CZ20001713A3 - Způsob výroby citalopramu - Google Patents

Způsob výroby citalopramu

Info

Publication number
CZ20001713A3
CZ20001713A3 CZ20001713A CZ20001713A CZ20001713A3 CZ 20001713 A3 CZ20001713 A3 CZ 20001713A3 CZ 20001713 A CZ20001713 A CZ 20001713A CZ 20001713 A CZ20001713 A CZ 20001713A CZ 20001713 A3 CZ20001713 A3 CZ 20001713A3
Authority
CZ
Czechia
Prior art keywords
preparing citalopram
citalopram
preparing
Prior art date
Application number
CZ20001713A
Other languages
English (en)
Other versions
CZ296533B6 (cs
Inventor
Hans Petersen
Klaus Peter Bogeso
Sommer Michael Bech
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37709809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CZ20001713(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CZ20001713A3 publication Critical patent/CZ20001713A3/cs
Publication of CZ296533B6 publication Critical patent/CZ296533B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CZ20001713A 1997-11-10 1997-11-10 Zpusob výroby citalopramu CZ296533B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB971825017A CN100338051C (zh) 1997-11-10 1997-11-10 西酞普兰的制备方法
PCT/DK1997/000511 WO1998019511A2 (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
CZ20001713A3 true CZ20001713A3 (cs) 2000-10-11
CZ296533B6 CZ296533B6 (cs) 2006-04-12

Family

ID=37709809

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20001713A CZ296533B6 (cs) 1997-11-10 1997-11-10 Zpusob výroby citalopramu

Country Status (21)

Country Link
US (1) US6291689B1 (cs)
EP (1) EP1032566B9 (cs)
JP (1) JP2002530296A (cs)
CN (1) CN100338051C (cs)
AR (1) AR029604A2 (cs)
AT (1) ATE232524T1 (cs)
AU (1) AU738526C (cs)
BR (1) BR9714924A (cs)
CA (1) CA2291068C (cs)
CZ (1) CZ296533B6 (cs)
DE (2) DE1032566T1 (cs)
DK (1) DK1032566T5 (cs)
EA (1) EA003132B1 (cs)
ES (1) ES2149141T4 (cs)
IL (1) IL135813A (cs)
IS (1) IS5473A (cs)
SK (1) SK6812000A3 (cs)
TR (1) TR200001314T2 (cs)
UA (1) UA62985C2 (cs)
WO (1) WO1998019511A2 (cs)
ZA (1) ZA9810059B (cs)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DK1042310T3 (da) 1997-11-11 2002-12-02 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
CA2291134C (en) * 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
AU764161B2 (en) 1998-12-23 2003-08-14 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
MXPA01010134A (es) 1999-04-14 2002-04-15 Lundbeck & Co As H Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
DK1298124T3 (da) * 1999-10-25 2007-07-09 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
WO2000012044A2 (en) 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
SK9282002A3 (en) 1999-12-28 2002-11-06 Lundbeck & Co As H Method for the preparation of citalopram, pharmaceutical composition comprising same and intermediates
ES2207312T3 (es) 1999-12-30 2004-05-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
UA72569C2 (uk) 2000-01-14 2005-03-15 Х. Луннбек А/С Спосіб одержання 5-ціанофталіду
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017417C1 (nl) * 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
HUP0300273A2 (hu) * 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás 5-szubsztituált 1-(4-fluorfenil)-1,3-dihidroizobenzofurán-származékok lépésenkénti alkilezésére
GR1004072B (el) * 2000-03-13 2002-12-02 H.Lundbeck A/S Μεθοδος παρασκευης της σιταλοπραμης
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
KR20020080481A (ko) 2000-03-13 2002-10-23 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
EA005094B1 (ru) 2000-03-14 2004-10-28 Х.Лундбекк А/С Способ получения циталопрама
WO2001068632A1 (en) * 2000-03-16 2001-09-20 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
US6491947B2 (en) 2000-11-03 2002-12-10 Chemlink Laboratories, Llc Expanded perborate salt, use, and method of production
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
ES2228824T3 (es) 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
DE60100016T2 (de) 2000-12-28 2003-04-17 H. Lundbeck A/S, Valby Verfahren zur herstellung von reinem citalopram
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
CN1660074A (zh) 2001-07-31 2005-08-31 H·隆德贝克有限公司 含有依他普仑的晶体组合物
US7196224B2 (en) * 2002-03-27 2007-03-27 Bando Chemical Industries, Ltd. 1,3,5-tris(arylamino)benzenes
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
WO2004026855A1 (en) * 2002-09-20 2004-04-01 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
ITMI20030479A1 (it) * 2003-03-13 2004-09-14 Adorkem Technology S P A Procedimento per la preparazione di un ciano-isobenzofurano.
CN101362743A (zh) 2003-03-21 2009-02-11 H.隆德贝克有限公司 用于制备西酞普兰和依他普仑的中间体
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram
EP1506963B1 (en) * 2003-10-28 2005-04-13 Adorkem Technology SpA Method for the preparation of citalopram
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
EP1723133A1 (en) * 2004-02-16 2006-11-22 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
EP2141156A1 (en) 2004-08-23 2010-01-06 Sun Pharma Global FZE Process for Preparation of Citalopram and Enantiomers
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (cs) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
RU2156763C2 (ru) * 1994-07-15 2000-09-27 Мейдзи Сейка Кабусики Кайся Азотсодержащие гетероциклические производные, фармацевтическая композиция на их основе и способ лечения или профилактики тромботических заболеваний
KR100357975B1 (ko) 1997-07-08 2002-10-25 하. 룬트벡 아크티에 셀스카브 시탈로프램의 제조방법
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DK1042310T3 (da) 1997-11-11 2002-12-02 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram

Also Published As

Publication number Publication date
ES2149141T1 (es) 2000-11-01
EP1032566B1 (en) 2003-02-12
WO1998019511A2 (en) 1998-05-14
EP1032566B9 (en) 2003-10-22
BR9714924A (pt) 2000-09-26
CN1286688A (zh) 2001-03-07
JP2002530296A (ja) 2002-09-17
CZ296533B6 (cs) 2006-04-12
CA2291068C (en) 2002-10-29
CN100338051C (zh) 2007-09-19
AU738526C (en) 2004-03-25
EA003132B1 (ru) 2003-02-27
EP1032566A2 (en) 2000-09-06
ES2149141T4 (es) 2004-11-16
CA2291068A1 (en) 1998-05-14
AU5116798A (en) 1998-05-29
IL135813A0 (en) 2001-05-20
IL135813A (en) 2003-07-31
US6291689B1 (en) 2001-09-18
DK1032566T5 (da) 2004-06-28
ZA9810059B (en) 1999-05-05
WO1998019511A3 (en) 1998-08-06
EA200000509A1 (ru) 2000-10-30
IS5473A (is) 2000-04-26
SK6812000A3 (en) 2000-10-09
DE69719098T2 (de) 2004-02-12
AU738526B2 (en) 2001-09-20
ES2149141T3 (es) 2003-10-01
DE1032566T1 (de) 2001-03-15
DK1032566T3 (da) 2003-06-10
UA62985C2 (en) 2004-01-15
AR029604A2 (es) 2003-07-10
DE69719098D1 (de) 2003-03-20
TR200001314T2 (tr) 2000-11-21
ATE232524T1 (de) 2003-02-15

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20081110