2004-02-12
EP1032566B1 (en) 2003-02-12
EA200000509A1 (ru) 2000-10-30
CA2291068C (en) 2002-10-29
US6291689B1 (en) 2001-09-18
ATE232524T1 (de) 2003-02-15
WO1998019511A3 (en) 1998-08-06
AR029604A2 (es) 2003-07-10
DE69719098D1 (de) 2003-03-20
UA62985C2 (en) 2004-01-15
SK6812000A3 (en) 2000-10-09
CZ20001713A3 (cs) 2000-10-11
ES2149141T1 (es) 2000-11-01
EA003132B1 (ru) 2003-02-27
CN1286688A (zh) 2001-03-07

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