DE60202615D1 - Kristalline zusammensetzung mit escitalopram - Google Patents

Kristalline zusammensetzung mit escitalopram

Info

Publication number
DE60202615D1
DE60202615D1 DE60202615T DE60202615T DE60202615D1 DE 60202615 D1 DE60202615 D1 DE 60202615D1 DE 60202615 T DE60202615 T DE 60202615T DE 60202615 T DE60202615 T DE 60202615T DE 60202615 D1 DE60202615 D1 DE 60202615D1
Authority
DE
Germany
Prior art keywords
escitalopram
crystalline composition
crystalline
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE60202615T
Other languages
English (en)
Other versions
DE60202615T2 (de
Inventor
Volsgaard Christensen
Ken Liljegren
Onne Elema
Lene Andresen
Shashank Mahashabde
Sebastian P Assenza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8160647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60202615(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of DE60202615D1 publication Critical patent/DE60202615D1/de
Publication of DE60202615T2 publication Critical patent/DE60202615T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
DE60202615T 2001-07-31 2002-07-25 Kristalline zusammensetzung mit escitalopram Revoked DE60202615T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200101164 2001-07-31
DK200101164 2001-07-31
PCT/DK2002/000513 WO2003011278A1 (en) 2001-07-31 2002-07-25 Crystalline composition containing escitalopram

Publications (2)

Publication Number Publication Date
DE60202615D1 true DE60202615D1 (de) 2005-02-17
DE60202615T2 DE60202615T2 (de) 2006-01-12

Family

ID=8160647

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60202615T Revoked DE60202615T2 (de) 2001-07-31 2002-07-25 Kristalline zusammensetzung mit escitalopram
DE60217932T Revoked DE60217932T2 (de) 2001-07-31 2002-07-25 Kristalline Zusammensetzung enthaltend Escitalopram

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60217932T Revoked DE60217932T2 (de) 2001-07-31 2002-07-25 Kristalline Zusammensetzung enthaltend Escitalopram

Country Status (40)

Country Link
US (3) US6916941B2 (de)
EP (2) EP1522539B1 (de)
JP (4) JP2005525993A (de)
KR (1) KR20040028947A (de)
CN (2) CN1660074A (de)
AR (1) AR034898A1 (de)
AT (2) ATE352546T1 (de)
AU (1) AU2002355624B2 (de)
BG (1) BG108571A (de)
BR (1) BR0206164A (de)
CA (1) CA2451915C (de)
CO (1) CO5560540A2 (de)
CY (1) CY1106413T1 (de)
DE (2) DE60202615T2 (de)
DK (2) DK1414435T3 (de)
EA (1) EA006213B1 (de)
EG (1) EG24206A (de)
ES (2) ES2233842T3 (de)
HK (1) HK1070000A1 (de)
HR (2) HRP20031073A2 (de)
HU (1) HUP0401946A2 (de)
IL (2) IL159326A0 (de)
IS (1) IS7077A (de)
MA (1) MA27349A1 (de)
ME (1) MEP2108A (de)
MX (1) MXPA04000849A (de)
MY (1) MY126238A (de)
NO (1) NO328346B1 (de)
NZ (1) NZ530157A (de)
PE (1) PE20030304A1 (de)
PL (1) PL366995A1 (de)
PT (2) PT1522539E (de)
RS (1) RS8304A (de)
SI (1) SI1414435T1 (de)
TN (1) TNSN04021A1 (de)
TR (1) TR200400189T2 (de)
UA (1) UA79930C2 (de)
UY (1) UY27404A1 (de)
WO (1) WO2003011278A1 (de)
ZA (1) ZA200309684B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
RS8304A (en) 2001-07-31 2006-12-15 H.Lundbeck A/S. Crystalline composition containing escitalopram
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EA200601641A1 (ru) * 2004-03-05 2006-12-29 Х. Лундбекк А/С Кристаллическая композиция, содержащая оксалат эсциталопрама
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
WO2006123243A2 (en) * 2005-05-20 2006-11-23 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US20070098804A1 (en) * 2005-08-29 2007-05-03 Judith Aronhime Solid particulate tadalafil having a bimodal particle size distribution
WO2007053796A2 (en) 2005-10-14 2007-05-10 Forest Laboratories, Inc. Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
US20070134322A1 (en) * 2005-12-14 2007-06-14 Forest Laboratories, Inc. Modified and pulsatile release pharmaceutical formulations of escitalopram
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
WO2008046617A1 (en) * 2006-10-20 2008-04-24 Ratiopharm Gmbh Escitalopram and solid pharmaceutical composition comprising the same
US20090048336A1 (en) * 2007-08-17 2009-02-19 Naveen Kumar Kolla Escitalopram oxalate powders
WO2009135646A2 (en) * 2008-05-05 2009-11-12 Farmaprojects, Sa Stable pharmaceutical compositions and their processes for preparation suitable for industrial scale
EP2116231A1 (de) 2008-05-07 2009-11-11 Hexal Ag Granulat mit Escitalopramoxalat
GR20080100696A (el) 2008-10-23 2010-05-13 Genepharm �.�. Φαρμακοτεχνικη μορφη με βελτιωμενη γευση του φαρμακευτικα αποδεκτου αλατος εσιταλοπραμης
ITMI20120448A1 (it) * 2012-01-30 2013-07-31 Carthesia Sas Composizione liofilizzata di escitalopram ossalato per somministrazione sublinguale
ITMI20120106A1 (it) * 2012-01-30 2013-07-31 Carthesia S A S Pastiglie liofilizzate di escitalopram ossalato per somministrazione sublinguale
CN106397248A (zh) * 2015-08-03 2017-02-15 深圳信立泰药业股份有限公司 一种lcz696结晶粉末及其制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) * 2017-04-10 2018-10-18 東和薬品株式会社 エスシタロプラム医薬組成物
CN107441052A (zh) * 2017-06-21 2017-12-08 山东京卫制药有限公司 一种含有草酸艾司西酞普兰的片剂及其制备方法
KR102089737B1 (ko) 2017-11-01 2020-03-16 한국화학연구원 에씨탈로프람을 함유한 미립구형 서방출 주사제 및 그의 제조방법
JP7453859B2 (ja) 2020-06-22 2024-03-21 東和薬品株式会社 エスシタロプラム錠剤

Family Cites Families (28)

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Publication number Priority date Publication date Assignee Title
GB1143703A (de) 1965-03-18
GB1358915A (en) 1971-09-13 1974-07-03 Merck & Co Inc Directly compressed tablet and composition therefor
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
ES2058061T3 (es) 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
GB9325644D0 (en) 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
US5683720A (en) 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
EP0714663A3 (de) 1994-11-28 1997-01-15 Lilly Co Eli Potenzierung von Wirkstoffresponz durch Serotonin 1A Rezeptor Antagonisten
AU5966196A (en) 1995-06-08 1997-01-09 Eli Lilly And Company Methods of treating cold and allergic rhinitis
CA2291067C (en) 1997-07-08 2002-07-30 H. Lundbeck A/S Method for the preparation of citalopram
GB9714841D0 (en) 1997-07-14 1997-09-17 Smithkline Beecham Plc Treatment method
US5840334A (en) 1997-08-20 1998-11-24 Fuisz Technologies Ltd. Self-binding shearform compositions
US5980941A (en) 1997-08-20 1999-11-09 Fuisz Technologies Ltd. Self-binding shearform compositions
US5869098A (en) 1997-08-20 1999-02-09 Fuisz Technologies Ltd. Fast-dissolving comestible units formed under high-speed/high-pressure conditions
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (en) * 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
IL142346A0 (en) 1998-10-20 2002-03-10 Lundbeck & Co As H Method for the preparation of citalopram
TWI230618B (en) * 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AR021155A1 (es) 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
AU7405000A (en) * 1999-09-28 2001-04-30 H. Lundbeck A/S Melt granulated composition and modified release dosage form prepared from said composition
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
RS8304A (en) 2001-07-31 2006-12-15 H.Lundbeck A/S. Crystalline composition containing escitalopram

Also Published As

Publication number Publication date
DE60202615T2 (de) 2006-01-12
NO328346B1 (no) 2010-02-01
MEP2108A (xx) 2010-02-10
JP2010150283A (ja) 2010-07-08
CN1311819C (zh) 2007-04-25
CA2451915C (en) 2010-09-21
CA2451915A1 (en) 2003-02-13
DK1414435T3 (da) 2005-05-09
EP1414435B1 (de) 2005-01-12
JP4971477B2 (ja) 2012-07-11
WO2003011278A1 (en) 2003-02-13
JP5192568B2 (ja) 2013-05-08
TNSN04021A1 (en) 2006-06-01
US6916941B2 (en) 2005-07-12
ZA200309684B (en) 2004-12-22
HRP20031073A2 (en) 2004-04-30
BR0206164A (pt) 2003-10-28
HUP0401946A2 (hu) 2005-01-28
CN1660074A (zh) 2005-08-31
NO20040380L (no) 2004-01-28
IL159326A (en) 2010-05-31
PT1522539E (pt) 2007-03-30
MXPA04000849A (es) 2004-05-14
ATE352546T1 (de) 2007-02-15
EP1414435A1 (de) 2004-05-06
ES2280892T3 (es) 2007-09-16
NZ530157A (en) 2007-06-29
PE20030304A1 (es) 2003-03-27
CY1106413T1 (el) 2011-10-12
ES2233842T3 (es) 2005-06-16
EA200400243A1 (ru) 2004-06-24
DE60217932D1 (de) 2007-03-15
DK1522539T3 (da) 2007-05-07
RS8304A (en) 2006-12-15
UY27404A1 (es) 2003-02-28
HK1070000A1 (en) 2005-06-10
CO5560540A2 (es) 2005-09-30
JP5719811B2 (ja) 2015-05-20
PT1414435E (pt) 2005-05-31
AU2002355624B2 (en) 2006-02-02
TR200400189T2 (tr) 2004-12-21
DE60217932T2 (de) 2007-08-30
UA79930C2 (en) 2007-08-10
US20030212128A1 (en) 2003-11-13
US20080305164A1 (en) 2008-12-11
EA006213B1 (ru) 2005-10-27
JP2011195591A (ja) 2011-10-06
AR034898A1 (es) 2004-03-24
JP2005525993A (ja) 2005-09-02
EP1522539A1 (de) 2005-04-13
MA27349A1 (fr) 2005-06-01
US20050147674A1 (en) 2005-07-07
EG24206A (en) 2008-10-21
HRPK20080410B3 (en) 2009-09-30
MY126238A (en) 2006-09-29
EP1522539B1 (de) 2007-01-24
IL159326A0 (en) 2004-06-01
HRP20080410A2 (en) 2008-10-31
SI1414435T1 (en) 2005-06-30
KR20040028947A (ko) 2004-04-03
CN1536997A (zh) 2004-10-13
US7420069B2 (en) 2008-09-02
IS7077A (is) 2003-12-15
PL366995A1 (en) 2005-02-07
ATE286730T1 (de) 2005-01-15
BG108571A (en) 2005-02-28
JP2012211186A (ja) 2012-11-01

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation