AR029604A2 - Intermediarios para la preparacion de citalopram y composicion farmaceutica antidepresiva que comprende el citalopram preparado - Google Patents

Intermediarios para la preparacion de citalopram y composicion farmaceutica antidepresiva que comprende el citalopram preparado

Info

Publication number
AR029604A2
AR029604A2 ARP990105341A ARP990105341A AR029604A2 AR 029604 A2 AR029604 A2 AR 029604A2 AR P990105341 A ARP990105341 A AR P990105341A AR P990105341 A ARP990105341 A AR P990105341A AR 029604 A2 AR029604 A2 AR 029604A2
Authority
AR
Argentina
Prior art keywords
citalopram
preparation
pharmaceutical composition
antidepressive
intermediaries
Prior art date
Application number
ARP990105341A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37709809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR029604(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR029604A2 publication Critical patent/AR029604A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Abstract

Un compuesto intermediario para la preparacion de citalopram de la formula (1) donde R1 es CN, alquilcarbonilo C1-6, o alquilaminocarbonilo C1-6, X es CH2OH, Y es CHOH, o cuando X e Y se toman conjuntamente forman un anillo Benzo (c) furano con el anillo benceno al que están unidos; y una composicion farmacéutica antidepresiva que comprende citalopram preparado a partir del intermediario.
ARP990105341A 1997-11-10 1999-10-22 Intermediarios para la preparacion de citalopram y composicion farmaceutica antidepresiva que comprende el citalopram preparado AR029604A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1997/000511 WO1998019511A2 (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram
CNB971825017A CN100338051C (zh) 1997-11-10 1997-11-10 西酞普兰的制备方法

Publications (1)

Publication Number Publication Date
AR029604A2 true AR029604A2 (es) 2003-07-10

Family

ID=37709809

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990105341A AR029604A2 (es) 1997-11-10 1999-10-22 Intermediarios para la preparacion de citalopram y composicion farmaceutica antidepresiva que comprende el citalopram preparado

Country Status (21)

Country Link
US (1) US6291689B1 (es)
EP (1) EP1032566B9 (es)
JP (1) JP2002530296A (es)
CN (1) CN100338051C (es)
AR (1) AR029604A2 (es)
AT (1) ATE232524T1 (es)
AU (1) AU738526C (es)
BR (1) BR9714924A (es)
CA (1) CA2291068C (es)
CZ (1) CZ296533B6 (es)
DE (2) DE1032566T1 (es)
DK (1) DK1032566T5 (es)
EA (1) EA003132B1 (es)
ES (1) ES2149141T4 (es)
IL (1) IL135813A (es)
IS (1) IS5473A (es)
SK (1) SK6812000A3 (es)
TR (1) TR200001314T2 (es)
UA (1) UA62985C2 (es)
WO (1) WO1998019511A2 (es)
ZA (1) ZA9810059B (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DE69714480T2 (de) 1997-11-11 2003-03-06 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
CN1149208C (zh) 1998-12-23 2004-05-12 H.隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
CN1142926C (zh) 1999-04-14 2004-03-24 H·隆德贝克有限公司 制备西酞普兰的方法
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
NZ512406A (en) * 1999-10-25 2004-01-30 H Method for the preparation of citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
CZ20022213A3 (cs) 1999-12-28 2002-09-11 H. Lundbeck A/S Způsob výroby citalopramu
SI1246813T1 (en) 1999-12-30 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
CZ20022601A3 (cs) 2000-01-14 2002-10-16 H. Lundbeck A/S Způsob výroby 5-kyanoftalidu
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
NL1017417C1 (nl) * 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
MXPA02008869A (es) * 2000-03-13 2003-02-10 Lundbeck & Co As H Metodo para la preparacion de citalopram.
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
NL1017500C1 (nl) * 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
EA200200968A1 (ru) * 2000-03-13 2003-02-27 Х.Лундбекк А/С Поэтапное алкилирование 5-замещенных 1-(4-фторфенил)-1,3-дигидроизобензофуранов
GR1004072B (el) * 2000-03-13 2002-12-02 H.Lundbeck A/S Μεθοδος παρασκευης της σιταλοπραμης
JP2003527386A (ja) * 2000-03-14 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
AU2001244086A1 (en) * 2000-03-16 2001-09-24 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
US6491947B2 (en) 2000-11-03 2002-12-10 Chemlink Laboratories, Llc Expanded perborate salt, use, and method of production
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
ES2228824T3 (es) 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
IL147162A0 (en) * 2000-12-28 2002-08-14 Lundbeck & Co As H Process for the preparation of pure citalopram
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
UA79930C2 (en) 2001-07-31 2007-08-10 Lundbeck & Co As H Crystalline composition containing escitalopram
CN100402489C (zh) * 2002-03-27 2008-07-16 坂东化学株式会社 新型1,3,5-三(芳氨基)苯类
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
AU2002330730A1 (en) * 2002-08-14 2004-03-03 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
WO2004026855A1 (en) * 2002-09-20 2004-04-01 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
ITMI20030479A1 (it) * 2003-03-13 2004-09-14 Adorkem Technology S P A Procedimento per la preparazione di un ciano-isobenzofurano.
EP1611118A2 (en) 2003-03-21 2006-01-04 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram
SI1506963T1 (en) * 2003-10-28 2005-10-31 Adorkem Technology Spa Method for the preparation of citalopram
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2005077927A1 (en) * 2004-02-16 2005-08-25 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
EP2141156A1 (en) 2004-08-23 2010-01-06 Sun Pharma Global FZE Process for Preparation of Citalopram and Enantiomers
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (es) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AU709070B2 (en) * 1994-07-15 1999-08-19 Meiji Seika Kabushiki Kaisha Novel compounds with platelet aggregation inhibitor activity
EP1015416B1 (en) 1997-07-08 2001-09-19 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DE69714480T2 (de) 1997-11-11 2003-03-06 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram

Also Published As

Publication number Publication date
EP1032566B9 (en) 2003-10-22
CZ20001713A3 (cs) 2000-10-11
CA2291068C (en) 2002-10-29
DE69719098T2 (de) 2004-02-12
IS5473A (is) 2000-04-26
WO1998019511A2 (en) 1998-05-14
EP1032566A2 (en) 2000-09-06
CA2291068A1 (en) 1998-05-14
DE69719098D1 (de) 2003-03-20
US6291689B1 (en) 2001-09-18
BR9714924A (pt) 2000-09-26
CN100338051C (zh) 2007-09-19
AU5116798A (en) 1998-05-29
ES2149141T3 (es) 2003-10-01
ATE232524T1 (de) 2003-02-15
EA200000509A1 (ru) 2000-10-30
SK6812000A3 (en) 2000-10-09
IL135813A0 (en) 2001-05-20
IL135813A (en) 2003-07-31
UA62985C2 (en) 2004-01-15
EP1032566B1 (en) 2003-02-12
TR200001314T2 (tr) 2000-11-21
CZ296533B6 (cs) 2006-04-12
DK1032566T3 (da) 2003-06-10
JP2002530296A (ja) 2002-09-17
ZA9810059B (en) 1999-05-05
ES2149141T4 (es) 2004-11-16
DK1032566T5 (da) 2004-06-28
ES2149141T1 (es) 2000-11-01
CN1286688A (zh) 2001-03-07
DE1032566T1 (de) 2001-03-15
AU738526C (en) 2004-03-25
WO1998019511A3 (en) 1998-08-06
AU738526B2 (en) 2001-09-20
EA003132B1 (ru) 2003-02-27

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