HUP0401166A2 - Eljárás citalopram előállítására - Google Patents
Eljárás citalopram előállításáraInfo
- Publication number
- HUP0401166A2 HUP0401166A2 HU0401166A HUP0401166A HUP0401166A2 HU P0401166 A2 HUP0401166 A2 HU P0401166A2 HU 0401166 A HU0401166 A HU 0401166A HU P0401166 A HUP0401166 A HU P0401166A HU P0401166 A2 HUP0401166 A2 HU P0401166A2
- Authority
- HU
- Hungary
- Prior art keywords
- citalopram
- preparation
- isobenzofurans
- subject
- pharmaceutically acceptable
- Prior art date
Links
- 229960001653 citalopram Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- -1 citalopram isobenzofurans Chemical class 0.000 title 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- DBSGLQIKLWDTTD-UHFFFAOYSA-N 1-oxo-3h-2-benzofuran-5-carbaldehyde Chemical compound O=CC1=CC=C2C(=O)OCC2=C1 DBSGLQIKLWDTTD-UHFFFAOYSA-N 0.000 abstract 1
- ORWKVZNEPHTCQE-UHFFFAOYSA-N acetic formic anhydride Chemical compound CC(=O)OC=O ORWKVZNEPHTCQE-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya eljárás citalopram és gyógyászatilag elfogadhatósói előállítására, ami abból áll, hogy az 1-(3-(dimetilamino)propil)-1-(4-fluorofenil)-1,3-dihidro-5-izobenzofuránkarbaldoximot, amielőnyösen difenilmetil vagy trifenilmetil csoporttal van O-helyettesítve, hangyasav-ecetsav anhidriddel kezelik. A találmánytárgya továbbá a citalopram és gyógyászatilag elfogadható sóinaktotálszintézise 5-formilftalidból kiindulva. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01830517A EP1281707B1 (en) | 2001-08-02 | 2001-08-02 | Process for the preparation of 5-subtituted isobenzofurans |
| PCT/EP2002/008550 WO2003011846A2 (en) | 2001-08-02 | 2002-07-29 | Process for the preparation of 5-substituted isobenzofurans |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401166A2 true HUP0401166A2 (hu) | 2004-09-28 |
| HUP0401166A3 HUP0401166A3 (en) | 2007-05-29 |
Family
ID=8184643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401166A HUP0401166A3 (en) | 2001-08-02 | 2002-07-29 | Process for preparation of citalopram isobenzofurans |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7166729B2 (hu) |
| EP (1) | EP1281707B1 (hu) |
| JP (1) | JP2005501056A (hu) |
| KR (1) | KR20040043176A (hu) |
| CN (1) | CN1298713C (hu) |
| AR (1) | AR036212A1 (hu) |
| AT (1) | ATE286037T1 (hu) |
| AU (1) | AU2002325385B2 (hu) |
| BG (1) | BG108554A (hu) |
| BR (1) | BR0211858A (hu) |
| CA (1) | CA2456004A1 (hu) |
| DE (1) | DE60108105T2 (hu) |
| DK (1) | DK1281707T3 (hu) |
| ES (1) | ES2234797T3 (hu) |
| HK (1) | HK1070357A1 (hu) |
| HU (1) | HUP0401166A3 (hu) |
| MX (1) | MXPA04001030A (hu) |
| PL (1) | PL368320A1 (hu) |
| PT (1) | PT1281707E (hu) |
| RO (1) | RO122147B1 (hu) |
| TW (1) | TWI225055B (hu) |
| WO (1) | WO2003011846A2 (hu) |
| ZA (1) | ZA200400841B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
| AU2003263155A1 (en) * | 2002-09-20 | 2004-04-08 | H. Lundbeck A/S | Method for manufacture of dihydroisobenzofuran derivatives |
| GB0601286D0 (en) | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
| CA2932121A1 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics Corporation | Ido inhibitors |
| CN106632182A (zh) * | 2016-12-07 | 2017-05-10 | 万全万特制药（厦门）有限公司 | 草酸艾司西酞普兰脱甲基杂质的制备方法 |
| DE112019006382T8 (de) * | 2018-12-22 | 2021-12-09 | Malladi Drugs And Pharmaceuticals Ltd. | NEUES VERFAHREN ZUR HERSTELLUNG VONR-PHENYLACETYLCARBINOL UND β-AMINOALKOHOLEN |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| NZ501737A (en) * | 1997-07-08 | 2001-10-26 | H | Method for the preparation of citalopram using Grignard reagent 4-halogen-fluorophenyl and 3-halogen-N,N-dimethyl-propylamine |
| CZ296537B6 (cs) * | 1999-04-14 | 2006-04-12 | H. Lundbeck A/S | Zpusob výroby citalopramu a meziprodukty |
| ITMI991486A1 (it) * | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
| IES20010143A2 (en) * | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
| IT1319686B1 (it) * | 2000-12-12 | 2003-10-23 | C D Farmasint S R L | Procedimento di preparazione di citalopram. |
-
2001
- 2001-08-02 DE DE60108105T patent/DE60108105T2/de not_active Expired - Fee Related
- 2001-08-02 DK DK01830517T patent/DK1281707T3/da active
- 2001-08-02 EP EP01830517A patent/EP1281707B1/en not_active Expired - Lifetime
- 2001-08-02 ES ES01830517T patent/ES2234797T3/es not_active Expired - Lifetime
- 2001-08-02 AT AT01830517T patent/ATE286037T1/de not_active IP Right Cessation
- 2001-08-02 PT PT01830517T patent/PT1281707E/pt unknown
-
2002
- 2002-07-29 RO ROA200400084A patent/RO122147B1/ro unknown
- 2002-07-29 KR KR10-2004-7001616A patent/KR20040043176A/ko not_active Application Discontinuation
- 2002-07-29 AU AU2002325385A patent/AU2002325385B2/en not_active Ceased
- 2002-07-29 BR BR0211858-0A patent/BR0211858A/pt not_active IP Right Cessation
- 2002-07-29 CA CA002456004A patent/CA2456004A1/en not_active Abandoned
- 2002-07-29 CN CNB028183231A patent/CN1298713C/zh not_active Expired - Fee Related
- 2002-07-29 MX MXPA04001030A patent/MXPA04001030A/es active IP Right Grant
- 2002-07-29 HU HU0401166A patent/HUP0401166A3/hu unknown
- 2002-07-29 JP JP2003517038A patent/JP2005501056A/ja active Pending
- 2002-07-29 PL PL02368320A patent/PL368320A1/xx not_active Application Discontinuation
- 2002-07-29 WO PCT/EP2002/008550 patent/WO2003011846A2/en active Application Filing
- 2002-07-31 TW TW091117176A patent/TWI225055B/zh active
- 2002-08-02 AR ARP020102955A patent/AR036212A1/es unknown
-
2004
- 2004-01-30 BG BG108554A patent/BG108554A/bg unknown
- 2004-01-31 US US10/776,625 patent/US7166729B2/en not_active Expired - Fee Related
- 2004-02-02 ZA ZA200400841A patent/ZA200400841B/en unknown
-
2005
- 2005-04-08 HK HK05102982A patent/HK1070357A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002325385B8 (en) | 2003-02-17 |
| PT1281707E (pt) | 2005-04-29 |
| HK1070357A1 (en) | 2005-06-17 |
| KR20040043176A (ko) | 2004-05-22 |
| EP1281707B1 (en) | 2004-12-29 |
| ES2234797T3 (es) | 2005-07-01 |
| US20040230065A1 (en) | 2004-11-18 |
| AR036212A1 (es) | 2004-08-18 |
| DE60108105T2 (de) | 2005-12-08 |
| TWI225055B (en) | 2004-12-11 |
| PL368320A1 (en) | 2005-03-21 |
| WO2003011846A3 (en) | 2003-11-27 |
| AU2002325385B2 (en) | 2007-07-05 |
| DE60108105D1 (de) | 2005-02-03 |
| BG108554A (bg) | 2005-03-31 |
| WO2003011846B1 (en) | 2003-12-24 |
| US7166729B2 (en) | 2007-01-23 |
| BR0211858A (pt) | 2004-09-21 |
| CA2456004A1 (en) | 2003-02-13 |
| DK1281707T3 (da) | 2005-05-02 |
| ATE286037T1 (de) | 2005-01-15 |
| WO2003011846A2 (en) | 2003-02-13 |
| MXPA04001030A (es) | 2004-12-03 |
| EP1281707A1 (en) | 2003-02-05 |
| CN1298713C (zh) | 2007-02-07 |
| ZA200400841B (en) | 2005-02-02 |
| CN1555370A (zh) | 2004-12-15 |
| JP2005501056A (ja) | 2005-01-13 |
| RO122147B1 (ro) | 2009-01-30 |
| HUP0401166A3 (en) | 2007-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |