AR017266A1 - Compuesto azabenzoimidazolico, composicion farmaceutica que lo comprende, metodo para sintetizarlo, metodo para modular la funcion de una serina/treoninaproteina-quinasa con dicho compuesto, metodo para identificar compuestos que modulan tal funcion y uso del mismo para preparar una composicion farm - Google Patents
Compuesto azabenzoimidazolico, composicion farmaceutica que lo comprende, metodo para sintetizarlo, metodo para modular la funcion de una serina/treoninaproteina-quinasa con dicho compuesto, metodo para identificar compuestos que modulan tal funcion y uso del mismo para preparar una composicion farmInfo
- Publication number
- AR017266A1 AR017266A1 ARP980104793A ARP980104793A AR017266A1 AR 017266 A1 AR017266 A1 AR 017266A1 AR P980104793 A ARP980104793 A AR P980104793A AR P980104793 A ARP980104793 A AR P980104793A AR 017266 A1 AR017266 A1 AR 017266A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- homocyclic
- independently selected
- modulate
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un compuesto de azabenzoimidazolico que posee una estructura descripta por las formulas I, II o III, en donde (a) R1, R2, R3, y R4 se seleccionanindependientemente del grupo que integran: (i) hidrogeno; (ii) alquilo saturado o no saturado; (iii) NX2X3, donde X2 y X3 se seleccionan independientemente delgrupo que integran: hidrogeno, alquilo saturado o no saturado, y anillos homocíclicos o heterocíclicos; (iv) halogeno o trihalometilo; (v) una cetona deformula -CO-X4, donde X4 se selecciona del grupo que conforman hidrogeno, alquilo,y anillos homocíclicos o heterocíclicos; (vi) un ácido carboxílico de formula-(X5)n-COOH o éster de formula -(Xb)n-COO-X7 donde X5, X6 y X7 se seleccionan independientemente del grupo que integran alquilo o anillos homocíclicos oheterocíclicos, y donde n vale 0 o 1; (vii) un alcohol de formula (X8)n-OH o un grupo alcoxi de formula -(X8)n-O-X9, donde X8 y X9 se eligenindependientemente del grupo que conforman hidrogeno, alquilo saturado o no saturado, y anillos homocíclicos o heterocíclicos, donde el anillo se sustituyeopcionalmente con uno o varios sustituyentes elegidos del grupo que integran alquilo, alcoxi, halogeno, trihalometilo, carboxilato, nitro y éster, y donde nvale 0 o 1; (viii) una amida deformula -NHCOX10, donde X10 se selecciona del grupo que integran alquilo, hidroxilo, y anillos homocíclicos o heterocíclicos, ydonde el anillo se sustituye opcionalmente con uno o varios sustituyentes independientemente seleccionados del grupo que conforman alquilo, alcoxi, halogeno,trihalometilo, carboxilato, nitro y éster; (ix) -SO2NX33X12, donde X33 y X32 se seleccionan del grupo que integran hidrogeno, alquilo y anillos homocíclicos oheterocíclicos; (x) un anillo homocíclico o heterocíclicosustituido con uno, dos o tres sustituyentes seleccionados independientemente del grupo que conformanalquilo, alcoxi, halogeno, trihalometilo, caboxilato, nitro y éster; (xi) un aldehído de formula -CO-H; y (xii) una sulfona de formula -SO2-X13, donde X13 seelige del grupo que conforman alquilo saturado o no saturado y anillos homocíclicos o heterocíclicos; (b) Z1 y Z2 se seleccionan independientemente del grupo
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6014597P | 1997-09-26 | 1997-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR017266A1 true AR017266A1 (es) | 2001-09-05 |
Family
ID=22027657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980104793A AR017266A1 (es) | 1997-09-26 | 1998-09-25 | Compuesto azabenzoimidazolico, composicion farmaceutica que lo comprende, metodo para sintetizarlo, metodo para modular la funcion de una serina/treoninaproteina-quinasa con dicho compuesto, metodo para identificar compuestos que modulan tal funcion y uso del mismo para preparar una composicion farm |
Country Status (28)
Country | Link |
---|---|
US (2) | US6093728A (es) |
EP (1) | EP1017384B1 (es) |
JP (1) | JP2001517699A (es) |
KR (1) | KR100547929B1 (es) |
CN (1) | CN1167420C (es) |
AR (1) | AR017266A1 (es) |
AT (1) | ATE281834T1 (es) |
AU (1) | AU748849B2 (es) |
BG (1) | BG64784B1 (es) |
BR (1) | BR9812682A (es) |
CA (1) | CA2305370C (es) |
DE (1) | DE69827516T2 (es) |
DK (1) | DK1017384T3 (es) |
ES (1) | ES2230719T3 (es) |
HK (1) | HK1032206A1 (es) |
HU (1) | HUP0004024A3 (es) |
IL (4) | IL135109A0 (es) |
NO (1) | NO325663B1 (es) |
NZ (2) | NZ503432A (es) |
PL (1) | PL191618B1 (es) |
PT (1) | PT1017384E (es) |
RU (1) | RU2230553C2 (es) |
SK (1) | SK285357B6 (es) |
TR (1) | TR200001546T2 (es) |
TW (1) | TW581815B (es) |
UA (1) | UA72448C2 (es) |
WO (1) | WO1999016438A1 (es) |
ZA (1) | ZA988797B (es) |
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JP2004528304A (ja) * | 2001-03-12 | 2004-09-16 | アバニール・ファーマシューティカルズ | IgEを調節し、細胞増殖を阻害するためのベンゾイミダゾール化合物 |
TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
TWI276631B (en) * | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
WO2005013950A2 (en) * | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
GB0423554D0 (en) | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
EP1962892A4 (en) * | 2005-11-22 | 2011-10-12 | Univ South Florida | INHIBITION OF CELL PROLIFERATION |
CA2649994A1 (en) | 2006-04-26 | 2007-11-08 | Cancer Research Technology Limited | Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds |
EP2078016B1 (en) * | 2006-10-19 | 2012-02-01 | Signal Pharmaceuticals LLC | Heteroaryl compounds, compositions thereof, and methods of treatment therewith |
EP2839839B1 (en) * | 2007-02-28 | 2018-01-17 | Yeda Research And Development Company Limited | Nuclear targeting sequences |
JP5352476B2 (ja) | 2007-06-05 | 2013-11-27 | 武田薬品工業株式会社 | キナーゼ阻害剤としての二環式複素環化合物 |
US8324395B2 (en) | 2007-08-23 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US8344135B2 (en) | 2007-08-29 | 2013-01-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
DK2229391T3 (da) | 2007-12-19 | 2014-10-13 | Cancer Res Inst Royal | Pyrido[2,3-B]pyrazin-8-substituerede forbindelser og deres anvendelse |
GB0807609D0 (en) | 2008-04-25 | 2008-06-04 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
US20100184851A1 (en) * | 2008-08-29 | 2010-07-22 | University Of South Florida | Inhibition of cell proliferation |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
US8697874B2 (en) | 2008-12-01 | 2014-04-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
JP2012197231A (ja) * | 2009-08-06 | 2012-10-18 | Oncotherapy Science Ltd | Ttk阻害作用を有するピリジンおよびピリミジン誘導体 |
NZ599549A (en) | 2009-10-26 | 2013-11-29 | Signal Pharm Llc | Methods of synthesis and purification of heteroaryl compounds |
PL2531502T3 (pl) | 2010-02-01 | 2014-08-29 | Cancer Research Tech Ltd | 1-(5-tert-Butylo-2-fenylo-2H-pirazol-3-ilo)-3-[2-fluoro-4-(1-metylo-2-okso-2,3-dihydro-1H-imidazo[4,5-b]pirydyn-7-yloksy)-fenylo]-mocznik i związki pokrewne oraz ich zastosowanie w terapii |
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CN104093398B (zh) | 2011-12-02 | 2017-03-15 | 西格诺药品有限公司 | 7‑(6‑(2‑羟基丙烷‑2‑基)吡啶‑3‑基)‑1‑((反式)‑4‑甲氧基环己基)‑3,4‑二氢吡嗪并[2,3‑b]吡嗪‑2(1h)‑酮、其固体形式的药物组合物及其使用方法 |
BR112014020786A2 (pt) | 2012-02-24 | 2020-10-27 | Signal Pharmaceuticals, Llc | método para tratamento de câncer de pulmão, método para alcançar um critério de avaliação de resposta em tumores sólidos, método para aumento da sobrevivência |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
EP2945636B1 (en) | 2013-01-16 | 2017-06-28 | Signal Pharmaceuticals, LLC | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith |
EP2970277B1 (en) | 2013-03-15 | 2021-07-28 | Knopp Biosciences LLC | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
WO2014172432A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
WO2014172426A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
BR112015026021A2 (pt) | 2013-04-17 | 2017-07-25 | Signal Pharm Llc | terapia de combinação compreendendo um inibidor de tor quinase e n-(3-(5-flúor-2-(4-(2-met-oxietoxi)fenilamino)pirimidin-4-ilamino)fenil)acrilamida para o tratamento de câncer |
TW201527300A (zh) | 2013-04-17 | 2015-07-16 | Signal Pharm Llc | 關於1-乙基-7-(2-甲基-6-(1H-1,2,4-三唑-3-基)吡啶-3-基)-3,4-二氫吡并[2,3-b]吡-2(1H)-酮之醫藥調配物、方法、固態型式及使用方法 |
JP6382949B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ,エルエルシー | 癌を治療するためのtorキナーゼ阻害剤及び5−置換キナゾリノン化合物を含む組合せ療法 |
MX2015014589A (es) | 2013-04-17 | 2016-04-25 | Signal Pharm Llc | Tratamiento de cancer con dihidropirazino-pirazinas. |
EA029072B1 (ru) | 2013-04-17 | 2018-02-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Комбинированная терапия, включающая соединение дигидропиразинопиразина и антагонист рецептора андрогена для лечения рака простаты |
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NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
US9512129B2 (en) | 2014-04-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer |
US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
US9737535B2 (en) | 2014-04-16 | 2017-08-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines |
NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
WO2016010886A1 (en) | 2014-07-14 | 2016-01-21 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
FI3572405T3 (fi) | 2014-09-12 | 2023-09-22 | Knopp Biosciences Llc | Benzoimidatsol-1,2-yyli amidit kv7 kanavan aktivaattoreina |
IL271491B2 (en) | 2017-06-22 | 2023-09-01 | Celgene Corp | Treatment of carcinoma of the liver characterized by hepatitis b virus infection |
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US5645982A (en) * | 1993-08-19 | 1997-07-08 | Systemix, Inc. | Method for screening potential therapeutically effective antiviral agents |
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1998
- 1998-09-23 WO PCT/US1998/019973 patent/WO1999016438A1/en active IP Right Grant
- 1998-09-23 AT AT98949464T patent/ATE281834T1/de not_active IP Right Cessation
- 1998-09-23 US US09/160,212 patent/US6093728A/en not_active Expired - Fee Related
- 1998-09-23 IL IL13510998A patent/IL135109A0/xx not_active IP Right Cessation
- 1998-09-23 DE DE69827516T patent/DE69827516T2/de not_active Expired - Fee Related
- 1998-09-23 ES ES98949464T patent/ES2230719T3/es not_active Expired - Lifetime
- 1998-09-23 EP EP98949464A patent/EP1017384B1/en not_active Expired - Lifetime
- 1998-09-23 HU HU0004024A patent/HUP0004024A3/hu unknown
- 1998-09-23 JP JP2000513574A patent/JP2001517699A/ja not_active Withdrawn
- 1998-09-23 CA CA002305370A patent/CA2305370C/en not_active Expired - Fee Related
- 1998-09-23 BR BR9812682-2A patent/BR9812682A/pt not_active Application Discontinuation
- 1998-09-23 DK DK98949464T patent/DK1017384T3/da active
- 1998-09-23 PT PT98949464T patent/PT1017384E/pt unknown
- 1998-09-23 AU AU95781/98A patent/AU748849B2/en not_active Ceased
- 1998-09-23 RU RU2000110736/15A patent/RU2230553C2/ru not_active IP Right Cessation
- 1998-09-23 PL PL339744A patent/PL191618B1/pl not_active IP Right Cessation
- 1998-09-23 SK SK415-2000A patent/SK285357B6/sk unknown
- 1998-09-23 NZ NZ503432A patent/NZ503432A/xx unknown
- 1998-09-23 UA UA2000042349A patent/UA72448C2/uk unknown
- 1998-09-23 IL IL15864998A patent/IL158649A0/xx not_active IP Right Cessation
- 1998-09-23 CN CNB988107538A patent/CN1167420C/zh not_active Expired - Fee Related
- 1998-09-23 KR KR1020007003192A patent/KR100547929B1/ko not_active IP Right Cessation
- 1998-09-23 TR TR2000/01546T patent/TR200001546T2/xx unknown
- 1998-09-25 TW TW087115979A patent/TW581815B/zh not_active IP Right Cessation
- 1998-09-25 ZA ZA9808797A patent/ZA988797B/xx unknown
- 1998-09-25 AR ARP980104793A patent/AR017266A1/es unknown
-
2000
- 2000-03-15 IL IL135109A patent/IL135109A/en unknown
- 2000-03-24 NO NO20001555A patent/NO325663B1/no unknown
- 2000-04-19 BG BG104356A patent/BG64784B1/bg unknown
-
2001
- 2001-04-23 HK HK01102854A patent/HK1032206A1/xx not_active IP Right Cessation
-
2002
- 2002-03-15 NZ NZ517808A patent/NZ517808A/en unknown
- 2002-11-15 US US10/294,802 patent/US6855723B2/en not_active Expired - Fee Related
-
2003
- 2003-10-29 IL IL158649A patent/IL158649A/en unknown
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