HUP0401946A2 - Escitalopramot tartalmazó kristályos gyógyszerkészítmény - Google Patents

Escitalopramot tartalmazó kristályos gyógyszerkészítmény

Info

Publication number
HUP0401946A2
HUP0401946A2 HU0401946A HUP0401946A HUP0401946A2 HU P0401946 A2 HUP0401946 A2 HU P0401946A2 HU 0401946 A HU0401946 A HU 0401946A HU P0401946 A HUP0401946 A HU P0401946A HU P0401946 A2 HUP0401946 A2 HU P0401946A2
Authority
HU
Hungary
Prior art keywords
oxalate
escitalopram
well
temperature
crystalline
Prior art date
Application number
HU0401946A
Other languages
English (en)
Inventor
Troels Volsgaard Christensen
Ken Liljegren
Michiel Onne Elema
Lene Andresen
Shashank Mahashabde
Sebastian P. Assenza
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8160647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0401946(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HUP0401946A2 publication Critical patent/HUP0401946A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány az escitalopram (nemzetközi szabad név), azaz a jól ismertantidepresszáns hatású citalopram S-enantiomerje oxalátsójának,szabatos kémiai névvel (S)-1-[3-(dimetilamino)propil]-1- -(4-fluorfenil)-1,3-dihidro-5-izobenzofuránkarbonitril-oxalátnakkristályos szemcséire, valamint ilyen kristályos szemcsékettartalmazó, szilárd halmazállapotú gyógyászati készítményekre, továbbáa kristályos szemcsék előállítására vonatkozik. Az escitalopram-oxalátkristályos szemcséinek átlagos szemcsemérete legalább 40 mm, előnyösen50 mm és 250 mm közötti. Az eljárás abban áll, hogy escitalopram-oxalát egy alkalmas oldószer-rendszerrel készült oldatát egy elsőhőmérsékletről fokozatosan lehűtik egy második hőmérsékletre,szabályozott hűtési profilt tartva, és az escitalopram-oxalát említettoldatát beojtják escitalopramoxalát kristályai hozzáadása útján alehűtés során, majd az említett második hőmérsékleten a rendszertadott időn át állni hagyják. Ó
HU0401946A 2001-07-31 2002-07-25 Escitalopramot tartalmazó kristályos gyógyszerkészítmény HUP0401946A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101164 2001-07-31
PCT/DK2002/000513 WO2003011278A1 (en) 2001-07-31 2002-07-25 Crystalline composition containing escitalopram

Publications (1)

Publication Number Publication Date
HUP0401946A2 true HUP0401946A2 (hu) 2005-01-28

Family

ID=8160647

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401946A HUP0401946A2 (hu) 2001-07-31 2002-07-25 Escitalopramot tartalmazó kristályos gyógyszerkészítmény

Country Status (40)

Country Link
US (3) US6916941B2 (hu)
EP (2) EP1522539B1 (hu)
JP (4) JP2005525993A (hu)
KR (1) KR20040028947A (hu)
CN (2) CN1660074A (hu)
AR (1) AR034898A1 (hu)
AT (2) ATE352546T1 (hu)
AU (1) AU2002355624B2 (hu)
BG (1) BG108571A (hu)
BR (1) BR0206164A (hu)
CA (1) CA2451915C (hu)
CO (1) CO5560540A2 (hu)
CY (1) CY1106413T1 (hu)
DE (2) DE60202615T2 (hu)
DK (2) DK1522539T3 (hu)
EA (1) EA006213B1 (hu)
EG (1) EG24206A (hu)
ES (2) ES2233842T3 (hu)
HK (1) HK1070000A1 (hu)
HR (2) HRP20031073A2 (hu)
HU (1) HUP0401946A2 (hu)
IL (2) IL159326A0 (hu)
IS (1) IS7077A (hu)
MA (1) MA27349A1 (hu)
ME (1) MEP2108A (hu)
MX (1) MXPA04000849A (hu)
MY (1) MY126238A (hu)
NO (1) NO328346B1 (hu)
NZ (1) NZ530157A (hu)
PE (1) PE20030304A1 (hu)
PL (1) PL366995A1 (hu)
PT (2) PT1522539E (hu)
RS (1) RS8304A (hu)
SI (1) SI1414435T1 (hu)
TN (1) TNSN04021A1 (hu)
TR (1) TR200400189T2 (hu)
UA (1) UA79930C2 (hu)
UY (1) UY27404A1 (hu)
WO (1) WO2003011278A1 (hu)
ZA (1) ZA200309684B (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1142926C (zh) 1999-04-14 2004-03-24 H·隆德贝克有限公司 制备西酞普兰的方法
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
IL159326A0 (en) 2001-07-31 2004-06-01 Lundbeck & Co As H Crystalline composition containing escitalopram
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
WO2005084643A1 (en) * 2004-03-05 2005-09-15 H. Lundbeck A/S Crystalline composition containing escitalopram oxalate
WO2006123243A2 (en) * 2005-05-20 2006-11-23 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US20070098804A1 (en) * 2005-08-29 2007-05-03 Judith Aronhime Solid particulate tadalafil having a bimodal particle size distribution
EA200801081A1 (ru) 2005-10-14 2008-10-30 Х. Лундбекк А/С Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона
US20070134322A1 (en) * 2005-12-14 2007-06-14 Forest Laboratories, Inc. Modified and pulsatile release pharmaceutical formulations of escitalopram
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
EP2086509A1 (en) * 2006-10-20 2009-08-12 Ratiopharm GmbH Escitalopram and solid pharmaceutical composition comprising the same
US20090048336A1 (en) * 2007-08-17 2009-02-19 Naveen Kumar Kolla Escitalopram oxalate powders
EP2291177A2 (en) * 2008-05-05 2011-03-09 Farmaprojects, S.A. Stable pharmaceutical compositions and their processes for preparation suitable for industrial scale
EP2116231A1 (en) 2008-05-07 2009-11-11 Hexal Ag Granulate comprising escitalopram oxalate
GR20080100696A (el) 2008-10-23 2010-05-13 Genepharm �.�. Φαρμακοτεχνικη μορφη με βελτιωμενη γευση του φαρμακευτικα αποδεκτου αλατος εσιταλοπραμης
ITMI20120448A1 (it) * 2012-01-30 2013-07-31 Carthesia Sas Composizione liofilizzata di escitalopram ossalato per somministrazione sublinguale
ITMI20120106A1 (it) * 2012-01-30 2013-07-31 Carthesia S A S Pastiglie liofilizzate di escitalopram ossalato per somministrazione sublinguale
CN106397249A (zh) * 2015-08-03 2017-02-15 深圳信立泰药业股份有限公司 一种高稳定性lcz696结晶粉末及其制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
JP6423133B1 (ja) * 2017-04-10 2018-11-14 東和薬品株式会社 エスシタロプラム医薬組成物
CN107441052A (zh) * 2017-06-21 2017-12-08 山东京卫制药有限公司 一种含有草酸艾司西酞普兰的片剂及其制备方法
KR102089737B1 (ko) * 2017-11-01 2020-03-16 한국화학연구원 에씨탈로프람을 함유한 미립구형 서방출 주사제 및 그의 제조방법
JP7453859B2 (ja) 2020-06-22 2024-03-21 東和薬品株式会社 エスシタロプラム錠剤

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Also Published As

Publication number Publication date
MXPA04000849A (es) 2004-05-14
MA27349A1 (fr) 2005-06-01
HRP20080410A2 (en) 2008-10-31
PT1414435E (pt) 2005-05-31
UY27404A1 (es) 2003-02-28
IS7077A (is) 2003-12-15
EG24206A (en) 2008-10-21
WO2003011278A1 (en) 2003-02-13
AR034898A1 (es) 2004-03-24
EP1414435A1 (en) 2004-05-06
HRP20031073A2 (en) 2004-04-30
JP2012211186A (ja) 2012-11-01
US20030212128A1 (en) 2003-11-13
AU2002355624B2 (en) 2006-02-02
BG108571A (en) 2005-02-28
CA2451915C (en) 2010-09-21
EP1522539A1 (en) 2005-04-13
EP1522539B1 (en) 2007-01-24
JP2011195591A (ja) 2011-10-06
DE60202615T2 (de) 2006-01-12
PT1522539E (pt) 2007-03-30
ES2280892T3 (es) 2007-09-16
DE60202615D1 (de) 2005-02-17
DK1414435T3 (da) 2005-05-09
HRPK20080410B3 (en) 2009-09-30
ATE352546T1 (de) 2007-02-15
CO5560540A2 (es) 2005-09-30
NZ530157A (en) 2007-06-29
NO20040380L (no) 2004-01-28
HK1070000A1 (en) 2005-06-10
SI1414435T1 (en) 2005-06-30
CN1536997A (zh) 2004-10-13
JP2005525993A (ja) 2005-09-02
BR0206164A (pt) 2003-10-28
CN1311819C (zh) 2007-04-25
TNSN04021A1 (en) 2006-06-01
US6916941B2 (en) 2005-07-12
DE60217932T2 (de) 2007-08-30
US20080305164A1 (en) 2008-12-11
TR200400189T2 (tr) 2004-12-21
ES2233842T3 (es) 2005-06-16
NO328346B1 (no) 2010-02-01
UA79930C2 (en) 2007-08-10
EA200400243A1 (ru) 2004-06-24
PE20030304A1 (es) 2003-03-27
IL159326A0 (en) 2004-06-01
CY1106413T1 (el) 2011-10-12
IL159326A (en) 2010-05-31
US7420069B2 (en) 2008-09-02
CA2451915A1 (en) 2003-02-13
KR20040028947A (ko) 2004-04-03
ZA200309684B (en) 2004-12-22
US20050147674A1 (en) 2005-07-07
EP1414435B1 (en) 2005-01-12
JP2010150283A (ja) 2010-07-08
DE60217932D1 (de) 2007-03-15
CN1660074A (zh) 2005-08-31
ATE286730T1 (de) 2005-01-15
PL366995A1 (en) 2005-02-07
MY126238A (en) 2006-09-29
MEP2108A (xx) 2010-02-10
JP4971477B2 (ja) 2012-07-11
JP5719811B2 (ja) 2015-05-20
EA006213B1 (ru) 2005-10-27
RS8304A (en) 2006-12-15
JP5192568B2 (ja) 2013-05-08
DK1522539T3 (da) 2007-05-07

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