MXPA04001030A - Proceso para la preparacion de isobenzofuranos 5-sustituidos. - Google Patents

Proceso para la preparacion de isobenzofuranos 5-sustituidos.

Info

Publication number
MXPA04001030A
MXPA04001030A MXPA04001030A MXPA04001030A MXPA04001030A MX PA04001030 A MXPA04001030 A MX PA04001030A MX PA04001030 A MXPA04001030 A MX PA04001030A MX PA04001030 A MXPA04001030 A MX PA04001030A MX PA04001030 A MXPA04001030 A MX PA04001030A
Authority
MX
Mexico
Prior art keywords
preparation
citalopram
pharmaceutically acceptable
substituted
isobenzofurans
Prior art date
Application number
MXPA04001030A
Other languages
English (en)
Inventor
Dall Asta Leone
Original Assignee
Infosint Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infosint Sa filed Critical Infosint Sa
Publication of MXPA04001030A publication Critical patent/MXPA04001030A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describe un proceso para la preparacion de citalopram y de sus sales farmaceuticamente aceptables, el cual comprende tratar una 1- [3-(dimetilamino) propil]-1 -(4-fIuorofenil)-1, 3-dihidro -5 -isobenzofurancarbaldoxima, O-sustituida preferentemente con un grupo trifenilmetilo o difenilmetilo, con anhidrido acetico formico. Ademas, se describe la sintesis total de citalopram, como base libre o en forma de su sal farmaceuticamente aceptable, que comienza de 5-fomifttalido.
MXPA04001030A 2001-08-02 2002-07-29 Proceso para la preparacion de isobenzofuranos 5-sustituidos. MXPA04001030A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01830517A EP1281707B1 (en) 2001-08-02 2001-08-02 Process for the preparation of 5-subtituted isobenzofurans
PCT/EP2002/008550 WO2003011846A2 (en) 2001-08-02 2002-07-29 Process for the preparation of 5-substituted isobenzofurans

Publications (1)

Publication Number Publication Date
MXPA04001030A true MXPA04001030A (es) 2004-12-03

Family

ID=8184643

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001030A MXPA04001030A (es) 2001-08-02 2002-07-29 Proceso para la preparacion de isobenzofuranos 5-sustituidos.

Country Status (23)

Country Link
US (1) US7166729B2 (es)
EP (1) EP1281707B1 (es)
JP (1) JP2005501056A (es)
KR (1) KR20040043176A (es)
CN (1) CN1298713C (es)
AR (1) AR036212A1 (es)
AT (1) ATE286037T1 (es)
AU (1) AU2002325385B2 (es)
BG (1) BG108554A (es)
BR (1) BR0211858A (es)
CA (1) CA2456004A1 (es)
DE (1) DE60108105T2 (es)
DK (1) DK1281707T3 (es)
ES (1) ES2234797T3 (es)
HK (1) HK1070357A1 (es)
HU (1) HUP0401166A3 (es)
MX (1) MXPA04001030A (es)
PL (1) PL368320A1 (es)
PT (1) PT1281707E (es)
RO (1) RO122147B1 (es)
TW (1) TWI225055B (es)
WO (1) WO2003011846A2 (es)
ZA (1) ZA200400841B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
WO2004026855A1 (en) * 2002-09-20 2004-04-01 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
JP5583592B2 (ja) 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション Ｉｄｏ阻害剤
CN106632182A (zh) * 2016-12-07 2017-05-10 万全万特制药（厦门）有限公司 草酸艾司西酞普兰脱甲基杂质的制备方法
WO2020129087A1 (en) * 2018-12-22 2020-06-25 Malladi Drugs And Pharmaceuticals Ltd. NOVEL PROCESS FOR THE PREPARATION OF R-PHENYLACETYLCARBINOL AND β-AMINOALCOHOLS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
EA001728B1 (ru) * 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
PL198024B1 (pl) * 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.

Also Published As

Publication number Publication date
AU2002325385B8 (en) 2003-02-17
JP2005501056A (ja) 2005-01-13
HUP0401166A2 (hu) 2004-09-28
HUP0401166A3 (en) 2007-05-29
US20040230065A1 (en) 2004-11-18
BG108554A (bg) 2005-03-31
DK1281707T3 (da) 2005-05-02
RO122147B1 (ro) 2009-01-30
HK1070357A1 (en) 2005-06-17
DE60108105T2 (de) 2005-12-08
EP1281707A1 (en) 2003-02-05
CA2456004A1 (en) 2003-02-13
WO2003011846B1 (en) 2003-12-24
US7166729B2 (en) 2007-01-23
KR20040043176A (ko) 2004-05-22
BR0211858A (pt) 2004-09-21
TWI225055B (en) 2004-12-11
WO2003011846A2 (en) 2003-02-13
WO2003011846A3 (en) 2003-11-27
PL368320A1 (en) 2005-03-21
AR036212A1 (es) 2004-08-18
ES2234797T3 (es) 2005-07-01
ZA200400841B (en) 2005-02-02
PT1281707E (pt) 2005-04-29
ATE286037T1 (de) 2005-01-15
CN1555370A (zh) 2004-12-15
EP1281707B1 (en) 2004-12-29
CN1298713C (zh) 2007-02-07
DE60108105D1 (de) 2005-02-03
AU2002325385B2 (en) 2007-07-05

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